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Population genetic structure and diversity of high value vulnerable medicinal plant Acorus calamus in India using RAPD and chloroplast microsatellite markers

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Journal of Forestry Research 2011年第3期22卷 367-377页

作者： H. S. Ginwal Neha Mittal arvind tomar V. K. Varshney Division of Genetics and Tree Propagation Forest Research Institute Dehradun Uttarakhand 248195 India Chemistry of Forest Products Division Forest Research Institute Dehradun Uttarakhand 248195 (India)

Acorus calamus is a highly valued medicinal plant with global distribution used in several drugs of health care systems. We evaluated the genetic diversity and population structure of 50 populations of A. calamus from different geographical regions in India through RAPD and chloroplast microsatellite markers. From the total screened 82 RAPD primers and 18 cpSSR primers, 10 RAPD and nine cpSSRs were found polymorphic. The selected 10 RAPD primers produced a total of 96 reproducible bands, out of which 65 were polymorphic （67.70%）. Whereas, the selected nine cpSSR markers produced 26 alleles and all of them were polymorphic. The mean genetic diversity （H T ） among populations using RAPD （H T = 0.263） and cpSSR （H T = 0.530） markers was higher in comparison to the mean genetic diversity within populations. Mean coefficient of gene differentiation （G ST ） between the populations was also high for both RAPD （G ST = 0.830） and cpSSR markers （G ST = 0.735）, whereas the estimated gene flow was very low for RAPD （Nm = 0.102） and for cpSSR （Nm = 0.179）. AMOVA analysis revealed that more genetic variation resided among the populations than within populations. Significant differences （p 0.001） were observed between the populations and individuals within the populations. Cluster analysis of RAPD and cpSSR data using UPGMA algorithm based on Nei’s genetic similarity matrix placed the 50 populations into two main clusters. The implication of the results of this study in devising strategy for conservation of A. calamus is discussed.

关键词： Acorus calamus cpSSR RAPD population structure genetic diversity

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COVID-19 in Liver Transplant Recipients-A Series with Successful Recovery

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 467-473页

作者： Ashok Choudhury Golamari Srinivasa Reddy Shantan Venishetty Viniyendra Pamecha Saggere Muralikrishna Shasthry arvind tomar Lalita Gauri Mitra Venkata Siva Tez Prasad Rajendra Prasad Mathur Debajyoti Bhattacharya Shiv Kumar Sarin Department of Hepatology and Liver Transplant Institute of Liver and Biliary SciencesNew DelhiIndia Department of HPB Surgery and Liver Transplant Institute of Liver and Biliary SciencesNew DelhiIndia Department of Pulmonary Medicine Institute of Liver and Biliary SciencesNew DelhiIndia Department of Critical Care Medicine Institute of Liver and Biliary SciencesNew DelhiIndia Department of Nephrology Institute of Liver and Biliary SciencesNew DelhiIndia

The severe acute respiratory syndrome corona virus-2 (referred to as SARS-CoV-2) pandemic had a great impact on public life in general as well as on populations with pre-existing disease and co-morbidities. Liver transplant and immunosuppressant medication predisposes to more severe disease and is often associated with poor outcome. The clinical features, disease course, treatment and process of modulating the immunosuppression is challenging. Here, we describe the clinical presentation, treatment and outcomes in six liver transplant recipients. Out of those six patients, three had mild, one had moderate and one had severe COVID-19, and one was asymptomatic. The immunosup-pression minimization or withdrawal was done based upon the clinical severity. Consideration of tocilizumab and/or convalescent plasma as well as antivirals i.e. remdesvir done in severe cases. The routine practice of prophylactic anti-coagulation, consideration of repurposed drugs (i.e. teico-planin and doxycycline), and watchful monitoring of asymptomatic recipients helped to achieve an uneventful recovery.

