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Epidemiological and Diagnostic Profile of Patients with Chronic Hepatitis B Virus from 2017 to 2021 in Parakou, Republic of Benin

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Advances in Infectious Diseases 2024年第1期14卷 147-161页

作者： Khadidjatou Saké Cossi Angelo Attinsounon Aboudou Raϊmi Kpossou Morayo Omm Ani Salami astrid alexandrine hountondji Kofi-Mensa Savi de Tovè Rhonel Ahanhanzo-Glèlè Kpémahoun René Kèkè Sossa Edmond Gbédo Jean Sehonou Nicolas Kodjoh Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Benin Department of Medicine and Medical Specialties Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Health Program to Fight AIDS Cotonou Benin National Program for the Control of Hepatitis Cotonou Benin

Introduction: Viral hepatitis B is a public health problem worldwide. The objective of this study was to determine the epidemiological and diagnostic profile of chronic carriers of hepatitis B virus seen for gastroenterology consultations in Parakou, Republic of Benin. Patients and Methods: This was a cross-sectional and descriptive study with retrospective data collection. Patients seen for gastroenterology consultations from January 1, 2017 to June 30, 2021 at the Regional Teaching Hospital of Borgou/Alibori (CHUD-B/A) and having been diagnosed as chronic carriers of hepatitis B virus were included. A minimum initial assessment was required to be included. The minimum sample size was calculated with Schwartz formula. The variable of interest was the detection of HBsAg twice and at least 6 months apart. The other variables studied were sociodemographic, clinical and paraclinical data. The data collected were analyzed using SPSS 17 software. Results: A total of 2786 patients were seen for gastroenterology consultations, including 1126 (40.4%) HBsAg-positive patients. Among them, 417 patients met the inclusion criteria and were the subject of the present study. The average age of the patients was 34.8 ± 10.5 years. Two hundred and forty-seven patients (65.7%) were male, representing a sex ratio of 1.9. The discovery of positive HBsAg status was made during systematic screening in 231 patients (55.4%). Scarifications were noted in 373 patients (89.4%). Asthenia was reported in 184 patients (44.1%). Co-infections with human immunodeficiency virus, hepatitis C and D viruses were 0% (0 in 92), 2.8% (4 in 146) and 14.3% (2 in 146), respectively. During the initial assessment, 274 patients (65.7%) were sero-negative for chronic HBeAg infection, 21 (5%) had clinically significant fibrosis including 16 (3.8%) at the stage of cirrhosis and 7 patients (5.4%) had hepatocellular carcinoma. Conclusion: In Parakou, chronic hepatitis B virus infection is common and affects young pe

关键词： Chronic Infection HBV Epidemiology Diagnosis Parakou

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Indications and Findings of Upper Gastrointestinal Endoscopy in Elderly Patients in Parakou, Republic of Benin

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Open Journal of Gastroenterology 2023年第12期13卷 411-419页

作者： Khadidjatou Sake Dénis Coffi Fanou Euloge Houndonougbo Marie-Claire Balle astrid alexandrine hountondji Aboudou Raïmi Kpossou Luc Valère Codjo Brun Jean Sehonou Nicolas Kodjoh Faculty of Medicine University of Parakou Parakou Benin Hepato-Gastroenterology Unit Military Hospital—Teaching Hospital of Parakou Parakou Benin Hepato-Gastroenterology Unit Saint Jean de Dieu Hospital of Tanguiéta Tanguiéta Benin Faculty of Health Sciences University of Abomey-Calavi Abomey-Calavi Benin

