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中国实验血液学杂志 1997年第3期5卷 324-324页

作者： X.J. Hao, P.m. Tang, D.L. Du, N. mao, m. Wu Beijing Institute of Basic medical Sciences, Beijing100850

To demonstrate that low c-myc expression mightexert the effects on differentiation and survival ofleukemic cells, antisense technique was used. Human 2. 7kb c-myc DNA fragment containing exon l, intron 1 and127nt exon... 详细信息

关键词： antisense transcripts plasmid transfection DNA intron exogenous staining morphological RNA

Research Article Focusing Properties of High-Order Harmonics

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Ultrafast Science 2021年第1期 31-38页

作者： maria Hoflund Jasper Peschel marius Plach Hugo Dacasa Kévin Veyrinas Eric Constant Peter Smorenburg Hampus Wikmark Sylvain maclot Chen Guo Cord arnold Anne L'Huillier Per Eng-Johnsson Department of Physics Lund UniversityP.O.Box 11822100 LundSweden Universitéde Bordeaux CNRSCEACentre Laser Intenses et Applications(CELIA)43 Rue P.Noailles33400 TalenceFrance Univ Lyon Univ Claude Bernard Lyon 1CNRSInstitut Lumière MatièreF-69622 VilleurbanneFrance ASmL Research ASML Netherlands B.V.5504 DR VeldhovenNetherlands

many applications of the extreme ultraviolet(XUV)radiation obtained by high-order harmonic generation(HHG)in gases require a small focus area in order to enable attosecond pulses to reach a high ***,high-order harmonics generated in Ar with a multiterawatt laser system in a loose focusing geometry are focused to a few micrometers using two toroidal mirrors in a Wolter configuration with a high demagnification *** a knife-edge measurement technique,we determine the position and size of the XUV foci as a function of harmonic *** show that the focus properties vary with harmonic order and the generation ***,based on a classical description of the harmonic dipole phase and assuming that the individual harmonics can be described as Gaussian beams,reproduce the experimental *** discuss how the generation geometry affects the intensity and duration of the focused attosecond pulses.

关键词： harmonic harmonics geometry

Task Scheduling and Synchronization in Robotic manufacturing Systems

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Task Scheduling and Synchronization in Robotic Manufacturing...

Prevalence of intestinal schistosomiasis in pre-school aged children: a pilot survey in marolambo District, madagascar

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作者： m.m.n Song, and Ning Xi manufacturing Systems Department, mD313S, SRL, Ford motor Company, Dearborn, m148121-2053, U.S.A. Department of Electrical Engineering, michigan State University, East Lansing, mI48824-1226, U.S.A.

＜正＞This paper presents a novel approach for solving the grand challenging problem in intelligent control, i.e. the analytical and robust integration of low-level system sensing and simple control with high-level system behavior and perception. The proposed max-Plus Algebra model combined with event-based planning and control provides an advanced mechanism to efficiently integrate task scheduling, sensing, planning and real-time execution in robotic manufacturing systems so that task scheduling, which usually deals with discrete events, as well as action planning, which usually deals with continuous events, can be treated in a unified analytical model, and the design of task synchronization becomes much easier. more importantly, the state-of-art characteristic of this approach is that interactions between discrete and continuous events can be considered in a unified framework. This characteristic allows robotic manufacturing systems to intelligently cope with unexpected events and uncertainties during well-scheduled tasks so that the efficiency and reliability of the task schedule and action synchronization can increase significantly. A robotic manufacturing system is used to illustrate the proposed approach. The experimental results clearly demonstrate the advantages of the proposed approach.

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Infectious Diseases of Poverty 2021年第3期10卷 124-124页

作者： Caitlin Sheehy Heather Lawson Emmanuel H.Andriamasy Hannah J.Russell Alice Reid Gina U.Raderalazasoa Graham Dodge Robbie Kornitschky James m.StJPenney Tahiry N.Ranaivoson Antsa Andria niaina Jenny S.Emmanoela Amaya L.Bustinduy JRussell Stothard Louis Andrianjaka Stephen A.Spencer The University of man Chester medical School University of Man ChesterManchester M139NTUK 不详

School-aged children(SAC)have a considerable burden of intestinal schistosomiasis in madagascar yet its burden in pre-school aged children(PSAC)is currently *** assess the at-risk status of PSAC,we undertook a pilot epidemiological survey in June 2019 examining children(n=89),aged 2-4-years of balanced gender,in six remote villages in marolambo District,*** included use of urine-circulating cathodic antigen(CCA)dipsticks and coproscopy of stool with duplicate Kato-Katz(K-K)thick smears.

