检索结果-南通市图书馆

Investigation of performance and emission characteristics using ethanol-blended gasoline fuel as a flex-fuel in two-wheeler vehicle mounted on a chassis dynamometer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clean Energy 2024年第3期8卷 174-193页

作者： Sourabh gupta Sumit Kanchan Rupinder Kaur Sarbjot Singh Sandhu School of Mechanical Engineering Lovely Professional UniversityPunjabIndia Division of Innovation and Entrepreneurship Lovely Professional UniversityPunjabIndia Department of Mechanical Engineering Dr BR Ambedkar National Institute of TechnologyJalandharIndia

This study investigated the performance and emissions of flex fuels in a 110-cc BS6-compliant fuel-injected two-wheeler without ethanol adaptation *** tests were carried out under controlled conditions on a chassis dynamometer at 1000,2000 and 3000 *** ethanol blends from 10%ethanol(E10)to 85%ethanol(E85).Parameters examined included brake power(BP)output,brake-specific fuel consumption(BSFC),peak in-cylinder pressure and exhaust ***,including carbon monoxide(CO),hydrocarbons(HC),nitrogen oxide(NOx)and unregulated emissions,were also *** the percentages of the ethanol blend increased from E10 to E85,there was a noticeable improvement in power *** 1000 r.p.m.,the BP ranged from 2.4 to 4.6 kW for different *** BSFC and the peak in-cylinder pressure followed a similar pattern,indicating enhanced performance and fuel efficiency with higher ethanol ***,using E85 at 1000 *** in a significant 41.08%reduction in exhaust temperature compared with E10,although this difference decreased with higher blend ***,replacing E10 with E85 at 1000 *** CO and HC emissions by 9.17%and 38.34%,*** contrast,NOx emissions increased at all *** with higher-ethanol blends,peaking at a 415 parts per million increase at 3000 ***,unregulated emissions decreased significantly with increased *** ethanol *** summary,the use of flex-fuel blends in a two-wheeler resulted in a modest increase in BP output,improved fuel efficiency and lower CO and HC *** findings are vital for optimizing ethanol blend utilization in two-wheeler engines under low-load conditions,considering both performance and environmental aspects.

关键词： flex fuel ethanol regulated emissions unregulated emissions chassis dynamometer performance characteristics

Bibliographic survey and comprehensive review on mechanical and durability properties of microorganism based self-healing concrete

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第9期18卷 1445-1465页

作者： Md Marghoobul HAQUE Kunal M.SHELOTE Namrata SINGH Supratic gupta Department of Civil Engineering Indian Institute of Technology DelhiNew Delhi 110016India

Concrete is the most widely utilized material for construction purposes,second only to water,in the ever-increasing need for construction *** is a brittle material and possesses a high risk of crack formation and consequent ***,which allows chemicals to enter and can cause concrete structures to lose their physico-mechanical and durability *** and rehabilitating concrete structures involves high costs and leads to various repair methods including coating,adhesives,polymers,supplementary cementitious materials(SCMs),and *** of the latest technologies is the use of microorganisms in *** added microorganisms lead to calcite precipitation and thereby heal the cracks *** study presents a comprehensive literature survey on bacteria-included concrete,before which a bibliographic survey is performed using VOSViewer *** addition to regular bacterial concrete,this study focuses on also using SCMs and fibers in bacterial concrete.A detailed literature review with data representation for various mechanical properties including compressive strength(CS),split tensile strength(SS),and flexure strength(FS),along with durability properties including carbonation,water absorption,resistance against chloride ion penetration,gas permeation,and resistance against cyclic freeze-and-thaw is presented.A study on the use of X-ray computed tomography(XCT)in bacterial concrete is highlighted,and the scope for future research,along with identification of the research gap,is presented.

