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Estimation of the density of neural,glial,and endothelial lineage cells in the adult mouse dentate gyrus

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Neural Regeneration Research 2022年第6期17卷 1286-1292页

作者： Joshua d.Rieskamp Patricia Sarchet Bryon M.smith Elizabeth d.Kirby Neuroscience Graduate Program The Ohio State UniversityColumbusOHUSA department of Psychology The Ohio State UniversityColumbusOHUSA department of Neuroscience The Ohio State UniversityColumbusOHUSA Chronic Brain Injury Program The Ohio State UniversityColumbusOHUSA

The dentate gyrus subregion of the mammalian hippocampus is an adult neural stem cell niche and site of lifelong *** regarding the role of adult-born neuron synaptic integration in hippocampal circuit function are framed by robust estimations of adultborn versus pre/perinatally-born neuron *** contrast,the non-neurogenic functions of adult neural stem cells and their immediate progeny,such as secretion of bioactive growth factors and expression of extracellular matrix-modifying proteins,lack similar framing due to few estimates of their number versus other prominent secretory ***,we apply immunohistochemical methods to estimate cell density of neural stem/progenitor cells versus other major classes of glial and endothelial cell types that are potentially secretory in the dentate gyrus of adult *** the cell types quantified,we found that GFAP^(+)SOX2^(+)stellate astrocytes were the most numerous,followed by Cd31^(+)endothelia,GFAP-SOX2^(+)intermediate progenitors,Olig2^(+)oligodendrocytes,Iba1+microglia,and GFAP^(+)SOX2^(+)radial glia-like neural stem *** did not observe any significant sex differences in density of any cell ***,neural stem/progenitor cells were present at a similar density as several cell types known to have potent functional roles via their *** findings may be useful for refining hypotheses regarding the contributions of these cell types to regulating hippocampal function and their potential therapeutic *** experimental protocols were approved by the Ohio State University Institutional Animal Care and Use Committee(protocol#2016A00000068)on July 14,2016.

关键词： adult neurogenesis dentate gyrus endothelia glia hippocampus neural stem cell secretome stereology

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Computational and experimental study on corrosion inhibition potential of the synergistic 1:1 combination of Arabic and cashew gums on mild steel

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Petroleum Research 2020年第2期5卷 170-180页

作者： david Ebuka arthur department of Chemistry Base UniversityAbujaNigeria

The synergistic study of Acacia Senegal (arabic gum) and Anacardium occidentale (cashew gum) combination in corrosion inhibition of mild steel was carried out to determine the inhibition efficiency of their combination. The gums were purified using standard methods and the blend prepared using the method as described by Femi – Oyewo et al. The blend was then used for corrosion study at two temperatures (303 K and 333 K) and the corrosion rates calculated. The adsorption process was found to satisfy the Langmuir isotherm and hence the sorption study reveals that the interaction is a physical one since the free energy of adsorption (ΔG^(o) ads kJ/mol) is given as (−16.47 and −15.61) kJ/mol at temperature T = 303 K and 333K accordingly. The GCMS technique was used to characterize the blend, five chemical compounds and their area percentage [6-O-(1-L-maloyl)-alpha-,beta-d-Glcp (veracylglucan A) (22.11%), 6-Octadecanoic acid (55.76%), Methylhexadecanoate (3.97%), 1-Pentadecane carboxylic acid (10.78%) and 9, 12-Octadecadienoic acid (7.38%)] were identified and subjected to computation corrosion study, the binding energy for the constituents of the blend on Fe surface were computed using Accelrys Material Studio and the mean values were found to be −327.097 kJ/mol, −446.943 kJ/mol, −602.826 kJ/mol, −608.625 kJ/mol and −693.749 kJ/mol respectively.

关键词： Arabic gum Cashew gum Synergy dFT Corrosion

smith's textbook of endourology / 2nd ed.

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Smith's textbook of endourology /

COMPLEXITY OF SYSTEM MAINTAINABILITY ANALYSIS BASEd ON THE INTERPRETIVE STRUCTURAL MOdELING METHOdOLOGY： TRANSdISCIPLINARY APPROACH

2007年

作者： smith arthur d.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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Journal of Systems Science and Systems Engineering 2016年第2期25卷 254-268页

作者： A. Ertas M.W. smith d. Tate W.d. Lawson T.B. Baturalp department of Mechanical Engineering Texas Tech University Lubbock TX USA 79410 department of Industrial design Xi 'an Jiaotong-Liverpool University Suzhou 215123 Jiangsu China department of Civil Engineering Texas Tech University Lubbock TX USA 79410

This paper outlines a diagnostic approach to quantify the maintainability of a Commercial off-the-Shelf （COTS）-based system by analyzing the complexity of the deployment of the system components. Interpretive Structural Modeling （ISM） is used to demonstrate how ISM supports in identifying and understanding interdependencies among COTS components and how they affect the complexity of the maintenance of the COTS Based System （CBS）. Through ISM analysis we have determined which components in the CBS contribute most significantly to the complexity of the system. With the ISM, architects, system integrators, and system maintainers can isolate the COTS products that cause the most complexity, and therefore cause the most effort to maintain, and take precautions to only change those products when necessary or during major maintenance efforts. The analysis also clearly shows the components that can be easily replaced or upgraded with very little impact on the rest of the system.

