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Comparison of mismatch repair and immune checkpoint protein profile with histopathological parameters in pancreatic,periampullary/ampullary,and choledochal adenocarcinomas

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 875-882页

作者： arzu Hazal Aydın nesrin Turhan Department of Pathology Aksaray University Aksaray Training and Research HospitalAksaray 68200Turkey Department of Pathology University of Health Sciences Ankara City HospitalAnkara 06800Turkey

BACKGROUnD Pancreatic,periampullary/ampullary,and choledochal adenocarcinomas are aggressive malignancies with a poor *** checkpoint blockade is a promising treatment option for several tumor types.H long terminal repeatassociating 2(HHLA2),which is analogous to programmed death-ligand 1(PDL1),is a recently discovered member of the B7/cluster of differentiation 28 family and is expressed in many *** To analyze the expression of HHLA2 and its association with the pathologic biomarkers that predict sensitivity to *** ninety-two adenocarcinoma cases located in the pancreas,ampulla,and distal common bile duct were *** study assessed 106 pancreaticoduodenectomy and distal/total pancreatectomy samples that were delivered to Ankara City Hospital between 2019 and *** was conducted to examine the expression of DnA mismatch repair(MMR),PD-L1,and HHLA2 *** Patients with high HHLA2 expression had a higher mean age than those with low *** HHLA2 expression was associated with high perineural ***2 expression was low in pathological stage T3(pT)3 cases and high in pathological stage T1,T2,and T4 *** was no correlation between HHLA2 expression and the expression of MMR proteins and *** Evaluation of HHLA2 expression in microsatellite stable and PD-L1-negative tumors may be useful for predicting the response of individuals to immunotherapy and may serve as a novel therapeutic target for immunotherapy in advanced-stage disease.

关键词： H long terminal repeat-associating 2 Programmed death-ligand 1 Adenocarcinoma Pancreas Ampulla of Vater Distal common bile duct

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Exact Solutions of Fisher and Generalized Fisher Equations with Variable Coefficients

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Acta Mathematicae Applicatae Sinica 2007年第4期23卷 563-568页

作者： arzu ■ün Cevat Kart Department of Mathematics Faculty of SciencesAnkara University06100 Tando■an-Ankara Turkey

In this work, we consider a Fisher and generalized Fisher equations with variable coefficients. Using truncated Painleve expansions of these equations, we obtain exact solutions of these equations with a constraint on... 详细信息

关键词： nonlinear evolution equations fisher equation generalized fisher equation backlund transformation painleve property

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Impact of sex on the outcomes of deceased donor liver transplantation

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World Journal of Transplantation 2024年第1期14卷 120-129页

作者： Oya M Andacoglu Isabel S Dennahy nicole C Mountz Luisa Wilschrey arzu Oezcelik Division of Transplantation and Advanced Hepatobiliary Surgery University of UtahSalt Lake CityUT 84112United States Department of Surgery University of EssenEssen D-45122Germany Department of Surgery The University of Oklahoma Health Sciences CenterOklahoma CityOK 73117United States Department of Surgery University of Oklahoma College of MedicineOklahoma CityOK 73117United States

BACKGROUnD Data examining the impact of sex on liver transplant(LT)outcomes are *** is clear that further research into sex-related differences in transplant patients is necessary to identify areas for *** of these differences may help to identify specific areas of focus to improve on the organ matching process,as well as the peri-and post-operative care of these *** To utilize data from a high-volume Eurotransplant center to compare characteristics of male and female patients undergoing liver transplant and assess association between sex-specific variables with short-and long-term post-transplant *** A retrospective review of the University of Essen’s transplant database was performed with collection of baseline patient characteristics,transplant-related data,and short-term *** of these data were made with Shapiro-Wilk,Mann-Whitney U,χ2 and Bonferroni tests applied where appropriate.A P value ofnts,261(33.5%)were *** patients suffered higher incidences of acute liver failure and lower incidences of alcohol-related or viremic liver disease(P=0.001).Female patients were more likely to have received an organ from a female donor with a higher donor risk index score,and as a high urgency offer(all Pne characteristics of male and female recipients were also significantly *** multivariate hazard regression analysis,recipient lab-Model for End-Stage Liver Disease score and donor cause of death were associated with long-term outcomes in ***-operative diagnosis of hepatocellular carcinoma,age at time of listing,duration of surgery,and units transfused during surgery,were associated with long-term outcomes in *** of complications was associated with long-term outcomes in both *** survival was similar in both males and females;however,when stratified by age,females<50 y

关键词： Liver transplant Outcomes Survival Peri-and post-operative care

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new exact solutions of the Mikhailov-novikov-Wang equation via three novel techniques

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Journal of Ocean Engineering and Science 2023年第1期8卷 103-110页

作者： arzu Akbulut Melike Kaplan Mohammed K.A.Kaabar Mathematics-Computer Department Art-Science FacultyEski¸s ehir Osmangazi UniversityEski¸s ehirTurkey Department of Computer Engineering Engineering and Architecture FacultyKastamonu UniversityKastamonuTurkey Institute of Mathematical Sciences Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia

The current work aims to present abundant families of the exact solutions of Mikhailov-novikov-Wang equation via three different *** adopted methods are generalized Kudryashov method(GKM),exponential rational function method(ERFM),and modified extended tanh-function method(METFM).Some plots of some presented new solutions are represented to exhibit wave *** results in this work are essential to understand the physical meaning and behavior of the investigated equation that sheds light on the importance of investigating various nonlinear wave phenomena in ocean engineering and *** equation provides new insights to understand the relationship between the integrability and water waves’phenomena.

