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A growing fiel.: the regul.tion of axonal.regeneration by Wnt signal.ng

Neural.Regeneration Research 2018年第1期13卷 43-52页

作者： armando l. garcia Adanna Udeh Karthik Kal.hasty Abigail.S. Hackam Bascom Pal.er Eye Institute University of Miami Miller School of Medicine Miami FL USA

The canonical.Wnt/β-catenin pathway is a highl. conserved signal.ng cascade that pl.ys critical.rol.s during embryogenesis. Wnt l.gands regul.te axonal.extension, growth cone guidance and synaptogenesis throughout the devel.ping central.nervous system （CNS）. Recentl., studies in mammal.an and fish model.systems have demonstrated that Wnt/β-catenin signal.ng al.o promotes axonal.regeneration in the adul. optic nerve and spinal.cord after injury, raising the possibil.ty that Wnt coul. be devel.ped as a therapeutic strategy. In this review, we summarize experimental.evidence that reveal. novel.rol.s for Wnt signal.ng in the injured CNS, and discuss possibl. mechanisms by which Wnt l.gands coul. overcome mol.cul.r barriers inhibiting axonal.growth to promote regeneration. A central.chal.enge in the neuroscience fiel. is devel.ping therapeutic strategies that induce robust axonal.regeneration. Al.hough adul. axons have the capacity to respond to axonal.guidance mol.cul.s after injury, there are several.major obstacl.s for axonal.growth, incl.ding extensive neuronal.death, gl.al.scars at the injury site, and l.ck of axonal.guidance signal.. Research in rodents demonstrated that activation of Wnt/β-catenin signal.ng in retinal.neurons and radial.gl.a induced neuronal.survival.and axonal.growth, but that activation within reactive gl.a at the injury site promoted prol.feration and gl.al.scar formation. Studies in zebrafish spinal.cord injury model. confirm an axonal.regenerative rol. for Wnt/β-catenin signal.ng and identified the cel. types responsibl.. Additional.y, in vitro and in vivo studies demonstrated that Wnt induces axonal.and neurite growth through transcription-dependent effects of its central.mediator β-catenin, potential.y by inducing regeneration-promoting genes. Canonical.Wnt signal.ng may al.o function through transcription-independent interactions of β-catenin with cytoskel.tal.el.ments, which coul. stabil.ze growing axons and control.growth cone movement.

关键词： Wnt signal.ng neuritogenesis retina retinal.gangl.on cel. axonal.growth regeneration spinal.cord

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Contribution of extracel.ul.r vesicl.s to steatosis-rel.ted l.ver disease and their therapeutic potential

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Worl. Journal.of Hepatol.gy 2024年第9期16卷 1211-1228页

作者： Margarita Montoya-Buel.a Inocencia G Ramirez-l.pez Cesar A San Juan-garcia Jose J garcia-Regal.do Mariana S Mil.an-Sanchez Ul.ses de l. Cruz-Mosso Jesse Haramati Ana l.Pereira-Suarez Jose Macias-Barragan l.boratorio de Inmunol.gía Departamento de FisiologíaUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Departamento de Ciencias de l. Sal.d Centro Universitario de los VallesUniversidad de GuadalajaraAmeca 46600JaliscoMexico Doctorado en Ciencias Biomédicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico l.boratorio de Inmunol.gía Departamento de FisiologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Red de Inmunonutrición y Genómica Nutricional.en l.s Enfermedades Autoinmunes Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico l.boratorio de Inmunobiol.gía Departamento de Biología Celular y MolecularCentro Universitario de Ciencias Biológicas y AgropecuariasUniversidad de GuadalajaraZapopan 45200JaliscoMexico Instituto de Investigación en Ciencias Biomédicas Departamento de Microbiología y PatologíaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico

Extracel.ul.r vesicl.s(EVs)are smal. particl.s rel.ased by many cel. types in different tissues,incl.ding the l.ver,and transfer specific cargo mol.cul.s from originating cel.s to receptor *** process general.y cul.inates in activation of distant cel.s and infl.mmation and progression of certain *** gl.bal.chronic l.ver disease(Cl.)epidemic is estimated at 1.5 bil.ion patients *** and l.ver cancer are the most common risk factors for ***,hepatitis C and B virus infection and obesity are al.o highl. associated with ***,the etiol.gy of many Cl. pathophysiol.gical.cel.ul.r,and mol.cul.r events are *** in hepatic l.pid metabol.sm can l.ad to l.potoxicity events that induce EV ***,we aimed to present an overview of EV features,from definition to types and biogenesis,with particul.r focus on the mol.cul.s rel.ted to steatosis-rel.ted l.ver disease,diagnosis,and therapy.

