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Real-life chromoendoscopy for dysplasia surveillance in ulcerative colitis

World Journal of Gastroenterology 2018年第35期24卷 4069-4076页

作者： Pasquale Klepp Anita Tollisen arne Roseth Milada Cvancarova Smastuen Solveig N Andersen Morten Vatn Bjorn A Moum Stephan Brackmann Unger-Vetlesen Institute Department of Internal MedicineLovisenberg Diaconal HospitalOslo 0456Norway Institute of Clinical Medicine University of OsloOslo 0317Norway Department of Pathology Akershus University HospitalLorenskog 1474Norway Department of Gastroenterology Oslo University HospitalOslo 0450Norway Department of Gastroenterology Akershus University HospitalLorenskog 1474Norway

AIM To evaluate the use of chromoendoscopy for surveillance of ulcerative colitis in a real-life community hospital *** Patients with extensive ulcerative colitis, having disease duration of more than 8 years and who presented between the years of 1999 to 2013, were offered enrolment in this single cohort prospective study. All participants underwent standard bowel preparation with sodium phosphate and chromoendoscopy. Two expert endoscopists, novice to chromoendoscopy, evaluated each segment of the colon with standarddefinition colonoscopes after spray application of 0.4% indigo carmine. All observed lesions were recorded and evaluated before being removed and/or biopsied. In addition, nontargeted biopsies were taken from each segment of the colon. The dysplasia detection rate and dysplasia detection yield were ascertained. RESULTS A total of 21 neoplastic lesions(2 carcinomas, 4 of high-grade dysplasia and 15 of low-grade dysplasia) and 27 nondysplastic lesions were detected in 16 of the total 67 patients(70% male; median disease duration: 17 years; median age at diagnosis: 25 years; 92% aminosalicylate-treated). The dysplasia detection rate was 10.5%(7/67 patients). The dysplasia detection yield was 20.8%(10/48) for targeted biopsies and 3.5%(11/318) for nontargeted biopsies. The sensitivity and specificity for the macroscopic evaluation of neoplasia using chromoendoscopy were 48% [95% confidence interval(CI): 26%-70%] and 96%(95%CI: 93%-98%), respectively. The positive predictive and negative predictive values were 42%(95%CI: 27%-59%) and 97%(95%CI: 95%-98%), respectively. A total of 19/21 dysplastic lesions were detected in mucosa with histologic *** Chromoendoscopy seems to be of value for dysplasia surveillance of ulcerative colitis in a community hospital setting. The yield of non-targeted biopsies is negligible.

关键词： Colorectal cancer Dysplasia Ulcerative colitis Surveillance Chromoendoscopy

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Intermittent blood flow restriction does not reduce atrophy following anterior cruciate ligament reconstruction

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Journal of Sport and Health science 2016年第1期5卷 115-118页

作者： Erik Iversen Vibeke Rostad arne Larmo Norwegian Olympic and Paralympic Committee and Confederation of Sports Oslo 0840 Norway Curato Rontgen Sandvika Oslo 0050 Norway

Background:A previous study has reported a 50% reduction in disuse atrophy of the quadriceps during the first 14 days after anterior cruciate ligament(ACL) reconstruction.A follow-up trial is needed to confirm these promising *** present study aims to investigate the effect of an occlusion stimulus on quadriceps atrophy after ACL ***:A total of 24 subjects participated in the *** were randomized into two *** the 2nd day after surgery,the occlusion group received an occlusion stimulus for 5 min,followed by removal of the occlusive pressure for 3 *** was repeated five times in one training session,twice *** the period of occlusive stimulus,the subjects performed 20 low load exercises for the *** control group followed the same exercise protocol,but without the occlusion *** in quadriceps anatomical cross section area(ACSA) were measured using axial magnetic resonance(MR) images at 40% and 50% of the length of the ***:Both groups had a significant reduction of quadriceps ACSA from 2 days before surgery to 16 days after *** the intervention period,the occlusion group lost 13.8% ± 1.1%(mean ± SEM) and the control group lost 13.1% ± 1.0% of their quadriceps ACSA,*** was no significant difference between the occlusion and control groups with regards to atrophy of the quadriceps ***:In conflict with other studies using a similar protocol,application of blood flow restriction the first 14 days after ACL reconstruction did not reduce quadriceps ACSA muscle atrophy measured by MR in a population of athletes.

关键词： ACL reconstruction Ascular occlusion Hypoxia ischemia Quadriceps atrophy

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Quality Control in Drug Manufacturing——The Use of PAT and QbD for Robust Processing

Quality Control in Drug Manufacturing——The Use of PAT and ...

