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Asian Journal of Andrology 2013年第1期15卷 149-151页

作者： Zichu Yang Alexander Laird ashley monaghan Morag Seywright Imran Ahmad Hing Y Leung Institute of Cardiovascular and Medical Sciences College of Medical Veterinary and Life Sciences University of Glasgow Glasgow Scotland G12 8QQ UK Department of Urology Gartnavel General Hospital NHS Great Glasgow and Clyde Glasgow Scotland G12 OYN UK pathology NHSGGC Southern General Hospital Glasgow Scotland G51 4TF UK The Beatson Institute for Cancer Research Glasgow Scotland G61 1BD UK

Seminal vesicle （SV） amyloidosis is a well-documented histological entity, but it is observed infrequently. Its incidence is on the rise, which is probably related to the increasing use of prostate biopsies to investigate patients with elevated serum prostate-specific antigen levels. Here, we report seven cases of incidental SV amyloidosis over a 3-year period and consider their relationship to the previously suggested aetiological factors. Based on our series, we conclude that incidental localized SV amyloidosis observed in diagnostic prostate biopsies does not warrant formal investigations for systemic amyloidosis.

关键词： accessory sex organs male prostate biopsies prostate cancer prostate diseases prostatitis seminal vesicle amyloidosis

A sting in the tail： the N-terminal domain of the androgen receptor as a drug target

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Asian Journal of Andrology 2016年第5期18卷 687-694页

作者： Amy E monaghan Iain J McEwan School of Medicine Medical Sciences and Nutrition Institute of Medical Sciences University of Aberdeen Foresterhill Aberdeen AB25 2ZD United Kingdom.

The role of androgen receptor （AR） in the initiation and progression of prostate cancer （PCa） is well established. Competitive inhibition of the AR ligand-binding domain （LBD） has been the staple of antiandrogen therapies employed to combat the disease in recent years. However, their efficacy has often been limited by the emergence of resistance, mediated through point mutations, and receptor truncations. As a result, the prognosis for patients with malignant castrate resistant disease remains poor. The amino-terminal domain （NTD） of the AR has been shown to be critical for AR function. Its modular activation function （AF-1） is important for both gene regulation and participation in protein-protein interactions. However, due to the intrinsically disordered structure of the domain, its potential as a candidate for therapeutic intervention has been dismissed in the past. The recent emergence of the small molecule EPI-O01 has provided evidence that AR-NTD can be targeted therapeutically, independent of the LBD. Targeting of AR-NTD has the potential to disrupt multiple intermolecular interactions between AR and its coregulatory binding partners, in addition to intramolecular cross-talk between the domains of the AR. Therapeutics targeting these protein-protein interactions or NTD directly should also have efficacy against emerging AR splice variants which may play a role in PCa progression. This review will discuss the role of intrinsic disorder in AR function and illustrate how emerging therapies might target NTD in PCa.

关键词： androgen receptor inhibitor intrinsically disordered structure N-terminal domain prostate cancer small molecules

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鸟类的资源分配和生活史策略(英文)

动物学报 2004年第6期50卷 942-947页

作者： Pat monaghan Environmental and Evolutionary Biology Graham Kerr Building University of Glasgow Glasgow G12 8QQ Scotland UK

本文综述了对资源分配理论的研究。使用了对小黑背鸥和红嘴山鸦的研究 ,表明卵产生中的资源分配和相关的生活史策略对个体发育和长期适合度有多方面的影响。

关键词：鸟类动物学适合度个体发育生活史种群存活使用资源分配

Oesophageal cancer metastases:An observational study of a more aggressive approach

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 997-1007页

作者： Lianne Pickett Mary Dunne Orla monaghan Liam Grogan Oscar Breathnach Thomas N Walsh Department of Surgery Connolly HospitalBlanchardstownDublin D15 X40DIreland Clinical Trials Resource Unit St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Radiation Oncology St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Medical Oncology Beaumont HospitalDublin D09 V2N0Ireland Department of Surgery RCSI BahrainAdliya 15503Bahrain

