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Open Journal of Pathology 2015年第1期5卷 1-7页

作者： Kazuhiro Kobayashi Masashi Matsuyama Fumimasa Etori Naomi Kawaguchi Kyoko Nambu asuka Sekiya Yuka Hiraku Kazushige Yamamoto Naoki Watanabe Tetsuya Yamada Takuji Tanaka Department of Tumor Pathology Gifu University Graduate School of Medicine Gifu City Japan Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospial Gifu City Japan Department of Obstetrics & Gynecology Gifu Municipal Hospial Gifu City Japan Department of Diagnostic Pathology Kizawa Memory Hospital Minokamo City Japan

An 84-year-old woman suffered from post-menopausal genital bleeding for 3 months. Based on the endometrial cytological findings (suggestive of high grade neuroendocrine carcinoma) showing that there were rosette-like and cord-like structures consisting of small rounded tumor cells with oval nuclei and scanty cytoplasm, radical hysterectomy was performed. Histopathological and immunohistochemical examinations on the operated specimens revealed primary high grade neuroendocrine carcinoma of the endometrium. Despite the extensive treatment against the malignancy, the patient died due to widespread metastases after 5 months after the surgery and autopsied.

关键词： Endometrium High Grade Neuroendocrine Carcinoma Undifferentiated Carcinoma Neuroendocrine Cells

THE DEATH OF TEXT MESSAGING

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中学生天地（高中学习版）（C版） 2013年第9期 37-37页

作者：徐元 asuka

Nowadays there are so many different ways of messaging someone that it could make people give up the traditional text *** messaging is the art of sending a short,electronic message between two *** in the last few year... 详细信息

关键词：中学英语课外阅读阅读材料

寻找当代的马丘比丘--秘鲁建筑师路易斯•隆吉的冒险之旅(使命)

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世界建筑导报 2021年第4期36卷 6-7页

作者：石泽玛雅不详

1911年,美国探险家海勒姆•宾厄姆发现了当今最具标志性的印加建筑群--马丘比丘。即使这一事件被称为“发现”,当地人引导海勒姆•宾厄姆所到之地是15世纪所建造的梯田“安迪内斯”遗址,而西班牙人在“发现”之前一个世纪就已到达印加土... 详细信息

1911年,美国探险家海勒姆•宾厄姆发现了当今最具标志性的印加建筑群--马丘比丘。即使这一事件被称为“发现”,当地人引导海勒姆•宾厄姆所到之地是15世纪所建造的梯田“安迪内斯”遗址,而西班牙人在“发现”之前一个世纪就已到达印加土地。幸运的是,马丘比丘未并被西班牙殖民者发现,并且在植被的覆盖下保存了近500年之久。在海勒姆•宾厄姆为该印加建筑群带来价值时,秘鲁民族国家建设核心是关于民族认同的讨论,这一过程从1821年开始,且尚未得到巩固。马丘比丘和乌鲁班巴河谷的其他印加考古遗址被选为这个新生国家的象征。印加建筑成为秘鲁身份创立的利用最多的象征。然而,在286年的殖民化和基督教化过程中,土著人民、印加文明的继承者及其传统没有受到轻视。尽管如此,适应能力较强的安第斯社区人民仍坚持守护他们在马丘比丘等建筑中获得的世界观/传统知识。

关键词：基督教化马丘比丘西班牙殖民者民族国家建设考古遗址西班牙人民族认同殖民化

Epigenetic Aberrant Hypermethylation of DNA in Endometrial Cancer: Application as a Biomarker

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Journal of Cancer Therapy 2011年第5期2卷 610-615页

作者： asuka Ono Iori Kisu Kouji Banno Megumi Yanokura Kenta Masuda Yusuke Kobayashi Kosuke Tsuji Arisa Ueki Wataru Yamagami Hiroyuki Nomura Nobuyuki Susumu Daisuke Aoki 不详

