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Nutraceutical with Anti-Inflammatory Activity for the Management of Airway Remodeling in Bronchial Asthma: Kalanchoe integraVar. Crenata (Andr.) Cuf Leaf Extract

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Pharmacology & Pharmacy 2014年第3期5卷 250-261页

作者： asiedu-gyekye isaac julius Awortwe Charles Nyamekye Effah Samuel Antwi Daniel Ansong Seidu Mahmood Adjei Samuel Banga N’guessan Benoit Kwame Amoateng Patrick Nkansah Edwin Department of Animal Experimentation Noguchi Memorial Institute for Medical Research College of Health Sciences Legon Ghana Department of Chemical Pathology School of Allied Health Sciences College of Health Sciences Korle-Bu Ghana Department of Pharmacology and Toxicology University of Ghana School of Pharmacy College of Health Sciences Legon Ghana Department of Physiology University of Ghana Medical School Col-lege of Health Sciences Korle-Bu Ghana Division of Pharmacology Faculty of Health Sciences University of Stellenbosch Cape Town South Africa

Background: Kalanchoe integra is widely used in folklore medicine as an antiasthmatic agent. Previous studies have shown the ameliorating effect of Kalanchoe integra leaf extract [KILE] on bronchial hyperesponsiveness and inflammation. Further, the stabilizing effect of Kalanchoe sp on mast cell degranulation, suggests that Kalanchoe species are suitable candidates for allergic asthma therapy. This study is designed to investigate the anti-asthmatic potential of KILE and monitor the accompanying histopathological and immunobiochemical changes that occur in an animal model of bronchial asthma using ovalbumin sensitized guinea pigs. Method: Thirty male guinea pigs were divided into five groups of six animals each. Bronchial asthma was simulated in guinea pigs using ovalbumin. Both low dose (300 mg/kg) and high dose extract (900 mg/kg) were administered daily for 42 days. Prednisolone (2.5 mg/kg) was the standard drug used. Results: Guinea pigs in all KILE treated groups maintained the integrity of their airway structures: bronchial folds and walls, alveoli, alveolar ducts and sacs. KILE and prednisolone caused a reduction in immune parameters (p 0.001), extent of bronchoconstriction, bronchial wall thickness and goblet cell accumulation in the sensitized guinea pigs. Conclusion: This study demonstrates the anti-asthmatic potential of KILE during prolonged administration by the oral route.

关键词： Kalanchoe Integra Asthma Bronchoconstriction Goblet Cells Perivascular Oedema

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Modelling the Potential Distribution of Vitellaria paradoxasubsp. nilotica(C.F. Gaertn) across the Kidepo Landscape of Uganda in the Face of Climate Change

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Journal of Geoscience and Environment Protection 2020年第8期8卷 14-24页

作者： isaac Tom Okurut John Bosco Lamoris Okullo Daniel Waiswa julius Muyizzi Department of Environmental Management School of Forestry Environmental and Geographical Sciences College of Agricultural & Environmental Sciences Makerere University Kampala Uganda Department of Forestry Biodiversity & Tourism School of Forestry Environmental and Geographical Sciences College of Agricultural & Environmental Sciences Makerere University Kampala Uganda Department of Geography Geo-Informatics and Climatic Sciences School of Forestry Environmental and Geographical Sci-ences College of Agricultural & Environmental Sciences Makerere University Kampala Uganda Department of Policy Planning and Information GIS and Remote Sensing Section National Environment Management Authority Kampala Uganda

Climate change and human activities are increasingly linked with the extinction of species globally. In semi-arid regions, these pressures threaten the natural distribution and ecology of species. The threat that the shea butter tree (Vitellaria paradoxa subsp. nilotica) faces from human activity is well researched yet the sensitivity of its distribution to climate change remains barely known. We set out to assess the potential distribution of Vitellaria under different climate change scenarios using a MaxEnt. A current distribution model was first developed using only biophysical variables of soil type, temperature, precipitation, land use type, and elevation. This model was then projected onto two global warming scenarios (RCP 4.5 & RCP 8.5) for 2050 and 2070 using multi-model averages (BCC-CSM, CSM4, and MIROC5) derived from three general circulation models. Reductions are seen in distribution area across the landscape with soil type being the most important variable. These results draw useful implications for conservation of Vitellaria in that they show how it is vulnerable is to a changing climate as its natural range is mostly reduced. Since climate change is important in the distribution of the shea butter tree, the areas with highest suitability in this study can be used in establishing the Shea butter tree sustainable use zones/area within the Kidepo Critical Landscape (KCL), Uganda.

关键词： Mapping Biophysical Variables General Circulation Models Dry Land MaxEnt

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水处理动态

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工业水处理 2005年第12期25卷 72-72页

作者： KEVIN A．KITZMAN julius isaac 纪永亮

冷却水的化学和非化学处理比较，从原水分析到蒸汽纯度。

关键词：水处理化学处理冷却水水分析

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