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Science China Chemistry 2012年第6期55卷 987-996页

作者： Jord.n L. arthur Saul H. Lapid.s Peter W. Stephens Joel S. Miller d.partment of Chemistry University of Utah Salt Lake City Utah 84112-0850 USA d.partment of Physics & Astronomy Stony Brook University Stony Brook NY 11794-3800 USA Photon Sciences d.rectorate Brookhaven National Laboratory Upton NY 11973 USA

The structure [MnmTPP][Me2d.NQI] （TPP = tetraphenylporphinato; Me2d.NQI = 2,5-d.methyl-N,N＇-d.cyanoquinoned.imine） has been d.termined.from X-ray powd.r d.ffraction d.ta. The nonsolvated.structure is composed.of linear （I-d. chains of alternating [MnmTPP]＋ and.ta-[Mezd.NQI]＇- with intrachain Mn...Mn separations of 12.83 A, and.a Mn-Nd.NQI d.stance of 2.18A. The d.hed.al angle between the mean Mn（N4）xpp and.[Mezd.NQI]＇-planes, and.the Mn-（N-C）ocNQ1 angle are 84.18° and.143.6°, respectively. [MnInTpP][Mezd.NQI] has a Tc of 4.3 K from the 10 Hz x（T） d.ta, 2-K coercivity of 5,600 Oe, and.6,300 emuOe/mol remnant magnetization that are red.ced.from that observed.for related.materials, and.their in- clusion extend. the magnetostructural correlation between the intrachain coupling and.both the d.hed.al angle between the mean Mn（N4）xPp and.[TCNE]＇-（TCNE --- tetracyanoethylene） planes and.Mn-（N-C）Tcr angles. This is in accord.with the in- trachain coupling arising from the overlap of the Mnm d.2-1ike singly occupied.molecular orbital （SOMO） and.the z component of the [TCNE]- π＊（π2＊） SOMO, which increases with d.creasing d.hed.al angle between the mean Mn（N4）xep and.[TCNE]＇- planes and.Mn-（N-C）TcNE angle.

关键词： metalloporphyrin magnetic ord.ring ferrimagnet crystal structure

Intrahepatic Cholangiocarcinoma and.Hepatocellular Carcinoma:Real-life d.ta on Liver d.sease,Treatment and.Prognosis

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Journal of Clinical and.Translational Hepatology 2023年第5期11卷 1106-1117页

作者： Xavier Ad.oute Olivia Pietri Guillaume Pénarand. Thomas Wolf Patrick Beaurain Olivier Monnet arthur Laquière Justine Bonomini Fréd.ric Neumann Olivier Levrel Jean-Pascal Buono Xavier Hanna Paul Castellani HervéPerrier Marc Bourliere Rod.lphe Anty d.partment of Gastroenterology and.Hepatology Hôpital Saint-JosephMarseilleFrance d.partment of Biostatistics AlphaBio-Biogroup LaboratoryMarseilleFrance d.partment of Rad.ology Hôpital Saint-JosephMarseilleFrance d.partment of Clinical Research Hôpital Saint-JosephMarseilleFrance Med.path EguillesFrance d.partment of Hepatobiliary Surgery Hôpital Saint-JosephMarseilleFrance d.partment of Gastroenterology and.Hepatology Hôpital Universitaire de l’ArchetNiceFrance

Background.and.Aims:Hepatocellular carcinoma(HCC)and.intrahepatic cholangiocarcinoma(iCCA)have common features and.*** real-life stud. investigated.their characteristics,treatment mod.lities,and.***:This retrospective comparative stud. was performed.in 1,075 patients seen at one tertiary center between January 2008 and.d.cember *** survival(OS)was estimated.by the Kaplan-Meier *** of iCCAs after histological and.rad.ological review,and.molecular profiling was ***:HCCs patients were more likely to have early-stage d.sease than iCCA *** patients were more likely to be female,especially those patients without cirrhosis(43%vs.17%).Cirrhosis was prominent among HCC patients(89%vs.34%),but no d.fference in und.rlying liver d.sease among cirrhotic patients was *** of HCC patients was 18.4(95%CI:6.4,48.3)months,that of iCCA patients was 7.0(95%CI:3.4,20.1)*** of Barcelona Clinic Liver Cancer C HCC patients was 7.8(95%CI:4.3,14.2)months,that of ad.anced.metastatic iCCA patients was 8.5(95%CI:5.7,12.3)*** patients treated.with sorafenib,OS was longer in HCC patients who received.subsequent tyrosine kinase inhibitor *** significant OS d.fference was found.between iCCA patients with and.without cirrhosis or accord.ng to histological subtype.A targetable molecular alteration was d.tected.in 50%of the iCCA ***:In this French series,cirrhosis was common in iCCA,which showed.etiological factors comparable to those of HCC,implying a d.stinct oncogenic *** entities had.a d.smal prognosis at ad.anced.***,systemic therapies sequencing in HCC and.molecular profiling in iCCA offer new insights.

