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The Relation between the Initial Type of Schedule Used to Administer Doxorubicin and long-Term Doxorubicin Cardiotoxicity

丛书名： Includes CD-ROM

2006年

作者： Boutros Sean G. luce Craig A. Millman arthur l. Zide Barry M

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Journal of Cancer Therapy 2014年第12期5卷 1145-1152页

作者： arthur J. Weiss Irwin l. Stoloff Antonio C. Simoes Richard D. lackman Division of Medical Oncology Thomas Jefferson University Hospital Philadelphia PA USA North Penn Hospital Landsdale PA USA Division of Orthopedic Oncology Cooper University Hospital Camden NJ USA

Background: As more patients survive cancer chemotherapy, problems associated with the late complications of therapy have become increasingly apparent;late doxorubicin cardio-myopathy being one of the most pressing. The relationship between initial dose, schedule employed, and etiology are still not well defined. This study attempts to clarify some of these issues. Methods: Patients receiving large total doses of doxorubicin by schedules designed to minimize peak drug levels were monitored in regard to their cardiac status for up to 31 years following completion of doxorubicin therapy. A computer program predicting the amount of doxorubicin retained by the heart vs. schedules employed was devised with the predictions of the computer program being compared to the clinical findings. Results: 1365 patients receiving doses of doxorubicin greater than 610 mgm./M2 were monitored for up to 31 years following completion of such therapy. No patient developed unequivocal clinical and pathologic evidence of a doxorubicin related cardiomyopathy. Knowing that human cardio-myocytes contain enzymes capable of neutralizing doxorubicin, a computer program predicted that by increasing their efficiency, the schedules employed substantially l decreased the relative amount of drug retained by the heart, findings compatible with both animal experiments and clinical results. Conclusions: administration of doxorubicin by schedules in which peak plasma levels of drug were minimized resulted in marked decreases in both acute and long-term cardiac toxicity;believed to be due to potentiation of myocardial enzymes capable of inactivating the drug.

关键词： late Doxorubicin Cardiotoxicity Initial Type of Doxorubicin Schedule

Quantification of Zoonotic Bacterial Pathogens within Commercial Poultry Processing Water Samples Using Droplet Digital PCR

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Advances in Microbiology 2013年第5期3卷 403-411页

作者： Michael J. Rothrock Kelli l. Hiett Brian H. Kiepper Kim Ingram arthur Hinton Poultry Processing and Swine Physiology Research Unit USDA-Agricultural Research Service Athens Georgia

Raw poultry and poultry products are a significant source of zoonotic bacterial pathogen transmission;thus the sensitive detection of major zoonotic pathogens (Salmonella spp., Campylobacter jejuni, and listeria monocytogenes) is a vital food safety issue. Recently, third generation PCR technology, known as droplet digital PCR (ddPCR) has been developed to be more accurate and sensitive to detect genetic targets than current quantification methods, but this technology has not been tested within an industrial setting. There is an on-going study within our laboratory is investigating the effects of sampling times and sampling methods on the cultural and molecular (via qPCR) quantification of dominant zoonotic pathogens within a poultry processing facility. This presents a unique opportunity to compare the quantification resulted from this emerging, third generation technology to traditional quantification methods currently employed by the poultry industry. The results show that ddPCR detected pathogen-specific genes from more pathogen:sampling time combinations than either the qPCR or culturing methods from the final scalder and chiller tanks at three stages of processing (Start, Mid, and End). In fact, both ddPCR and qPCR substantially outperformed culture methods commonly used in poultry processing food safety-related studies, with Salmonella recovered only from the Mid and End sampling times from the scalder tank. While neither C. jejuni nor l. monocytogenes were recovered culturally, ddPCR was able to detect their respective genes commonly throughout the processing day in both the scalder and chiller water samples. Additionally, the use of unfiltered processing water provided significantly greater detection of bacterial and pathogen-specific gene abundances than did an analysis of larger volumes of filtered water. Considering the ddPCR-derived concentrations of the bacterial pathogens were consistent with what was previously found culturally in commercial poultry

关键词： ddPCR Poultry Processing Zoonotic Pathogens qPCR

leaf temperature of soybean grown under elevated CO2 increases Aphis glycines （Hemiptera＂ Aphididae） population growth

