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Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients

World Journal of Gastroenterology 2011年第25期17卷 3069-3072页

作者： Timothée Noterdaeme Luc Longrée Christian Bataille arnaud deroover Anne Lamproye Jean Delwaide Yves Beguin Pierre Honoré Olivier Detry Department of Abdominal Surgery and Transplantation CHU de LiègeUniversity of Liège Department of Medicine Division of Hematology and OncologyCHC LiègeUniversity of Liège Department of Internal Medicine CHR HuyUniversity of Liège Department of Hepatogastroenterology CHU de LiègeUniversity of Liège Department of Medicine Division of HematologyCHU LiègeUniversity of Liège

Hepatitis B （HBV） reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases. Chemotherapy-induced HBV reacti- vation may ultimately lead to terminal acute liver failure. Liver transplantation （LT） currently remains the only definitive treatment option for such cases, but is generally denied to patients suffering from malignancy. Here, the authors describe 2 cases of cancer-free and HBV graft renfection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma. These 2 cases, and some other reports in the literature, may suggest that patients suffering from hematologic malignan- cies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good.

关键词： Liver transplantation Contraindication Cancer Liver failure Chemotherapy Hepatitis 13 virus

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Prognostic value of ^(18)F-FDG PET/CT in liver transplantation for hepatocarcinoma

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World Journal of Gastroenterology 2015年第10期21卷 3049-3054页

作者： Olivier Detry Laurence Govaerts arnaud deroover Morgan Vandermeulen Nicolas Meurisse Serge Malenga Noella Bletard Charles Mbendi Anne Lamproye Pierre Honoré Paul Meunier Jean Delwaide Roland Hustinx Department of Abdominal Surgery and Transplantation CHU LiegeB4000 LiegeBelgium Department of Nuclear Medicine CHU Liege University of Liege ULg CHU B4000 LiegeBelgium Department of Radiology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Pathology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium Department of Hepato-Gastroenterology CHU LiegeUniversity of LiegeULg CHUB4000 LiegeBelgium

AIM:To evaluate the prognostic value of pretreatment F D G p o s i t r o n e m i s s i o n t o m o g ra p h y c o m p u t e d tomography(PET-CT) in patients with hepatocarcinoma treated by liver transplantation(LT).METHODS:The authors retrospectively analyzed the data of 27 patients(mean age 58 ± 9 years) who underwent FDG PET-CT before LT for *** follow-up was 26 ± 18 *** FDG PET/CT was performed according to a standard clinical protocol:4 MBq FDG/kg body weight,uptake 60 min,low-dose non-enhanced *** authors measured the SUVmax and SUVmean of the tumor and the normal *** tumor/liver activity ratios(RSUVmax and RSUVmean) were tested as prognostic factors and compared to the following conventional prognostic factors:MILAN,CLIP,OKUDA,TNM stage,alphafoetoprotein level,portal thrombosis,size of the largest nodule,tumor differentiation,microvascular invasion,underlying cirrhosis and liver ***:Overall and recurrence free survivals were80.7%and 67.4%at 3 years,and 70.6%and 67.4%at 5 years,*** to a multivariate Cox model,only FDG PET/CT RSUVmax predicted recurrence free *** though the MILAN criteria alone were not predictive,it is worth noting that none of the patients outside the MILAN criteria and with RSUVmax<1.15 ***:FDG PET/CT with an RSUVmax cutoff value of 1.15 is a strong prognostic factor for recurrence and death in patients with HCC treated by LT in this retrospective *** prospectivestudies should test whether this metabolic index should be systematically included in the preoperative assessment.

关键词： Cancer Hepatoma Hepatocellular cancer Liver transp

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