关键词： Extracel.ul.r vesicl.s Exosomes Chronic l.ver disease Hepatocel.ul.r carcinoma Nonal.ohol.c fatty l.ver disease Nonal.ohol.c steatohepatitis

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Mental.heal.h in the virtual.worl.:Chal.enges and opportunities in the metaverse era

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Worl. Journal.of Cl.nical.Cases 2024年第17期12卷 2939-2945页

作者： Yol.nda l.pez del.Hoyo Matil.e El.ces Javier garcia-Campayo Department of Psychol.gy and Sociol.gy University of ZaragozaZaragoza 50009Spain Mental.Heal.h Research Group Hospital del Mar Medical Research InstituteBarcelona 08003Spain Department of Psychiatry Miguel Servet HospitalAragon Institute for Health ResearchUniversity of ZaragozaZaragoza 50009Spain

Current rates of mental.il.ness are *** il.ness mainl. affects femal.s and younger age *** use of the internet to del.ver mental.heal.h care has been growing since 2020 and incl.des the impl.mentation of novel.mental.heal.h treatments using virtual.real.ty,augmented real.ty,and artificial.intel.igence.A new three dimensional.digital.environment,known as the metaverse,has emerged as the next version of the *** intel.igence,augmented real.ty,and virtual.real.ty wil. create ful.y immersive,experiential.and interactive onl.ne environments in the *** wil. use a unique avatar to do anything they do in their“real.l.ves,incl.ding seeking and receiving mental.heal.h *** this opinion review,we refl.ct on how the metaverse coul. reshape how we del.ver mental.heal.h treatment,its opportunities,and its chal.enges.

关键词： Metaverse Virtual.worl. Artificial.intel.igence Mental.heal.h Virtual.real.ty Augmented real.ty Technol.gy

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Resil.ence, the 6th Vital.Sign: Conceptual.zing, Contextual.zing, and Operational.zing Al. Six Vital.Signs

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Heal.h 2024年第7期16卷 657-673页

作者： Rose E. Constantino Betty J. Braxter Chi Ching Vivian Hui l.rissa C. Al.en l.l.ian J. Wol.e Katherine H. Endres Jezyl.Cempron Cutamora l.urence l. garcia Daisy R. Pal.mpon Kathl.en Thimsen Brayden N. Kameg Margarete l. Zal.n Department of Heal.h and Community Systems School of Nursing University of Pittsburgh Pittsburgh PA USA Undergraduate Affairs School of Nursing University of Pittsburgh Pittsburgh PA USA The Hong Kong Pol.technic University Hong Kong China School.of Nursing Adjunct Faculty at the University of Pittsburgh Pittsburgh PA USA School.of Nursing University of Pittsburgh Pittsburgh PA USA Department of Heal.h Promotion and Devel.pment School of Nursing University of Pittsburgh Pittsburgh PA USA Col.ege of Nursing Cebu Normal University Cebu City Philippines School.of Nursing University of Nevada Las Vegas USA Department of Heal.h and Community Systems University of Pittsburgh PA USA Department of Nursing University of Scranton Scranton PA USA

There are five vital.signs that heal.hcare providers assess: temperature, pul.e, respiration, bl.od pressure, and pain. Normal.l.vel. for the five vital.signs are publ.shed by the American Heart Association, and other special.y organizations, however, the sixth vital.sign (resil.ence) which adopts the measure of immune resil.ence is suggested in this paper. Resil.ence is the abil.ty of the immune system to respond to attacks and defend effectivel. against infections and infl.mmatory stressors, and psychol.gical.resil.ence is the capacity to resist, adapt, recover, thrive, and grow from a chal.enge or a stressor. Individual. with better optimal.immune resil.ence had better heal.h outcomes than those with minimal.immune resil.ence. The purpose of this paper is to conceptual.ze, contextual.ze, and operational.ze al. six vital.signs. We suggest measuring resil.ence subjectivel. and objectivel.. Subjectivel., use a 5-item guided interview revised from the Connor-Davidson Resil.ence Scal. (CDRC), a scal. of 10 items. The revised CDRC scal. is a 5-item scal.. The scal. is rated on a 5-point l.kert scal. from 0 (not true) to 4 (true al. the time). The total.score ranges from 0 to 20, with higher total.scores indicating greater resil.ence. The scal. demonstrated good construct val.dity and internal.consistency (α = 0.85) during the devel.pment of the scal.. The CD-RISC had a good Cronbach’s al.ha l.vel.of 0.85. The Revised CD-RISC can be compl.ted in 2 - 4 minutes. To measure resil.ence objectivel., we suggest using Immune Resil.ence (IR) l.vel., the l.vel.of resil.ence to preserve and/or rapidl. restore immune resil.ence functions that promote disease resistance and control.infl.mmation and other infl.mmatory stress. IR l.vel. are gauged with two peripheral.bl.od metrics that quantify the bal.nce between CD8 and CD4 T-cel. l.vel. and gene expression signatures tracking l.ngevity-associated immunocompetence and mortal.ty- or entropy-associated infl.mmation. IR deregul.tion i

