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QoS Constrained Network Coding Technique to Data Transmission Using IoT

Computer Systems Science & Engineering 2022年第11期43卷 531-544页

作者： A.Sathishkumar T.rammohan S.Sathish Kumar J.Uma K.Srujan Raju Aarti Sangwan M.Sivachitra M.Prabu Department of ECE The Kavery Engineering CollegeMecheri636453TamilnaduIndia Department of EEE Karpagam College of EngineeringCoimbatore641032India Department of EEE M.Kumarasamy College of EngineeringKarur639113India Department of Computer Science and Engineering CMR Technical CampusHyderabad501401India Department of CST Manav Rachna UniversityFaridabad121004India Department of EEE Kongu Engineering CollegePerundurai638060India Department of EEE Nandha Engineering CollegePerunduraiTamilnadu638052India

The research work presents,constrained network coding technique to ensure the successful data transmission based composite channel cmos technology using dielectric *** charge fragmentation and charge splitting are two components of the filtered switch domino(FSD)*** behavior of selected switching is achieved using generator called conditional pulse generator which is employed in Multi Dynamic Node Domino(MDND)*** FSD and MDND technique need wide area compared to existing single nodekeeper domino *** aim of this research is to minimize dissipation of power and to achieve less consumption of *** proposed research,works by introducing the method namely Interference and throughput aware Optimized Multicast Routing Protocol(IT-OMRP).The main goal of this proposed research method is to introduce the system which can forward the data packets towards the destination securely and *** achieve the bandwidth and throughput in optimized data transmission,proposed multicast tree is selected by Particle Swarm Optimization which will select the most optimal host node as the branches of multi cast *** node selection is done by considering the objectives residual energy,residual bandwidth and *** node selection multi cast routing is done with the concern of interference to ensure the reliable and successful data *** case of transmission range size is higher than the coverage sense range,successful routing is ensured by selecting secondary host forwarders as a backup which will act as intermediate relay *** NS2 simulator is used to evaluate research outcome from which it is proved that the proposed technique tends to have increased packet delivery ratio than the existing work.

关键词： Multicast routing optimal node selection secondary relay nodes probability of interference residual energy bandwidth throughput

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Modeling the Impact of Cell Type and Substrate Stiffness on Cell Traction

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Open Journal of Biophysics 2013年第4期3卷 222-231页

作者： Srikanth Raghavan Aravind R. rammohan Martial Hervy Science & Technology Division Corning Incorporated Corning USA

We propose a mathematical model to suggest a unified explanation behind the observation that some cell types tend to spread more efficiently on stiff substrates and are able to adapt their internal stiffness to the external stiffness. Our model also offers an explanation regarding the dependence of cell spreading on cell type. We show that our model for stiffness adaptation is in good agreement with experimental data. We also apply our model to calculate the energy of traction on bulk substrates as well as thin coatings, thereby extracting estimates of critical coating thickness as a function of cell type and coating bulk modulus.

关键词： Cell-Matrix Adhesion Extracellular Matrix Polyacrylamide Gels Elasticity Theory Mechanotransduction Stem Cell Modeling

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Assessment on facile Diels-Alder approach of α-pyrone and terpenoquinone for the expedient synthesis of various natural scaffolds

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Natural Products and Bioprospecting 2022年第1期12卷 137-157页

作者： Aluru rammohan Albert F.Khasanov Dmitry S.Kopchuk Duvvuru Gunasekar Grigory V.Zyryanov Oleg N.Chupakhin Ural Federal University 19 Mira St.Ekaterinburg 620002Russian Federation Natural Products Division Department of ChemistrySri Venkateswara UniversityTirupati 517502India Ural Division of the Russian Academy of Sciences I.Ya.Postovsky Institute of Organic Synthesis22 S.Kovalevskoy St.Ekaterinburg 620219Russian Federation

The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in *** this aspect,the Diels-Alder reaction(DAR)has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic ***,α-pyrone and terpeno-quinone are two versatile key intermediates that are prevalent in various bioactive natural compounds for instance,(±)-crinine,(±)-joubertinamine,(±)-pancratistatin,(−)-cyclozonarone,and 8-ephipuupehedione,***,the current review summarizes the Diels-Alder reaction application ofα-pyrone and terpenoquinone to the construc-tive synthesis of various natural products over the past two decades(2001-2021).Equally,it serves as a stencil for the invention and development of new synthetic strategies for high-complex molecular structured natural and heterocy-clic molecules.

