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Spatial and Contextual Path Network for Image Inpainting

Intelligent Automation & Soft Computing 2024年第2期39卷 115-133页

作者： Dengyong Zhang Yuting Zhao Feng Li arun Kumar Sangaiah Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation Changsha University of Science and TechnologyChangsha410114China School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China International Graduate Institute of AI National Yunlin University of Science and TechnologyYunlinTaiwan Department of Electrical and Computer Engineering Lebanese American UniversityByblosLebanon

Image inpainting is a kind of use known area of information technology to repair the loss or damage to the *** feature extraction is the core of image *** enough space for information and a larger receptive field is very important to realize high-precision image ***,in the process of feature extraction,it is difficult to meet the two requirements of obtaining sufficient spatial information and large receptive fields at the same *** order to obtain more spatial information and a larger receptive field at the same time,we put forward a kind of image restoration based on space path and context path *** the space path,we stack three convolution layers for 1/8 of the figure,the figure retained the rich spatial *** the context path,we use the global average pooling layer,where the accept field is the maximum of the backbone network,and the pooling module can provide global context information for the maximum accept *** order to better integrate the features extracted from the spatial and contextual paths,we study the fusion module of the two *** fusionmodule first path output of the space and context path,and then through themass normalization to balance the scale of the characteristics,finally the characteristics of the pool will be connected into a feature vector and calculate the weight *** of images in order to extract context information,we add attention to the context path refinement *** modules respectively from channel dimension and space dimension to weighted images,in order to obtain more effective *** show that our method is better than the existing technology in the quality and quantity of themethod,and further to expand our network to other inpainting networks,in order to achieve consistent performance improvements.

关键词： Image inpainting attention deep learning convolutional network

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Viral etiologies of acute liver failure

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World Journal of Virology 2024年第3期13卷 26-40页

作者： Brian W McSteen Xiao-Han Ying Catherine Lucero arun B Jesudian Department of Medicine New York-Presbyterian/Weill Cornell CampusNew YorkNY 10021United States Department of Gastroenterology and Hepatology Weill Cornell MedicineNew YorkNY 10021United States

Acute liver failure(ALF)is a rare cause of liver-related mortality worldwide,with an estimated annual global incidence of more than one million *** drug-induced liver injury,including acetaminophen toxicity,is the leading cause of ALF in the Western world,viral infections remain a significant cause of ALF and the most common cause in many developing *** the high mortality rates associated with ALF,healthcare providers should be aware of the broad range of viral infections that have been implicated to enable early diagnosis,rapid treatment initiation when possible,and optimal management,which may include liver *** review aims to provide a summary of viral causes of ALF,diagnostic approaches,treatment options,and expected outcomes.

关键词： Acute liver failure Viral hepatitis Hepatitis B Hepatitis C Hepatitis A Liver disease Hepatology

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Understanding myofibroblast origin in the fibrotic lung

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 142-150页

作者： Mahsa Zabihi Mahtab Shahriari Felordi arun Lingampally Saverio Bellusci Xuran Chu Elie El Agha Department of Medicine V Internal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)German Center for Lung Research(DZL)Justus-Liebig University GiessenGiessen 35392Germany Cardio-Pulmonary Institute(CPI) Giessen 35392Germany Institute for Lung Health(ILH) Giessen 35392Germany Department of Medicine II Internal MedicinePulmonary and Critical CareUniversities of Giessen and Marburg Lung Center(UGMLC)German Center for Lung Research(DZL)Justus-Liebig University GiessenGiessen 35392Germany Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhouZhejiang 325035China

Idiopathic pulmonary fibrosis(IPF)is characterized by accumulation of myofibroblasts(MYFs)and extracellular matrix components,which leads to severe distortion and scarring of the gas exchange units of the lung,the alveoli,and ultimately respiratory ***-associated MYFs are therefore widely regarded as the culprits that compromise the architectural makeup of the lung in fibrotic *** the past decade,the cellular source of MYFs has been intensely *** rationale for such studies is that identifying the origin of these cells might help identify novel therapeutic targets and candidates to treat IPF *** advances in basic and translational research employing lineage tracing and multi-omics approaches have helped address the identity of MYF precursors,highlight the underlying heterogeneity,and to a less extent investigate MYF fate during fibrosis *** this review,we discuss the current understanding of such important aspects of MYF biology as well as recent developments in the treatment of IPF.

