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Long-term effectiveness of luteinizing hormone-releasing hormone agonist or antiandrogen monotherapy in elderly men with localizect prostate cancer （T1-2）： a retrospective study

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Asian Journal of Andrology 2007年第2期9卷 253-258页

作者： Rupesh Raina Geetu Pahalajani ashok Agarwal Craig Zippe Department of Medicine and Pediatrics Metrohealth Medical Center （Case School of Medicine） Cleveland Ohio 44109 USA Glickman Urological Institute Cleveland Clinic Foundation at Mary Mount Cleveland Clinic Foundation Ohio 44125 USA

Aim： To evaluate the long-term effectiveness, side effects and compliance rates of two types of drugs （luteinizing hormone-releasing hormone [LHRH] agonist and antiandrogen） that were used individually to treat patients with localized prostate cancer （T1-2） at our institution. Methods： Ninety-seven patients who were diagnosed in the period from April 1997 to January 2000 as having clinically localized prostate cancer （T1-2） received either LHRH agonist （leuprolide acetate 7.5 mg/month） monotherapy （group 1, n = 62） or antiandrogen monotherapy （group 2, n = 35; 18 received bicalutamide 50 mg q.d., 13 received nilutamide 150 mg t.i.d, and 4 received flutamide 250 mg t.i.d.）. The mean age in both groups was 76 years. Results： The mean follow-up time was （50.8 ±8.5） months in group 1 and （43.1 ± 2.2） months in group 2. Prostate-specific antigen （PSA） levels rose in only 1 of the 62 patients （1.6%） in group 1, and in 20 of the 35 patients （57.1%） in group 2. In group 2, 10 of the 20 patients （50 %） with increasing PSA levels were treated with LHRH salvage therapy, and eight （80%） responded. Hot flashes （54.8%） and lethargy （41.9%） were the most common side effects in group 1. In contrast, nipple-tenderness （40%） and light-dark adaptation （17.1%） were more often seen in group 2. Only 1 of the 62 patients （1.6%） in group 1 switched to another medication because of adverse side effects; whereas 8 of the 35 patients （22.9%） in group 2 did so. Conclusion： Unlike antiandrogen monotherapy, LHRH agonist monotherapy provided long-term durable control of localized prostate cancer （T1-2）. It can also be an effective treatment option for patients whose disease failed to respond to antiandrogen monotherapy. The limitations of our study are the lack of health outcomes analysis and a small sample size.

关键词： localized prostate cancer antiandrogen prostate-specific antigen luteinizing hormone-releasing hormone agonist androgen ablation monotherapy

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Novel Lyapunov-based rapid and ripple-free MPPT using a robust model reference adaptive controller for solar PV system

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Protection and Control of Modern Power Systems 2023年第1期8卷 205-229页

作者： Saibal Manna ashok Kumar Akella Deepak Kumar Singh Department of Electrical Engineering National Institute of Technology JamshedpurJharkhand 831014India

The technological,economic,and environmental benefits of photovoltaic(PV)systems have led to their wide-spread adoption in recent years as a source of electricity ***,precisely identifying a PV system’s maximum power point(MPP)under normal and shaded weather conditions is crucial to conserving the maximum generated *** of the biggest concerns with a PV system is the existence of partial shading,which produces multiple peaks in the P–V characteristic *** these circumstances,classical maximum power point tracking(MPPT)approaches are prone to getting stuck on local peaks and failing to follow the global maximum power point(GMPP).To overcome such obstacles,a new Lyapunov-based Robust Model Reference Adaptive Controller(LRMRAC)is designed and implemented to reach GMPP rapidly and *** proposed controller also achieves MPP accurately under slow,abrupt and rapid changes in radiation,temperature and load *** and OPAL-RT real-time simulators in various scenarios are performed to verify the superiority of the proposed approach over the other state-of-the-art methods,i.e.,ANFIS,INC,VSPO,and P&*** and GMPP are accomplished in less than 3.8 ms and 10 ms,*** on the results presented,the LRMRAC controller appears to be a promising technique for MPPT in a PV system.