关键词： Liver transplant COVID-19 SARS-CoV-2 Liver injury Remdesivir Convalescent plasma

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Thermodynamic properties and phase diagram of quark matter within non-extensive Polyakov chiral SU(3)quark mean field model

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Chinese Physics C 2024年第5期48卷 60-71页

作者： Dhananjay Singh arvind Kumar Department of Physics Dr.B R Ambedkar National Institute of Technology JalandharJalandhar–144008PunjabIndia

In the present study,we applied Tsallis non-extensive statistics to investigate the thermodynamic properties and phase diagram of quark matter in the Polyakov chiral SU(3)quark mean field *** this model,the properties of the quark matter were modified through the scalar fieldsσ,ζ,δ,χ,vector fieldsω,ρ,ϕ,and Polyakov fieldsΦandΦ¯at finite temperature and chemical ***-extensive effects were introduced through a dimensionless parameter q,and the results were compared to those of the extensive case(q→1).In the non-extensive case,the exponential in the Fermi-Dirac(FD)function was modified to a q-exponential *** influence of the q parameter on the thermodynamic properties,pressure,energy,and entropy density,as well as trace anomaly,was *** speed of sound and specific heat with non-extensive effects were also ***,the effect of non-extensivity on the deconfinement phase transition as well as the chiral phase transition of u,d,and s quarks was *** found that the critical end point(CEP),which defines the point in the(T−μ)phase diagram where the order of the phase transition changes,shifts to a lower value of temperature,TCEP,and a higher value of chemical potential,μCEP,as the non-extensivity is increased,that is,q>1.

关键词： quark matter quark mean field model QCD phase diagram non-extensive statistics

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Simultaneous inversion of permeability,skin and boundary from pressure transient test data in three-dimensional single well reservoir model

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Petroleum Research 2024年第2期9卷 265-272页

作者： arvind Kumar Lin Liang Keka Ojha Schlumberger India Indian Institute of Technology(ISM) DhanbadIndia

This study presents a novel approach for simultaneous inversion of the key reservoir parameters like horizontal permeability,vertical permeability,skin,and boundary distances for spatial distribution across the grid cells in a 3D single well reservoir model(SWRM).These parameters are first estimated from the standard pressure transient analysis of well test pressure and rate data,which also act as a priori for the inverse problem.A field-worthy layer cake geological model is prepared based on the prior information obtained from pressure transient analysis,followed by a sequential flow simulation of field well test *** simulation results provide the model pressure versus rate data as the synthetic data for this study.A cost function is defined incorporating the well test pressure data and model pressure data,which would determine the *** inversion process is to optimize the spatial distribution of reservoir parameters to minimize the difference between the measured pressure transient data and the modelled one,which is obtained from the multiphase fluid flow simulator that solves the implicit black-oil fluid-flow diffusivity equations at every step.A Gauss-Newton(GN)inversion scheme is used for the *** reliability of inversion results depends on the accuracy of priori reservoir parameters fed to the solver,which can be refined if required through uncertainty parameter optimization(UPO).This approach helps to obtain a faster and reliable update of reservoir parameters in a layer cake homogeneous geomodel,hereby introducing the required *** increases the confidence and reliability of a geomodel,which is further used for various production prediction strategies.

关键词： Well test Pressure transient Inversion Permeability Boundary

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Identification of earthquake induced structural damage based on synchroextracting transform

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 475-487页

作者： Roshan Kumar Gaurav Kumar Wei Zhao arvind R Yadav Gang Yu Jayendra Kumar Evans Amponsah Department of Electronic and Information Technology Miami College of Henan UniversityHenan 475004China Alliance University Alliance College of Engineering and DesignBanglore 562106India Department of Electronics and Comm Parul UniversityVadodra 391760India School of Electrical Engineering University of JinanJinan 250022China Department of Electronics and Comm NIT JamshedpurJamshedpur 831014India Department of Civil engineering Kwame Nkrumah University of Science and TechnologyKumasi 10959Ghana

Several popular time-frequency techniques,including the Wigner-Ville distribution,smoothed pseudo-Wigner-Ville distribution,wavelet transform,synchrosqueezing transform,Hilbert-Huang transform,and Gabor-Wigner transform,are investigated to determine how well they can identify damage to *** this work,a synchroextracting transform(SET)based on the short-time Fourier transform is proposed for estimating post-earthquake structural *** performance of SET for artificially generated signals and actual earthquake signals is examined with existing *** other tested techniques,SET improves frequency resolution to a great extent by lowering the influence of smearing along the time-frequency ***,interpretation and readability with the proposed method are improved,and small changes in the time-varying frequency characteristics of the damaged buildings are easily detected through the SET method.