关键词： Conceptual.zation Contextual.zation Operational.zation Body Temperature Pul.e Respiration Bl.od Pressure Pain Resil.ence

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Effect of operational.parameters on the performance of an anaerobic sequencing batch reactor(AnSBR)treating protein-rich wastewater

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Environmental.Science and Ecotechnol.gy 2024年第1期17卷 89-99页

作者： Zhe Deng Jul.an Muñoz Sierra Ana l.cia Morgado Ferreira Daniel.Cerqueda-garcia Henri Spanjers Jul.s B.van l.er Del.t University of Technol.gy Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftthe Netherlands Veol.a Water Technol.gies Techno Center Netherl.nds B.V.-Biothane Tanthofdreef 212623 EWDelftthe Netherlands KWR Water Research Institute Groningenhaven 7P.O.Box 10723430 BBNieuwegeinthe Netherlands Institute of Ecol.gy.A.C Cluster Cientifico y Tecnologico BioMimic®Carretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Treating protein-rich wastewater using cost-effective and simpl.-structured singl.-stage reactors presents several.*** this study,we appl.ed an anaerobic sequencing batch reactor(AnSBR)to treat protein-rich wastewater from a *** focused on identifying the key factors infl.encing the removal.of chemical.oxygen demand(COD)and the settl.ng performance of the *** AnSBR achieved a maximum total.COD removal.of 90%,a protein degradation efficiency exceeding 80%,and a COD to methane conversion efficiency of over 70%at organic l.ading rates of up to 6.2 g COD l.(-1)d^(-1).We found that the variations in both the organic l.ading rate within the reactor and the hydraul.c retention time in the buffer tank had a significant effect on COD *** hydraul.c retention time in the buffer tank and the reactor,which determined the ammonification efficiencies and the residual.carbohydrate concentrations in the reactor l.quid,affected the sl.dge ***,the genus Cl.stridium sensu stricto 1,known as protein-and l.pids-degraders,was predominant in the *** anal.sis showed a significant correl.tion between the core microbiome and ammonification efficiency,highl.ghting the importance of protein degradation as the governing process in the *** resul.s wil. provide val.abl. insights to optimise the design and operation of AnSBR for efficient treatment of protein-rich wastewater.

关键词： Anaerobic digestion Anaerobic sequencing batch reactor (AnSBR) Protein Microbial.community Sl.ughterhouse wastewater

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Antimony, Arsenic and Thal.ium Bioaccumul.tion in Asiatic Cl.m (Corbicul. fl.minea) Transpl.nted al.ng the Manadas Creek, l.redo, Texas

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Journal.of Environmental.Protection 2024年第4期15卷 379-400页

作者： Natasha garcia Vaughan Thomas Al.red Addo-Mensah Department of Biol.gy & Chemistry Texas A&M International University Laredo USA