关键词： Photovoltaic(PV) MPPT Partial shading Lyapunov-based robust model reference adaptive control(LRMRAC) Lyapunov stability

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Development of multi-functional nano-paint for energy harvesting applications

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Progress in Natural Science:Materials International 2018年第1期28卷 1-6页

作者： Bir B.Bohara ashok K.Batra Department of Physics Chemistry and Mathematics (Materials Science Group) College of Engineering Technology and Physical Sciences Alabama A&M University

The multi-functionality of lead magnesium niobate-lead titanate/paint（PMN-PT/paint） nanocomposite films for energy harvesting via piezoelectric and pyroelectric effects is described. PMN-PT/paint films have been fabricated by a conventional paint-brushing technique to provide a low-cost, low-temperature and low–energy route to create multi-functional films. The properties investigated included dielectric constants, ε' and ε'', as a function of temperature, frequency and composition. From these parameters, it is indicated that the dielectric constants and AC conductivity(σAC) increase with an increase of filler content and temperature, implying an improvement of the functionality of the films. The results revealed that σACobeyed the relation σAC=Aωs, and exponents, was found to decrease by increasing the temperature. The correlated barrier hopping was the dominant conduction mechanism in the nanocomposite films. The efforts were made to investigate the performance of nanocomposite films to mechanical vibrations and thermal variations. A cantilever system was designed and examined to assess its performance as energy harvesters. The highest output voltage and power for a PMN-PT/paint based harvester with a broad frequency response operating in the-31-piezoelectric mode were 65 mV and 1 nW, *** and power were shown to be enhanced by application of thermal variations. Thus, films could be utilized for combined energy harvesting via piezoelectric and pyroelectric characteristics.

关键词： Dielectric Pyroelectricity Piezoelectricity Nanocomposites PMN-PT Energy harvesting

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Preliminary slope stability analysis and discontinuities driven susceptibility zonation along a crucial highway corridor in higher Himalaya, India

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Journal of Mountain Science 2020年第4期17卷 801-823页

作者： Barsa ACHARYA Kripamoy SARKAR ashok Kumar SINGH Sowmiya CHAWLA Department of Applied Geology Indian Institute of Technology(Indian School of Mines)Dhanbad826004India Department of Civil Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad826004India

Identification of failure susceptible slopes through different rock engineering approach is highly valuable in landslide risk management along crucial highway corridors in the high mountainous region. In this study, a critical highway(NH-5) segment in higher Himalaya has been investigated using the various rock mass characterization schemes based on detailed field observations. Since the highway corridor is highly susceptible to discontinuities-driven failures, consisting of jointed rock masses;Mean and Combined kinematic feasibility analysis has been performed for 20 highway slopes. Observed slope mass classes have been compared to the feasibility percentage of discontinuities driven failures(wedge, toppling, and planar) and accordingly the kinematic feasibility zonation along highway segment has been done for each as well as overall failure types. Based on the slope mass conditions and discontinuities driven failures probability(%), responsive remedial measures have been proposed for individual highway slopes to ensure safe and uninterrupted transportation.

关键词： Slope characterization Kinematic analysis Failure zonation map Himalayan highways Landslide Slope stability

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Proteomic analysis reveals dysregulated cell sign aling in ejaculated spermatozoa from in fertile men

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Asian Journal of Andrology 2019年第2期21卷 121-130页

作者： Luna Samanta Rakesh Sharma Zhihong Cui ashok Agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Zoology School of Life SciencesRavenshaw UniversityCuttackOdisha 753003India Institute of Toxicology The Third Military Medical UniversityChongqing 400038China

Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile *** from infertile men were fractioned on three-layer density gradient(80%,60%,and 40%).Fraction 1(Fl)refers to the least mature stage having the lowest den sity,whereas the fraction 4(F4)in eludes the most dense and morphologically mature motile *** 2(F2)and fraction 3(F3)represent the intermediate *** were extracted and separated by dimensional *** were digested with trypsin and analyzed on a LTQ-Orbitrap Elite hybrid mass spectrometer *** annotations of proteins were obtained using bioinformatics tools and pathway databases.A total of 1585 proteins were detected in the four fractions of spermatozoa.A dysregulated protein turnover and protein folding may lead to accumulation of defective proteins or proteins that otherwise would have been eliminated during the process of maturation,resulting in the impairment of sperm fun *** nt chaper one expressi on may be a major con tributing factor to the defective sperm *** n receptor was predicted as a transcription regulator in one of the networks and the affected pathways were chaperone-mediated stress response,proteosomal pathway,and sperm *** down regulation of key pathways and protei ns which compromises the fertilizi ng potential of spermatozoa may provide in sight into the mecha nisms that lead to male infertility.

