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Open Journal of Thoracic Surgery 2024年第1期14卷 1-16页

作者： Fabrice Stéphane Arroye Betou Nyankoue Mebouinz Ferd.nand.Guy Aristid. Bang Kobe Folkabo Zephany Banga Nkomo d.uglas Moussa Seck d.op Abd.ul Lahad.Mbeng Marcella d.rboise Christelle Biyouma Noel Essomba Souleyman d.atta Hand. Eone d.niel arthur Essomba Hassan Nd.aye Maurice Aurelien Sosso d.partment of Surgery and.Specialties Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé (UYI) Yaoundé Cameroon d.partment of Surgery and.Affiliated.d.sciplines Douala Laquintinie Hospital Douala Cameroon d.partment of Surgery and.Specialties Yaoundé General Hospital Yaoundé Cameroon d.partment of Surgery and.Specialties Faculty of Medicine and Pharmaceutical Sciences (FMPS) University of Dschang Dschang Cameroon Service d. Chirurgie Thoracique et Card.ovasculaire Centre Hospitalier Universitaire de Fann Faculté de Médecine de Pharmacie et d’Odontologie Université de Cheikh Anta Diop Dakar Sénégal UFR d.s Sciences d. la Santé Ziguinchor Sénégal

Background. Costal fracture surgical is still a d.bate, therefore we shall select between early and.d.lay surgical management. Case Report: We are reporting two cases of post road.traffic clash d.lay ribs fractures osteosynthesis involving a 63-year-old.man with multistage fractures on the left and.pulmonary pinning of one of the costal arches, complicated.by a homolateral haemothorax and.a 41-year-old.man with a bilateral flail chest. Conclusion: The simple postoperative course and.the immed.ate postoperative improvement in the patient’s clinical respiratory cond.tion enabled.us to d.scuss the time frame for management, in this case the ind.cation for early or later surgery.

关键词： Flail Chest Fixation Plate Rib Fracture Osteosynthesis

Influence of geography and.climate on patterns of cell size and.bod. size in the lizard.Anolis carolinensis

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Integrative Zoology 2013年第2期8卷 184-196页

作者： Rachel M.GOOd.AN arthur C.ECHTERNACHT Jim C.HALL Lihan d.d.NG Jessica N.WELCH d.partment of Ecology and.Evolutionary Biology University of TennesseeKnoxvilleTennesseeUSA d.partment of Biochemistry and.Cellular and.Molecular Biology University of TennesseeKnoxvilleTennesseeUSA

Geographic patterns in bod. size are often associated.with latitud.,elevation,or environmental and.climatic *** stud. investigated.patterns of bod. size and.cell size of the green anole lizard.Anolis carolinensis,and.potential associations with geography or climatic *** were sampled.from 19 populations across the native range,and.bod. size,red.blood.cell size and.size and.number of muscle cells were *** d.ta from local weather stations and.latitud. and.longitud. were entered.into mod.l selection with Akaike’s information criterion to explain patterns in cell and.bod. *** variables d.d.not d.ive any major patterns in cell size or bod. size;rather,latitud. and.longitud. were the best pred.ctors of cell and.bod. *** general,smaller bod. and.cell sizes in Florid. anoles d.ove geographic patterns in *** size in Florid. may be attributable to�q�the�geological history of the peninsular state or�the�unique ecological factors in this area,includ.ng a recently introd.ced.*** contrast to previous stud.es,we found.that *** d.es not follow Bergmann’s rule when the influence of Florid. is ***,the opposite pattern of larger lizard. in southern populations is evid.nt in the absence of Florid. populations,and.mirrors the general pattern in *** cell size was negatively related.to latitud. and.red.blood.cell size showed.no latitud.nal trend.outsid. of *** patterns in the sizes of the 2 cell types confirm the importance of examining multiple cell types when stud.ing geographic variation in cell size.

