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Acta Metallurgica Sinica(English Letters) 2023年第7期36卷 1078-1094页

作者： Tuhin das Salim V.Brahimi Jun Song Stephen Yue Department of Materials Engineering McGill UniversityMontrealQC H3A OC5Canada Industrial Fasteners Institute ClevelandOH 44131USA

A newly proposed rapid fracture test in four-point bending was used to evaluate the effect of tempering on the hydrogen embrittlement(HE)susceptibility of an AISI 4135 steel,where it was tempered to four different strength(or hardness)*** was observed that HE susceptibility increases with the increase in *** was shown that there will be minimal impact of hydrogen(H)on the fracture of materials with hardness 37 HRC and below,even if they are completely saturated with *** the other hand,H will have similar detrimental effect on fracture properties of quench and tempered(Q and T)steels having hardness higher than 45 *** to brittle transition behavior was observed for a critical hardness(or strength)range as well as for a critical concentration level of ***,a critical H concentration was observed to exist for each of the strength *** was performed in addition to microstructural characterization using transmission electron microscopy(TEM).A very good correlation was observed between the fast fracture test results and *** fast fracture test was further compared with a conventional incremental step load(ISL)test for the evaluation of HE *** ISL test results and fracture surface characteristics corroborate very well with the observations from the fast fracture *** study successfully establishes the fast fracture test as a novel technique to study HE susceptibility and mechanism(s).

关键词： Hydrogen embrittlement(HE) Mechanical testing Fracture mechanics Martensitic steel Hardness Dislocation density

Rate-dependent mechanical behavior of jointed rock with an impersistent joint under different infill conditions

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第5期14卷 1380-1393页

作者： Sachin kumar Gaurav Tiwari Venkitanarayanan Parameswaran Arghya das Department of Civil Engineering Indian Institute of TechnologyKanpurIndia

Transition in the rate-dependent mechanical response of rock was investigated due to the presence of impersistent joint with different infill *** types of samples,***,jointed with no grouting,jointed and grouted with cement,and jointed and grouted with epoxy,were fabricated using model material.A series of dynamic split Hopkinson pressure bar(SHPB) tests was conducted on prepared samples with strain rates varying between 53-130 salong with static uniaxial compression tests(10s).Progression of fracture/failure along samples was monitored using high-speed imaging and digital image correlation(DIC).Strength was observed to be significantly lower for jointed samples as compared to intact ***,the increasing trend of strength with strain rates remained similar for all types of *** was observed to be a better grout due to greater improvement in the strength of epoxy grouted jointed samples than cement grouted samples under both static and dynamic *** changes were observed in fracture behavior(initiation,pattern and mechanism)with strain rate for intact and jointed unfilled/grouted *** was dominated by shear and tensile cracks at high strain rates compared to tensile cracks at low strain rates in all *** static loading conditions,the location of cracks initiation shifts away from joint tips with increasing strain rate and depending upon existing infill conditions(unfilled/grouted).

关键词： Jointed rocks Grouted joint Dynamic loading Strain rates

Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle

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Journal of Integrative Medicine 2022年第5期20卷 463-472页

作者： Asmita Pal Sucharita das Soumalee Basu Rita kundu Department of Botany University of CalcuttaKolkataWest Bengal 700019India Department of Microbiology University of CalcuttaKolkataWest Bengal 700019India

Objective‘Multi-targeting’drugs can prove fruitful to combat drug-resistance of multifactorial disease—cervical *** study envisioned to reveal if Thuja homeopathic mother tincture(MT)and its bioactive component could combat human papillomavirus(HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated *** Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species(ROS)generation by 2’,7’-dichlorodihydrofluorescein diacetate(DCFDA)staining and loss in mitochondrial membrane potential(MMP)by rhodamine(Rh)123 *** and autophagy inductions were studied by acridine orange(AO)ethidium bromide(EB)staining and immunoblot analyses of marker *** bioactive component of Thuja MT detected by gas chromatography-mass spectrometry was studied for antiproliferative and antimigratory properties along with in silico prediction of its cellular targets by molecular docking and oral drug forming *** Thuja MT showed significant antiproliferative and antimigratory potential in SiHa cells at a 50%inhibitory concentration(IC50)dosage of 17.3μL/*** increase in DCFDA fluorescence and loss in Rh123 fluorescence prove that Thuja MT acted through the burst of ROS and loss in MMP ***/EB-stained cells under the microscope and immunoblot analyses supported Thuja-induced cellular demise via dual pathways—apoptosis and *** showed cleavage of caspase-3 and poly adenosine diphosphate-ribose polymerase-1(PARP-1)along with upregulation of Beclin-1,microtubule-associated protein 1 light chain 3B(LC3B)-II,and p62 ***,the apoptotic cascade followed a caspase-3-dependent pathway supported by PARP-1 cleavage,while autophagic death was Beclin-1-dependent and mediated by accumulation of LC3BII and p62 ***,detected as the bioactive principle of Thuja MT showed greater anti-pro