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Insect Science 2011年第4期18卷 419-425页

作者： Bridget F. O'Neill arthur R. Zangerl Evan H. Delucia Clare Casteel Jorge A. Zavala May R. Berenbaum Departments ofEntomology University of Illinois Urbana-Champaign Urbana Illinois USA Departments of Plant Biology University of Illinois Urbana-Champaign Urbana Illinois USA Departments of Institute of Genomic Biology University of Illinois Urbana-Champaign Urbana Illinois USA Consejo Nacional de InvesUgaciones Cientificas y Technicas Catedra de Bioquimica Facultad de Agronomia University of Buenos Aires Pontificia Universidad Catolica Argentina Buenos Aires Argentina

Plants grown under elevated carbon dioxide （CO2） experience physiological changes that influence their suitability as food for insects. To determine the effects of living on soybean （Glycine max linnaeus） grown under elevated CO2, population growth of the soybean aphid （Aphis glycines Matsumura） was determined at the SoyFACE research site at the University of Illinois, Urbana-Champaign, Illinois, USA, grown under elevated （550μl/l） and ambient （370 μl/l） levels of CO2. Growth of aphid populations under elevated CO2 was significantly greater after 1 week, with populations attaining twice the size of those on plants grown under ambient levels of CO2. Soybean leaves grown under elevated levels of CO2 were previously demonstrated at SoyFACE to have increased leaf temperature caused by reduced stomatal conductance. To separate the increased leaf temperature from other effects of elevated CO2, air temperature was lowered while the CO2 level was increased, which lowered overall leaf temperatures to those measured for leaves grown under ambient levels of CO2. Aphid population growth on plants grown under elevated CO2 and reduced air temperature was not significantly greater than on plants grown under ambient levels of CO2. By increasing Glycine max leaf temperature, elevated CO2 may increase populations of Aphis glycines and their impact on crop productivity.

关键词： Aphis glycines Matsumura elevated CO2 Glycine max linnaeus leaftemperature

Electrophysiologic Effects of Propafenone on Action Potential of Neonatal and Adult Purkinje Fibers

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中国医科大学学报 1991年第S2期20卷 37-42页

作者：徐惠郝丽英张克仪 arthur S.Pickoff Adrienne Stolfi Dept of Pediatrics The First Affiliated Hospital China Medical University Shenyang China Department of Pediatrics Tulane University Medical Center USA M.D. Department of Pediatrics Tulane University Medical Center USA

The electrophysiological effects of 5.8×10-6 mol/l propafenonewere studied in neonatal canine Purkinje fiber compared with changes in theadult canine. The method used was microelectrode technique. This study sug-gests that Purkinje fibers are less sensitive to propafenone in the neonate than inthe adult, but at shorter ample lengths, the difference between them is not sig-nificant.

关键词： propafenone action potential Purkinje fibers

SUGAR CANE BORER CONTROl THROUGH F-1 ST ERIlIZATION

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核农学报 1990年第1期4卷 57-63页

作者： V.arthur,J.M.M.Walder,F.M.Wiendl Uniuersity of St.Paul Piracicaba Brazil Nuclear Energy Center for Agriculture Uniuersity of St.Paul Piracicaba Brazil Nuclear Energy Center for Agriculture Uniuersity of St.Paul Piracicaba Brazil Nuclear Energy Center for Agriculture

To induce sterilization into the F—l generation,pupae of the sugar-cane borer Diatraea saccharalis(F.)were irradiated at the age of six *** radiation source was a Gammabeam 650 Cobalt-60 *** pu-pae were irradiated at... 详细信息

关键词： lrradiagion Diatraeo saccharalis sterilization

Molecular phylogeny of Trametes and related genera,and description of a new genus leiotrametes

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Fungal Diversity 2012年第4期55卷 47-64页