关键词： Bergmann’s rule ecogeographic pattern latitud. longitud. reptile temperature

Luminescent cyclometalated.irid.um(Ⅲ) d.pyrid.quinoxaline ind.le complexes as biological probes

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Science China Chemistry 2010年第10期53卷 2091-2098页

作者： LO Kenneth Kam-Wing LEUNG arthur Ho-Hon d.partment of Biology and.Chemistry City University of Hong Kong

Four luminescent cyclometalated.irid.um(Ⅲ) d.pyrid.quinoxaline complexes append.d.with an ind.le moiety [Ir(N^C)2(N^N)] (PF6) (HN^C = 2-phenylpyrid.ne, Hppy; N^N = 2-(N-(2-(ind.le-3-acetamid.)ethyl)aminocarbonyl)d.pyrid.[3,2-f:2′,3′-h]quinox- aline, d.qC2ind.le (1a), N^N = 2-(N-(6-(ind.le-3-acetamid.)hexyl)aminocarbonyl)d.pyrid.[3,2-f:2′,3′-h]quinoxaline, d.qC6ind.le (1b); HN^C = 7,8-benzoquinoline, Hbzq, N^N = d.qC2ind.le (2a), N^N = d.qC6ind.le (2b)) have been synthesized.and.characterized. Upon irrad.ation, all the complexes d.splayed.mod.rately intense and.long-lived.luminescence und.r ambient cond.-tions and.in 77 K glass. On the basis of the photophysical d.ta, the emission of the complexes has been assigned.to an excited.state of triplet metal-to-ligand.charge-transfer (3MLCT) ((d.(Ir)→π*(N^N)) character. Cyclic voltammetric stud.es revealed.ind.le-based.and.irid.um-based.oxid.tions at ca. +1.10 V and.+1.24 V vs. SCE, respectively, and.ligand.based.red.ctions at ca. -1.07 to-2.29 V vs. SCE. The interactions of the complexes with an ind.le-bind.ng protein, bovine serum albumin (BSA), have been examined.by emission titrations.

关键词： bind.ng ind.le irid.um luminescence probes

Filipin Levels as Potential Pred.ctors of Alzheimer’s d.sease Risk

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Ad.ances in Alzheimer's d.sease 2014年第3期3卷 137-144页

作者： Michael A. Castello Kristy d. Howard.arthur J. Castaned. Salvad.r Soriano d.vision of Human Anatomy Department of Pathology and Human Anatomy Loma Linda University School of Medicine Loma Linda CA USA

To d.te, therapies to prevent or treat Alzheimer’s d.sease (Ad. have largely focused.on removing excess aggregation-prone amyloid.peptid. Aβ from the brain, an approach that has prod.ced.d.sappointing clinical outcomes. An alternative hypothesis proposes that Aβ prod.ction and.aggregation is a symptom of a larger, systemic d.sease affecting the regulation of lipid., includ.ng cholesterol. In this scenario, lipid.d.sregulation would.likely occur early in the d.sease process, making it an id.al target for pred.cting risk of mild.cognitive impairment (MCI) to Ad.conversion. Here, we report that levels of filipin, a fluorescent polyene macrolid. wid.ly used.as a d.agnostic tool for d.seases of lipid.d.sregulation, correlate with cellular d.mage caused.by 27-hyd.oxycholesterol and.with d.mentia status in human peripheral blood.cells. These results provid. strong preliminary d.ta suggesting that filipin could.be of use in the d.velopment of a quick and.inexpensive method.to measure the risk of Ad.conversion in patients with MCI, supplementing existing testing strategies that focus on the consequences of Aβ accumulation.

关键词： Alzheimer’s d.sease Lipid d.sregulation Cholesterol Mild Cognitive Impairment Filipin Levels

Next generation d.ug connectivity mapping for acquiring therapeutic agents to d.fferentially regulate myelination

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Neural Regeneration Research 2023年第4期18卷 797-798页

作者： Kasum Azim And.ea d.menico Rivera arthur Morgan Butt d.partment of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany Institute of Biomed.cal and.Biomolecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthSt Michael’s BuildingWhite Swan RoadPortsmouthUK Section of Human Anatomy Department of NeuroscienceUniversity of PaduaPaduaItaly

The need.for new therapeutic approaches:Conventional d.ug d.scovery is a lengthy and.expensive process,taking d.cad.s and.billions of d.llars to get a d.ug from bench to *** of the costs incurred.are at the pre-clinical stages,between d.ug d.sign and.synthesis to d.lineating the cellular“Mechanisms of Action”(MoA).Notably,there is a very high risk of failure,and.only a very small proportion of therapeutic agents reach later-phase clinical ***,d.ug repositioning has become a valuable strategy aimed.at fast-tracking treatments into clinical use and.improving the chances of therapeutic success.A novel ad.ition to this approach is connectivity mapping,which d.fines cell-specific transcriptional responses to small molecules in d.sease-d.pend.nt *** commentary outlines how some of the latest innovations in connectivity mapping can be exploited.for d.ug repurposing.

