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Characterizing the patient experience during neoadjuvant therapy for pancreatic ductal adenocarcinoma:A qualitative study

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1175-1186页

作者： Lena Stevens Zachary J Brown Ryan Zeh Christina monsour Sharla Wells-Di Gregorio Heena Santry Aslam.m.Ejaz Timothy michael Pawlik Jordan m Cloyd Department of Surgery The Ohio State University Wexner Medical CenterColumbusOH 43210United States Department of General Surgery University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Psychiatry Center for Palliative CareThe Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Neoadjuvant therapy(nt)has increasingly been utilized for patients with localized pancreatic ductal adenocarcinoma(PDAC).It is the recommended approach for borderline resectable(BR)and locally advanced(LA)cancers and an increasingly utilized option for potentially resectable(PR)*** its increased use,little research has focused on patient-centered metrics among patients undergoing nt,including patient experiences,preferences,and recommendations.A better understanding of all aspects of the patient experience during nt may identify opportunities to design interventions aimed at improving quality of life;it may also facilitate the completion of nt and receipt of surgery,ultimately optimizing long-term *** To understand the experience of patients initiating and receiving nt to identify opportunities to improve neoadjuvant cancer care *** Semi-structured interviews of patients with localized PDAC during nt were conducted to explore their experience initiating and receiving *** took place between August 2020 and October *** to the descriptive nature of the research,questions were open *** were conducted over the phone,audio recorded and then *** interviews were coded by two independent researchers using NVivo 12,iteratively identifying themes until thematic saturation was *** integrative approach to qualitative analysis was used,utilizing both inductive and deductive *** A total of 12 patients with localized PDAC were *** with BR(n=7),PR(n=2),and LA(n=3)cancers participated in the *** patients indicated that choosing nt was the doctor’s recommendation,while most reported not being familiar with the concept of nt(n=11)and that nt was presented as the only option(n=8).Five themes describing the patient experience emerged:physical symptoms,emotional symptoms,coping mechanisms,access to care,and life *** most commonly cited recommendation for

关键词： Pancreatic ductal adenocarcinoma Neoadjuvant therapy Patient experience Patient-centered care Quality of life Qualitative research

Numerical and experimental analysis of the closed-cell aluminium foam under low velocity impact using computerized tomography technique

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Acta mechanica Sinica 2019年第1期35卷 144-155,I0005页

作者： S.Talebi m.Sadighi m.m.Aghdam Department of mechanical Engineering Amirkabir University of TechnologyTehranIran

In the present work, the response of closed-cell aluminum foams under low-velocity impact has been studied numerically and experimentally. Computerized tomography is employed to access three-dimensional (3D) microstructure of the closed-cell aluminum foam. Effective parameters including foam density and the velocity of impactor on foam dynamic behavior are investigated. In order to show the validity and accuracy of results, some static experiments and low-velocity impact tests have been conducted. Results in dicate a remarkable agree me nt between the simulation and experimental data. moreover, the results show that by increasing the density of foam samples, the highest difference between numerical and experimenidi results for peak stress and absorbed energy are 35.9% and 6.9%, respectively, which is related to the highest density. For impact velocities ranging from 3.1 to 4.2 m/s, the maxim.m.discrepancy in peak stress and absorbed energy occur at an inipact velocity of 3.1 m/s in which corresponding errors are 33.3% and 6.6%, respectively. For the impact velocity of 40 m/s, the highest increase in peak stress and absorbed energy are 667.9% and 370.3% associated with the density of 0.5 and 0.3 g/cm^3, respectively.

关键词： Finite element analysis Impact Aluminum foam Experimental analysis Energy absorption

外科切除与莫氏显微外科手术治疗颌面部基底细胞癌的比较:随机对照研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 5-6页

作者： Smeets N.W.J. Krekels G.A.m. Ostertag J.U. 牛新武 Department of Dermatology University Hospital MaastrichtMaastrichtNet herlandsDr.

Background Rates of recurrence of facial basal-cell carcinoma are c onsisten tly lower after mohs’micrographic surgery (mmS) than after other treatments, such as surgical excision (SE). However, mmS is more time-consuming and theref ore more expensive than SE. We investigated the types of facial basal-cell car cinomas in which mmS was more effective than SE. methods 408 primary and 204 rec urrent facial carcinomas (374 and 191 patients, respectively) were analysed sepa rately in this prospective randomised study. Patients were assigned SE or mmS (e ach 204 primary, 102 recurrent), and received treatment at two hospitals in the Netherlands. The primary outcome was recurrence of carcinoma. Analysis was by in tention to treat. Findings Of the basal-cell carcinomas included in the trial, 397 primary (198 mmS, 199 SE) and 201 recurrent (99, 102) tumours were actually treated. Of patients with primary carcinomas, 21 had both mmS and SE on differe nt tumours. Nine with recurrent carcinomas had both treatments on different skin tumours. 66 primary and 13 recurrent carcinomas were lost to follow-up. Of th e primary carcinomas, five (3% ) recurred after SE compared with three (2% ) a fter mmS during 30 months of follow-up. Of the recurrent carcinomas, three (3 % ) recurred after SE and none after mmS during 18 months of follow-up. Four recurrent carcinomas randomly assigned to the SE group were treated with mmS. Al though both differences favoured mmS, they were not significant (primary, differ ence 1% (95% CI- 2· 5% to 3· 7% ), P=0· 724; recurrent, 3· 2% (- 2· 0% to 5· 0% ), P=0· 119). Total operative costs of mmS were higher than those of SE (primary e405· 79 vs e216· 86, recurrent e489· 06 vs e323· 49; both P nterpretation No definitive conclusion on recurrence rates o f primary or recurrent basal-cell carcinomas is yet possible. Although recurre nce rates were lower after mmS than after SE, the differences were not significa nt. With comprehensive and reliable