关键词： androgen receptor chaperone immature sperm infertile men proteasome spermatozoa

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Long-term liver allograft fibrosis:A review with emphasis on idiopathic post-transplant hepatitis and chronic antibody mediated rejection

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World Journal of Hepatology 2022年第8期14卷 1541-1549页

作者： Mukul Vij ashwin Rammohan Mohamed Rela Department of Pathology Dr.Rela Institute and Medical CenterChennai 600044Tamil NaduIndia Institute of Liver disease and Transplantation Dr.Rela Institute and Medical CenterChennai 600044Tamil NaduIndia

Liver transplantation(LT)is a life-saving surgical procedure and the current standard of care for most patients with end stage liver *** improvements in organ preservation techniques,perioperative care,and immunosuppression,there is better patient and graft survival following LT,and assessment of the liver allograft in long-term survivors is becoming increasingly *** or de novo viral or autoimmune injury remains the most common causes of chronic hepatitis and fibrosis following liver transplantation in ***,no obvious cause can be identified in many adults with controlled recurrent disease and the majority of pediatric LT recipients,as they have been transplanted for non-recurrent liver *** surveillance liver biopsies post LT have been evaluated in several adult and pediatric centers to identify long-term pathological *** findings are frequently present in liver biopsies obtained after a year post *** significance of these findings is uncertain as many of these are seen in protocol liver biopsies from patients with clinically good allograft function and normal liver chemistry *** narrative review summaries the factors predisposing to long-term liver allograft fibrosis,highlighting the putative role of idiopathic post-LT hepatitis and chronic antibody mediated rejection in its pathogenesis.

关键词： Liver allograft fibrosis Long term Idiopathic hepatitis Chronic antibody mediated rejection

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Novel insights into the pathophysiology of varicocele and its association with reactive oxygen species and sperm DNA fragmentation

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Asian Journal of Andrology 2016年第2期18卷 186-193,J0003页

作者： Chak-Lam Cho Sandro C Esteves ashok Agarwal Division of Urology Department of Surgery Kwong Wah Hospital 25 Waterloo Road Yau Ma Tei Hong Kong ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 campinas SP 13075-460 Brazil American Center for Reproductive Medicine 10681 Carnegie Avenue X-11 Cleveland OH 44195 USA.

Varicocele has been associated with reduced male reproductive potential. With the advances in biomolecular techniques, it has been possible to better understand the mechanisms involved in testicular damage provoked by varicocele. Current evidence suggests the central role of reactive oxygen species （ROS） and the resultant oxidative stress （OS） in the pathogenesis of varicocele-associated male subfertility although the mechanisms have not yet been fully described and it is likely to be multifactorial. Excessive ROS is associated with sperm DNA fragmentation, which may mediate the clinical manifestation of poor sperm function and fertilization outcome related to varicocele. Testing of ROS/OS and DNA fragmentation has the potential to provide additional diagnostic and prognostic information compared to conventional semen analysis and may guide therapeutic management strategies in individual patient.

