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Neoadjuvant and adjuvant treatment strategies for hepatocellular carcinoma

World Journal of Gastroenterology 2019年第28期25卷 3704-3721页

作者： Clifford Akateh Sylvester m Black Lanla Conteh Eric D miller Anne Noonan Eric Elliott Timothy m Pawlik Allan Tsung Jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Transplant Surgery Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Gastroenterology Hepatology and Nutrition Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Department of Radiation Oncology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of medical Oncology Department of Internal Medicine The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Diagnostic Radiology Department of Radiology The Ohio State University Wexner Medical Center Columbus OH 43210 United States Division of Surgical Oncology Department of Surgery The Ohio State University Wexner Medical Center Columbus OH 43210 United States

Hepatocellular carcinoma (HCC) is the most common liver malignancy worldwide and a major cause of cancer-related mortality for which liver resection is an important curative-intent treatment option. However, many patients present with advanced disease and with underlying chronic liver disease and/or cirrhosis, limiting the proportion of patients who are surgical candidates. In addition, the development of recurrent or de novo cancers following surgical resection is common. These issues have led investigators to evaluate the benefit of neoadjuvant and adjuvant treatment strategies aimed at improving resectability rates and decreasing recurrence rates. While high-level evidence to guide treatment decision making is lacking, recent advances in locoregional and systemic therapies, including antiviral treatment and immunotherapy, raise the prospect of novel approaches that may improve the outcomes of patients with HCC. In this review, we evaluate the evidence for various neoadjuvant and adjuvant therapies and discuss opportunities for future clinical and translational research.

关键词： Hepatocellular carcinoma Neoadjuvant therapy Adjuvant therapy Neoplasm recurrence Hepatectomy Liver cirrhosis

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Genetic mapping and survey of powdery mildew resistance in the wild Central Asian ancestor of cultivated grapevines in Central Asia

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Horticulture Research 2020年第1期7卷 1444-1458页

作者： Summaira Riaz Cristina m.menéndez Alan Tenscher Daniel Pap m.Andrew Walker Department of Viticulture and Enology University of CaliforniaDavisCA 95616USA Instituto de Ciencias de la Vid y del Vino(ICVV) Universidad de La Rioja-CSICGobierno de La RiojaCarretera de Burgos Km6Finca La GrajeraLogroñoLa Rioja 26007Spain

Cultivated grapevines(Vitis vinifera)lack resistance to powdery mildew(Pm)with few *** to this pathogen within *** has been reported in earlier studies and identified as the Ren1 locus in two Central Asian table grape *** Pm-resistant cultivated varieties and accessions of the wild ancestor *** *** were soon identified raising questions regarding the origin of the *** this study,F1 breeding populations were developed with a Pm susceptible *** *** breeding line and a Pm-resistant *** *** was carried out with five Ren1 locus linked SSR markers.A Pm resistance locus explaining up to 96%of the phenotypic variation was identified in the same genomic position,where the Ren1 locus was previously *** SSR marker alleles linked with the resistance locus were *** report results of Pm resistance in multiple accessions of *** collected as seed lots or cuttings from five countries in the Caucasus and Central Asia.A total of 20 females from 11 seed lots and 19 males from nine seed lots collected from Georgia,Armenia,and Azerbaijan were resistant to *** male and one female plant collected as cuttings from Afghanistan and Iran were also resistant to *** analysis of markers linked with the Ren1 locus in conjunction with disease evaluation data found a high diversity of allelic haplotypes,which are only possible via recombination events occurring over a long time *** analysis of two alleles of the SSR marker that cosegregates with the resistance found SNPs that were present in the wild progenitor and in cultivated *** levels of Pm resistance among the tested accessions were also *** lines of evidence suggest that the powdery mildew fungus may have been present in Asia for a longer time than currently thought,giving the wild progenitor *** *** time to coevolve with and develo