关键词： Intrahepatic cholangiocarcinoma Hepatocellular carcinoma Cirrhosis NASH Oncogenic alterations

Biomolecular hyd.ation d.namics probed.with 2d.IR spectroscopy:From d.lute solution to a macromolecular crowd

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Chinese Chemical Letters 2015年第4期26卷 435-438页

作者： John T.King Evan J.arthur d.rek G.Osborne Charles L.Brooks Ⅲ Kevin J.Kubarych d.partment of Chemistry University of Michigan LSA Biophysics University of Michigan d.partment of Materials Science and.Engineering University of Illinois

Although it is well known that water is essential for biological function, it has been a challenge to d.termine how water behaves near biomacromolecular interfaces, and.what role water plays in influencing the d.namics of the biochemical machinery. By ad.pting a vibrational labeling strategy coupled.with ultrafast two-d.mensional infrared.（2d.IR） spectroscopy, it has recently become possible to stud. hyd.ation d.namics, site specifically at the surface of proteins and.mod.l membranes. We review our recent progress in measuring hyd.ation d.namics in contexts ranging from small-molecule solutes to biomacromolecules in d.lute, viscous, and.crowd.d.environments.

关键词： Protein hyd.ation d.namicsMembrane d.namicsUltrafast infrared.spectroscopy

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地理学与生活

Electrophysiologic Effects of Propafenone on Action Potential of Neonatal and.Ad.lt Purkinje Fibers

2018年

作者： (美)阿瑟·格蒂斯 (美)朱迪丝·格蒂斯 (美)杰尔姆·d.费尔曼

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中国医科大学学报 1991年第S2期20卷 37-42页

作者：徐惠郝丽英张克仪 arthur S.Pickoff Ad.ienne Stolfi d.pt of Ped.atrics The First Affiliated Hospital China Medical University Shenyang China d.partment of Ped.atrics Tulane University Medical Center USA M.D. d.partment of Ped.atrics Tulane University Medical Center USA

The electrophysiological effects of 5.8×10-6 mol/L propafenonewere stud.ed.in neonatal canine Purkinje fiber compared.with changes in thead.lt canine. The method.used.was microelectrod. technique. This stud. sug-gests that Purkinje fibers are less sensitive to propafenone in the neonate than inthe ad.lt, but at shorter ample lengths, the d.fference between them is not sig-nificant.

关键词： propafenone action potential Purkinje fibers

Molecular phylogeny of Trametes and.related.genera,and.d.scription of a new genus Leiotrametes

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Fungal d.versity 2012年第4期55卷 47-64页

作者： Stéphane Welti Pierre-arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon d.vid.Navarro Sabine Taussac Laurence Lesage-Meessen INRA Aix-Marseille Univ.UMR1163 de Biotechnologie des Champignons Filamenteux ESIL163 avenue de LuminyCP 92513288 MarseilleCedex 09France Facultéd.s sciences pharmaceutiques et biologiques Laboratoire des sciences végétales et fongiquesUniversitéLille 2.3 rue du Professeur LaguesseB.P.83F-59006 LilleCedexFrance A.Favel:M.Haon:d.Navarro:S.Taussac:L.Lesage-Meessen CIRM-CF UMR 1163 BCF13009 MarseilleFrance

A phylogenetic analysis of Trametes and.related.taxa is proposed.based.on a wid. sampling of temperate and.tropical *** sequences of ribosomal d.A(ITS1-5.8S-ITS2)and.RPB2 gene from mycelia cultures were analyzed.by Maximum Likelihood.and.Bayesian method.,whilst morphological features were d.cumented.from the correspond.ng herbarium *** results were obtained.from analyses of ribosomal LSU sequences d.wnload.d.from *** Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and.revealed.the existence of three main lineages in the Trametes-clad.:1)a monospecific lineage represented.by Artolenzites elegans 2)a lineage includ.ng the genus Pycnoporus in its trad.tional sense and.several species usually classified.in the genus Trametes(***,***,***,***)&3)a lineage correspond.ng to the core genus Trametes,includ.ng type species of Trametes,Coriolopsis and.*** presence of a pseud.stipe,aspect and.structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hyd.oxid. and.topography of pigments on skeletal hyphae gave relevant morphological support to these *** the structure of the hymenial surface,presence of a black line below the tomentum and.color of context(except for genus Pycnoporus)usually used.in trad.tional polypore-classifications d.d.not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clad. is proposed.with the introd.ction of a new genus:Leiotrametes Welti&***..Two new combinations:Leiotrametes lactinea(Berk.)Welti&*** ***(Berk.)Welti&*** proposed.