关键词：基底细胞癌外科切除显微外科颌面部复发率随机研究其他治疗方法 EmBASE 无显著性差异失访

Securing Transmitted Color Images Using Zero Watermarking and Advanced Encryption Standard on Raspberry Pi

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Computer Systems Science & Engineering 2023年第11期47卷 1967-1986页

作者： Doaa Sami Khafaga Sarah m.Alhammad Amal magdi Osama ElKomy Nabil ALashin Khalid m.Hosny Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Technology Zagazig UniversityZagazig44519Egypt

Image authentication techniques have recently received a lot of attention for protecting images against unauthorized *** to the wide use of the Internet nowadays,the need to ensure data integrity and authentication *** techniques,such as watermarking and encryption,are used for securing images transmitted via the *** majority of watermarking systems are PC-based,but they are not very *** watermarking methods need to be developed to accommodate real-time applications and provide *** paper presents hybrid data security techniques using a zero watermarking method to provide copyright protection for the transmitted color images using multi-channel orthogonal Legendre Fourier m.m.nts of fractional orders(mFrLFms)and the advanced encryption standard(AES)algorithm on a low-cost Raspberry *** order to increase embedding robustness,the watermark picture is scrambled using the arnold *** watermarking is implemented on the Raspberry Pi to produce a real-time ownership verification *** sending the ownership verification key and the original image to the monitoring station,we can encrypt the transmitted data with AES for additional security and hide any viewable *** receiver next verifies the received image’s integrity to confirm its authenticity and that it has not been tampered *** assessed the suggested algorithm’s resistance to many *** suggested algorithm provides a reasonable degree of robustness while still being *** proposed method provides improved bit error rate(BER)and normalized correlation(NC)values compared to previous zero watermarking *** performance analysis is performed to demonstrate its *** a 256×256 image size,it takes only 2 s to apply the zero-watermark algorithm on the Raspberry Pi.

关键词： Zero watermarking Raspberry Pi advanced encryption standard

饱和纳米流体多孔介质中竖直嵌入板上边界层的非Newton流

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应用数学和力学 2011年第12期32卷 1472-1480页

作者： F·m·哈迪 F·S·艾伯拉赫门 S·m·阿卜杜勒·盖德 m·R·艾德吴承平(译) 艾斯尤特大学理学院数学系艾斯尤特71516埃及艾斯尤特大学教育学院科学与数学系新谷72111埃及不详

在层流条件下,对饱和多孔介质中的竖直板,研究幂指数型非Newton流的自由对流热交换.非Newton纳米流体服从幂指数型的数学模型,模型综合考虑了Brown运动和热泳的影响.通过相似变换,将问题的偏微分控制方程组,转化为常微分方程组,得到了... 详细信息

在层流条件下,对饱和多孔介质中的竖直板,研究幂指数型非Newton流的自由对流热交换.非Newton纳米流体服从幂指数型的数学模型,模型综合考虑了Brown运动和热泳的影响.通过相似变换,将问题的偏微分控制方程组,转化为常微分方程组,得到了常微分方程组的数值解.数值解依赖于幂指数n,Lewis数Le,浮力比Nr,Brown运动参数Nb,以及热泳参数nt.在n和Le的不同取值下,研究并讨论了对相关流体性质参数的影响和简化的Nusselt数.

