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Frontiers of Structural and Civil Engineering 2019年第3期13卷 674-685页

作者： Tanvi SINGH Mahesh PAL V.k.arora Department of Civil Engineering National Institute of TechnologyKurukshetraHaryana 136119India

M5 model tree,random forest regression(RF)and neural network(NN)based modelling approaches were used to predict oblique load carrying capacity of batter pile groups using 247 laboratory experiments with smooth and rough pile *** length(L),angle of oblique load(a),sand density(ρ),number of batter piles(B),and number of vertical piles(V)as input and oblique load(Q)as output was *** suggest improved performance by RF regression for both pile groups.M5 model tree provides simple linear relation which can be used for the prediction of oblique load for field data *** developed using RF regression approach with smooth pile group data was found to be in good agreement for rough piles *** based approach was found performing equally well with both smooth and rough *** analysis using all three modelling approaches suggest angle of oblique load(a)and number of batter pile(B)affect the oblique load capacity for both smooth and rough pile groups.

关键词： batter piles oblique load test neural network M5 model tree random forest regression ANOVA

Dominating expression of negative regulatory factors downmodulates major histocompatibility complex Class-Ⅱexpression on dendritic cells in chronic hepatitis C infection

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World Journal of Gastroenterology 2016年第22期22卷 5173-5182页

作者： Shallu Tomer Yogesh k Chawla Ajay Duseja Sunil k arora Department of Immunopathology Postgraduate Institute of Medical Education and Research Department of Hepatology Postgraduate Institute of Medical Education and Research

AIM: To elucidate the molecular mechanisms leading to development of functionally impaired dendritic cells(DCs) in chronic hepatitis C(CHC) patients infected with genotype 3 ***: This prospective study was conducted on the cohorts of CHC individuals identified as responders or non-responders to antiviral therapy. Myeloid DCs were isolated from the peripheral blood of each subject using CD1c(BDCA1)+ DC isolation kit. Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus(HCV) viral proteins followed by LPS stimulation. Phenotyping was done by flowcytometry and gene expression profiling was evaluated by real-time ***: Non-responders [sustained virological response(SVR)-ve] to conventional antiviral therapy had significantly higher expression of genes associated with interferon responsive element such as IDO1 and PD-L1(6-fold) and negative regulators of JAk-STAT pathway such as SOCS(6-fold) as compared to responders(SVR+ve) to antiviral therapy. The downregulated genes in non-responders included factors involved in antigen processing and presentation mainly belonging to major histocompatibility complex(MHC) Class-Ⅱ family as HLA-DP, HLA-DQ(2-fold) and superoxide dismutase(2-fold). Cells grown in the presence of HCV viral proteins had genes downregulated for factors involved in innate response, interferon signaling, DC maturation and co-stimulatory signaling to T-cells, while the genes for cytokine signaling and Toll-like receptors(4-fold) were upregulated as compared to cells grown in absence of viral ***: Underexpressed MHC class-Ⅱ genes and upregulated negative regulators in non-responders indicate diminished capacity to present antigen and may constitute mechanism of functionally defective state of DCs.

关键词： Dendritic cells Hepatitis C Non-responders Negative regulators Major histocompatibility complex Class-Ⅱ genes

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ZrV2O7的热膨胀和非简谐振动

硅酸盐学报 2009年第5期37卷 696-702页

作者： SAkUNTALA T[印度] arora a k[印度] RAO Rekha[印度] 印度巴巴原子研究中心高压物理部孟买400085 英迪拉甘地原子研究中心材料科学部马德拉斯603102

因零膨胀材料在工程上的潜在应用,近10多年来,对材料的热膨胀特性得以深入了解。本文对ZrW2O8的负热膨胀现象的研究进展进行了简要回顾,并特别指出理解非简谐振动的重要性。讨论了ZrV2O7的声子特性和非简谐振动,其负热膨胀的高温相和具... 详细信息

因零膨胀材料在工程上的潜在应用,近10多年来,对材料的热膨胀特性得以深入了解。本文对ZrW2O8的负热膨胀现象的研究进展进行了简要回顾,并特别指出理解非简谐振动的重要性。讨论了ZrV2O7的声子特性和非简谐振动,其负热膨胀的高温相和具有正的热膨胀的低温相特征。此外,还比较了ZrV2O7和ZrW2O8的热膨胀特性。

关键词：热膨胀 Raman光谱学非简谐振动釩酸锆钨酸锆

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Investigation of coupled cobalt-silver nanoparticle system by plan view TEM

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Progress in Natural Science:Materials International 2012年第3期22卷 186-192页

作者： Daniel Fox Ruggero Verre Brendan J. O'Dowd Sunil k. arora Colm C. Faulkner Igor V. Shvets School of Physics and CRANN Trinity College Dublin CRANN Advanced Microscopy Laboratory Trinity College Dublin

We present a transmission electron microscopy (TEM) investigation of a coupled cobalt and silver nanoparticle system. A plan view in situ lift-out method for preparing samples for TEM using the focused ion beam (FIB) microscope was used. This technique is used to prepare high quality TEM samples with site specificity in a short time and with a high success rate. We demonstrate the ability of the plan view sample preparation technique to provide information about an ordered system of nanoparticles which could not be observed using standard FIB cross sectioning of the sample. High resolution TEM and energy dispersive X-ray spectroscopy mapping of both cross sectional and plan view samples are presented, clearly showing the significant benefit of plan view TEM analysis for certain samples.