关键词： α-Pyrone Diels-Alder reaction(DAR) Marine natural compounds Terpenoquinone Total synthesis

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Supramolecular interactions of novel imidazolyl pyrimidines with MRSA DNA

Supramolecular interactions of novel imidazolyl pyrimidines ...

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全国第十九届大环化学暨第十一届超分子化学学术讨论会

作者：李迪 rammohan R.Yadav Bheemanaboina 周成合 Institute of Bioorganic&Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing MunicipalitySchool of Chemistry and Chemical Engineering Southwest University CSIR-Indian Institute of Integrative Medicine (IIIM)

＜正＞A series of novel imidazolyl pyrimidines were synthesized and their antibacterial activities were *** was found that compound 2 could bind with DNA gyrase to form biosupermolecule through hydrogen *** study disclosed that molecule 2 could effectively intercalate into MRSA DNA to form a steady 2-DNA supramolecular complex, which might further block DNA replication to exert the powerful bioactivities.

关键词： pyrimidine organophosphorus antibacterial MRSA DNA

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Design and Synthesis of Isopropanol-bridged Sulfonyl Carbazoles as Novel Potential Antimicrobial Agents

Design and Synthesis of Isopropanol-bridged Sulfonyl Carbazo...

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中国化学会·第十六届全国有机合成化学学术研讨会

作者：王娟 rammohan R.Yadav Bheemanaboina Cheng-He Zhou 西南大学 School of Chemistry and Chemical Engineering Southwest University CSIR-Indian Institute of Integrative Medicine (IIIM)

Natural and synthetic congeners of carbazole comprise a large group of therapeutically useful agents in medicinal *** a series of novel isopropanol-bridged sulfonyl carbazoles as novel potential antimicrobial agents were designed and synthesized via multi-step procedure from commercial aniline and carb azole in an effort to overcome drug *** of the prepared compounds exerted powerful antibacterial activities toward a panel of Gram-positive and Gram-negative organisms,including drug-resistant *** active molecules could effectively intercalate into methicillin-resistant Staphylococcus aureus DNA via supramolecular interactions,which might block DNA replication to exhibit their powerful antibacterial activity.

关键词： sulfonamide carbazole antibacterial DNA

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Sulfonamide-derived Four-component Hybrids as Potentially Unique Multi-targeting Inhibitors: Design, Synthesis and Antimicrobial Evaluation

Sulfonamide-derived Four-component Hybrids as Potentially Un...

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中国化学会·第十五届全国有机合成化学学术研讨会

作者： Yuan-Yuan Hu rammohan R.Yadav Bheemanaboina 周成合 School of Chemistry and Chemical Engineering Southwest University CSIR-Indian Institute of Integrative Medicine (IIIM) 西南大学

A series of novel sulfonamide-based four-component hybrids as potentially new antimicrobial agents were designed and synthesized in an effort to overcome drug resistance .Bioactivity assays revealed that some target compounds exhibited significantly inhibitory efficiencies toward bacteria and fungi including clinically drug-resistant *** derivative showed potent activity(MIC=8μg/mL) against clinically drug-resistant Escherichia coli, 64-fold more active than *** further preliminary antibacterial action mechanism exploration suggested that metronidazole derivative was able to disturb *** membrane effectively , and intercalate into bacterial DNA isolated from clinically resistant *** through noncovalent bonds to form supramolecular complex, thus exerting its powerful antimicrobial activity in inhibiting the growth of *** strains .

关键词： sulfonamide azole antibacterial DNA synthesis

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Design and Synthesis of Novel Enone-bridged Indole Nitroimidazoles and Their Supramolecular Interactions with Sensitive Bacterial DNA and HSA

Design and Synthesis of Novel Enone-bridged Indole Nitroimid...