关键词： Thuja Homeopathy Thujone Cervical cancer Apoptosis-autophagy crosstalk

Benchmarking dynamic properties of structures using non-contact sensing

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 387-405页

作者： Boshra Besharatian Amrita das Abdelrahman Awawdeh Sattar Dorafshan Marc Maguire Department of Civil Engineering University of North DakotaGrand ForksND 58201USA Durham School of Architectural Engineering and Construction University of Nebraska-LincolnOmahaNE 68182USA

Non-contact sensing can be a rapid and convenient alternative for determining structure response compared to conventional *** vision has been broadly implemented to enable accurate non-contact dynamic response measurements for *** study has analyzed the effect of non-contact sensors,including type,frame rate,and data collection platform,on the performance of a novel motion detection *** recordings of a cantilever column were collected using a high-speed camera mounted on a tripod and an unmanned aerial system(UAS)equipped with visual and thermal *** test specimen was subjected to an initial deformation and *** acceleration data were collected using an accelerometer installed on the cantilever *** displacement from each non-contact sensor and the acceleration from the contact sensor were analyzed to measure the specimen′s natural frequency and damping *** specimen′s first fundamental frequency and damping ratio results were validated by analyzing acceleration data from the top of the specimen and a finite element model.

关键词： dynamic response non-contact sensing infrared thermography vision-based unmanned aerial system computer vision

Molecular and cellular pathophysiology of circulating cardiomyocyte-specific cell free DNA (cfDNA): Biomarkers of heart failure and potential therapeutic targets

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Genes & Diseases 2023年第3期10卷 948-959页

作者： Abhi Dutta Moumita das Ankita Ghosh Santanu Rana Raja Peary Mohan College Integrated Biological Research Facility(RIBRF) Raja Peary Mohan CollegeUttarparaHooghlyWest Bengal 712258India

Pathological cardiac damage during heart failure is associated with cell death and damage associated molecular patterns (DAMPs) release which triggers a viscous cycle of sterile inflammation to mediate maladaptive cardiac tissue remodelling during the progression to heart failure. DAMPs like cytokines, chemokines, and nuclear or mitochondrial genomic fragments are released in the pathological myocardium. Interestingly, circulating or cytosolic DNA fragments can play a role in the disease by interaction with nucleic acid sensors expressed in cardiomyocyte and non-myocyte neighbouring cells. The circulating cell free DNA (cfDNA) fragments have been clinically reported as markers for various diseases including cardiovascular pathophysiology. Such cfDNA within the DAMP pool can mediate intra- and inter-cellular signalling cascade to upregulate transcriptional expression of inflammatory mediators and trigger oxidative stress within cells. The cellular role of such genomic equivalents varying with chronic or acute stress might be correlated with the cell death forms encountered in myocardium during disease progression. Thus, cfDNA can be phenotypically correlated as a critical player towards upregulation of pathological processes like interstitial fibrosis, cardiomyocyte contractile dysfunction and cell death. Herein, we review the association of cfDNA with heart failure and analyse their potential usage as novel and effective therapeutic targets towards augmentation of cardiac function.