Endometrial cancer is the seventh most common cancer worldwide among females and accounts for about 40% of cancers of the uterus in Japan. An increase in incidence and a reduction in onset age of this disease are also likely, which makes it important to define the pathogenesis and develop effective treatment. However, the mechanism of canceration in the endometrium is unclear and development of endometrial cancer cannot be explained only by mutations of cancer-related genes. In contrast, epigenetic analyses have shown the importance of aberrant DNA hypermethylation in the canceration mechanism. In development of type 1 endometrial cancer, breakdown of the DNA mismatch repair system plays a large role, with changes in the human mutL homologue 1 (hMLH1) gene being of most importance. Studies to detect aberrant DNA hypermethylation of cancer cells present in microscopic amounts in vivo and to apply these data to diagnosis of cancer have been started. Epigenetic changes have also been examined as a marker of sensitivity to anticancer drugs. Aberrant hypermethylation of checkpoint with forkhead-associated and ring finger (CHFR), a mitotic phase checkpoint gene, is correlated with sensitivity to treatment with microtubule inhibitors and may be a marker for the response of endometrial cancer to anticancer drugs. Epigenetic aberrant DNA methylation of other genes may also be useful as clinical biomarkers for diagnosis and treatment of endometrial cancer.

关键词： Epigenetics Endometrial Cancer Aberrant DNA Hypermethylation hMLH1 CHFR Biomarker

A Case of Warthin’s Tumor Together with IgG4-Related Sialadenitis

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Open Journal of Pathology 2024年第3期14卷 81-89页

作者： Ryogo Aoki Risa Ito asuka Ohashi Riyoko Niwa Masashi Matsuyama Sachiko Oka Naomi Kawaguchi Toshimasa Sakakima Daichi Kodama Naoki Watanabe Daisuke Okamoto Takafumi Naiki Takuji Tanaka Department of Diagnostic Pathology (DDP) & Research Center of Diagnostic Pathology (RC-DiP) Gifu Municipal Hospital Gifu Japan Department of Central Clinical Laboratory Gifu Municipal Hospital Gifu Japan Department of Hematology Gifu Municipal Hospital Gifu Japan

Warthin’s tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland. The tumor contains the epithelial oncocyte cells with the presence of rich-mitochondria and their surrounding abundant lymphocytes. A relatively new disease entity of IgG4-related disease frequently occurs in the salivary gland. However, the coexistence of Warthin’s tumor and IgG4-related disease is scarcely observed. We have recently experienced a rare case of Warthin’s tumor with IgG4-related sialadenitis. A 51-year-old man presented to our hospital, complaining of a mass with right submandibular tenderness and spontaneous pain. A computed tomography scan of the cervical region revealed a suspicion of lymph node proliferative disease, including malignant lymphoma. Elevated serum levels of IL-2R: 1843 U/ml (reference value 122 - 496 U/ml), IgG: 3430 mg/dl (reference value 861 - 1747 mg/dl), and IgG4: 3140 mg/dl (reference value 11 - 121 mg/dl) were observed. Other laboratory data showed within normal ranges. The cervical tumor was diagnosed as Warthin’s tumor by the findings of fine-needle aspiration cytology and biopsy examination. Immunohistochemistry revealed numerous IgG4- and IgG-positive cells with fibrosis surrounding the epithelial component of Warthin’s tumor, suggesting IgG4-rerated sialadenitis. Finally, we diagnosed the cervical tumor as Warthin tumor with IgG4-related sialadenitis. This is the second report describing a case of Warthin’s tumor with possible involvement of IgG4-related sialadenitis.