关键词： Exact solutions Generalized Kudryashov method Modified extended tanh-function method Symbolic computation PDEs

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new conservation laws and exact solutions of the special case of the fifth-order KdV equation

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Journal of Ocean Engineering and Science 2022年第4期7卷 377-382页

作者： arzu Akbulut Melike Kaplan Mohammed K.A.Kaabar Department of Mathematics-Computer Art-Science FacultyEskisehir Osmangazi UniversityEskisehirTurkey Department of Mathematics Art-Science FacultyKastamonu UniversityKastamonuTurkey Institute of Mathematical Sciences Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia

The current study deals with the Kaup-Kupershmidt(KK)equation to construct formal Lagrangian,con-servation laws,and exact *** is basically a special case of the 5th-order KdV *** conservation laws obtained by using the conservation theorem are trivial conservation *** addition,exact solutions are found via the modified simple equation(MSE)*** a suitable value of solu-tions,the 3D surfaces have been plotted using *** plots giving novel exact solutions are made to reveal important wave *** obtained results in this work concerning our investigated equation are essential to explain many physical and oceanographic applications involving ocean gravity waves and many other related phenomena.

关键词： Conservation laws Exact solutions Symbolic computation Modified simple equation method

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new solitary waves and exact solutions for the fifth-order nonlinear wave equation using two integration techniques

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Journal of Ocean Engineering and Science 2023年第5期8卷 475-480页

作者： Ahmed H.Arnous Mohammad Mirzazadeh Lanre Akinyemi arzu Akbulut Department of Physics and Engineering Mathematics Higher Institute of EngineeringEl Shorouk AcademyCairoEgypt Department of Engineering Sciences Faculty of Technology and EngineeringEast of GuilanUniversity of GuilanRudsar-VajargahIran Department of Mathematics Lafayette CollegeEastonPennsylvaniaUSA Department of Mathematics Computer Faculty of Art ScienceEskisehir Osmangazi UniversityEskisehirTurkey

In this paper,we discussed the enhanced Kudryashov’s and general projective Riccati equations tech-niques for obtaining exact solutions to the fifth-order nonlinear water wave(FOnLWWE)*** the enhanced Kudryashov’s method,we were able to achieve solitary wave and singular soliton ***-shock hybrid wave,singular soliton,and periodic wave solutions were discovered when we em-ployed the general projective Riccati equations *** can say the given methods are effective and powerful for obtaining exact *** findings in this paper are critical for explaining a wide range of scientific and oceanographic applications involving ocean gravity waves and other related phenomena.

关键词： Enhanced Kudryashov method Riccati equation Water waves Fifth-order nonlinear model Solitons

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Legends of the dashboard: an empirical evaluation of split and joint layout designs for geovisual analytics interfaces

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International Journal of Digital Earth 2023年第1期16卷 1395-1417页

作者： Izabela Gołębiowska Tomasz Opach arzuÇöltekin Jolanta Korycka-Skorupa Jan Ketil Rød Faculty of Geography and Regional Studies University of WarsawWarsawPoland Department of Geography Norwegian University of Science and TechnologyTrondheimNorway Institute for Interactive Technologies University of Applied Sciences and Arts Northwestern SwitzerlandWindischSwitzerland

Geodashboards are often designed with explanatory elements guiding *** elements(*** or annotations)need to be carefully designed to mitigate split attention or information integration *** this paper,we report expert interviews followed by a controlled experiment where we compare two interface designs with a focus on the split attention effect:(1)a multiple-legend layout with explanatory elements located next to each view,and(2)a single-legend layout with all explanatory elements gathered in one *** legend layouts did not affect the performance,but affected user satisfaction.75%of the participants preferred the multiple-legend layout,and rated it with a higher usability score,mainly attributing this preference to the proximity of legend elements to the view of *** tracking data strongly and clearly verifies that participants indeed make use of the proximity:With the single-legend,the majority of eye-movement transitions were between the single-legend and the closest view to the legend,whereas with multiple-legend participants have shorter and more frequent legend visits,as well as more transitions between legends and *** together,the design lesson we learned from this experiment can be summarized as‘split the legend elements,but make it close to the explained elements’.