关键词： Apoptosis Circulating DNA Fibrosis Heart failure Inflammation Nucleic acid receptor

Decrypting a path based approach for identifying the interplay between PI3k and GSk3 signaling cascade from the perspective of cancer

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Genes & Diseases 2022年第4期9卷 868-888页

作者： Abhijit das Barshana Bhattacharya Souvik Roy Department of Pharmacology NSHM Knowledge CampusKolkata-Group of InstitutionsKolkata 700053India

Cancer is one of those leading diseases worldwide, which takes millions of lives every year. Researchers are continuously looking for specific approaches to eradicate the deadly disease, ensuring minimal adverse effects along with more therapeutic significance. Targeting of different aberrantly regulated signaling pathways, involved in cancer, is surely one of the revolutionary chemotherapeutic approach. In this instance, GSk3 and PI3k signaling cascades are considered as important role player for both the oncogenic activation and inactivation which further leads to cancer proliferation and metastasis. In this review, we have discussed the potential role of GSk3 and PI3k signaling in cancer, and we further established the crosstalk between PI3k and GSk3 signaling, through showcasing their cross activation, cross inhibition and convergence pathways in association with cancer. We also exhibited the effect of GSk3 on the efficacy of PI3k inhibitors to overcome the drug resistance and preventing the cell proliferation, metastasis in a combinatorial way with GSk3 inhibitors for a better treatment strategy in clinical settings.

关键词： Cancer Chemotherapy Drug resistance GSk3 PI3k

Enhanced strength in novel nanocomposites prepared by reinforcing graphene in red soil and fly ash bricks

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International Journal of Minerals,Metallurgy and Materials 2019年第10期26卷 1322-1328页

作者： Jit Sarkar D.k.das Department of Metallurgical and Materials Engineering Indian Institute of TechnologyKharagpur 721302West BengalIndia Department of Mechanical Engineering Indian Institute of Technology(Indian School of Mines)Dhanbad 826004JharkhandIndia

Low-dimensional nanomaterials such as graphene can be used as a reinforcing agent in building materials to enhance the strength and durability. Common building materials burnt red soil bricks and fly ash bricks were reinforced with various amounts of graphene, and the effect of graphene on the strength of these newly developed nanocomposites was studied. The fly ash brick nanocomposite samples were cured as per their standard curing time, and the burnt red soil brick nanocomposite samples were merely dried in the sun instead of being subjected to the traditional heat treatment for days to achieve sufficient strength. The water absorption ability of the fly ash bricks was also discussed. The compressive strength of all of the graphene-reinforced nanocomposite samples was tested, along with that of some standard (without graphene) composite samples with the same dimensions, to evaluate the effects of the addition of various amounts of graphene on the compressive strength of the bricks.

关键词： graphene burnt red soil brick fly ash brick nanocomposites compressive strength

Aspect based sentiment analysis using multi-criteria decision-making and deep learning under COVID-19 pandemic in India

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CAAI Transactions on Intelligence Technology 2023年第1期8卷 219-234页

作者： Rakesh Dutta Nilanjana das Mukta Majumder Biswapati Jana Department of Computer Science and Application Hijli CollegeKharagpurIndia WBSEDCL Midnapore ZoneMidnaporeWest BengalIndia Department of Computer Science and Application University of North BengalSiliguriIndia Department of Computer Science Vidyasagar UniversityMidnaporeWest BengalIndia

The COVID-19 pandemic has a significant impact on the global economy and *** the pandemic continues to cause casualties in millions,many countries have gone under *** this period,people have to stay within walls and become more addicted towards social *** express their emotions and sympathy via these online ***,popular social media(Twitter and Facebook)have become rich sources of information for Opinion Mining and Sentiment Analysis on COVID-19-related *** have used Aspect Based Sentiment Analysis to anticipate the polarity of public opinion underlying different aspects from Twitter during lockdown and stepwise unlock *** goal of this study is to find the feelings of Indians about the lockdown initiative taken by the Government of India to stop the spread of ***-specific COVID-19 tweets have been annotated,for analysing the sentiment of common *** classify the Twitter data set a deep learning model has been proposed which has achieved accuracies of 82.35%for Lockdown and 83.33%for Unlock data *** suggested method outperforms many of the contemporary approaches(long shortterm memory,Bi-directional long short-term memory,Gated Recurrent Unit etc.).This study highlights the public sentiment on lockdown and stepwise unlocks,imposed by the Indian Government on various aspects during the Corona outburst.