BACKGROUND The prognosis for oesophageal carcinoma is poor,but once distant metastases emerge the prognosis is considered *** is no consistent protocol for the early identification and aggressive management of *** To examine the outcome of a policy of active postoperative surveillance with aggressive treatment of confirmed *** A prospectively maintained database of 205 patients diagnosed with oesophageal carcinoma between 1998 and 2019 and treated with curative intent was interrogated for patients with metastases,either at diagnosis or on follow-up surveillance and treated for *** cohort was compared with incomplete clinical responders to neoadjuvant chemoradiotherapy(nCRT)who subsequently underwent surgery on their primary *** survival was estimated using the Kaplan-Meier method,and the log-rank test was used to compare survival differences between *** Of 205 patients,11(5.4%)had metastases treated for cure(82%male;median age 60 years;9 adenocarcinoma and 2 squamous cell carcinomas).All had undergone neoadjuvant chemotherapy or chemoradiotherapy,followed by surgery in all but 1 *** the 11 patients,4 had metastatic disease at diagnosis,of whom 3 were successfully downstaged with nCRT before definitive surgery;2 of these 4 also developed oligometastatic recurrence and were treated with curative *** definitive treatment,7 had treatment for metachronous oligometastatic disease;5 of whom underwent metastasectomy(adrenal×2;lung×2;liver×1).The median overall survival was 10.9 years[95%confidence interval(CI):0.7-21.0 years],which was statistically significantly longer than incomplete clinical responders undergoing surgery on the primary tumour without metastatic intervention[n=62;median overall survival=1.9(95%CI:1.1-2.7;P=0.012].The cumulative proportion surviving 1,3,and 5 years was 100%,91%,and 61%,respectively compared to 71%,36%,and 25%for incomplete clinical responders undergoing surge

关键词： Oesophageal metastases Oligometastases Active surveillance Treatment for cure Metastasectomy Survival

Mitral pseudostenosis due to a large left atrial myxoma

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Journal of Geriatric Cardiology 2018年第3期15卷 244-245页

作者： Konstantinos C Theodoropoulos Giovanni Masoero Gianpiero Pagnano Nicola Walker Alexandros Papachristidis Mark J monaghan Department of Cardiology King's College Hospital NHS Foundation Trust. King's College London London UK

Myxomas are benign cardiac tumours that are mostly （75%） located in the left atrium, but they also can be found in the right atrium （15%-20%）, in the right ventricle （4%） and in the left ventricle （3%）.

关键词： Mitral stenosis Myxoma Transesophageal echocardiography

TRIM65 E3 ligase targets VCAM-1 degradation to limit LPS-induced lung inflammation

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Journal of Molecular Cell Biology 2020年第3期12卷 190-201页

作者： Yong Li Xuan Huang Fang Guo Tianhua Lei Shitao Li Paula monaghan-Nichols Zhisheng jiang Hong-Bo Xin Mingui Fu Department of Biomedical Science School of MedicineUniversity of Missouri-Kansas CityKansas CityMO 64108USA Institute of Translational Medicine Nanchang UniversityNanchang 330031China Institute of Cardiovascular Diseases Department of PathophysiologyHengyang Medical CollegeUniversity of South ChinaHengyang A21001China Department of Physiological Sciences Center for Veterinary and Health sciencesOklahoma State UniversityStillwaterOK 7A078USA

Although the adhesion molecules-mediated leukocyte adherence and infiltration into tissues is an important step of inflammation,the post-translational regulation of these proteins on the endothelial cells is poorly ***,we report that TRIM65,an ubiquitin E3 iigase of tripartite protein family,selectively targets vascular cell adhesion molecule 1(VCAM-1)and promotes its ubiq-uitination and degradation,by which it critically controls the duration and magnitude of sepsis-induced pulmonary ***65 is constitutively expressed in human vascular endothelial *** TNFa-induced endothelial activation,the protein levels ofTRIM65 and VCAM-1 are inversely *** of wild-type TRIM65,but not expression of aTRIM65 mutant that lacks E3 ubiquitin ligase function in endothelial cells,promotes VCAM-1 ubiquitination and degradation,whereas small interference RNA-mediated knockdown of TRIM65 attenuates VCAM-1 protein *** experiments show that TRIM65 directly interacts with VCAM-1 protein and directs its polyubiquitination,by which TRIM65 controls monocyte adherence and infiltration into tissues during ***,TRIM65-deficient mice are more sensitive to lipopolysaccharide-induced death,due to sustained and severe pulmonary *** together,our studies suggest that TRIM65-mediated degradation of VCAM-1 represents a potential mechanism that controls the duration and magnitude of infiammation.

关键词： TRIM65 VCAM-1 endothelial activation lung inflammation ubiquitination

Healthcare staff well-being and use of support services during COVID-19:a UK perspective

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General Psychiatry 2021年第3期34卷 143-153页

作者： Anika R Petrella Luke Hughes Lorna A Fern Lisa monaghan Benjamin Hannon Adam Waters Rachel M Taylor Cancer Division University College London Hospitals NHS Foundation TrustLondonUK Staff Psychological and Welfare Service University College London Hospitals NHS Foundation TrustLondonUK Centre for Nurse Midwife and AHP Led Research(CNMAR)University College London Hospitals NHS Foundation TrustLondonUK