关键词： Schistosoma mansoni Soil-transmitted helminthiasis Paediatric Praziquantel mass drug administration

Insights into triterpene synthesis and unsaturated fatty-acid accumulation provided by chromosomallevel genome analysis of Akebia trifoliata subsp . australis

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Horticulture Research 2021年第1期8卷 419-433页

作者： Hui Huang Juan Liang Qi Tan Linfeng Ou Xiaolin Li Caihong Zhong Huilin Huang Ian max moller Xianjin Wu Songquan Song Key Lab oratory of Resea rch and Utilizati on of Eth nomedic inal Pla nt Reso ur ces of Hunan Province College of Biological and Food EngineeringHuaihua UniversityHuaihua 418000China Kunming Institute of Botany Chinese Academy of Scie ncesKunming 650201China State Key Lab oratory Br eed ing Base of Dao-di Herbs National Resource Center for Chinese Materia MedicaChina Academy of Chinese Medical ScienceBeijing 100700China Department of molecular Biology and Genetics Aarhus UniversityFlakkebjergDK-4200 SlagelseDenmark Institute of Botany Chinese Academy of SciencesBeijing 100093China

Akebia trifoliata *** is a well-known medicinal and potential woody oil plant in *** limited genetic information available for *** *** has hindered its ***,a high-quality chromosomelevel genome sequence of *** *** is *** de novo genome assembly of 682.14 mb was generated with a scaffold N50 of 43.11 *** genome includes 25,598 protein-coding genes,and 71.18%(485.55 mb)of the assembled sequences were identi fi ed as repetitive *** ongoing massive burst of long terminal repeat(LTR)insertions,which occurred~1.0 million years ago,has contributed a large proportion of LTRs in the genome of *** *** analysis shows that *** *** is closely related to Aquilegia coerulea and forms a clade with Papaver somniferum and Nelumbo nucifera,which supports the well-established hypothesis of a close relationship between basal eudicot *** expansion of UDP-glucoronosyl and UDP-glucosyl transferase gene families and fi-amyrin synthase-like genes and the exclusive contraction of terpene synthase gene families may be responsible for the abundant oleanane-type triterpenoids in *** ***,the acyl-ACP desaturase gene family,including 12 stearoyl-acyl-carrier protein desaturase(SAD)genes,has expanded exclusively.A combined transcriptome and fatty-acid analysis of seeds at fi ve developmental stages revealed that homologs of SADs,acyl-lipid desaturase omega fatty acid desaturases(FADs),and oleosins were highly expressed,consistent with the rapid increase in the content of fatty acids,especially unsaturated fatty *** genomic sequences of *** *** will be a valuable resource for comparative genomic analyses and molecular breeding.

关键词： analysis saturated expanded

Prognostic value of increased carbohydrate antigen in patients with heart failure

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World Journal of Cardiology 2014年第4期6卷 205-212页

作者： Ana B méndez Jordi Ordonez-Llanos Andreu Ferrero mariana Noguero Teresa mir Josefina mora Antoni Bayes-Genis Sònia mirabet Juan Cinca Eulàlia Roig Cardiology Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Biochemistry Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Cardiology Department Hospital Germans Trias I Pujol

AIm:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(nt-proBNP) in stable heart failure(HF) ***:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to *** were included in the study if they had a previous documented episode of HF and received HF ***125 and nt-proBNP concentrations were *** independent association between nt-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) ***:The mean age of the 156 patients was 72 ± 12 *** follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for *** CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P nt heart transplantation vs 45 ± 78 KU/L in survivors(P markers were elevated vs not elevated(HR = 8.95,95%CI:3.11-25.73; P ntermediate when only nt-proBNP was elevated vs not elevated(HR = 4.15,95%CI:1.41-12.24; P moreover,when CA125 was added to the clinical model with nt-proBNP,a 4%(P mprovement in the IDI was ***:CA125 > 60 KU/L identified patients in stable HF with poor *** CA125 level adds prognostic value to nt-proBNP level in predicting HF outcomes.

关键词： Heart failure Prognosis Carbohydrate antigen 125 Brain natriuretic peptides Survival

Ventilation practices in burn patients—an international prospective observational cohort study

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Burns & Trauma 2021年第1期9卷 47-57页