关键词： aspect based sentiment analysis bi-directional gated recurrent unit COVID-19 deep learning k-means clustering multi-criteria decision-making natural language processing

Depicting the role of gas–solid interactions on the hydrodynamics of converging pneumatic riser

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Chinese Journal of Chemical Engineering 2022年第2期35卷 190-195页

作者： Rashmi Dhurandhar Sumit H.Dhawane Jyoti Prakash Sarkar Bimal das Department of Chemical Engineering National Institute of TechnologyDurgapur 713209West BengalIndia Department of Chemical Engineering Maulana Azad National Institute of TechnologyBhopal 462003Madhya PradeshIndia

The understanding of the flow characteristics and effect of gas–solid interactions in pneumatic risers is fundamental to investigate to ensure effective design cost-effective ***,to understand the effect of gas–solid interactions on the hydrodynamics of newly proposed conversing risers,this study mainly focused on predicting pressure drop in the dilute phase pneumatic conveying *** experiments were conducted in a converging riser having a convergence angle of 0.2693°.Various solid particles such as sago,black mustard,and alumina have been considered to study the effect of particle sizes and density on the pressure *** experimental outcomes indicate that the total pressure drop increases with an increase in the solid density and gas mass flow ***,smaller particle sizes are also increased the pressure *** empirical correlation is developed for the prediction of total pressure dropΔPTin converging pneumatic riser via dimensional *** dependent variables such as particle and air density,drag force,acceleration due to gravity,the mass flow rate of air and particle,the diameter of particle and converging riser,the height of converging riser were considered to develop the empirical *** established relationship is tested,and experimental data have been fitted for its *** estimated relative error of less than 0.05 proved the significance of the developed ***,it can be stated that the established relationship is useful in studying the effects of various parameters on the pressure drop across the length of the conversing riser.

关键词： Pneumatic conveying Pressure drop Converging riser Gas-solid dynamics

Nitrate removal from groundwater using chemically modified coconut husk based granular activated carbon:characterization of the adsorbent,kinetics and mechanism

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Systems Microbiology and Biomanufacturing 2023年第2期3卷 370-383页

作者： Solomon k.M.Huno Jewel das Eric Dvan Hullebusch Ajit P.Annachhatre Eldon R.Rene Pollution Prevention and Resource Recovery Chair Group Department of Water SupplySanitation and Environmental EngineeringIHE Delft Institute of Water EducationP.O.Box 30152601 DA DelftThe Netherlands Environmental Engineering and Management Department of EnvironmentEnergy and Climate ChangeSchool of EnvironmentResource and DevelopmentAsian Institute of Technology58 Moo 9Km.42Paholyothin HighwayP.O.Box 4Klong Luang 12120Pathum ThaniThailand National University of Ireland Galway University RoadGalway H91 TK33Ireland Bangladesh Council of Scientific and Industrial Research(BCSIR) BCSIR Laboratories ChattogramChattogram 4220Bangladesh Universite Paris Cite Institut de Physique du Globe de ParisCNRSF‑75005 ParisFrance School of Engineering Indian Institute of Technology MandiA4‑209MandiHimachal Pradesh 175001India

In this study,a highly porous chemically activated granular activated carbon(GAC)was prepared from coconut husk and tested as an adsorbent to remove nitrate from contaminated *** prepared GAC was characterized by Fouriertransform infrared spectroscopy(FTIR),thermogravimetric and differential thermal analysis(TGA/DTA),scanning electron microscopy(SEM)and the Brunauer-Emmett-Teller(BET)surface area(SBET)*** effects of various process parameters such as initial nitrate concentration,contact time and adsorbent dose on nitrate removal efficiency(response)by the modified GAC were investigated using the statistically significant response surface methodology and Box-Behnken design of *** experimental data were fitted to well-known adsorption isotherms and kinetic models to ascertain the mechanism of the adsorption *** of variance(ANOVA)was performed to determine the significance of the individual and the interactive effects of process variables on the *** BET surface area(SBET)and micropore volume of the prepared GAC from coconut husk was 1120 m^(2)/g and 0.392 cm^(3)/g,*** experimental results showed that physisorption was the main adsorption mechanism governing the process,while the rate of adsorption was limited at initial nitrate concentrations>10 mg/*** Langmuir mono-layer adsorption isotherm best fitted the experimental data with a maximum adsorption capacity of 6.0±1.3 mg/g(~92.5%)with an adsorbent dose of 0.1 g/50 mL,an equilibrium time of 6 h at 28±2℃,and at pH 7.6(±0.2).Among the tested process variables,the adsorbent dose and initial nitrate concentration showed significant effects on the nitrate removal efficiency.

关键词： Nitrate adsorption Groundwater Granular activated carbon Response surface methodology(RSM) Box-Behnken Coconut Husk