关键词： bacterial concrete bibliographic survey biomineralization carbonation fibers

Early Paleozoic basement diorite of arc-magmatism from Kutch basin, Western India

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第2期43卷 296-307页

作者： Piyush gupta Sandeep Singh Shakti Singh Rathore Argha Narayan Sarkar Geochronology Laboratory KDMIPEOil and Natural Gas Corporation Ltd.9Kaulagarh RoadDehradun 248195India Department of Earth Sciences Indian Institute of TechnologyRoorkee 247667India

In this study,we report for theﬁrst time an Early Palaeozoic basement diorite from the drilled well Nirona-A in the Banni Half-Graben of the Kutch basin,western *** 40Ar–39Ar dates provided a plateau age of 441.84±2.66 Ma and another pseudo plateau of 441.28±5.82 to 388.08±16.65 Ma for the basement *** ages constrain the basement formation age to the Late Ordovician-Early Silurian *** obtained basement ages are correlatable with the later part of Cambro-Ordovician alkaline magmatism that has been reported from the Huqf area in Central Oman,whereas their lithological and petrographic correlativity with base-ment diorites occurring in the Dinsi Body of Nagar Parkar igneous complex in Pakistan can also be *** geochemical studies characterized the diorite with enrich-ment of LILE(Rb,Ba,and K)and LREE(La,Ce,Nd),strong depletion of HFSE(Nb,Sr,P,and Ti),along with weakly negative Eu *** geochemical signatures indicate their petrogenetic afﬁliation with mantle-derived magmas,as well as their tectonic setting to be arc-related,having post-collisional continental-arc type afﬁ****440 Ma basement of Kutch,therefore,appears to rep-resent the later thermal event associated with the reworked Neoproterozoic subduction-related suite from Greater India’s northwest edge,which has implications for Gond-wana assembly in the northwest Indian subcontinent.

关键词： Kutch basin 40Ar–39Ar ages Early palaeozoic basement Continental-arc magmatism Calc-alkaline magmatism

Evaluation of sodium borocaptate(BSH)and boronophenylalanine(BPA)as boron delivery agents for neutron capture therapy(NCT)of cancer:an update and a guide for the future clinical evaluation of new boron delivery agents for NCT

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cancer Communications 2024年第8期44卷 893-909页

作者： Rolf F.Barth Nilendu gupta Shinji Kawabata Department of Pathology The Ohio State UniversityColumbusOhioUSA Department of Radiation Oncology The Ohio State UniversityColumbusOhioUSA Department of Neurosurgery Osaka Medical and Pharmaceutical UniversityTakatsukiOsakaJapan

Boron neutron capture therapy(BNCT)is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron-10,a stable isotope,is irradiated with neutrons of the appropriate energy to produce boron-11 in an unstable form,which undergoes instantaneous nuclear fission to produce high-energy,tumoricidal alpha *** primary purpose of this review is to provide an update on the first drug used clinically,sodium borocaptate(BSH),by the Japanese neurosurgeon Hiroshi Hatanaka to treat patients with brain tumors and the second drug,boronophenylalanine(BPA),which first was used clinically by the Japanese dermatologist Yutaka Mishima to treat patients with cutaneous ***,BPA has become the primary drug used as a boron delivery agent to treat patients with several types of cancers,specifically brain tumors and recurrent tumors of the head and neck *** focus of this review will be on the initial studies that were carried out to define the pharmacokinetics and pharmacodynamics of BSH and BPA and their biodistribution in tumor and normal tissues following administration to patients with high-grade gliomas and their subsequent clinical use to treat patients with highgrade ***,wewill summarize the studies thatwere carried out in Japan with BSH and subsequently at our own institution,The Ohio State University,and those of several other ***,we will describe studies carried out in Japan with BPA and then in the United States that have led to its use as the primary drug that is being used clinically for ***,although there have been intense efforts to develop new and better boron delivery agents for BNCT,none of these have yet been evaluated *** present reportwill provide a guide to the future clinical evaluation of new boron delivery agents prior to their clinical use for BNCT.

