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Promoting integrative medicine by computerization of traditional Chinese medicine for scientific research and clinical practice: The suiteTCM Project

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Journal of Integrative Medicine 2013年第2期11卷 135-139页

作者： arthur de sá ferreira Laboratory of Computational simulation and Modeling in Rehabilitation Post-graduation Program of Rehabilitation Science Augusto Motta University Center

BACKGROUND： Chinese and contemporary Western medical practices evolved on different cultures and historical contexts and, therefore, their medical knowledge represents this cultural divergence. Computerization of traditional Chinese medicine （TCM） is being used to promote the integrative medicine to manage, process and integrate the knowledge related to TCM anatomy, physiology, semiology, pathophysiology, and therapy. METHODs： We proposed the development of the suiteTCM software, a collection of integrated computational models mainly derived from epidemiology and statistical sciences for computerization of Chinese medicine scientific research and clinical practice in all levels of prevention. The software includes components for data management （DataTCM）, simulation of cases （simTCM）, analyses and validation of datasets （sciTCM）, clinical examination and pattern differentiation （DiagTCM, TongueTCM, and PulseTCM）, intervention selection （AcuTCM, HerbsTCM, and DietTCM）, management of medical records （ProntTCM）, epidemiologic investigation of sampled data （ResearchTCM）, and medical education, training, and assessment （studentTCM）. DIsCUssION： The suiteTCM project is expected to contribute to the ongoing development of integrative medicine and the applicability of TCM in worldwide scientific research and health care. The suiteTCM 1.0 runs on Windows XP or later and is freely available for download as an executable application.

关键词： traditional Chinese medicine evidence-based practice computer-assisted decision making

simTCM: A human patient simulator with application to diagnostic accuracy studies of Chinese medicine

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Journal of Integrative Medicine 2015年第1期13卷 9-19页

作者： arthur de sá ferreira Antonio Guilherme Pacheco Postgraduation Program in Rehabilitation science Augusto Motta University Center Program of scientific Computing

OBJECTIVE： The aim of this work is to develop and implement the simTCM, an advanced computationa model that incorporates relevant aspects from traditional Chinese medicine （TCM） theory as well as advanced statistical and epidemiological techniques for simulation and analysis of human patients. METHODs： simTCM presents five major attributes for simulation： representation of true and false profiles for any single pattern; variable count of manifestations for each manifestation profile; empirical distributions of patterns and manifestations in a disease-specific population; incorporation of uncertainty in clinical data; and the combination of the four examinations. The proposed model is strengthened by following international standards for reporting diagnostic accuracy studies, and incorporates these standards in its treatment of study population, sample size calculation, data collection of manifestation profiles, exclusion criteria and missing data handling, reference standards, randomization and blinding and test reproducibility. REsULTs： simulations using data from patients diagnosed with hypertension and post-stroke sensory- motor impairments yielded no significant differences between expected and simulated frequencies of patterns （P = 0.22 or higher）. Time for convergence of simulations varied from 9.90 s （9.80, 10.27） to 28.31 s （26.33, 29.52）. The ratio iteration profile necessary for convergence varied between 1：1 and 5：1. CONCLUsION： This model is directly connected to forthcoming models in a large project to design and implement the suite TCM： ProntTCM, sciTCM, DiagTCM, studentTCM, Research TCM, HerbsTCM, AcuTCM, and DataTCM. It is expected that the continuity of the suiteTCM project enhances the evidence-based practice of Chinese medicine.

关键词： medicine, Chinese traditional evidence-based medicine computer-assisted decision making rehabilitation medicine (TCM)

dental-derived stem cells in tissue engineering:the role of biomaterials and host response

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Regenerative Biomaterials 2024年第1期3卷 17-26页

作者： Weihao Yuan Luiza de Almeida Queiroz ferreira Bo Yu sahar Ansari Alireza Moshaverinia Weintraub Center for Reconstructive Biotechnology Section of ProsthodonticsSchool of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA department of Restorative dentistry School of DentistryUniversidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil section of Restorative dentistry School of DentistryUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA department of Bioengineering Henry Samueli School of Engineering and Applied SciencesUniversity of CaliforniaLos AngelesLos AngelesCA 90095USA

dental-derived stem cells(DsCs)are attractive cell sources due to their easy access,superior growth capacity and low *** can respond to multiple extracellular matrix signals,which provide biophysical and biochemical cues to regulate the fate of residing ***,the direct transplantation of DsCs suffers from poor proliferation and differentiation toward functional cells and low survival rates due to local ***,elegant advances in the design of novel biomaterials have been made to give promise to the use of biomimetic biomaterials to regulate various cell behaviors,including proliferation,differentiation and *** could be tailored with multiple functionalities,e.g.,*** is an emerging need to summarize recent advances in engineered biomaterials-mediated delivery and therapy of DsCs and their potential ***,we outlined the design of biomaterials for supporting DsCs and the host response to the transplantation.