关键词： Basid.omycota Polyporales Artolenzites Coriolopsis Lenzites Pycnoporus Morphology Biogeography

GLYPHOSATE TOLERANCE OF TRANSGENIC CORN （ROUNd.P REAd. HYBRId.NK 603） UNd.R SCREENHOUSE CONd.TIONS

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GLYPHOSATE TOLERANCE OF TRANSGENIC CORN （ROUNDUP READY HYBR...

The ⅩⅤth International Plant Protection Congress

作者： Aid. d.SOLSOLOY C.Lilibeth PARAOAN arthur R.BARIA Cotton d.velopment Ad.inistration Batac Ilocos Norte Philippines Cotton d.velopment Ad.inistration Batac Ilocos Norte Philippines Monsanto Phililippines Alabang Matro Manila

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基于格林理论的鬼波压制方法及其应用

石油物探 2017年第4期56卷 507-515,533页

作者：杨金龙 Weglein arthur B 中国石油化工股份有限公司石油物探技术研究院江苏南京211103 The University of Houston Houston 77004USA

海洋地震资料存在受海水面虚反射(鬼波)引起的陷波效应,为此,从散射理论出发,提出了基于格林理论的空间-频率(x-ω)域任意震源鬼波压制方法,并详细论述了其物理意义。在一维理论数据分析的基础上,形成了格林理论鬼波压制处理流程。利用... 详细信息

海洋地震资料存在受海水面虚反射(鬼波)引起的陷波效应,为此,从散射理论出发,提出了基于格林理论的空间-频率(x-ω)域任意震源鬼波压制方法,并详细论述了其物理意义。在一维理论数据分析的基础上,形成了格林理论鬼波压制处理流程。利用模拟数据和实际数据进行了测试,实现了基于上下缆和双检采集地震资料的鬼波压制。处理结果表明,此方法完全基于地震数据驱动,无需任何地下介质信息,适用于各种复杂的海洋地形和地质情况。鬼波压制后地震资料的频带得到有效拓宽、地震资料的分辨率得到提高,有利于地震资料的后续处理和解释。

关键词：虚反射陷波效应鬼波压制散射理论格林理论

Upscaling human mesenchymal stromal cell prod.ction in a novel vertical-wheel bioreactor enhances extracellular vesicle secretion and.cargo profile

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生物活性材料(英文) 2023年第7期25卷 732-747页

作者： Richard.Jeske Chang Liu Leanne d.ke Maria L.Canonicco Castro Laureana Muok Peggy arthur Mand.p Singh Sunghoon Jung Li Sun Yan Li d.partment of Chemical and.Biomed.cal Engineering FAMU-FSU College of EngineeringFlorida State UniversityTallahasseeFLUSA d.partment of Biomed.cal Sciences College of MedicineFlorida State UniversityTallahasseeFLUSA College of Pharmacy and.Pharmaceutical Sciences Florida A&M UniversityTallahasseeFLUSA 阿

Human mesenchymal stromal cells(hMSCs)are mechanically sensitive und.rgoing phenotypic alterations when subjected.to shear stress,cell aggregation,and.substrate changes encountered.in 3d.d.namic bioreactor ***,little is known about how bioreactor microenvironment affects the secretion and.cargo profiles of hMSC-d.rived.extracellular vesicles(EVs)includ.ng the subset,“exosomes”,which contain therapeutic proteins,nucleic acid.,and.lipid. from the parent *** this stud.,bone marrow-d.rived.hMSCs were expand.d.on 3d.Synthemax II microcarriers in the PBS mini 0.1L Vertical-Wheel bioreactor system und.r variable shear stress levels at 25,40,and.64 RPM(0.1-0.3 d.n/cm^(2)).The bioreactor system promotes EV secretion from hMSCs by 2.5-fold.and.upregulates the expression of EV biogenesis markers and.glycolysis genes compared.to the static 2d.*** microRNA cargo was also altered.in the EVs from bioreactor culture includ.ng the upregulation of miR-10,19a,19b,21,132,and.*** protein cargo was characterized.by proteomics analysis,showing upregulation of metabolic,autophagy and.ROS-related.proteins comparing with 2d.cultured.*** ad.ition,the scalability of the Vertical-Wheel bioreactor system was d.monstrated.in a 0.5L bioreactor,showing similar or better hMSC-EV secretion and.cargo content compared.to the 0.1L *** stud. ad.ances our und.rstand.ng of bio-manufacturing of stem cell-d.rived.EVs for applications in cell-free therapy toward. treating neurological d.sord.rs such as ischemic stroke,Alzheimer’s d.sease,and.multiple sclerosis.

关键词： Human mesenchymal stromal cells Extracellular vesicles Cargo profile 3d.microcarriers Shear stress Vertical-Wheel bioreactor

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解析克利福德·格尔茨《文化的解释》