Background The COVID-19 pandemic has drastically increased demands on healthcare workers(HCWs)leaving them vulnerable to acute psychological distress,burnout and post-traumatic *** response,supportive services in a central London hospital mobilised mental health support specifically for *** This rapid evaluation assessed HCW psychological welfare during the acute phase of the COVID-19 pandemic and their use of supportive services made *** During the acute phase of COVID-19(April to May 2020)all staff working for the hospital were invited to complete an online survey assessing well-being(self-rated health,moral distress exposure,symptoms of burnout and psychological distress)and use of available supportive services(awareness of,use and perceived helpfulness).Associations among personal characteristics and psychological well-being were explored using correlations and linear *** A total of 1127 staff participated in the rapid *** average,psychological distress was high(mean(SD):22(7.57))regardless of role,with 84%of this sample scoring above the general population mean(14.5).Nearly half of the sample reported feeling emotionally drained and a profile emerged displaying higher levels of psychological distress and burnout in those who were younger and exposed to morally distressing situations,with this group also exhibiting greater support service *** levels of burnout were associated with increased psychological distress when controlling for personal *** this acute phase of the pandemic,majority of staff used at least one service and rated it as *** HCWs experienced high levels of psychological distress requiring continued support as the COVID-19 pandemic *** HCWs were aware of supportive services,uptake *** order to mitigate the risk of burnout and post-traumatic stress,long-term,effective strategies that facilitate staff accessing support are urgently required.

关键词： distress younger staff

Plackett & Burman技术在新的天然产物筛选中的应用

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国外医药（抗生素分册） 1992年第4期13卷 258-262,270页

作者： monaghan RL 史荣梅

从微生物中寻找新的天然产物,特别是天然产物为次级代谢物时,选择合适的发酵条件是非常重要的。本文描述应用plackett&Burman技术尽快地选择寻找新的天然产物的发酵培养基和条件。

关键词：天然产物微生物 P ackett Burman

Superior sinus venosus atrial septal defect

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Journal of Geriatric Cardiology 2018年第10期15卷 649-652页

作者： Konstantinos C Theodoropoulos Alexandros Papachristidis Giovanni Masoero Michael Papitsas Valentina Cospite Fulya Avci Demir Daniel M.Sado Mark J.monaghan Department of Cardiology King 's College HospitalKing's College LondonLondonUK Department of Cardiology St Thomas'HospitalLondonUK

Atrial septal defect (ASD)is the third commonest congenital heart disease in *** most common type of ASD is the ostium secundum accounting for 75%-80%of all *** common are the ostium primum (accounting for 15%of all A... 详细信息

关键词： Atrial septal defect Cardiovascular magnetic resonance Sinus venosus defect Transesophageal echocardiography

Malignancy and mortality in a population-based cohort of patients with coeliac disease or ‘gluten sensitivity’

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World Journal of Gastroenterology 2007年第1期13卷 146-151页

作者： LA Anderson SA McMillan RGP Watson P monaghan AT Gavin C Fox LJ Murray Queen's University Belfast Centre for Clinical and Population Sciences Belfast United Kingdom Royal Group of Hospitals Regional Immunology Service Belfast United Kingdom Royal Group of Hospitals Institute of Clinical Science Belfast United Kingdom. Queen's University Belfast Northern Ireland Cancer Registry Belfast United Kingdom

AIM: To determine the risk of malignancy and mortality in patients with a positive endomysial or anti-gliadin an- tibody test in Northern Ireland. METHODS: A population-based retrospective cohort study design was used. Laboratory test results used in the diagnosis of coeliac disease were obtained from the Regional Immunology Laboratory, cancer statistics from the Northern Ireland Cancer Registry and mortal- ity statistics from the General Registrar Office, Northern Ireland. Age standardized incidence ratios of malignant neoplasms and standardized mortality ratios of all-cause and cause-specific mortality were calculated. RESULTS: A total of 13 338 people had an endomysial antibody and/or an anti-gliadin antibody test in Northern Ireland between 1993 and 1996. There were 490 pa- tients who tested positive for endomysial antibodies and they were assumed to have coeliac disease. There were 1133 patients who tested positive for anti-gliadin anti- bodies and they were defined as gluten sensitive. Ma- lignant neoplasms were not significantly associated with coeliac disease; however, all-cause mortality was signifi- cantly increased following diagnosis. The standardized incidence and mortality ratios for non-Hodgkin’s lym- phoma were increased in coeliac disease patients but did not reach statistical significance. Lung and breast cancer incidence were significantly lower and all-cause mortal-ity, mortality from malignant neoplasms, non-Hodgkin’s lymphoma and digestive system disorders were signifi- cantly higher in gluten sensitive patients compared to the Northern Ireland population. CONCLUSION: Patients with coeliac disease or gluten sensitivity had higher mortality rates than the Northern Ireland population. This association persists more than one year after diagnosis in patients testing positive for anti-gliadin antibodies. Breast cancer is significantly re- duced in the cohort of patients with gluten sensitivity.

关键词： Coeliac disease Cancer Mortality Gluten sensitivity