关键词： Geodashboard layout design legend split attention user study eye tracking

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Thermal Efficiency for Each Zone of a Solar Pond

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Chinese Physics Letters 2011年第10期28卷 281-283页

作者： BEZİR CİCEK nalan ŞAHİnŞEnCAn arzu Department of Physics Faculty of ScienceSuleyman Demirel UniversityTurkey Department of Mechanical Education Technical Education FacultySüleyman Demirel UniversityTurkey

A salt gradient solar pond with a surface area of 3.5×3.5 m^(2) and a depth of 2 m is *** collapsible covers are used to reduce thermal energy loss from the surface of the solar pond during the night and to increase the thermal efficiency of the pond solar energy harvesting during *** covers can be rotated between 0 and 180°by a controlled electric motor and has insulation and reflection *** thermal efficiency for each solar pond zone is investigated theoretically and experimentally.

关键词： properties insulation harvesting

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Chronic otitis media and middle ear variants:Is there relation?

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World Journal of Clinical Cases 2023年第15期11卷 3481-3490页

作者： Fatma Dilek Gokharman Düzgün Can Senbil Sonay Aydin Erdal Karavas Ozge Ozdemir arzu Gülsah Yalcin Pınar nercis Kosar Department of Radiology Ankara Training and Research HospitalAnkara 06230Turkey Department of Radiology Erzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Radiology Bandırma 17 Eylül UniversityBalıkesir 10200Turkey

BACKGROUnD Chronic otitis media(COM)is an inflammatory disease that lasts for a long *** is common in developing *** loss can result from *** relationship between variations in middle ear anatomy and COM was investigated in our *** To compare the prevalence of middle ear anatomic variations between the cases with COM and healthy *** This retrospective study included 500 patients with COM and 500 healthy *** presence of those variants was determined:Koerner’s septum,facial canal dehiscence,high jugular bulb,jugular bulb dehiscence,jugular bulb diverticulum,sigmoid sinus anterior location and deep tympanic *** A total of 1000 temporal bones were *** incidences of these variants were respectively(15.4%-18.6%),(38.6%-41.2%),(18.2%-4.6%),(2.6%-1.2%),(1.2%-0%),(8.6%-0%),(0%-0%).It was observed that only high jugular bulb(Pnd anteriorly located sigmoid sinus frequencies(P=0.002)in the case group were statistically significantly higher than the control *** COM is a multifactorial disease and variants of middle ear have always been important in terms of potential risk for complication during surgery but rarely associated with COM as an etiology or as a consequence of the *** didn't find a positive correlation between COM and Koerner’s septum and facial canal *** ended up with a significant conclusion with the variants of dural venous sinuses-high jugular bulb,dehiscence of jugular bulb,diverticulum of jugular bulb and anteriorly located sigmoid sinus-that have been studied less and frequently associated with inner ear illnesses.

关键词： Chronic otitis media Radiology Inflammation Hearing loss Mastoid cells Head and neck

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Healthcare-associated Staphylococcus aureus infections in children in Turkey:A six-year retrospective,single-center study

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 354-362页

作者： nurhayat Yakut Zeynep Ergenc Sevgi Aslan Tuncay Sezin Bayraktar Elvan Sayin arzu Ilki Eda Kepenekli Division of Pediatric Infectious Diseases Department of PediatricsMarmara University School of MedicineIstanbulTurkey Department of Pediatrics Marmara University School of MedicineIstanbulTurkey Department of Medical Microbiology Marmara University School of MedicineIstanbulTurkey

Objective:To describe clinical and epidemiological characteristics,antimicrobial susceptibility and mortality-associated factors of healthcare-associated infections(HCAIs)caused by Staphylococcus(S.)aureus in ***:We conducted a retrospective,single-centre study of pediatric HCAIs caused by *** from a tertiary care hospital in Turkey between February 2014 and December *** clinical and epidemiological characteristics and antimicrobial susceptibility of the methicillin-susceptible and methicillin-resistant ***(MSSA and MRSA)isolates was ***:A total of 310 pediatric patients were ***,225(72.6%)isolates were MSSA and 85(27.4%)were *** *** isolates were susceptible to teicoplanin,vancomycin,linezolid,tigecycline,mupirocin,and *** resistance rates were high(89.0%),while fosfomycin,gentamicin,and clindamycin resistance rates were low(1.3%,1.0%,and 2.3%,respectively).Except susceptibility to fosfomycin,which was significantly lower in 2014 compared to 2018 and 2019,no significant difference was found in the antimicrobial susceptibility of *** isolates between the *** characteristics and mortality rate were similar comparing MRSA and MSSA causing *** mortality rate of HCAIs caused by *** was 6.5%(20 patients).Malignancy was an independent risk factor associated with mortality in the multivariate analysis(OR 5.446,95%CI 1.573-18.849).Conclusions:Our findings demonstrate that MSSA remained the most causative agent of HCAIs caused by *** mortality rate was 6.5%,the antibiotic resistance rate was quite high for penicillin and diagnosis of malignancy was the main risk factor for increasing mortality in *** findings could help improve the management of HCAIs caused by *** in children.

关键词： Healthcare-associated infections Staphylococcus aureus Children Antimicrobial susceptibility Mortality

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