关键词： Warthin’s Tumor Sialadenitis IgG4-Related Disease Immunohistochemistry

Long-term survival of more than 3 years among patients with advanced non-small cell lung cancer treated with chemotherapy

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World Journal of Respirology 2013年第3期3卷 110-115页

作者： Rieko Kaira Kyoichi Kaira Takehito Shukuya Hirotsugu Kenmotsu Akira Ono Haruyasu Murakami asuka Tsuya Yukiko Nakamura Tateaki Naito Masahiro Endo Nobuyuki Yamamoto Toshiaki Takahashi Division of Thoracic Oncology Shizuoka Cancer Center Sunto-gun Shizuoka 411-8777 Japan Division of Diagnostic Radiology Shizuoka Cancer Center Sunto-gun Shizuoka 411-8777 Japan

AIM: To evaluate the prognostic factors of long-term survival of more than 3 years in patients with advanced non-small cell lung cancer(NSCLC). METHODS: We retrospectively analyzed the records of 474 patients with advanced ⅢB/Ⅳ NSCLC who received chemotherapy as initial treatment between September 2002 and March ***: The median survival time(MST) was 12.5 mo and the 3 year and 5 year survival rates were 14.6% and 5.3%, respectively. Long-term survival of more than 3 and 5 years was observed in 65 and 16 patients, respectively. The MST for the 65 patients was61.5 mo(range, 60.1-81.0 mo). In the 474 patients, a good performance status(PS), female sex, non-smoking status and adenocarcinoma histology were significantly associated with a favorable outcome. Furthermore, female sex, a good PS, non-smoking status and adenocarcinoma histology were significantly correlated with longterm survival of more than 3 years and most of these patients(89.2%, 58/65) received epidermal growth factor receptor-tyrosine kinase inhibitors as any line treatment. Survival analysis of long-term survivors showed that a PS of 0 was an independent prognostic factor for predicting favorable outcomes. CONCLUSION: Our results suggest that a good PS and adenocarcinoma histology play an important role in long-term survival of more than 3 years. A PS of 0 was an independent prognostic factor for predicting favorable outcomes in patients with advanced NSCLC who survived for more than 3 years.

关键词： Non-small cell lung cancer Long-term survivor Chemotherapy Performance status Epidermal growth factor receptor-tyrosine kinase inhibitors

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人见人爱GIRL高雅配色新法则

国际服装技术 2006年第2期 20-27页

作者： Kaz Ogawa（model）（摄影） Yoshihito ishizawa（still）（摄影） Ayako Yonaga Xi Yanfeng（翻译）

在办公室提升个人好感度、人见人爱的颜色组合是本次的主题SHIHO十分中意今冬流行的绿色和粉色相互搭配。办公室造型还是以协调的颜色为根本，以打造可爱风格为目标。运用优雅浓郁的颜色，让心情也变得暧和起来。

关键词：法则配色办公室颜色色组

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天使怪盗,出动！

少年人生 2005年第21期 6-7页

作者：衫崎由琦琉 D.N.ANGEL/asuka

眼前这张漂亮到没话说让人敲桌子掉眼珠的美丽彩图,唤起了心底对***这漫画回忆, 好像已经很久没有在看了……毕竟,现在红火的漫画有那么多也怪不得读者们看花了眼。只是杉崎由绮琉实在狡诈,把彩图画的那么漂亮,只是拿出来在你面前轻轻... 详细信息

眼前这张漂亮到没话说让人敲桌子掉眼珠的美丽彩图,唤起了心底对***这漫画回忆, 好像已经很久没有在看了……毕竟,现在红火的漫画有那么多也怪不得读者们看花了眼。只是杉崎由绮琉实在狡诈,把彩图画的那么漂亮,只是拿出来在你面前轻轻一晃。

关键词：人能

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Mimetic Word

中学生天地（高中学习版）（C版） 2012年第12期 32-32页

作者：蒋国东 asuka

在看欧美影视剧时，你有没有发现剧中人物经常会说一些象声词（mimetic word）？通过语境不难揣测它们所要传达的意思或语气，但在平时的对话中，你会想到使用它们吗？

关键词：中学英语课外阅读阅读材料

Happiness Is a Choice

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中学生天地（高中学习版）（C版） 2011年第3期 53-53页

作者：吕吉尔 asuka

Are you happy? Everyone seems to be in search for *** say that "I’ll be happy when I get my new promotion." Or,"I’ll be happy when I have an expensive car." The list goes on and *** probably have a few of your own t... 详细信息

关键词：中学英语课外阅读阅读材料