关键词： cross-term damage detection earthquake signal synchroextracting transform time-frequency

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Hepatocardiorenal syndrome in liver cirrhosis:Recognition of a new entity?

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World Journal of Gastroenterology 2024年第2期30卷 128-136页

作者： Henry H L Wu Amina Rakisheva arvind Ponnusamy Rajkumar Chinnadurai Renal Research Kolling Institute of Medical ResearchRoyal North Shore Hospital&The University of SydneySt.Leonards(Sydney)2065New South WalesAustralia Department of Cardiology City Cardiological CenterAlmaty 050000Kazakhstan Department of Renal Medicine Royal Preston HospitalPreston PR29HTUnited Kingdom Donal O’Donoghue Renal Research Centre&Department of Renal Medicine Northern Care Alliance National Health Service Foundation TrustSalford M68HDUnited Kingdom

Emerging evidence and perspectives have pointed towards the heart playing an important role in hepatorenal syndrome(HRS),outside of conventional understanding that liver cirrhosis is traditionally considered the sole origin of a cascade of pathophysiological mechanisms directly affecting the kidneys in this *** the absence of established heart disease,cirrhotic cardiomyopathy may occur more frequently in those with liver cirrhosis and kidney *** is a specific form of cardiac dysfunction characterized by blunted contractile responsiveness to stress stimuli and altered diastolic relaxation with electrophysiological *** the clinical description of these potential cardiac-related complications of the liver,the role of the heart has traditionally been an overlooked aspect of circulatory dysfunction in *** from a physiological sense,temporality(prior onset)of cardiorenal interactions in HRS and positive effects stemming from portosystemic shunting demonstrated an important role of the heart in the development and progression of kidney dysfunction in cirrhotic *** this review,we discuss current concepts surrounding how the heart may influence the development and progression of HRS,and the role of systemic inflammation and endothelial dysfunction causing circulatory dysfunction within this *** temporality of heart and kidney dysfunction in HRS will be *** a subgroup of patients who receive portosystemic shunting,the dynamics of cardiorenal interactions following treatment is *** research to determine the unknowns in this topic is anticipated,hopefully to further clarify the intricacies surrounding the liver-heart-kidney connection and improve strategies for management.

关键词： Hepatorenal syndrome Cardiorenal syndrome Cirrhosis Cardiac dysfunction Circulatory dysfunction

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Diabetes is affecting everyone everywhere

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World Journal of Diabetes 2024年第2期15卷 305-307页

作者： Parul Chawla Gupta Mona Duggal arvind Kumar Morya Department of Ophthalmology Post Graduate Institute of Medical Education&ResearchChandigarh 160012PunjabIndia School of Public Health Post Graduate Institute of Medical Education and ResearchChandigarh 160002PunjabIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

The article titled“Accessibility and Utilization of Healthcare Services Among Diabetic Patients:Is Diabetes a Poor Man’s Ailment?”gave insights into a pandemic systemic disease known as diabetes *** modern-era pandemic affects everyone,regardless of their financial *** a result,diabetes is not a systemic disease which just involves people of low socioeconomic status.