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抗生素质量与安全论坛

作者： arne Torstensson PhD Senior Analytical Advisor AstraZeneca R＆D Sweden

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The inositol metabolism pathway as a target for neuroprotective strategies

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Neural Regeneration Research 2015年第12期10卷 1928-1929页

作者： arne M.Nystuen Andy W.Yang Department of Genetics Cell Biology and AnatomyUniversity of Nebraska Medical Center Currently at Neurotech Inc.

Neurodegeneration is characterized by the progressive and permanent loss of *** typically results in a debilitating loss of function in an otherwise healthy *** diseases have enormous direct health care costs,with som... 详细信息

关键词： The inositol metabolism pathway as a target for neuroprotective strategies

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Realizing Official Statistics on Accidents at Work in Norway

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Journal of Statistical science and Application 2016年第1期4卷 48-52页

作者： Jensen, arne Brathen, Remy Cand.polit Political scienceStatistics Norway Division for Health Statistics Akersveien 26NO-0033 Oslo Norway Cand.polit Political scienceStatistics Norway Division for Health Statistics Akersveien 26NO-0033 Oslo Norway

Statistics Norway has been engaged in the development of official statistics on accidents at work for the last ten years and represents Norway in international bodies like Eurostat working groups. Some of the work was documented and presented back in 2011 at the ISI Dublin convention and a review of further developments the last four years could shed even more light over the efforts made. There has been implemented a new data collection system at the national level that involves data and files based on forms for reporting accidents at work being sent from the Norwegian Labour and Welfare Administration （NLW） to Statistics Norway. Nevertheless there are still some challenges to be met. These include the use of different versions of the NLW forms, the scanning and extraction of data in the NLW, the implementation of a secure electronic solution for transmitting data between the NLW and Statistics Norway, the reading and interpretation of tiff-files and the lessons to be learned from other countries. The ambition is that Statistics Norway produces methodological sound official statistics on accidents at work within the first half of 2015 and transmits data and files to Eurostat that are necessary and sufficient to fulfil EU regulations within the first half of 2016.

关键词： international reports EU regulations data collection system statistical challenges.

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Reviewing 30 years of studies on the Common Cuckoo:accumulated knowledge and future perspectives

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Chinese Birds 2013年第1期4卷 3-14页

作者： arne MOKSNES Frode FOSSΦY Eivin RΦSKAFT Brd G.STOKKE 挪威科技大学生物学系

In Europe, eggs of the Common Cuckoo (Cuculus canorus) have been found in more than 125 different host species. However, very few species are frequently parasitized. The Cuckoo is divided into several distinct races termed gentes. Females of each gens specialize in parasitizing a particular host species. More than 20 such gentes are recognized in Europe. Each female Cuckoo lays eggs of constant appearance. Most gentes can be separated based on their distinct egg types, which in many cases mimic those of their hosts. Different gentes may occur in sympatry or may be separated geographically. Some gentes may occur in restricted parts of the host’s distribution area. These patterns raise some fundamental questions like: Why are some passerine species preferred as hosts while others are not? Why does a host population consist of individuals either accepting or rejecting Cuckoo eggs? Why is there marked variation in egg rejection behavior between various host populations? How distinct and host-specialized are Cuckoo gentes? These questions are discussed in relation to existing knowledge and future perspectives.

关键词： brood parasitism host defense coevolutionary arms race Common Cuckoo gentes

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High-fat diet and oral infection induced type 2 diabetes and obesity development under different genetic backgrounds

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Animal Models and Experimental Medicine 2023年第2期6卷 131-145页

作者： Iqbal M.Lone Nadav Ben Nun Aya Ghnaim arne S.schaefer Yael Houri-Haddad Fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Periodontology and Synoptic Dentistry Institute for Dental Craniofacial SciencesCharite-University of MedicineBerlinGermany Department of Prosthodontics Dental SchoolThe Hebrew UniversityJerusalemIsrael

Background:Type 2 diabetes(T2D)is an adult-onset and obese form of diabetes caused by an interplay between genetic,epigenetic,and environmental ***,we have assessed a cohort of 11 genetically different collaborative cross(CC)mouse lines comprised of both sexes for T2D and obesity developments in response to oral infection and high-fat diet(HFD)***:Mice were fed with either the HFD or the standard chow diet(control group)for 12 weeks starting at the age of 8 *** week 5 of the experiment,half of the mice of each diet group were infected with Porphyromonas gingivalis and Fusobacterium nucleatum bacteria *** the 12-week experimental period,body weight(BW)was recorded biweekly,and intraperitoneal glucose tolerance tests were performed at weeks 6 and 12 of the experiment to evaluate the glucose tolerance status of ***:Statistical analysis has shown the significance of phenotypic variations between the CC lines,which have different genetic backgrounds and sex effects in different experimental *** heritability of the studied phenotypes was estimated and ranged between 0.45 and *** applied machine learning methods to make an early call for T2D and its *** results showed that classification with random forest could reach the highest accuracy classification(ACC=0.91)when all the attributes were ***:Using sex,diet,infection status,initial BW,and area under the curve(AUC)at week 6,we could classify the final phenotypes/outcomes at the end stage of the experiment(at 12 weeks).