关键词： Boron neutron capture therapy(BNCT) boronophenylalanine(BPA) brain tumors head and neck cancer sodium borocaptate(BSH)

Investigating the Evolution of Amati Parameters with Redshift

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第1期24卷 188-200页

作者： Meghendra Singh Darshan Singh Kanhaiya Lal Pandey Dinkar Verma Shashikant gupta Delhi Metro Rail Corporation Limited New Delhi 110001India GD Goenka University Gurugram 122103India Department of Physics Mata Raj Kaur Institute of Engineering and TechnologyRewari 123401India Department of Physics School of Advanced SciencesVellore Institute of TechnologyVellore 632014India

Gamma-ray bursts(GRBs) are among the brightest objects in the Universe and, hence, can be observed up to a very high redshift. Properly calibrated empirical correlations between intensity and spectral correlations of GRBs can be used to estimate the cosmological parameters. However, the possibility of the evolution of GRBs with redshift is a long-standing puzzle. In this work, we used 162 long-duration GRBs to determine whether GRBs below and above a certain redshift have different properties. The GRBs are split into two groups, and we fit the Amati relation for each group separately. Our findings demonstrate that estimations of the Amati parameters for the two groups are substantially dissimilar. We perform simulations to investigate whether the selection effects could cause the difference. Our analysis shows that the differences may be either intrinsic or due to systematic errors in the data, and the selection effects are not their true origin. However, in-depth analysis with a new data set comprised of 119 long GRBs shows that intrinsic scatter may partly be responsible for such effects.

关键词： Cosmology gamma rays:general (cosmology:)large-scale structure of universe galaxies:high-redshift

Techno-economic and environmental impact analysis of electric two-wheeler batteries in India

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Clean Energy 2024年第3期8卷 147-156页

作者： Aman gupta Ditipriya Bose Sandeep Tiwari Vikrant Sharma Jai Prakash Department of Green Energy and Sustainable Development Zakir Husain College of Engineering and Technology Aligarh Muslim UniversityUttar Pradesh-202002India Battery Testing Facility National Institute of Solar EnergyGurugram-Faridabad RoadGwal PahariGurugram-122003HaryanaIndia

This paper presents a comprehensive techno-economic and environmental impact analysis of electric two-wheeler batteries in *** technical comparison reveals that sodium-ion(Na-ion)and lithium-ion(Li-ion)batteries outperform lead-acid batteries in various parameters,with Na-ion and Li-ion batteries exhibiting higher energy densities,higher power densities,longer cycle lives,faster charge rates,better compactness,lighter weight and lower self-discharge *** economic comparison,Na-ion batteries were found to be~12-14%more expensive than Li-ion ***,the longer lifespans and higher energy densities of Na-ion and Li-ion batteries can offset their higher costs through improved performance and long-term ***-acid batteries have the highest environmental impact,while Li-ion batteries demonstrate better environmental performance and potential for ***-ion batteries offer promising environmental advantages with their abundance,lower cost and lower toxic and hazardous material *** recycling processes can further enhance the environmental benefits of Na-ion ***,this research examines the potential of Na-ion batteries as a cheaper alternative to Li-ion batteries,considering India’s abundant sodium resources in regions such as Rajasthan,Chhattisgarh,Jharkhand and others.

关键词： electric two-wheelers environmental impact assessment lead-acid batteries lithium-ion batteries sodium-ion batteries techno-economic analysis

Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2024年第7期11卷 80-94页

作者： Pan Liu Can Yue Bo Meng Tianhe Xiao Sijie Yang Shuo Liu Fanchong Jian Qianhui Zhu Yuanling Yu Yanyan Ren Peng Wang Yixin Li Jinyue Wang Xin Mao Fei Shao Youchun Wang Ravindra kumar gupta Yunlong Cao Xiangxi Wang CAS Key Laboratory of Infection and Immunity National Laboratory of MacromoleculesInstitute of BiophysicsChinese Academy of Sciences University of Chinese Academy of Sciences Cambridge Institute of Therapeutic Immunology&Infectious Disease(CITIID) University of Cambridge Biomedical Pioneering Innovation Center(BIOPIC) Peking University Changping Laboratory Joint Graduate Program of Peking-Tsinghua-NIBS Academy for Advanced Interdisciplinary Studies Peking University Peking-Tsinghua Center for Life Sciences Tsinghua University Chinese Academy of Medical Sciences&Peking Union Medical College