关键词： Diabetes Incidence and prevalence Diabetes mellitus

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Glacier area change (1993-2019) and its relationship to debris cover, proglacial lakes, and morphological parameters in the Chandra-Bhaga Basin, Western Himalaya, India

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Journal of Mountain Science 2024年第4期21卷 1287-1306页

作者： VATSAL Sarvagya AZAM Mohd Farooq BHARDWAJ Anshuman MANDAL Arindan BAHUGUNA Ishmohan RAMANATHAN Alagappan RAJU N.Janardhana tomar Sangita Singh Department of Civil Engineering Indian Institute of Technology IndoreSimrol 453552India School of Geosciences University of AberdeenKing’s CollegeAberdeen AB243FXUnited Kingdom Interdisciplinary Centre for Water Research Indian Institute of ScienceBengaluru 560012India Space Application Centre Ahmedabad 380015India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography Norwegian University of Science and TechnologyTrondheim No-7491Norway

Glacier inventories serve as critical baseline data for understanding the impacts of climate change on *** present study maps the outlines of glaciers in the Chandra-Bhaga Basin(western Himalaya)for the years 1993,2000,2010,and 2019 using Landsat Thematic Mapper(TM),Enhanced Thematic Mapper(ETM),and Operational Land Imager(OLI)datasets.A total of 251 glaciers,each having an area above 0.5 km^(2),were identified,which include 216 clean-ice and 35 debris-covered *** changes are estimated for three periods:1993-2000,2000-2010,and *** total glacierized area was 996±62 km^(2) in 1993,which decreased to 973±70 km^(2) in *** mean rate of glacier area loss was higher in the recent decade(2010-2019),at 0.036 km^(2),compared to previous decades(0.029 km^(2) in 2000-2010 and 0.025 km^(2) in 1993-2000).Supraglacial debris cover changes are also mapped over the period of 1993 and *** is found that the supraglacial debris cover increased by 14.12±2.54 km^(2)(15.2%)during *** field surveys on Chhota Shigri,Panchi II,Patsio,Hamtah,Mulkila,and Yoche Lungpa glaciers were carried out to validate the glacier outlines and supraglacial debris cover estimated using satellite *** of various morphological parameters on retreat were also *** is observed that small,clean ice,south oriented glaciers,and glaciers with proglacial lakes are losing area at faster rates than other glaciers in the basin.

关键词： Glacier Area change Debris cover Morphology Proglacial lake

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Chiglitazar and Thiazolidinedione in patients with type 2 diabetes:Which is better?

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World Journal of Diabetes 2024年第3期15卷 565-567页

作者： Kotha Sugunakar Reddy Archana Gaur Sakthivadivel Varatharajan arvind Kumar Morya Department of General Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Physiology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Medicine All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

This published Meta-Analysis by Lin et al is an indirect comparison between two drugs Chiglitazar and Thiazolidinedione which are commonly used for glycemic control in type-Ⅱ diabetes *** terms of safety and efficacy... 详细信息

关键词： Type-Ⅱdiabetes mellitus Glucose intolerance Hyperglycemia Research methodology

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Bidirectional link between periodontitis and systemic inflammation in diabetic retinopathy

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World Journal of Diabetes 2024年第7期15卷 1651-1653页

作者： Prateek Nishant Sony Sinha Ranjeet Kumar Sinha arvind Kumar Morya Department of Ophthalmology ESIC Medical CollegePatna 801103BiharIndia Department of Ophthalmology-Vitreo-Retina Neuro-Ophthalmology and OculoplastyAll India Institute of Medical SciencesPatna 801507BiharIndia Department of Community Medicine Patna Medical CollegePatna 800004BiharIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia

Periodontitis is independently associated with numerous lifestyle *** patients have approximately threefold increased odds of periodontitis,which in turn increases the risk of systemic *** study by Thazhe Poyil et al is an effort to establish the inflammatory link between diabetic retinopathy(DR)and periodontitis based on the periodontal inflamed surface area in diabetic patients with and without *** further advance the study,we suggest refining the eligibility criteria to explicitly state the clinical correlates of periodontitis and DR,larger sample size and improved sampling methodology,matching of baseline characteristics of the two groups,as well as improved statistical approach and interpretation of the study *** of hemoglobin A1c(HbA1c)in studies comparing type 2 diabetes mellitus patients with DR of matched severity with and without periodontitis could provide a clearer picture of whether HbA1c level is indeed influenced by periodontitis.

关键词： Glucose intolerance Hyperglycemia Inflammation Research methodology Vision

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