关键词： breeding resistance Central

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Optimization of pumping conditions in end pumped Tm: YAP lasers with the consideration of thermal effects

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Optoelectronics Letters 2022年第7期18卷 415-418页

作者： R.m.El-Agmy A.A.El-maaref N.m.Al-Hosiny Department of Physics College of ScienceJouf UniversityP.O.Box 2014SkakaSaudi Arabia Department of Physics College of ScienceTaif UniversityP.0.Box I109Taif 21944Saudi Arabia

In this work,we presented the measurements and calculations for the optimal pump conditions and their effects on thermal lens,fracture limit and laser efficiencies of end pumped Tm-doped yttrium aluminum perovskite(Tm:YAP)laser rod pumped at 1064 *** results showed that the measured overall efficiency of produced laser at~1.98μm is enhanced from 3.9%to 6.9%when the pump spot diameter is reduced from 390μm to 210μ*** maximum output power and oscillation threshold are also enhanced with reduced pump spot *** maximum thermal stress and focal length of thermally induced lens are also addressed.

关键词： pumped pump pumping

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Hydrogen storage of mgi-xmxH2 （m--Ti, V, studied using first-principles calculations re）

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Chinese Physics B 2012年第9期21卷 477-483页

作者： m.Bhihi m.Lakhal H.Labrim A. Benyoussefa A.EI Kenz O.mounkachi E.K.Hlil Laboratoire de magnetisme et de Physique des Hautes Energies associe au CNRST (URAC 12) Departement de PhysiqueB.P. 1014 Faculte des Sciences Universite Mohammed V-Agdal Rabat Morocco National Centre for Energy Sciences and Nuclear Techniques ONESTEN Morocco Institute of Nanomaterials and Nanotechnologies MACslR Rabat Morocco Hassan II Academy of Science and Technology Rabat Morocco Institut N6el CNRS-UJF 38042 Grenoble Cedex 9 France

In this work, the hydrogen storage properties of the mg-based hydrides, i.e., mgl-xmxH2 （m=Ti, V, Fe, 0≤ x ≤ 0.1）, are studied using the Korringa-Kohn-Rostoker （KKR） calculation with the coherent potential approximation （CPA） . In particular, the nature and concentrations of the alloying elements and their effects are studied. moreover, the material＇s stability and hydrogen storage thermodynamic properties are discussed. In particular, we find that the stability and the temperature of desorption decrease without significantly affecting the storage capacities.

关键词： first-principles calculation formation energy electronic structure hydrogen storage

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Impact of poly chlorinated biphenyl (Aroclor 1254) and vitamin C on antioxidant system of rat ventral prostate

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Asian Journal of Andrology 2004年第1期6卷 19-22页

作者： m. Sridhar P. Venkataraman S. Dhanammal A. Arunkumar m.m. Aruldhas N. Srinivasan J. Arunakaran Department of Endocrinology Dr. ALM Post Graduate Institute of Basic Medical Sciences University of MadrasTaramani Chennai 600 113 India

Aim: To evaluate the effect of polychlorinated biphenyls (PCB) and vitamin C on ventral prostatic antioxidant system in adult male rats. methods: A group of 20 adult male rats were administered ip Aroclor 1254 in corn oil at a dose of 2 mg·kg-1·day-1 for 30 days. Ten control rats were administered only the vehicle. After 30 days the treated rats were divided at random into 2 sub-groups of 10 animals each. One sub-group received vitamin C at a dose of 500 mg·kg-1·day-1 for 10 days. The other group was maintained as Aroclor 1254 control. Twenty-four hours after the last treatment the rats were killed by decapitation. Ventral prostatic homogenate was prepared and used for the estimation of enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) and hydrogen peroxide (H2O2), lipid peroxidation (LPO) and prostatic acid phosphatase. The serum levels of total T3, total T4, TSH, testosterone and estradiol were also assayed. Results: The body weight and ventral prostatic weight were reduced in PCB treated rats. The activities of SOD, CAT, GST and acid phosphatase were decreased while the levels of H2O2 and lipid peroxidation were increased in the ventral prostate of PCB treated rats. Administration of vitamin C restored these parameters. Serum levels of thyroid hormones, estradiol and testosterone were decreased in PCB treated animals. Administration of vitamin C restored the thyroid hormone levels. Conclusion: PCB induces oxidative stress and decreases the antioxidant enzymes in the ventral prostate of adult male rats; the effects could be reversed by the administration of vitamin C.