关键词： COTS Based System maintainability complexity Interpretive Structural Modeling

Vacuum interrupter,high reliability component of distribution switches,circuit breakers and contactors

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第3期8卷 335-342页

作者： SLAdE Paul G. MAYO Stephen smith R.Kirkland TAYLOR Erik d. Eaton Electrical HorseheadsNY 14845USA

The use of vacuum interrupters(VIs)as the current interruption component for switches,circuit breakers,reclosers and contactors operating at distribution voltages has escalated since their introduction in the mid-1950’*** electrical product has developed a dominating position for switching and protecting distribution *** are even being introduced into switching products operating at transmission *** the reasons for the VI’s popularity are its compactness,its range of application,its low cost,its superb electrical and mechanical life and its ease of *** major advantage is its well-established *** this paper we show how this reliability has been achieved by design,by mechanical life testing and by electrical performance *** introduce the“sealed for life”concept for the VI’s *** discuss this in terms of what is meant by a practical leak rate for VIs with a life of over 30 *** show that a simple high voltage withstand test is an easy and effective method for monitoring the long-term vacuum *** we evaluate the need for routine inspection of this electrical product when it is used in adverse ambient environments.

关键词： Vacuum interrupter (VI) Reliability Mechanical life Electrical life

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膨胀金属管轴向破坏的试验研究

钢结构(中英文) 2009年第8期 87-88页

作者： C.Graciano G.Martínez d.smith

膨胀金属薄膜广泛应用于世界各地的人行道设计和装饰用途。在文献中,很少有关于膨胀金属结构单元特性的信息。本文旨在研究压应力作用下方形和圆管状的膨胀金属薄膜的轴向破坏。当金属开始膨胀时,在金属片中可得到一种类似于钻石的单元... 详细信息

膨胀金属薄膜广泛应用于世界各地的人行道设计和装饰用途。在文献中,很少有关于膨胀金属结构单元特性的信息。本文旨在研究压应力作用下方形和圆管状的膨胀金属薄膜的轴向破坏。当金属开始膨胀时,在金属片中可得到一种类似于钻石的单元,然后这些单元的特点是有两个几何轴线。一系列的试验测试可以印证膨胀金属的主轴和压力载荷之间角度的影响。从结果来看,根据轴线的方向有三种类型的破环模式:1)模式1的特点是塑性破坏机制;2)模式2会在个别元件处产生局部屈曲;3)模式3为管壁的整体屈曲。

关键词：膨胀金属能量吸收轴向破坏粉碎力效率

Redefinition of Fatty Liver disease from NAFLd to MAFLd through the Lens of drug development and Regulatory Science

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 374-382页

作者： Yasser Fouad Melissa Palmer Minjun Chen Arie Regev Rajarshi Banerjee Rob Myers Robert Riccio Richard Torstenson Ramy Younes Puneet SArora Henrik Landgren Morten A.Karsdal Martin Blake david A.Shapiro Hans-Juergen Gruss Muhammad Y.Sheikh dina Attia Steven Bollipo Alastair d.smith Bradley Freilich Robert G.Gish detlef Schuppan department of Gastroenterology Hepatologyand Endemic MedicineFaculty of MedicineMinia UniversityMiniaEgypt Gan-nex/Ascletis Pharma Co Ltd BeijingChina Liver Consulting LLC New YorkNYUSA division of Bioinformatics and Biostatis-tics National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonARUSA Eli Lilly and Company IndianapolisINUSA Perspectum diagnostics Ltd OxfordUK Gilead Sciences Inc Foster CityCAUSA Syneos Health LLC MorrisvilleNCUSA Allergan Marlow International BuckinghamshireUKAstraZenecaCambridgeUK Boehringer Ingel-heim International GmbHIngelheimGermany Genentech IncSouth San FranciscoCAUSA AbbVie MarlowBuck-inghamshireUK Nordic Bioscience A/S HerlevDenmark Resonance Health BurswoodWAAustralia Intercept Phar-maceuticals Inc San DiegoCAUSA Fresno Clinical Research Center FresnoCAUSA Gastroenterology and Hepatology department Beni-Suef UniversityBeni SuefEgypt department of Gastroenterology and Endoscopy John Hunter HospitalNewcastleNSWAustralia School of Medicine and Public Health University of NewcastleNewcastleNSWAustralia Kan-sas City Research Institute Kansas CityMOUSA division of Gastroenterology and Hepatology Loma Linda UniversityLoma LindaCAUSA Institute of Translational Immunology and Research Center for Immune Therapy University Medical CenterMainzGermany division of Gastroenterology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Metabolic(dysfunction)-associated fatty liver disease(MAFLd)affects a third of the population and is a leading cause of liver-related *** no effective treatments exist,novel approaches to drug development are ***,outdated terminology and definitions of the disease are hampering efforts to develop new drugs and *** international consensus panel has put forth an influential proposal for the disease to be renamed from nonalcoholic fatty liver disease(NAFLd)to MAFLd,includ-ing a proposal for how the disease should be *** allies with the many stakeholders in MAFLd care―including patients,patients’advocates,clinicians,researchers,nurse and allied health groups,regional societies,and others―we are aware of the negative consequences of the NAFLd term and *** share the sense of urgency for change and will act in new ways to achieve our *** there is much work to be done to overcome clinical inertia and reverse worrisome recent trends,the MAFLd initiative provides a firm foundation to build *** provides a roadmap for moving for-ward toward more efficient care and affordable,sustainable drug and device innovation in MAFLd *** hope it will bring promising new opportunities for a brighter future for MAFLd care and improve care and outcomes for patients of one of the globe’s largest and costliest public health *** this viewpoint,we have revisited this initiative through the perspectives of drug development and regulatory science.