关键词： dental-derived stem cells biomaterials host response tissue engineering

Asserted and neglected issues linking evidence-based and Chinese medicines for cardiac rehabilitation

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World Journal of Cardiology 2014年第5期6卷 295-303页

作者： arthur de sá ferreira Nathalia Gomes Ribeiro de Moura Laboratory of Computation simulation and Modeling in Rehabilitation Postgraduate Program of Rehabilitation Science Centro Universitário Augusto Motta/UNISUAM CEP 21041-010 Rio de Janeiro Brazil

High blood pressure is among the most prevalent chronic disease in adults that impacts on the quality of life of patients, which are often subjected to physical rehabilitation. Chinese medicine intervention in patients with hypertension presents promising albeit inconclu-sive results, mostly due to methodological issues. This paper discusses asserted and neglected issues linking evidence-based and Chinese medicines as related to systemic arterial hypertension, as well as their impact on the physical rehabilitation of those patients. On the one hand, natural history of hypertension, pulse palpa-tion, and herbal therapy are among the asserted issues because of the scientific evidence collected about them, either in favor or against its integration to the current medical practice. On the other hand, anatomical varia-tions of vessels and comparative physiology are among the most commonly neglected issues because previous researches on integrative medicine ignored the pos-sible effects of these issues as related to the study's outcome. The asserted issues highlighted in this paperstimulate the increasing use of Chinese medicine for health care and the continuity of research on integra-tive medicine in the cardiovascular field for rehabilita-tion. The neglected issues poses additional challenges that must not be overlooked in future research on this topic so that the integration of both traditional and cur-rent knowledge may be of benefit to the population with cardiovascular disease.

关键词： Cardiovascular disease Hypertension Chinese medicine Rehabilitation Integrative medicine

Contribution of glial cells to the neuroprotective effects triggered by repetitive magnetic stimulation:a systematic review

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Neural Regeneration Research 2024年第1期19卷 116-123页

作者： susana A.ferreira Nuno Pinto Inês serrenho Maria Vaz Pato Graça Baltazar Centro de Investigação em Ciências da saúde(CICs-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da saúde Universidade da Beira InteriorCovilhãPortugal GRUBI-systematic Reviews Group University of Beira InteriorCovilhãPortugal

Repetitive transcranial magnetic stimulation has been increasingly studied in different neurological diseases,and although most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trigge red by repetitive transcranial magnetic stimulation in these diseases has been increasingly *** systematically review the effects of repetitive magnetic stimulation on non-neuronal cells two online *** of science and PubMed were searched fo r the effects of high-frequency-repetitive transcranial magnetic stimulation,low-frequencyrepetitive transcranial magnetic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive magnetic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was high-frequency-repetitive magnetic stimulation,and in models of disease,most studies report that high-frequency-repetitive magnetic stimulation led to a decrease in astrocyte and mic roglial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of oligodendrocyte *** trend towards decreased microglial and astrocyte reactivity as well as increased oligodendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial magnetic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting the absence of effects on these paramete *** what concerns the use of magnetic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating possible diffe rential effects of repetitive transcranial magneti

关键词： astrocyte glia high-frequency repetitive magnetic stimulation inflammation low-frequency repetitive magnetic stimulation microglia neurologic disorders oligodendrocyte repetitive magnetic stimulation theta-burst stimulation

Temporal and spatial differences in human activities performed in Urban Green spaces of Vilnius(Lithuania)

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Geography and sustainability 2024年第2期5卷 302-317页

作者： Luís Valença Pinto Carla sofia santos ferreira Paulo Pereira Research Centre for Natural Resources Environment and society(CERNAs) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGs)are relevant to city well-being,as recognized by the United Nations’sustainable development Goals(sDGs).However,few studies have studied the temporal use of *** work assessed the seasonal,weekly,and daily use of three urban green spaces(Vingis Park,Bernardino Garden,and Jomantas Park)in Vilnius(Lithuania).The study is based on an on-site observation-based survey,which recorded users’characteristics,activities,and weather conditions during summer and *** results showed that UGs’s seasonal,weekly,and daily use differed according to park and users’*** with a higher diversity of facilities had a high seasonal difference in the number of observed *** numbers were higher in the summer for activities with children,social activities,sports,and water activities than in the *** Park had the lowest variability in user *** variables were linked to changes in users’*** precipitation and lower temperature were associated with reducing the number of users and the diversity of registered *** of the stationary activities were observed during *** diversity of the observed activities was associated with the available facilities rather than the park *** distribution of stationary activities was spatially correlated with facility/equipment(benches,playgrounds,sports,and fitness equipment)and proximity to water *** results of this study are relevant for UGs design,planning,and management.