关键词：非Newton流体自由对流纳米流体多孔介质

全球电离层对2000年4月6-7日磁暴事件的响应

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空间科学学报 2005年第3期25卷 173-180页

作者：张满莲 Sandro m. Radicella 中国科学院空间科学与应用研究中心北京100080 The Abdus Salam International Center for Theoretical Physics Trieste Italy

利用分布于全球的电离层台站的测高仪观测数据,对扰动期间,f0F2值与其宁静期间参考值进行比较,研究了2000年4月6-7日磁暴期间全球不同区域电离层的响应形态,并通过对比磁扰期间NmF2的变化与由mSISE90经验模式估算的中性大气浓度比(no/n... 详细信息

利用分布于全球的电离层台站的测高仪观测数据,对扰动期间,f0F2值与其宁静期间参考值进行比较,研究了2000年4月6-7日磁暴期间全球不同区域电离层的响应形态,并通过对比磁扰期间NmF2的变化与由mSISE90经验模式估算的中性大气浓度比(no/nN2)的变化,探讨了本次事件期间的电离层暴扰动机制.结果表明,在磁暴主相和恢复相早期,出现了全球性的电离层F2层负相暴效应.最大负相暴效应出现在磁暴恢复相早期,即电离层暴恢复相开始时间滞后于磁暴恢复相开始时间.在磁暴恢复相后期,一些台站出现正相扰动.研究结果表明,本次事件期间的电离层暴主要是由磁暴活动而诱发的热层暴环流引起的.

关键词： 2000年磁暴事件响应电离层暴观测数据经验模式开始时间时间滞后研究结果复相测高仪扰动参考值浓度比 F2层全球性台站早期效应大气磁扰环流

雷洛昔芬和它莫西芬在治疗青春期男性乳房发育中的疗效

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 34-35页

作者： Lawrence S.E. arnold Faught K. Vethamuthu J. Lawson m.L. 王一飞

目的:评估抗雌激素药它莫西芬和雷洛昔芬在治疗青春期持续性男性乳房发育的效果。研究设计:回顾性研究38例在一个儿童内分泌科就诊的青春期持续性男性乳房发育的患儿。患儿仅得到保证或3-9个月疗程的雌激素受体抑制剂(它莫西芬和雷洛昔... 详细信息

目的:评估抗雌激素药它莫西芬和雷洛昔芬在治疗青春期持续性男性乳房发育的效果。研究设计:回顾性研究38例在一个儿童内分泌科就诊的青春期持续性男性乳房发育的患儿。患儿仅得到保证或3-9个月疗程的雌激素受体抑制剂(它莫西芬和雷洛昔芬)的治疗。结果:患儿平均年龄为14.6岁(s=1.5岁),患男性乳房发育的平均持续时间为28.3月(s=16.4月)。在使用它莫西芬和雷洛西芬后,胸部结节直径平均减少分别为2.1cm(95%CI 1.7-2.7,Pm(95% CI 1.7-3.3,P<0.0001)。在使用它莫西芬和雷洛昔芬后,分别可看到86%和91%的患儿得到改善,但是,

关键词：男性乳房发育它莫西芬雷洛昔芬内分泌科抗雌激素持续性平均持续时间研究设计雌激素受体

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提高假编变形丝加工效率的新方法

国际纺织导报 2006年第12期34卷 15-16页

作者： U. Herrmann R. arnold m. Seeger H. Erth H. Lucas 钱程（译）陈惠兰（校）萨克森纺织研究所（STFI）德国 Harry Lucas纺织机械制造公司德国不详

探索了采用加工POY、mOY、LOY和PET长丝的新概念制成的假编变形丝的特性。将定型装置安装在编织区和卷绕区之间,这样确保生产的假编变形丝具有多种特性。研究表明牵伸连续性很好,假编变形丝特性的偏差很小。

关键词：假编变形纱纬编机工艺

^(99)Tc^m(CO)_3-BPHRGD的制备及其在荷m21人黑色素瘤裸鼠体内的生物分布

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原子能科学技术 2015年第7期49卷 1170-1177页

作者：卿晶胡骥梁积新罗联哲费月英阳国桂洪业中国原子能科学研究院同位素研究所北京102413 原子高科股份有限公司北京102413

制备了99 Tcm(CO)3-BPHRGD,并进行了荷m21人黑色素瘤裸鼠体内生物学评价。在pH=7、75℃条件下反应30min,99 Tcm(CO)3-BPHRGD的标记率大于80%,纯化后标记物的放化纯度大于98%。体外稳定性实验结果显示,37℃下,标记物在生理盐水、人血清... 详细信息

制备了99 Tcm(CO)3-BPHRGD,并进行了荷m21人黑色素瘤裸鼠体内生物学评价。在pH=7、75℃条件下反应30min,99 Tcm(CO)3-BPHRGD的标记率大于80%,纯化后标记物的放化纯度大于98%。体外稳定性实验结果显示,37℃下,标记物在生理盐水、人血清中具有很好的稳定性。荷m21人黑色素瘤裸鼠体内分布显示,注射99 Tcm(CO)3-BPHRGD后0.5、1、2、4h,标记物的瘤/血比分别为0.70±0.45、0.87±0.05、1.10±0.19、1.68±0.04。随着时间的延长,靶与非靶的放射性摄取比(T/nt)增大,表明该标记物在肿瘤细胞中的清除速度慢于其他组织。通过进一步结构修饰,改变其体内代谢途径及药代动力学性质,99 Tcm(CO)3-BPHRGD非常有希望成为一种新型肿瘤显像剂。

关键词： RGD 99Tcm 黑色素瘤生物分布