关键词： Focused ion beam Transmission electron microscopy Lift-out Co Ag Nanoparticle

On some new fuzzy entropy measure of Pythagorean fuzzy sets for decision-making based on an extended TOPSIS approach

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Journal of Management Analytics 2024年第1期11卷 87-109页

作者： H.D.arora Anjali Naithani Department of Mathematics Amity Institute of Applied SciencesAmity University Uttar PradeshNoidaIndia

Fuzzy entropy measures are valuable tools in decision-making when dealing with uncertain or imprecise *** exist many entropy measures for Pythagorean Fuzzy Sets(PFS)in the literature that fail to deal with the problem of providing reasonable or consistent results to the *** deal with the shortcomings of the existing measures,this paper proposes a robust fuzzy entropy measure for PFS to facilitate decision-making under *** usefulness of the measure is illustrated through an illustration of decision-making in a supplier selection problem and compared with existing fuzzy entropy *** Technique for Order Performance by Similarity to Ideal Solution(TOPSIS)approach is also explored to solve the decision-making *** results demonstrate that the proposed measure can effectively capture the degree of uncertainty in the decision-making process,leading to more accurate decision outcomes by providing a reliable and robust ranking of alternatives.

关键词： Pythagorean fuzzy sets entropy measures multi criteria decision analysis TOPSIS method supplier selection

Spatio-temporal variation of depth to groundwater level and its driving factors in arid and semi-arid regions of India

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Regional Sustainability 2024年第2期5卷 103-122页

作者： Suchitra PANDEY Geetilaxmi MOHAPATRA Rahul arora Department of Economics and Finance Birla Institute of Technology&SciencePilani333031India

Climate change and increasing anthropogenic activities,such as over-exploitation of groundwater,are exerting unavoidable stress on groundwater *** study investigated the spatio-temporal variation of depth to groundwater level(DGWL)and the impacts of climatic(precipitation,maximum temperature,and minimum temperature)and anthropogenic(gross district product(GDP),population,and net irrigated area(NIA))variables on DGWL during *** study considered DGWL in 113 observation wells and piezometers located in arid western plains(Barmer and Jodhpur districts)and semi-arid eastern plains(Jaipur,Ajmer,Dausa,and Tonk districts)of Rajasthan State,*** methods were employed to examine the annual and seasonal patterns of DGWL,and the generalized additive model(GAM)was used to determine the impacts of climatic and anthropogenic variables on *** 1994-2020,except for Barmer District,where the mean annual DGWL was almost constant(around 26.50 m),all other districts exhibited increase in DGWL,with Ajmer District experiencing the most *** results also revealed that 36 observation wells and piezometers showed a statistically significant annual increasing trend in DGWL and 34 observation wells and piezometers exhibited a statistically significant decreasing trend in ***,32 observation wells and piezometers showed an statistically significant increasing trend and 37 observation wells and piezometers showed a statistically significant decreasing trend in winter;33 observation wells and piezometers indicated a statistically significant increasing trend and 34 had a statistically significant decreasing trend in post-monsoon;35 observation wells and piezometers exhibited a statistically significant increasing trend and 32 observation wells and piezometers showed a statistically significant decreasing trend in pre-monsoon;and 36 observation wells and piezometers reflected a statistically significant increasing trend and 30 observation

关键词： Climate change Generalized additive model(GAM) Depth to groundwater level(DGWL) Climatic and anthropogenic variables Arid and semi-arid regions

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Dendritic cells: The warriors upfront-turned defunct in chronic hepatitis C infection

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World Journal of Hepatology 2015年第19期7卷 2202-2208页

作者： Meenakshi Sachdeva Yogesh k Chawla Sunil k arora Department of Immuno-pathology Post Graduate Institute of Medical Education and Research Department of Hepatology Post Graduate Institute of Medical Education and Research

Hepatitis C virus(HCV) infection causes tremendousmorbidity and mortality with over 170 million people infected worldwide. HCV gives rise to a sustained, chronic disease in the majority of infected individuals owing to a failure of the host immune system to clear the virus. In general, an adequate immune response is elicited by an efficient antigen presentation by dendritic cells(DCs), the cells that connect innate and adaptive immune system to generate a specific immune response against a pathogen. However, HCV seems to dysregulate the activity of DCs, making them less proficient antigen presenting cells for the optimal stimulation of virusspecific T cells, hence interfering with an optimal antiviral immune response. There are discordant reports on the functional status of DCs in chronic HCV infection(CHC), from no phenotypic or functional defects to abnormal functions of DCs. Furthermore, the molecular mechanisms behind the impairment of DC function are even so not completely elucidated during CHC. Understanding the mechanisms of immune dysfunction would help in devising strategies for better management of the disease at the immunological level and help to predict the prognosis of the disease in the patients receiving antiviral therapy. In this review, we have discussed the outcomes of the interaction of DCs with HCV and the mechanisms of DC impairment during HCV infection with its adverse effects on the immune response in the infected host.