作者： Gerie J.Glas Janneke Horn markus W.Hollmann Benedikt Preckel Kirsten Colpaert manu malbrain Ary Serpa Neto Karim Asehnoune marcello Gamma de Abreu Ignacio martin-Loeches Paolo Pelosi Folke Sjoerg Jan m.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro marc Jeschke Jeffrey Lipman matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa manoel Silva Junior Cintia m.C.Grion marjorie Burnett Frederik mondrup Francois Ravat mathieu Fontaine Renan Le Floch mathieu Jeanne morgane Bacus maite Chaussard marcus Lehnhardt Bassem Daniel mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim.m.ria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting marcus J.Schultz LAmiNAR investigators Academic medical Center University of AmsterdamAmsterdamAZ 1105The Netherlands Department of Anaesthesia and Intensive Therapy medical University of Lublin Aleje Racklawickie 1–20-059 Lublin–Poland AZ JAN PALFIJN GEnt Watersportlaan 5–9000 Gent–Belgium ABC medical School SaPauloBangúSP 5001Brazil Service d’Anesthésie Réanimation Chirurgicale Nantes 44093France University Hospital Carl Gustav Carus Dresden 01307Germany St James University Hospital Dublin D08 NHY1Ireland University of Genoa GenoaGE 16128Italy Linkoing University Hospital Linkoing 58185Sweden maasstad Hospital RotterdamDZ 3079The Netherlands Red Cross Hospital BeverwijkLE 1942The Netherlands martini Hospital GroningenNT 9728The Netherlands University of Texas medical Branch GalvestonTX 77555USA Turin CTO Burn Center TurinTO 10126Italy Rigshospitalet Copenhagen 2100Denmark La Paz University Hospital Madrid 28046Spain Ross Tilley Burn Centre Sunnybrook Health Sciences CentreToronto M4N 3M5Canada Royal Brisbane and Women’s Hospital Queensland UniversityHerstonQLD 4029Australia Australian and New Zealand Intensive Care Research Centre.monash University MelbourneVIC 3004Australia GH St-Louis-Lariboisière APHPParis 75010France BG Klinik Ludwigshafen Ludwigshafen 67071Germany Papanikoalou Hospital Thessaloniki 54621Greece middlemore Hospital OtahuhuAuckland 2025New Zealand Haukeland University Hospital Bergen 5021Norway Uppsala University Hospital Uppsala 75185Sweden Concord Repatriation General Hospital NSW University of SydneyConcord 2139Australia Ziekenhuis Netwerk Antwerpen-Stuivenberg Antwerpen 2060Belgium Universidade de Sao Paulo Sao Paulo 01246-903Brazil Universidade Estadual de Londrina Londrina 86057-970Brazil Sunnybrook Health Sciences Centre Toronto M4N 3M5Canada CHU Lyon St Luc Lyon 69007France CHU Nantes Service dánesthesie reanimation chirugicale Nantes 44093France Hopital Roger Salengro CHRU LilleLille 59037France Saint-Louis Hospital Paris 75010France BG University Hospital Bergmannsheil Bo

Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from *** study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical *** tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maxim.m.airway pressures were *** association between V_(T) and VFD-28 was analyzed using a competing risk *** settings were presented for all patients,focusing on the first day of *** also compared ventilation settings between patients with and without inhalation ***:A total of 160 patients from 28 ICUs in 16 countries were *** V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maxim.m.airway pressuresmH_(2)***:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation *** of low V_(T) was not associated with a reduction in *** registration:*** *** of registration:9 December 2014.

关键词： mechanical ventilation Inhalation trauma Lung-protective Critical care

Discovery of Potent, Selective and Reversible Caspase-3 Inhibitors

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合成化学 2004年第Z1期12卷 13-13页

作者： André Giroux John Colucci Christopher I. Bayly Daniel J. mckay Sophie Roy Steve Xanthoudakis John Vaillancourt Dita m. Rasper John Tam Paul Tawa Donald W. Nicholson Robert J. Zamboni Department of medicinal Chemistry Department of Biochemistry and molecular Biology Merck Frosst Centre for Therapeutic Research Merck Frosst Canada & Co. P.O. Box 1005 Pointe-Claire-DorvalQuebec Canada H9R 4P8

Recent studies towards understanding the molecular mechanisms of apoptosis have revealed the importance of a group of cysteinyl aspartate specific proteases, the caspases, in the programmed cell death process (Hengartner, m.O. Nature 2000, 407, 770). Caspase-3, in particular,has been characterized as the dominant effector caspase involved in the proteolytic cleavage of a variety of protein substrates including cytoskeletal proteins, kinases and DNA repair enzymes during apoptosis (Nicholson, D. W. Cell Death Differ. 1999, 6, 1028). The development of potent and selective caspase-3 inhibitors has thus emerged as an attractive therapeutic target. In the presentation,the identification of a series of potent, selective and reversible non-peptidyl caspase-3 inhibitors containing a pyrazinone core (1) will be presented. SAR optimization at R1, R2, R3 and R4 led to the discovery of inhibitors such as 2 with excellent in vitro activities (IC50 against rh-caspase-3: 5 nm; IC50 against camptothecin induced apoptotic cell death in nt2 cells: 20 nm). Compounds such as 2 also displayed excellent in vivo activities in a number of animal models of acute injuries (see: methot, N. et al, J. Exp. med. 2004, 119, 199; Toulmond, S. et al, British J. Pharm. 2004, 141,689; Holtzman,D.m. et al, JBC, 2002, 277, 30128), and selected examples will be discussed during the presentation.

关键词： programmed cell death cytoskeletal proteins molecular mechanisms identification of animal models DNA repair in vitro