关键词： Idiopathic pulmonary fibrosis Myofibroblasts Fibrotic disease Myofibroblast heterogeneity Lineage tracing

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Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas Shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

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Development,validation,and transportability of several machine-learned,non-exercise-based VO_(2max)prediction models for older adults

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Journal of Sport and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven P.Hooker Humberto Parada Jr. John Bellettiere arun Kumar Herbert Wertheim School of Public Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Department of Epidemiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Epidemiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Computer Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen uptake(VO_(2max))non-exercise-based prediction equations,fewer using machine learning(ML),and none specifically for older *** direct measurement of VO_(2max)is infeasible in large epidemiologic cohort studies,we sought to develop,validate,compare,and assess the transportability of several ML VO_(2max)prediction ***:The Baltimore Longitudinal Study of Aging(BLSA)participants with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine(SVM)algorithms were trained to predict VO_(2max)*** developed these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and predicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection operator,linear-and tree-boosted extreme gradient boosting,random forest,and support vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong predictor of *** ML can improve the accuracy of prediction as compared to simpler approaches but estimates of association with mortality remain sensitive to *** studies should seek to reproduce these results so that VO_(2max),an important vital sign,can be more broadly studied as a modifiable target for promoting functional resiliency and healthy aging.

关键词： Cardiorespiratory fitness Prediction algorithms Epidemiology Mortality

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Paradigm shift in transfusion practices during early COVID-19 pandemic:A single center retrospective study

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World Journal of Virology 2024年第2期13卷 78-86页

作者： Sumukh arun Kumar Sushmita Prabhu Ankushi Sanghvi Maya Gogtay Mithil Gowda Suresh Harshit Khosla Yuvaraj Singh Ajay Kumar Mishra Susan George Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Hematology and Oncology University of Nebraska Medical CenterOmahaNE 68198United States Hospice and Palliative Care UTHSC and McGovern School of MedicineTexasTX 77030United States Department of Gastroenterology and Hepatology UMass Chan Medical SchoolWorcesterMA 01655United States Division of Cardiology Saint Vincent HospitalWorcesterMA 01608United States

BACKGROUND The advent of coronavirus disease 2019(COVID-19)unveiled the worst national blood crisis that the United States had witnessed in over a *** the pandemic influencing the different stages of the acquisition of blood products outside the hospital setting,we aimed to explore the possible barriers contributing to the shortage of blood products within the medical *** COVID era and pre-COVID *** We conducted a retrospective cross-sectional study on hospitalized patients distinguishing the pattern of blood transfusion during the COVID and pre-COVID era in a community *** was tabulated to include the number of red blood cell(RBC)transfusions and if transfusions met restrictive blood transfusion criteria as per institutional ***-square was applied to test the statistical association between qualitative *** t test and Mann Whitney U test were applied respectively to test the mean difference of quantitative *** A total of 208 patients were included in the study,of which 108 were during COVID era and 100 were during pre-COVID *** leading reason for admission in both the COVID era and pre-COVID era transfused patients was shortness of breath(53.7%and 36%P=0.001),followed by gastrointestinal bleeding(25.9%and 21%P=0.001).There was a higher percentage of RBC transfusions in the intensive care unit in the COVID-era group than in the pre-COVID era group(38.9%vs 22%,P=0.008).The restrictive transfusion criteria were met in 62%vs 79%in the COVID and pre-COVID eras,respectively(P=0.008).CONCLUSION The COVID-era group received RBC transfusions with less stringent adherence to restrictive blood transfusion practices in comparison to pre-COVID era group.

关键词： Blood transfusion Restrictive transfusion COVID-19 Pre-COVID-19 Blood shortage Pandemic

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Mechanical and Physical Properties of Pineapple Leaf and Sun Hemp Fibre Reinforced Hybrid Natural Composite Fabricated by Compression Moulding Method

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Journal of Bionic Engineering 2022年第1期19卷 257-267页

作者： A.arun Premnath Centre for Composite Science and Tribology Sri Chandrasekharendra Saraswathi Viswa MahavidyalayaKanchipuramTamilnadu631561India

The implementation of natural fibres in polymer composites will result in biodegradable,low cost,recyclable materials for automobile and structural *** the process of making natural fibre composites viable in the global market,it is essential to understand its mechanical and physical *** the present investigation,mechanical and physical properties of pineapple Leaf(PALF)and Sun Hemp(SH)Fibre reinforced with epoxy matrix was studied in terms of weight(wt)%of fibre loading and chemical *** composites were fabricated by compression moulding technique with PALF fibre content varying from 10,15 and 20%of weight *** PALF and SHF were treated with NaOH solution for 1 h at room *** various mechanical properties such as tensile,compression,flexural and impact strength were measured as per ASTM *** density and water absorption were also measured to study the physical properties of the fabricated *** treated composites exhibit a rough surface because of the removal of the cellulose layer which results in better adhesion between the matrix/fibre interface than untreated *** NaOH treated fibres composites outperformed untreated fibre composites in terms of mechanical and physical properties except for impact *** morphological studies of the worn surfaces are examined using Scanning Electron Microscope(SEM).