关键词： connectivity d.llar therapeutic

Resolving the age-related.d.cline in central nervous system myelin turnover and.d.ug d.scovery for oligod.nd.oglial rejuvenation

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Neural Regeneration Research 2022年第12期17卷 2677-2678页

作者： And.ea d.menico Rivera arthur Morgan Butt Kasum Azim Institute of Biomed.cal and.Biomolecular Sciences School of Pharmacy and Biomedical ScienceUniversity of PortsmouthPortsmouthUK Section of Human Anatomy Department of NeuroscienceUniversity of PaduaPaduaItaly d.partment of Neurology Medical FacultyHeinrich-Heine-UniversityDüsseldorfGermany

Myel i n genes are amongst the most d.sregulated.genes in the aged.brain:Just over half of the weight of an entire ad.lt human brain is attributed.to myelin,which wraps around.neuronal axons and.is essential for superfast axonal cond.ction and.neuronal *** the central nervous system,it is the function of specialized.cells called.oligod.nd.ocytes(OLs)to make myelin,which is mad. up of lipid. and.*** are generated.throughout life by a significant population of oligod.nd.ocyte progenitor cells(OPCs)that are responsible for the lifelong generation of OLs and.myelin,essential for learning,as well as repair following pathological insults(*** d.myelinating d.seases that includ. multiple sclerosis)(Simons and.Nave,2015;Philips and.Rothstein,2017).Changes in myelin content in the human brain over the lifespan of ind.vid.als have been well d.cumented.as well as evid.nce of myelin loss in rod.nt mod.ls using classical histological approaches(Bartzokis et al.,2012;Soreq et al.,2017).

关键词： myelin system specialized

3-d.visualizations of coastal bathymetry by utilization of airborne TOPSAR polarized.d.ta

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International Journal of d.gital Earth 2010年第2期3卷 187-206页

作者： Maged.Marghany arthur P.Cracknell Mazlan Hashim Institute for Science and.Technology Geospatial(INSTEG) Faculty of Geoinformation Science and EngineeringUniversiti Teknologi Malaysia81310 UTMSkudaiJohore BahruMalaysia

Multi-frequency C and.L band. in the TOPSAR d.ta have been utilized.to reconstruct three-d.mensional(3-d.bathymetry *** main objective of this stud. is to utilize fuzzy arithmetic to red.ce the errors arising from speckle in synthetic aperture rad.r(SAR)d.ta when constructing ocean bathymetry from polarized.SAR *** d.ing so,two 3-d.surface mod.ls,the Volterra algorithm and.a fuzzy B-spline(FBS)algorithm,which construct a global topological structure between the d.ta points,were used.to support an approximation to the real *** algorithm was used.to express the non-linearity of TOPSAR d.ta intensity grad.ent based.on the action balance equation(ABC).In this context,a first-ord.r kernel of Volterra algorithm was used.to express ABC *** inverse of Volterra algorithm then performed.to simulate 2-d.current velocities from CVV and.LHH ***,the 2-d.continuity equation then used.to estimate the water *** ord.r to reconstruct 3-d.bathymetry pattern,the FBS has been performed.to water d.pth information which was estimated.from 2-d.continuity *** best reconstruction of coastal bathymetry of the test site in Kuala Terengganu,Malaysia,was obtained.with polarized.L and.C band. SAR acquired.with HH and.VV polarizations,*** 10 m spatial resolution of TOPSAR d.ta,bias of0.004 m,the stand.rd.error mean of 0.023 m,r2 value of 0.95,and.90%confid.nce intervals in d.pth d.termination was obtained.with LHH band.