关键词： collaborative cross genetic covariance heritability high-fat diet machine learning mouse model obesity type 2 diabetes

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Psychiatric side effects of pegylated interferon alfa-2b as compared to conventional interferon alfa-2b in patients with chronic hepatitis C

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World Journal of Gastroenterology 2005年第12期11卷 1769-1774页

作者： Michael R Kraus arne sch(a|¨)fer Herbert Csef Michael scheurlen Medizinische Poliklinik

AIM: To assess systematically the spectrum and extent of depressive symptoms comparing patient groups receiving peginterferon or conventional ***: Ninety-eight patients with chronic hepatitis C and interferon-based therapy (+ribavirin) were consecutively enrolled in a longitudinal study. Patients were treated with conventional interferon alfa-2b (48/98patients; 5 MIU interferon alfa-2b thrice weekly) or peginterferon alfa-2b (50/98 patients; 80-150 μgpeginterferon alfa-2b) in combination with weight-adapted ribavirin (800-1 200 mg/d). Repeated psychometric testing was performed before, three times during and once after antiviral therapy: Depression was evaluated by the Hospital Anxiety and Depression scale (HADS), anger/hostility by the Symptom Checklist-90 Items Revised (scL-90-R).RESULTS: Therapy with pegylated interferon alfa-2bproduces comparable scores for depression (ANOVA:P = 0.875) as compared to conventional *** of depression scores were even higher and cases of clinically relevant depression were frequent during therapy with peginterferon. scores for anger/hostility were comparable for both therapy ***: Our findings suggest that the extent and frequency of depressive symptoms in total are not reduced by peginterferon. Monitoring and management of neuropsychiatric toxicity especially depression have to be considered as much as in antiviral therapy with unmodified interferon.

关键词： Pegylated interferon Hepatitis C Side effects Depression Interferon alfa

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纳米结构的炭钌复合物——一种提高超级电容器性能的电极材料(英文)

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新型炭材料 2007年第4期22卷 302-306页

作者：崔光磊周新红智林杰 arne Thomas Klaus Müllen 马普协会高分子所青岛科技大学化学与分子学院山东青岛266042 马普协会胶体界面所

报道了一种利用氧化硅模板,裂解简单易得的含钌有机物制备纳米结构炭/钌复合物的方法。在该复合物中,钌纳米颗粒均匀地分布在多孔的炭基体中。该复合物被电氧化所得炭/RuO.2xH2O的超级电容性质明显提高(10mV/s时229F/g )。

关键词：电极纳米材料超级电容器炭钌

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利用多波段分光仪观测生物有效UV辐射、臭氧总量和云的影响

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气象科技 2001年第3期29卷 58-62页

作者： arne Dahlback 除多挪威大气研究所

该文介绍了一种利用紫外分光仪进行辐照度观测获取生物有效UV辐射、臭氧总量和云的光学厚度的方法。这些量是观测的辐照度与辐射传输计算相结合后测定的。该方法被用于具有 4个中心波长为 30 5、32 0、340和 380nm ,宽度为 10nm的 4波... 详细信息

该文介绍了一种利用紫外分光仪进行辐照度观测获取生物有效UV辐射、臭氧总量和云的光学厚度的方法。这些量是观测的辐照度与辐射传输计算相结合后测定的。该方法被用于具有 4个中心波长为 30 5、32 0、340和 380nm ,宽度为 10nm的 4波段分光仪。将这种仪器与高精度分光光度计在美国圣迭戈不同天气条件下进行了为期 1周的对比观测。当太阳天顶角 (SZA) <80°时 ,CIE 权重UV辐射剂量率的相对误差为 1.4± 3.2 %。晴天条件下 ,当SZA <80°时 ,相对误差为 0 .6± 1.5%。该仪器观测的辐照度推算的臭氧总量对云并不敏感。这种仪器还与Dobson和Brewer仪器在挪威奥斯陆进行了一年多的对比观测。整个观测期间 (包括有云的情况 )获得的臭氧总量相对误差为 0 .3± 2 .9%。当晴天和SZA <6 0°时 ,标准差减小到 1.9%。将仪器观测中所获得的臭氧总量和云的光学厚度输入到辐射传输模式 ,可以计算从 2 90～ 4 0 0nm分辨率为 1nm的整个光谱。这样计算的光谱与同时用高精度分光光度计观测的光谱在晴天及有云的条件下非常一致 ,所以 ,这种光谱可以用于测定任何作用光谱的辐射剂量率。而计算这种光谱只需要一个UV B通道和一个UV

关键词：多波段分光仪 UV辐射剂量臭氧总量云透过率太阳天顶角光学厚度

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