作者： Stéphane Welti Pierre-arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon David Navarro Sabine Taussac laurence lesage-Meessen INRA Aix-Marseille Univ.UMR1163 de Biotechnologie des Champignons Filamenteux ESIL163 avenue de LuminyCP 92513288 MarseilleCedex 09France Facultédes sciences pharmaceutiques et biologiques Laboratoire des sciences végétales et fongiquesUniversitéLille 2.3 rue du Professeur LaguesseB.P.83F-59006 LilleCedexFrance A.Favel:M.Haon:D.Navarro:S.Taussac:l.lesage-Meessen CIRM-CF UMR 1163 BCF13009 MarseilleFrance

A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical *** sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by Maximum likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium *** results were obtained from analyses of ribosomal lSU sequences downloaded from *** Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(***,***,***,***)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and *** presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these *** the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:leiotrametes Welti&***..Two new combinations:leiotrametes lactinea(Berk.)Welti&*** ***(Berk.)Welti&*** proposed.

关键词： Basidiomycota Polyporales Artolenzites Coriolopsis lenzites Pycnoporus Morphology Biogeography

Neutrinos,large Scientific Facilities and Science Innovation--An Interview with Prof,arthur ***

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Bulletin of the Chinese Academy of Sciences 2017年第3期31卷 133-136页

作者： arthur B.McDonald 无不详 ihep

In the middle of May,2017,Professor Ar thur ***,director of the Sudbury Neutrino Observatory(SNO)in Canada and Nobel Prize laureate in Physics in 2015,visited the Institute of High Energy Physics(IHEP),Chinese Academy of Sciences(CAS).After a brief visit to the laboratories for particle physics at IHEP,he shared his opinions on the future of neutrino physics,neutr ino exper iments,and other large scienti f ic faci l ities in China and worldwide.

关键词： arthur B McDonald Neutrinos Bay An Interview with Prof

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Irritable bowel syndrome symptom severity improves equally with probiotic and placebo

2018年

作者： (美)阿瑟·O.洛夫乔伊

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World Journal of Gastroenterology 2016年第48期22卷 10631-10642页

作者： Anna lyra Markku Hillila Teppo Huttunen Sofia Mannikko Mikko Taalikka Julia Tennila Anneli Tarpila Sampo lahtinen arthur C Ouwehand lea Veijola DuPont Nutrition and Health Global Health and Nutrition ScienceDanisco Sweeteners Oy02460 KantvikFinland Clinic of Gastroenterology University of Helsinki and University Hospital00290 HelsinkiFinland 4Pharma ltd Lemminkaisenkatu 120520 TurkuFinland Mehilainen Oy Pohjoinen Hesperiankatu 1700260 HelsinkiFinland

AIM To determine the effects of lactobacillus acidophilus NCFM on irritable bowel syndrome(IBS) symptoms and quality of life(Qo l).METHODS In this randomized triple-blind trial, adult IBS volunteerswho were recruited according to Rome Ⅲ criteria received 109 or 1010 colony-forming units of NCFM or placebo daily for 12 wk. IBS Symptom Severity Score(IBS-SSS), which constituted the primary outcome, and secondary outcomes, including individual IBS symptoms, IBS-related Qol questionnaire, anxiety and depression, defecation frequency, and stool consistency, were assessed at baseline at the end of the 8-wk runin period, after 4 and 12 wk of intervention, and after a 4-wk *** A total of 340 of 391 randomized volunteers completed the trial. IBS-SSS improved over 12 wk of treatment in all treatment groups, decreasing by a mean ± SD of 44.0 ± 80.2, 50.8 ± 82.4, and 48.3 ± 72.2 in the placebo, active low-dose, and active high-dose groups, respectively. Similarly, secondary outcomes did not differ between treatment groups. However, in a post hoc analysis of volunteers with moderate to severe abdominal pain at baseline(VAS > 35/100), the treatment significantly reduced the sensation of abdominal pain. Pain scores fell by 20.8 ± 22.8, 29.4 ± 17.9, and 31.2 ± 21.9 in the placebo, active low-dose, and active high-dose groups, respectively(P value for placebo vs combined active doses = 0.0460).CONClUSION NCFM alleviates moderate to severe abdominal pain, consistent with earlier observations of this strain mitigating visceral pain through increased analgesic receptor expression.

关键词： Irritable bowel syndrome Functional bowel disorder Symptom questionnaire Quality of life Visceral pain Abdominal pain lactobacillus acidophilus Probiotic Intervention