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中国化学会·第十五届全国有机合成化学学术研讨会

作者： Zhen-Zhen Li rammohan R.Yadav Bheemanaboina 周成合 Institute of Bioorganic & Medicinal Chemistry School of Chemistry and Chemical EngineeringSouthwest University Indian Institute of Integrative Medicine 西南大学

A series of novel enone-bridged indole nitroimidazoles were designed and *** the compounds were prepared in high yields from *** of the new compounds displayed preferable antibacterial efficacies towards the tested *** active molecule could also be efficiently stored and carried by human serum albumin and targeting sensitive bacterial DNA via supramolecular interactions.

关键词： nitroimidazole antibacterial DNA HSA

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Development of Quinolones-based Benzimidazoles as P. aeruginosa DNA Cleaving Agents

Development of Quinolones-based Benzimidazoles as P. aerugin...

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中国化学会第十四届全国有机合成化学学术研讨会

作者： Ya-Nan Wang rammohan R.Yadav Bheemanaboina Cheng-He Zhou Institute of Bioorganic & Medicinal Chemistry Key Laboratory of Applied Chemistry of Chongqing Municipality School of Chemistry and Chemical Engineering Southwest University

Quinolones are the most important first-line artificial antibacterial drugs with broad antibacterial spectra,high bioavailability,good pharmacokinetics and excellent curative *** is a relatively large conjugate rigid plane structure similar to purine nucleoside bases and possesses superior electro rich properties.A great deal of literature has reported that aromatic heterocyclic azole-modified quinolones displayed good antibacterial *** the importance of quinolones and benzimidazoles,a series of new 1-benzimidazolyl quinolones as potential antimicrobial agents were first designed and synthesized with the aim of overcoming drug *** evaluation found that 2-fluorobenzyl modified 1-benzimidazolyl quinolone 5b showed remarkable antimicrobial activities against the clinical resistant strains(***).Molecular docking indicated that it could efficiently bind with topoisomerase IV-DNA complexes and its complexes(with Cu)could cleave DNA and thus exert the powerful bioactivities.

关键词： quinolone benzimidazole molecular docking DNA cleaving

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Design and synthesis of novel sulfonamides and their supramolecular antimicrobial evaluation

Design and synthesis of novel sulfonamides and their supramo...

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全国第十九届大环化学暨第十一届超分子化学学术讨论会

作者：扈圆圆 rammohan R.Yadav Bheemanaboina 周成合 Institute of Bioorganic&Medicinal Chemistry School of Chemistry and Chemical EngineeringSouthwest University CSIR-Indian Institute of Integrative Medicine (IIIM)

＜正＞The rational design and synthesis of supramolecular structures have been a rapidly expanding field because of various architectures and *** particular, sulfonamides have gradually attracted widespread attention in the supramolecular ***, piperazine-bridged sulfonamide azolyl ethanols as antimicrobial agents were designed and *** 2 gave most active activity（MIC = 8 g/mL） against clinical drug-resistant Escherichia coli in this series of *** 2 not only formed supramolecular complexes with enzymes but also with ***, there is great potential for compound 2 as antibacterial agent to become a dual orientation of enzymes and DNA.

关键词： supramolecular sulfonamides azolyl ethanols E.coli DNA molecular docking

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A Facile Synthesis toward Novel Potential Antimicrobial Purine-benzimidazole Hybrid

A Facile Synthesis toward Novel Potential Antimicrobial Puri...

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中国化学会第十四届全国有机合成化学学术研讨会

作者： Ya-Nan Wang rammohan R.Yadav Bheemanaboina Cheng-He Zhou Institute of Bioorganic & Medicinal Chemistry School of Chemistry and Chemical EngineeringSouthwest University

Purines are considered as the most ubiquitous and functional N-heterocyclic compounds in *** modifications of natural purines have been in the focus of many drug discovery *** is structurally similar to purine,and its derivatives could compete with purines,distinctly inhibit the synthesis of nucleic acids and proteins,thereby kill bacterial strains or inhibit their *** a facile synthetic approach was reported toward the purine-benzimidazole hybrids as potential novel antimicrobial *** synthetic route mainly involved cyclization and nucleophilic substitution reactions which has several advantages including available materials,easy operation and moderate ***,various substituents on benzene ring and different amines on purine ring were also introduced for evaluating their effects on biological activities.

关键词： purine benzimidazole antimicrobial cyclization

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