关键词： NAFLd MAFLd NASH Fatty liver disease Liver Fibrosis

Process control factors for continuous microbial perchlorate reduction in the presence of zero-valent iron

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Frontiers of Environmental Science & Engineering 2014年第3期8卷 386-393页

作者： Robert d. arthur Jagadish TORLAPATI Kyung-Hee SHIN daniel K. CHA Yeomin YOON Ahjeong SON department of Civil Engineering Auburn University Auburn AL 36849 USA Korea Environment Institute Seoul 122-706 Republic of Korea department of Civil and Environmental Engineering University of Delaware Newark DE 19716 USA department of Civil and Environmental Engineering University of South Carolina Columbia SC 29208 USA department of Environmental Science and Engineering Ewha Womans University Seoul 120-750 Korea

Process control parameters influencing microbial perchlorate reduction via a flow-through zero-valent iron （ZVI） column reactor were investigated in order to optimize perchlorate removal from water. Mixed perchlorate reducers were obtained from a wastewater treatment plant and inoculated into the reactor without further acclimation. Examined parameters included hydraulic residence time （HRT）, pH, nutrients requirement, and perchlorate reduction kinetics. The minimum HRT for the system was concluded to be 8 hr. The removal efficiency of 10 mg. L-1 influent perchlorate concentration was reduced by 20%-80% without control to the neutral pH （HRT = 8 hr）. Therefore pH was determined to be an important parameter for microbial perchlorate reduction. Furthermore, a viable alternative to pH buffer was discussed. The microbial perchlorate reduction followed the first order kinetics, with a rate constant （K） of 0.761 hr-1. The results from this study will contribute to the implementation of a safe, cost effective, and efficient system for perchlorate reduction to below regulated levels.

关键词： perchlorate zero-valent iron (ZVI) microbial reduction hydrogen

Addressing the impact of canine distemper spreading on an isolated tiger population in northeast Asia

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Integrative Zoology 2023年第6期18卷 994-1008页

作者： dawei WANG James L.d.smith Francesco ACCATINO Jianping GE Tianming WANG Ministry of Education Key Laboratory for Biodiversity Science and Engineering NFGA Key Laboratory for Conservation Ecology of Northeast Tiger and Leopard&College of Life SciencesBeijing Normal UniversityBeijingChina department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMNUSA UMR SAdAPT INRAEAgroParisTechUniversitéParis-SaclayPALAISEAU CedexFrance

The continuation of the isolated Amur tiger(Panthera tigris altaica)population living along the China-Russia border is facing serious challenges due to factors such as its small size(including 38 individuals)and canine distemper virus(CdV).We use a population viability analysis metamodel,which consists of a traditional individual-based demographic model linked to an epidemiological model,to assess options for controlling the impact of negative factors through domestic dog management in protected areas,increasing connectivity to the neighboring large population(including more than 400 individuals),and habitat *** intervention,under inbreeding depression of 3.14,6.29,and 12.26 lethal equivalents,our metamodel predicted the extinction within 100 years is 64.4%,90.6%,and 99.8%,*** addition,the simulation results showed that dog management or habitat expansion independently will not ensure tiger population viability for the next 100 years,and connectivity to the neighboring population would only keep the population size from rapidly ***,when the above three conservation scenarios are combined,even at the highest level of 12.26 lethal equivalents inbreeding depression,population size will not decline and the probability of extinction will bedings highlight that protecting the Amur tiger necessitates a multifaceted synergistic *** key management recommendations for this population underline the importance of reducing CdV threats and expanding tiger occupancy to its former range in China,but re-establishing habitat connectivity to the neighboring population is an important long-term objective.

关键词： Amur tiger canine distemper virus habitat connectivity metamodel population viability analysis(PVA)