关键词： Pineapple leaf fibre Compression moulding Mechanical properties Physical properties Morphological studies

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Natural compounds in the regulation of proteostatic pathways: An invincible artillery against stress, ageing, and diseases

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Acta Pharmaceutica Sinica B 2021年第10期11卷 2995-3014页

作者： arun Upadhyay Department of Biochemistry Central University of Rajasthan 305817India

Cells have different sets of molecules for performing an array of physiological *** acids have stored and carried the information throughout evolution,whereas proteins have been attributed to performing most of the cellular *** perform these functions,proteins need to have a unique conformation and a definite *** attributes are achieved by a highly coordinated protein quality control(PQC)system comprising chaperones to fold the proteins in a proper threedimensional structure,ubiquitin-proteasome system for selective degradation of proteins,and autophagy for bulk clearance of cell *** kinds of stresses and perturbations may lead to the weakening of these protective cellular machinery,leading to the unfolding and aggregation of cellular proteins and the occurrence of numerous pathological ***,modulating the expression and functional efficiency of molecular chaperones,E3 ubiquitin ligases,and autophagic proteins may diminish cellular proteotoxic load and mitigate various pathological *** medicine and small molecule-based therapies have been well-documented for their effectiveness in modulating these pathways and reestablishing the lost proteostasis inside the cells to combat disease *** present article summarizes various similar reports and highlights the importance of the molecules obtained from natural sources in disease therapeutics.

关键词： Proteostasis Proteinopathies Chaperones Ubiquitin proteasome system Autophagy Cancer Neurodegeneration Ageing Natural molecules Drug discovery

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit Dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra Kumar Pandey Valentina De Falco arun Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Fertilization and Soil Ploughing Practices under Changing Physical Environment Lead to Soil Organic Carbon Dynamics under Conservation Agriculture in Rice-Wheat Cropping System: A Scoping Review

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Agricultural Sciences 2024年第1期15卷 82-113页

作者： Salwinder Singh Dhaliwal Arvind Kumar Shukla Sanjib Kumar Behera Sarwan Kumar Dubey Agniva Mandal Mehakpreet Kaur Randhawa Sharanjit Kaur Brar Gagandeep Kaur Amardeep Singh Toor Sohan Singh Walia Priyadarshani arun Khambalkar Department of Soil Science Punjab Agricultural University Ludhiana India Rajmata Vijayaraje Scindia Krishi Vishwa Vidyalaya Gwalior India Indian Institute of Soil Science (ISSS) Bhopal India Indian Council of Agricultural Research—Central Soil Salinity Research Institute (ICAR-CSSRI) Karnal India Department of Agricultural Chemistry and Soil Science Bidhan Chandra Krishi Viswavidyalaya Mohanpur India Department of Crop and Soil Sciences Washington State University Pullman USA School of Organic Farming Punjab Agricultural University Ludhiana India Department of Soil Science Rajmata Vijayaraje Sciendia Krishi Viswa Vidalaya Gwalior India

Ploughing and fertilization practices in rice-wheat system have deteriorated the soil carbon (C) pools. Conservation agriculture (CA) based management approaches have proven to enhance C sequestration and reverse the loss of soil-organic-carbon (SOC), which further enhances soil fertility. Different fractions of SOC pools react to the alterations in management practices and indicate changes in SOC dynamics as compared to total C in the soil. Higher SOC levels in soil have been observed in case of reduced/no-till (NT) practices than conventional tillage (CT). However, between CT and zero tillage/NT, total SOC stocks diminished with an increase in soil depth, which demonstrated that the benefits of SOC are more pronounced in the topsoil under NT. Soil aggregation provides physical protection to C associated with different-sized particles, thus, the improvement in soil aggregation through CA is an effective way to mitigate soil C loss. Along with less soil disturbance, residual management, suitable crop rotation, rational application of manures and fertilizers, and integrated nutrient management have been found to be effective in not only improving soil C stock but also enhancing the soil health and productivity. Thus, CA can be considered as a potential method in the build-up of SOC of soil in rice-wheat system.

关键词： Tillage Conservation Agriculture Soil Organic Carbon Carbon Fractions Rice-Wheat System Organic Amendments

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