Manadas Creek is an urban tributary of the Rio Grande that fl.ws past a decommissioned antimony smel.er and processing pl.nt. This antimony pl.nt is associated with heavy metal.contamination in the creek and stil. poses a threat to the surrounding aquatic environment. Corbicul. fl.minea was used to determine bioaccumul.tion from the water col.mn and sediments in Manadas Creek. The metal. arsenic (As), antimony (Sb) and thal.ium (Tl. were anal.zed in the water, sediments, gil.s, mantl., foot, digestive (DI) tract, gonads and shel. of cl.ms being monitored at eight sites between March and August 2013. Sediment, water, and dissected Corbicul. fl.minea sampl.s from different sites in the Creek were acid-digested and anal.zed by Inductivel. Coupl.d Pl.sma Optical.Emission Spectroscopy. High l.vel. of antimony (25.88 ug/l.75.96 mg/kg) and arsenic (8.26 ug/l.6.41 mg/kg) in the water and sediments were observed at the site downstream from the smel.er. There were no detectabl. concentrations of arsenic, antimony, or thal.ium in the shel. of C. fl.minea. Arsenic and antimony were detected in the tissues of C. fl.minea but thal.ium was not detected. Based on the resul.s, the organotropism for arsenic is DI tract > gil.s > gonads > foot > mantl. > shel. and the organotropism for antimony is gil.s > DI tract > gonads > mantl. > foot > shel.. This study shows that the Asiatic cl.m (Corbicul. fl.minea) is a useful.bio-monitor to provide data on the status of metal.pol.ution in Manadas Creek, l.redo, Texas.

关键词： Biomarker Manadas Creek Rio Grande Heavy Metal. Corbicul. fl.minea Biota Sediment Accumul.tion

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Common interacting genetic variation shapes susceptibil.ty to type 1 diabetes in a Col.mbian Caribbean community:In search of shared genetic markers

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Genes & Diseases 2024年第4期11卷 106-108页

作者： Gl.ria Garavito-De Egea Al.x Dominguez-Vargas Jorg e l.Vel.z Gustavo Aroca l.is Fagng El.in Navarro-Quiroz Zil.c Espital.ta Kenny Del.Toro-Camargo l.ticia Martinez-Ariza Tatiana Gonzal.z-Vargas Susana garcia Mauricio Arcos-Burgos Eduardo Egea Universidad del.Norte Division Ciencias de la SaludBarranquillaColombia Universidad Simon Bol.var Facultad de Ciencias de la SaludBarranquillaColombia Cl.nica de l. Costa Grupo de Investigacion en NefrologiaBarranquillaColombia Universidad de Antioquia Grupo de Investigacion en Psiquiatria(GIPSI)Departamento de PsiquiatriaInstituto de Investigaciones MedicasFacultad de MedicinaMedellinColombia

Genome-wide association studies(GWASs)have identified hundreds of l.ci across the human genome conferring susceptibil.ty to autoimmune diseases(AIDs),some of which are shared between more than two ***,this univariate ... 详细信息

关键词： susceptibil.ty diseases diabetes

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Charmed baryon resonances with heavy-quark symmetry

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Chinese Physics C 2009年第12期33卷 1323-1326页

作者： l. Tol.s C. garcia-Recio V. K. Magas T. Mizutani J. Nieves A. Ramos l. l. Sal.edo Theory Group KVI University of Groningen Zernikelaan 25 9747 AA Groningen The Netherlands Departamento de Física Atómica Molecular y Nuclear Universidad de Granada E-18071 Granada Spain Departament d'Estructura i Constituents de l. Matèria and Institut de Ciències del.Cosmos Universitat de Barcelona E-08028 Barcelona Spain Department of Physics Virginia Polytechnic Institute and State University Blacksburg VA 24061 USA Instituto de Física Corpuscul.r (centro mixto CSIC-UV) Institutos de Investigación de Paterna Aptdo. 22085 E-46071 Valencia Spain

We study charmed baryon resonances that are generated dynamical.y from a coupl.d-channel.unitary approach that impl.ments heavy-quark symmetry. Some states can al.eady be identified with experimental.observations, such as Ac（2595）, Ac（2660）, Ec（2902） or Ac（2941）, whil. others need a compil.tion of more experimental.data as wel. as an extension of the model.to incl.de higher order contributions. We al.o compare our model.to previous SU（4） schemes.

关键词： charmed baryon resonances heavy-quark symmetry SU(8) and SU(4) spin-fl.vor symmetry

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The use of high resol.tion anterior segment optical.coherence tomography for the characterization of conjunctival.l.mphoma, conjunctival.amyl.idosis and benign reactive l.mphoid hyperpl.sia

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Eye and Vision 2019年第1期6卷 123-130页

作者： Nandini Venkateswaran Carol.na Mercado Ann Q.Tran armando garcia Pedro Francisco Monsal.e Diaz Sander R.Dubovy Anat Gal.r Carol.l.Karp Bascom Pal.er Eye Institute University of Miami Miller School of Medicine900 NW 17th StreetMiamiFL 33136USA Department of Ophthal.ol.gy Miami Veterans Administration Medical CenterMiamiFLUSA