关键词： Dendritic cells Hepatitis C Mechanism of functiona

Immunology of hepatocellular carcinoma

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World Journal of Hepatology 2015年第17期7卷 2080-2090页

作者： Meenakshi Sachdeva Yogesh k Chawla Sunil k arora Department of Immuno- pathology Postgraduate Institute of Medical Education and Research Department of Hepatology Postgraduate Institute of Medical Education and Research

Hepatocellular carcinoma(HCC) is primarily a malignancy of the liver, advancing from a damaged, cirrhotic liver to HCC. Globally, HCC is the sixth most prevalent cancer and the third-most prevalent reason for neoplastic disease-related deaths. A diverse array of infiltrating immunocytes regulates the development and progression of HCC, as is the case in many other cancers. An understanding of the various immune components during HCC becomes necessary so that novel therapeutic strategies can be designed to combat the disease. A dysregulated immune system(including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. Alterations in either the innate or adaptive arm of the immune system and cross-talk between them make the immune system tolerant to tumors, leading to disease progression. In this review, we have discussed the status and roles of various immune effector cells(e.g., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC.

关键词： Hepatocellular carcinoma Immune cells Immune-dysregulation Adaptive immunity Innateimmunity

Increased Activity of Nk Cells and Plasmacytoid Dendritic Cells in HIV-Exposed Seronegative (ESN) Individuals

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World Journal of AIDS 2012年第1期2卷 6-16页

作者： Anuj Singla Roland Jacobs Reinhold E. Schmidt Ajay Wanchu Sunil k. arora Clinic for Immunology and Rheumatology Hannover Medical School Hannover Germany Departments of Immunopathology Post Graduate Institute of Medical Education and Research Chandigarh India Internal Medicine Post Graduate Institute of Medical Education and Research Chandigarh India

The mechanisms involved in resistance to HIV-1 infection, especially the role of innate immune response, have not been thoroughly explored in individuals who are repeatedly exposed to HIV-1, but do not get the infection, termed as Exposed sero-negative or ESN. Frequency and activation state of natural killer (Nk) cells and plasmacytoid dendritic cells (pDC) in ESNs from North India were compared with those in recently infected HIV positives (RHIV), chronically infected HIV positives (HIV+) and healthy controls (HC). The activation state of Nk cells in terms of cytokine response (IFNγ & TNFα) was significantly higher in ESNs compared to the healthy controls, recently infected HIV+ and chronically infected HIV+. Although the number of circulating pDC in different study groups was not significantly different, yet these cells seem to have significantly higher activation state in terms of IFNα production (ex-vivo in response to CpG ODN) in ESNs when compared with other groups. Increased activation status of Nk cells and pDC in Exposed but Seronegative individuals indicates their continuous stimulation with HIV antigens due to regular exposure with infected partners and which might be imparting resistance to viral infection in these individuals.

关键词： HIV Exposed Seronegative Innate Immune Responses Nk Cells Plasmacytoid Dendritic Cells

In silico prediction of phytoconstituents from Ehretia laevis targeting TNF-αin arthritis

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Digital Chinese Medicine 2021年第3期4卷 180-190页

作者： Subhash R.Yende Sapan k.Shah Sumit k.arora keshav S.Moharir Govind k.Lohiya Department of Pharmacology Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutical Chemistry Priyadarshini J.L.College of PharmacyNagpurMaharashtra 440016India Department of Pharmacognosy and Phytochemistry Gurunanak College of PharmacyNagpurMaharashtra 440026India Department of Pharmaceutics Gurunanak College of PharmacyNagpurMaharashtra 440026India

Objective Rheumatoid arthritis(RA)is an autoimmune disease involving the synovial lining of the major *** therapies have noteworthy side *** study involved in silico evaluation of Ehretia laevis(***)phytoconstituents targeting tumor necrosis factor-α(TNF-α).Methods Molecular docking studies performed to investigate the binding pattern of the plant *** phytoconstituents along with the crystal structure of TNF-α(PDB ID:2 AZ5)using AutoDock Vina followed by a study of interacting amino acid residues and their influence on the inhibitory potentials of the active *** the pharmacokinetic profile and toxicity screening carried out using Swiss ADME and pk *** The docked results suggest that lupeol(-9.4 kcal/mol)andα-amyrin(-9.4 kcal/mol)has best affinity towards TNF-αcompared to standard drug thalidomide(-7.4 kcal/mol).The active chemical constituents represents better interaction with the conserved catalytic residues,leading to the inhibition/blockade of the TNF-α-associated signaling pathway in ***,pharmacokinetics and toxicity parameters of these phytochemicals were within acceptable limits according to ADMET *** The binding potential of phytoconstituents targeting TNF-αshowed promising ***,it encourages the traditional use of *** and provides vital information on drug development and clinical treatment.

关键词： Rheumatoid arthritis Ehretia laevis In silico Molecular docking Pharmacokinetics Tumor necrosis factor-α(TNF-α) Lupeol α-Amyrin

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