关键词： Urban parks seasonal differences Temporal use Time of day spatial distribution of UGs users

A Rapid Parameter of Enzyme-Treated Cellulosic Material Revealed by Reducing sugar Release

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Journal of Renewable Materials 2024年第3期12卷 539-551页

作者： Verônica Távilla ferreira silva Adriane Maria ferreira Milagres departamento de Biotecnologia Escola de Engenharia de LorenaUniversidade de São PauloLorenaSP12602-810Brazil

This study was conducted to evaluate the effectiveness of enzymes in purifying and reducing the degree of polymerization of cellulose for the production of dissolving *** goal was to determine the contributions of xylanase(X)and endoglucanase(EG)in the treatment of pulp,specifically by quantifying the formation of soluble and insoluble reducing sugars using the dinitrosalycilic acid(DNs)***,the release of soluble reducing sugars(Rssol)was enhanced after xylanase treatment,while endoglucanase(EG)treatment led to changes in insoluble reducing sugars(RsIns).The maximum synergism was observed for RsIns when a high ratio of endoglucanase to xylanase(320EG:5X/g pulp)was *** relative contribution of endoglucanase to Rsins was determined to be 15.6%of the total reducing *** viscosity of pulps treated with xylanase decreased only by 7%,whereas endoglucanase treatment significantly reduced viscosity by 45%.Modifications in the particle size were observed after pulp treatment with the combination of endoglucanase and *** summary,the DNs test is a rapid and effective method for evaluating the efficiency of enzyme treatments on *** measurement of RsIns correlates with changes in pulp viscosity to different extents,providing valuable insights into the effectiveness of enzyme treatments.

关键词： Endoglucanase xylanase cellulose fiber pulp synergism

RPLP0/TBP are the most stable reference genes for human dental pulp stem cells under osteogenic differentiation

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World Journal of stem Cells 2024年第6期16卷 656-669页

作者： Daniel B ferreira Leticia M Gasparoni Cristiane F Bronzeri Katiucia B s Paiva Laboratory of Extracellular Matrix Biology and Cellular Interaction Department of AnatomyInstitute of Biomedical SciencesUniversity of São PauloSão Paulo 05508-000São PauloBrazil

BACKGROUND Validation of the reference gene(RG)stability during experimental analyses is essential for correct quantitative real-time polymerase chain reaction(RT-qPCR)data ***,in an unreliable way,several studies use genes involved in essential cellular functions[glyceraldehyde-3-phosphate dehydro-genase(GAPDH),18s rRNA,andβ-actin]without paying attention to whether they are suitable for such experimental conditions or the reason for choosing such ***,such studies use only one gene when Minimum Information for Publication of Quantitative Real-Time PCR Experiments guidelines recom-mend two or more *** impacts the credibility of these studies and causes dis-tortions in the gene expression *** tissue engineering,the accuracy of gene expression drives the best experimental or therapeutical *** cultivated DPsCs under two conditions:Undifferentiated and osteogenic dif-ferentiation,both for 35 *** evaluated the gene expression of 10 candidates for RGs[ribosomal protein,large,P0(RPLP0),TATA-binding protein(TBP),GAPDH,actin beta(ACTB),tubulin(TUB),aminolevulinic acid synthase 1(ALAs1),tyro-sine 3-monooxygenase/tryptophan 5-monooxygenase activation protein,zeta(YWHAZ),eukaryotic translational elongation factor 1 alpha(EF1a),succinate dehydrogenase complex,subunit A,flavoprotein(sDHA),and beta-2-micro-globulin(B2M)]every 7 d(1,7,14,21,28,and 35 d)by *** data were analysed by the four main algorithms,ΔCt method,geNorm,NormFinder,and BestKeeper and ranked by the RefFinder *** subdivided the samples into eight *** All of the data sets from clonogenic and osteogenic samples were analysed using the RefFinder *** final ranking showed RPLP0/TBP as the two most stable RGs and TUB/B2M as the two least stable *** theΔCt method or NormFinder analysis showed TBP/RPLP0 as the two most stable ***,geNorm analysis showed RPLP0/EF1αin the first *** algorithms’two least stab

关键词： dental pulp stem cells Reference gene Housekeeping gene Endogenous gene Osteogenic differentiation RefFinder

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 883-893页

作者： Brendha Cação Coimbra Marina Alessandra Pereira Leonardo Cardili Venancio Avancini ferreira Alves Evandro sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGROUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone sP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).Of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CONCLUsION Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 stomach neoplasms Immunohistochemistry Metastasis