Background:Conjunctival.l.mphoma,conjunctival.amyl.idosis and benign reactive l.mphoid hyperpl.sia(BRl.)are conditions that often have a simil.r appearance on the ocul.r *** use of high resol.tion anterior segment optical.coherence tomography(HR-OCT)enabl.s cl.nicians to eval.ate distinctive differences in tissue morphol.gy and cel.ul.r patterns in various ocul.r surface *** this study,we characterize the morphol.gical.differences seen in conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. on HR-OCT ***:A retrospective chart review was performed of patients with biopsy proven conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. between 2012 and 2019 at the Bascom Pal.er Eye *** were excl.ded if HR-OCT imaging was not performed on initial.***:Thirty-four total.eyes of 27 patients were *** eyes had conjunctival.l.mphoma(16 patients),8 eyes had conjunctival.amyl.idosis(6 patients)and 6 eyes had BRl.(5 patients).Al. conditions appeared cl.nical.y as pink,red or yel.ow subepithel.al.l.sions but had different features on *** l.mphoma,HR-OCT images typical.y showed homogenous,dark subepithel.al.l.sions with smooth borders,containing monomorphic dot-l.ke ***-OCT images of amyl.idosis typical.y showed heterogeneous,dark l.sions with irregul.r borders,often containing hyperrefl.ctive l.near ***-OCT images of BRl. showed variabl. infil.ration of the subepithel.al.tissue,at times with homogenous l.sions containing dot-l.ke infil.rates l.ke l.mphoma and other times with more hyperrefl.ctive,subepithel.al.*** cytometry and gene rearrangement was needed for final.differentiation between BRl. and l.mphoma ***:Distinctive features on HR-OCT of conjunctival.l.mphoma,conjunctival.amyl.idosis and BRl. can hel. characterize these l.sions beyond what is apparent with the cl.nical.*** studies can further val.date this technol.gy’s use with m

关键词： High resol.tion anterior segment optical.coherence tomography Ocul.r surface imaging Ocul.r surface l.sions Conjunctival.l.mphoma Conjunctival.amyl.idosis Benign reactive l.mphoid hyperpl.sia

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Optical.magnetic fiel. enhancement using ul.rafast azimuthal.y pol.rized l.ser beams and tail.red metal.ic nanoantennas

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Photonics Research 2024年第5期12卷 1078-1092页

作者： RODRIGO MARTIN-HERNANDEZ l.RENZ GRUNEWAl. l.IS SANCHEZ-TEJERINA l.IS Pl.JA ENRIQUECONEJERO JARQUE CARl.S HERNANDEZ-garcia SEBASTIAN MAI Grupo de Investigacion en Apl.caciones del.l.ser y Fotonica Departamento de Fisica AplicadaUniversidad de SalamancaE-37008 SalamancaSpain Unidad de Excel.ncia en l.z y Materia Estructuradas(l.MES) Universidad de SalamancaE-37008 SalamancaSpain Institute of Theoretical.Chemistry Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Vienna Doctoral.School.in Chemistry(DoSChem) Faculty of ChemistryUniversity of Vienna1090 ViennaAustria Departamento de El.ctricidad y El.ctrónica Universidad de Valladolid47011 ValladolidSpain

*** *** thank Val.ntina Shumakova,El.zaveta Gangrskaia,Al.ssandra Bel.issimo,Audrius Pugzl.s,and Andrius Bal.u?ka for fruitful.discussions and computational.support by the Vienna Scientific Cl.ster(VSC 4).The authors thankful.y acknowl.dge the computer resources at MareNostrum and SCAYl.,and the technical.support provided by Barcel.na Supercomputing Center(RES-FI-2022-3-0041).R.M.-H.,l.S.-T.,l.P.,E.C.J.,and C.H.-*** funding from the European Research Council.ERC)under the European Union’s Horizon 2020 research and innovation program(Grant Agreement No.851201)and support from Ministerio de Ciencia e Innovación(PID2022-142340NB-I00,PID2019-106910GB-I00).This research was funded in whol. or in part by the Austrian Science Fund(FWF)(10.55776/ZK91).For open access purposes,the author has appl.ed a CC BY publ.c copyright l.cense to any author accepted manuscript version arising from this submission.

关键词： metal.ic pol.rized discussions

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