关键词： polychlorinated biphenyls Aroclor 1254 ventral prostate antioxidants lipid peroxidation thyroid hormone vitamin C

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Development and experimental validation of kinetic models for the hydrogenation/dehydrogenation of mg/Al based metal waste for energy storage

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Journal of magnesium and Alloys 2022年第10期10卷 2761-2774页

作者： m.Passing C.Pistidda G.Capurso J.Jepsen O.metz m.Dornheim T.Klassen Institute of Hydrogen Technology Helmholtz-Zentrum HereonMax-Planck-Straße 1 DGeestacht 21502Germany Institute of materials Technology Helmut Schmidt UniversityHolstenhofweg 85 DHamburg 22043Germany

With the increased use of renewable energy sources,the need to store large amounts of energy will become increasingly important in the near future.A cost efficient possibility is to use the reaction of recycled mg waste with hydrogen as thermo-chemical energy *** to the high reaction enthalpy,the moderate pressure and appropriate temperature conditions,the broad abundance and the recyclability,the mg/Al alloy is perfectly suitable for this *** further development of a previous work,in which the performance of recycled mg/Al waste was presented,a kinetic model for hydro-and dehydrogenation is derived in this *** and pressure dependencies are determined,as well as the rate limiting step of the *** experiments are carried out in an autoclave with a scaled-up powder mass,which is also used to validate the model by simulating the geometry with the scaled-up experiments at different conditions.

关键词： Thermo-chemical energy storage Hydrogen storage metal hydride magnesium based waste Recycling

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An adaptive neuro-fuzzy sliding mode controller for mImO systems with disturbance

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Chinese Journal of Chemical Engineering 2017年第4期25卷 463-476页

作者： mahmoud m.Saafan mohamed m.Abdelsalam mohamed S.Elksas Sabry F.Saraya Fayez F.G.Areed Computers and Control Systems Engineering Department Faculty of EngineeringMansoura UniversityEgypt

This paper introduces the mathematical model of ammonia and urea reactors and suggested three methods for designing a special purpose controller. The first proposed method is Adaptive model predictive controller, the second is Adaptive Neural Network model Predictive Control, and the third is Adaptive neuro-fuzzy sliding mode controller. These methods are applied to a multivariable nonlinear system as an ammonia–urea reactor system. The main target of these controllers is to achieve stabilization of the outlet concentration of ammonia and urea, a stable reaction rate, an increase in the conversion of carbon monoxide(CO) into carbon dioxide(CO_2) to reduce the pollution effect, and an increase in the ammonia and urea productions, keeping the NH_3/CO_2 ratio equal to 3 to reduce the unreacted CO_2 and NH_3, and the two reactors' temperature in the suitable operating ranges due to the change in reactor parameters or external disturbance. Simulation results of the three controllers are compared. Comparative analysis proves the effectiveness of the suggested Adaptive neurofuzzy sliding mode controller than the two other controllers according to external disturbance and the change of parameters. moreover, the suggested methods when compared with other controllers in the literature show great success in overcoming the external disturbance and the change of parameters.