关键词： antioxidants infertility male reproduction oxidative stress sperm DNA damage sperm DNA fragmentation varicocele varicocelectomy

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Liver injury associated with drug intake during pregnancy

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World Journal of Hepatology 2021年第7期13卷 747-762页

作者： Priyanka Kamath ashwin Kamath Sheetal D Ullal Department of Pharmacology Kasturba Medical CollegeMangaloreManipal Academy of Higher EducationManipalKarnatakaIndia-575001

Drug use during pregnancy is not ***-induced liver injury(DILI)is a potential complication that is rare but can adversely affect both the mother and the *** many drugs can directly cause hepatotoxicity,idiosyncratic liver injury is common in *** of adverse drug reactions,lack of adequate literature regarding drug safety in pregnancy,and the inherent difficulty in diagnosing DILI during pregnancy make the management of this condition *** review attempts to describe the existing literature regarding DILI in pregnancy,which is mainly in the form of case reports;several studies have looked at the safety of antithyroid drugs,antiretroviral drugs,and paracetamol,which have an indication for use in pregnancy;the relevant data from these studies with regard to DILI has been *** addition,the review describes the diagnosis of DILI,grading the disease severity,assessment of causality linking the drug to the adverse event,regulatory guidelines for evaluating the potential of drugs to cause liver injury,efforts to ensure better participation of women in clinical trials and studies in pregnant women population in particular,and the challenges involved in generating adequate research *** establishment of DILI registries in various countries is an encouraging development;however,there is a need for promoting active,spontaneous reporting of adverse events during pregnancy to ensure rapid generation of evidence regarding the safety of a drug in pregnant women.

关键词： Drug induced liver injury Pregnant women Liver failure Adverse effects Pregnancy outcome Registries

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Electrochemical Biosensor for Rapid Detection of Viable Bacteria and Antibiotic Screening

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Journal of Analysis and Testing 2019年第1期3卷 117-122页

作者： Nuvia Maria Saucedo Sira Srinives ashok Mulchandani Department of Chemistry University of CaliforniaRiversideCA 92521USA Department of Chemical and Environmental Engineering University of CaliforniaRiversideCA 92521USA Present Address:Department of Chemistry Southern Adventist UniversityCollegedaleTN 37315USA Present Address:Department of Chemical Engineering Mahidol University25/25 Puttamonthon 4 Rd.10SalayaNakhon Pathom 73170Thailand

We have developed a biosensor for the detection of live/viable bacteria based on the response of the conductive polymer 4-(3-pyrrolyl)butyric acid to glucose-induced *** polymer was electrochemically deposited and then functionalized with lectin through EDC/NHS chemistry to capture cells near the sensor surface and introduce selectivity for *** addition of glucose to a three-electrode electrochemical cell containing 10 mM phosphate buffer and the bacteria-immobilized sensor produced an increase in the *** the bound bacteria were treated with antibiotics,the addition of glucose produced a notably reduced signal exhibiting the sensor’s potential to screen for the most effective antibiotic *** biosensor having real-time responses,minimal sample preparation,and the ability to screen antibiotics demonstrates the speed,ease,and suitability essential for application in point-of-care *** detection range was determined to be 6.0×10^(3)-9.2×10^(7)CFU/mL.

关键词： Point of care Pathogen Infectivity Antibiotic Lectin Potentiometry

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A modeling and simulation framework for UAVs utilizing 4G-LTE cellular networks

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第5期9卷 108-139页

作者： Shafagh Jafer Stephen Jones ashok Vardhan Raja Department of Electrical ComputerSoftwareand Systems Engineering Embry-Riddle Aeronautical UniversityDaytona Beach32114 FLUSA

Only a small amount of work has been published on the topic of exploiting existing Long-Term Evolution-Advanced(LTE)cellular communication network infrastructure for Unmanned Aerial Vehicles(UAV)data *** paper documents a modeling and simulation(m&s)framework that has been developed utilizing the powerful OMNeT++simulation tool for assessing the feasibility and effectiveness of this prospect in various UAV *** multiple scenarios,we have studied the data rate requirements for communications between small and medium-sized UAVs and base *** this framework,we have shown that the data rate requirements for the links are within the data throughput achieved by LTE *** developed framework implements a propagation model endorsed by the 3GPP LTE project team and also accurately models the high mobility of *** framework is highly configurable and extensible and boasts of automatic aggregation of results and chart *** outcomes of this research may be utilized by industry for rapidly deploying highly mobile,low-cost UAVs in a wide range of applications and scenarios.

关键词： Unmanned air vehicle communication UAV Data Link OMNET++ 4GLTE modeling and simulation.

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