Selective pressures have given rise to a number of SARS-CoV-2 variants during the prolonged course of the COVID-19 pandemic. Recently evolved variants differ from ancestors in additional glycosylation within the spike protein receptor-binding domain(RBD). Details of how the acquisition of glycosylation impacts viral fitness and human adaptation are not clearly understood. Here, we dissected the role of N354-linked glycosylation, acquired by BA.2.86 sub-lineages, as a RBD conformational control element in attenuating viral infectivity. The reduced infectivity is recovered in the presence of heparin sulfate, which targets the‘N354 pocket’ to ease restrictions of conformational transition resulting in a ‘RBD-up’ state, thereby conferring an adjustable infectivity. Furthermore, N354 glycosylation improved spike cleavage and cell–cell fusion, and in particular escaped one subset of ADCC antibodies. Together with reduced immunogenicity in hybrid immunity background, these indicate a single spike amino acid glycosylation event provides selective advantage in humans through multiple mechanisms.

关键词： coronavirus glycosylation viral fitness adjustable infectivity co-factor usage viral evolution conformational modulator

Hepatocellular carcinoma immune microenvironment and check point inhibitors-current status

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Hepatology 2024年第3期16卷 353-365页

作者： Tarana gupta Nikhil Sai Jarpula Division of Hepatology Department of MedicinePandit Bhagwat Dayal Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia

Hepatocellular carcinoma(HCC)is the most common primary tumor of the liver and has a high mortality *** Barcelona Clinic Liver Cancer staging system in addition to tumor staging also links the modality of treatment available to a particular *** recent description of the tumor microenvironment(TME)in HCC has provided a new concept of immunogenicity within the *** HCC has been shown to be more immunogenic with higher expression of cytotoxic T lymphocytes and decreased elements for immunosuppression such as regulatory T *** immunogenic milieu provides a better response to immunotherapy especially immune checkpoint inhibitors(ICIs).In addition,the recent data on combining locoregional therapies and other strategies may convert the less immunogenic state of the TME towards higher ***,data are emerging on the use of combinations of locoregional therapy and ICIs in unresectable or advanced HCC and has shown better survival outcomes in this difficult population.

关键词： Hepatocellular carcinoma Tumor immune microenvironment Immune checkpoint inhibitor Atezolizumab Bevacizumab Pembrolizumab

Modularly assembled multiplex prime editors for simultaneous editing of agronomically important genes in rice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第2期5卷 67-78页

作者： Ajay gupta Bo Liu Saad Raza Qi-Jun Chen Bing Yang Division of Plant Science and Technology Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Center for Crop Functional Genomics and Molecular Breeding China Agricultural UniversityBeijing 100193China Donald Danforth Plant Science Center St.LouisMO 63132USA

Prime editing(PE)technology enables precise alterations in the genetic code of a genome of *** offers great potential for identifying major agronomically important genes in plants and editing them into superior variants,ideally targeting multiple loci simultaneously to realize the collective effects of the ***,we report the development of a modular assembly-based multiplex PE system in rice and demon-strate its efficacy in editing up to four genes in a single transformation *** duplex PE(DPE)system achieved a co-editing efficiency of 46.1%in the T0 generation,converting TFIIAg5 to xa5 and xa23 to *** resulting double-mutant lines exhibited robust broad-spectrum resistance against multiple Xanthomonas oryzae pathovar oryzae(Xoo)strains in the T1 *** addition,we success-fully edited OsEPSPS1 to an herbicide-tolerant variant and OsSWEET11a to a Xoo-resistant allele,achieving a co-editing rate of 57.14%.Furthermore,with the quadruple PE(QPE)system,we edited four genes—two for herbicide tolerance(OsEPSPS1 and OsALS1)and two for Xoo resistance(TFIIAg5 and OsSWEET11a)—using one construct,with a co-editing efficiency of 43.5%for all four genes in the T0 *** performed multiplex PE usingfive more constructs,including two for triplex PE(TPE)and three for QPE,each targeting a different set of *** editing rates were dependent on the activity of pegRNA and/or *** instance,optimization of ngRNA increased the PE rates for one of the targets(OsSPL13)from 0%to 30%but did not improve editing at another target(OsGS2).Overall,our modular assembly-based system yielded high PE rates and streamlined the cloning of PE reagents,making it feasible for more labs to utilize PE for their editing *** have significant implications for advancing gene editing techniques in plants and may pave the way for future agricultural applications.

关键词： prime editing rice bacterial blight herbicide tolerance multiplex genome editing