Introduction: Elderly people are considered fragile and at greater risk of having malignant gastrointestinal tumors. The objective of this work was to report the reasons for performing gastrointestinal endoscopy and the lesions found during the endoscopy of this target population in Parakou. Patients and Study Methods: This was a descriptive and cross-sectional study with a retrospective collection of data from January 2016 to December 2017, then from January 2020 to December 2021. It took place in the Regional Teaching Hospital of Borgou-Alibori in Parakou and in the private gastrointestinal endoscopy center of Parakou (Northern Gastrointestinal Exploration Center). All patients aged at least 60 years who had undergone an upper gastrointestinal endoscopy during the study period were included. The variables studied were: the sex, age, indications for the examination, endoscopic lesions and data from the anatomo-pathological examination. Results: In total, out of 1540 upper gastrointestinal endoscopies performed during the study period, 249 (16.17%) involved patients aged 60 years and over. The sex ratio was 1.26. The main indication for the examination was epigastric pain (123 cases, i.e. 49.40%) followed by vomiting (53 cases, i.e. 21.29%). In terms of lesions, non-tumorous gastropathy came first in the stomach (206 cases, i.e. 82.73%) while esophageal lesions were dominated by esophageal candidiasis and cardial incompetence (39 cases, i.e. 15.66% in each of the two situations). In the duodenum, ulcer was noted in 30 patients (12.05%). In 38 patients, 12 (31.58%) were tested positive for Helicobacter pylori infection. Cancers of the gastrointestinal tract were confirmed in 11 patients (4.42%). Conclusion: Upper gastrointestinal endoscopy remains an excellent examination for the exploration of the upper gastrointestinal tract. In Parakou, epigastric pain represents the main indication for this examination in subjects over 60 years of age. Inflammatory or ulcerated n

关键词： Upper Gastrointestinal Endoscopy Elderly Subjects Inflammatory Gastropa-thy Candidiasis Cancer Parakou

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Endoscopic Aspects of Caustic Injuries of the Upper Gastrointestinal Tract in Parakou, Benin Republic: A Multicenter Study

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Journal of Biosciences and Medicines 2023年第10期11卷 15-24页

作者： Saké Khadidjatou Fanou Coffi Dénis Agbeille Mohamed Falilatou hountondji astrid alexandrine Tamou Sambo Bio Elie Tchaou Blaise Adélin Sehonou Jean Kodjoh Nicolas Faculty of Medicine University of Parakou Parakou Benin Military Teaching Hospital-Regional Teaching Hospital of Parakou Parakou Benin Faculty of Health Sciences University of Abomey Calavi Cotonou Benin

Objective: Caustic ingestion is a medico-surgical emergency. The objective of this study is to describe endoscopic lesions of the upper gastrointestinal tract secondary to caustic ingestion in Parakou, Benin Republic. Patients and Methods: This was a retrospective and descriptive cross-sectional study. The study was multicenter in the gastrointestinal endoscopy units of the Teaching Hospital Center of Borgou-Alibori and the Military Teaching Hospital of Parakou. It covered the period from July 2015 to October 2021. This included any patient who ingested a caustic substance and performed a gastroscopy in one of the two endoscopy units. The variables studied were: socio-demographic data, the nature of the caustic substance ingested, the time between the caustic ingestion and the performance of gastroscopy and injuries of the upper gastrointestinal tract. Results: Out of the 24 patients included, 19 were men, i.e. a sex ratio of 3.8. Their average age was 25.54 ± 12.04 years with extremes of 6 and 50 years. Five subjects (20.83%) were under the age of 18 and the ingestion was accidental in them. Among the 19 patients aged at least 18 years, caustic ingestion was voluntary in 14 (73.68%). The caustic substance ingested was either a base (sodium hydroxide or caustic soda) or an acid (sulfuric acid) in 14 cases (58.33%) and 10 cases (41.67%), respectively. The time between the caustic ingestion and the performance of gastroscopy varied from 1 to 1095 days. The endoscopic lesions objectified were: stenosis (37.5%), ulcerations (29.17%), necrosis (20.83%), or erythema (12.25%). Conclusion: In Parakou, caustic ingestion, usually bases, is often voluntary in adult men. Endoscopic lesions were often ulcerative but sometimes necrotic.

关键词： Caustic Injuries Bases Acids Endoscopy Parakou

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