关键词： disturbance sliding ammonia stabilization outlet predictive monoxide dioxide overcome steam

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Structural and plasma characterization of the power effect on the chromium thin film deposited by DC magnetron sputtering

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Optoelectronics Letters 2020年第5期16卷 369-372页

作者： S.Alsheikh Salo B.Abdallah m.Akel m.Kakhia S.Alsheikh Salo B.AbdallahM.AkelM.Kakhia Department of PhysicsAtomic Energy CommissionDamascus P.O.Box 6091Syria1

The chromium(Cr)films on silicon Si(100)substrate are prepared using DC magnetron sputtering technique at an argon gas pressure of 3 Torr for different applied powers(40—140 W).The chemical composition,the thicknesses and the structural characterization of the deposited Cr films are studied and analyzed using energy dispersive X-ray spectroscopy(EDX),scanning electron microscopy(SEm),and X-ray diffraction(XRD),***,the generated plasma parameters,including floating potential,plasma potential,electron density,ion density and electron temperature,have been measured,and the automated Langmuir probe is used for the Cr films *** ion and metal fluxes are also *** results show that the Cr film thickness enhances with the higher applied *** Cr deposited films properties are characterized and correlated with the measured plasma parameters.

关键词： deposited chromium film

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Sequence stratigraphic evaluation for the Abu madi Formation,Abu madi/El Qar'a/Khilala gas fields,onshore Nile Delta,Egypt

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Petroleum Research 2023年第4期8卷 514-523页

作者： Farouk I.metwalli Amir Ismail m.S.metwally Ibrahim m.El Shafei Geology Department Faculty of ScienceHelwan UniversityCairoEgypt Desert Research Center CairoEgypt Petrobel Oil Company CairoEgypt

The present study aims to integrate a large set of geological and geophysical data into a comprehensive model describing the depositional features of the Abu madi/El Qar'a/Khilala gas *** model is based on the sequence stratigraphic framework of the Abu madi Formation defined using cores,well logs,and time-migrated seismic *** trace attribute sections and relative acoustic impedance sections are also used.A possible depositional pattern for the main Level Ill is established,based on the lithological and petrophysical information derived from the seismic data *** Abu madi For-mation can be regarded as a depositional sequence recording the progressive drowning of the incised *** sequence is bounded at the base by an erosional unconformity,created by a drop in the level of the Late messinian Sea,and at the top by a drowning unconformity related to the Early Pliocene *** bottom of Level II divides the Abu madi sequence into two smaller *** both sequences,gas-bearing traps can be found in the Lowstand Systems Tracts,represented by the fluvial Level Ill and fluvial-deltaic Level Il,respectively.

关键词： Abu madi gas field El Qar'a area Khilala area Sequence stratigraphy analysis Onshore Nile Delta Abu madi Formation

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Leaf area development, dry weight accumulation and solar energy conversion efficiencies of Phaseolus vulgaris L. under different soil moisture levels near Nairobi, Kenya

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Journal of Environmental Sciences 1999年第4期11卷 449-456页

作者： m.m.muniafu J.N.m.macharia C.J.Stigter G.L.Coulson Department of Botany University of NairobiNairobiKenya TTmI-Project Department of MeteorologyWageningen Agricultural UniversityDuivendaal 26701 AP WageningenNetherlands T TmI-Project Departmen t of BotanyUniversi ty of Nai robiKenya

Leaf area development, dry weight accumulation and solar energy conversion efficiencies of Phaseolus vulgaris L. cv GLP\|2 under two soil moisture levels in two contrasting seasons near Nairobi, Kenya were investigated. The experiment confirms that dry weights and yields of Phaseolus vulgaris are limited by a drought induced decrease in leaf area, leading to less radiation interception as a source for assimilation. However, photosynthetic efficiency in Phaseolus vulgaris also appears to decrease and to contribute to these effects. Finally, an even larger decreases of economic efficiency as obtained in the second season, where stress lasted much later into the season, reveals that such a drought also limits considerably the partitioning and translocation of assimilates to the seeds of Phaseolus vulgaris. The efficiencies obtained are in line with the better literature data for other crops.

关键词： economic efficiency Phaseolus vulgaris L. photosynthetic efficiency radiation absorption/interception tube solarimeters

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