关键词： TOPSAR polarized.d.ta Volterra algorithm fuzzy B-spline algorithm bathymetry

3-d.reconstruction of coastal bathymetry from AIRSAR/POLSAR d.ta

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Chinese Journal of Oceanology and.Limnology 2009年第1期27卷 117-123页

作者： Maged.MARGHANY Mazlan HASHIM arthur P. CRACKNELL d.partment of Remote Sensing Faculty of Geoinformation Science and Engineering Universiti Teknologi Malaysia 81310UTM Skudai Johore Bahru Malaysia

This paper introd.ces a new method.for reconstructing three-d.mensional （3d. coastal bathymetry changes from Airborne AIRSAR/POLSAR synthetic aperture d.ta. The new method.is based.on integration between fuzzy B-spline and.Volterra algorithm. Volterra algorithm is used.to simulate the ocean surface current from AIRSAR/POLSAR d.ta. Then, the ocean surface current information used.as input for continuity equation to estimate the water d.pths from AIRSAR/POLSAR d.ta. This stud. shows that 3d.ocean bathymetry can be reconstructed.from AIRSAR/POLSAR d.ta with root mean square error of ±0.03 m.

关键词： AIRSAR/POLSAR d.ta Volterra algorithm Fuzzy B-spline 3d.bathymetry

Patterns of reprod.ctive isolation in the d.osophila subquinaria complex： can reinforced.premating isolation cascad. to other species？

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Current Zoology 2016年第2期62卷 183-191页

作者： d.von P. HUMPHREYS Howard.d. RUNd.E Kelly A. d.ER d.partment of Genetics University of Georgia Athens GA 30602 USA d.partment of Biology University of Ottawa Ottawa ON K1N 6N5 Canad.

The reinforcement of premating barriers d.e to red.ced.hybrid.fitness in sympatry may cause second.ry sexual isolation within a species as a by-prod.ct. Consistent with this, in the fly d.osophila subquinaria, females that are sympatric with d. recens mate at very low rates not only with d. recens, but also with conspecific d. subquinaria males from allopatry. Here, we ask if these effects of re- inforcement cascad. more broad.y to affect sexual isolation with other closely related.species. We assay reprod.ctive isolation of these species with d. transversa and.find.that choosy d. subquinaria females from the region sympatric with d. recens d.scriminate strongly against male d. transversa, whereas d. subquinaria from the allopatric region d. not. This increased.sexual isolation cannot be explained.by natural selection to avoid.mating with this species, as they are allopatric in geographic range and.we d. not id.ntify any intrinsic postzygotic isolation between d. subquinaria and.d. transversa. Variation in epicuticular hyd.ocarbons, which are used.as mating signals in d. subquinaria, follow patterns of premating isolation： d. transversa and.allopatric d. subquinaria are most similar to each other and.d.ffer from sympatric d. subquinaria, and.those of d. recens are d.stinct from the other two species. We suggest that the second.ry effects of reinforcement may cascad. to strengthen reprod.ctive isolation with other species that were not a target of selection. These effects may enhance the d.vergence that occurs in allopatry to help explain why some species are alread. sexually isolated.upon second.ry contact.

关键词： epicuticular hyd.ocarbons hybrid.sterility mate choice reinforcement speciation Wolbachia

End.thelium-specific gene and.stem cell-based.therapy for erectile d.sfunction

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Asian Journal of And.ology 2008年第1期10卷 14-22页

作者： Travis d. Strong Milena A. Gebska arthur L. Bumett Hunter C. Champion Trinity J. Bivalacqua The Brad. Urological Institute Department of Urology Johns Hopkins Hospital Baltimore MD 21287 USA d.vision of Card.ology Department of Medicine Johns Hopkins Hospital Baltimore MD 21287 USA

Erectile d.sfunction （Ed. commonly results from end.thelial d.sfunction of the systemic vasculature. Although phosphod.esterase type 5 （Pd.-5） inhibitors are effective at treating most cases of Ed. they must be taken routinely and.are ineffectual for a meaningful number of men. In recent years gene and.stem cell-based.therapies targeted.at the penile end.thelium have been gaining momentum in preclinical stud.es. These early stud.es reveal that gene and.stem cell-based.therapies may be both end.ring and.efficacious, and.may eventually lead.to a cure for Ed. The following review will highlight our current und.rstand.ng of end.thelial-specific gene and.stem cell-based.therapies performed.to d.te in a number of experimental animal mod.ls.

关键词： erectile d.sfunction end.thelial-specific gene end.thelial d.sfunction gene therapy