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Can testosterone therapy be offered to men on active surveillance for prostate cancer？ Preliminary results

Asian Journal of Andrology 2016年第1期18卷 16-20页

作者： Ravi Kacker Mariam Hult Ignacio F San Francisco William P Conners Pablo A rojas William C Dewolf Abraham Morgentaler Men's Health Boston Brookline MA USA Pontifical Catholic University of Chile Santiago Chile Department of Urology Beth Israel Deaconess Medical Center Boston MA USA

This report presents our experience with T therapy in a cohort of T-deficient men on active surveillance （AS） for Gleason 3 ＋ 3 and Gleason 3 ＋ 4 prostate cancer （PCa）. A retrospective chart review identified 28 men with T deficiency who underwent T therapy （T group） for at least 6 months while on AS for PCa. A comparison group of 96 men on AS for PCa with untreated T deficiency （no-T group） was identified at the same institution. The AS protocol followed a modified Epstein criteria and allowed inclusion of men with a single core of low-volume Gleason 3 ＋ 4 PCa. Mean age was 59.5 and 61.3 years, and mean follow-up was 38.9 and 42.4 months for the T and no-T groups, respectively. Of all 28 men in the T group, 3 （10.7%） men developed an increase in Gleason score while on AS. Of 22 men in the T group with Gleason 3 ＋ 3 disease, 7 （31.8%） men developed biopsy progression including 3 men （13.6%） who developed Gleason 3 ＋ 4 PCa. Of 6 men with Gleason 3 ＋ 4 disease at baseline, 2 （33.3%） men developed an increase in tumor volume, and none developed upgrading beyond Gleason 3 ＋ 4. All 96 men in the no-T group had Gleason 3 ＋ 3 disease at baseline and, 43 （44.7%） developed biopsy progression, including 9 men （9.38%） with upgrading to Gleason 7 （3 ＋ 4）. Biopsy progression rates were similar for both groups and historical controls. Biopsy progression in men on AS appears unaffected by T therapy over 3 years. Prospective placebo-controlled trials of T therapy in T-deficient men on AS should be considered given the symptomatic benefits experienced by treated men.

关键词： active surveillance prostate cancer testosterone

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Book Review of Mitad Payo, Mitad Gitano

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Sociology Study 2016年第9期6卷 615-617页

作者： Sueli Rocha-rojas Texas A&M University College Station Texas USA

Jesus Ulled was born in 1937, in Rio de Janeiro, Brazil, and moved at an early age with his family to Barcelona, Spain. He is a well-known journalist, the founder of the magazines Que Leer and Clio, the author of the recently published novel Final de Travesla （2016）, and his first book was Mitad Payo, Mitad Gitano, written in 2012.

关键词：书评里约热内卢巴塞罗那新闻记者西班牙创始人

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Novelties in Campyloneurum(Polypodiaceae) from Mesoamerica

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American Journal of Plant Sciences 2017年第4期8卷 921-940页

作者： Alexander Francisco rojas-Alvarado Universidad Nacional de Costa Rica Heredia Costa Rica

Three new species are described and another is recognized in Campyloneurum. Two species occur in Mexico to El Salvador and the others two are present in Nicaragua, Costa Rica and Panama. The new species are Campyloneurum acutum A. rojas, C. leoniae A. rojas and C. madrense A. rojas. The first species differs from C. xalapense by broader rhizome scales, acute to attenuate blade apex, commonly two series of areoles between parallel veins, commonly one sori per areole and hydathodes absent or few evident. Campyloneurum leoniae differs from C. irregulare by more compact and non-pruinose rhizomes, thinner stipes, relatively broader, thinner and more opaque laminae, and distribution at lower elevations. Campyloneurum madrense is different to C. angustifolium because it has narrower and darker rhizome scales with denticulate margin, long scales cells and distributed at lower elevations. Finally, Campylonerum pittieri is here recognized as valid species and it differs from the similar C. amphostenon by longer rhizomes with appressed scales that have a patent, long acuminate apices, relative broader laminae, veins evident and distribution at higher elevations.

关键词： Campyloneurum amphostenon Complex Campyloneurum angustifolium Complex Campyloneurum xalapense Lectotype Designed New Species Ferns Species Recognized

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Five New Species of DiplaziumSw. (Athyriaceae) from Nicaragua, Costa Rica and Colombia

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American Journal of Plant Sciences 2018年第5期9卷 933-945页

作者： Alexander Francisco rojas-Alvarado Universidad Nacional Heredia Costa Rica

Five new species are described in the genus Diplazium Sw. from Nicaragua, Costa Rica and Colombia, as results of studies in the Neotropical ferns. The new species are Diplazium chirripoense A. rojas, Diplazium cornutum A. rojas, Diplazium crassirhizoma A. rojas, Diplazium lustrosum A. rojas and Diplazium rodriguezii A. rojas. The first species is related to D. skutchii Lellinger, but differs from it by having glabrous stipe, glabrous blade abaxially, hyaline and entire indusia, and distributed and higher elevations. The second species is different to D. diplazioides (Klotzsch et H. Karst.) Alston by having densely scaly stipe, rachis and costa, relative bigger pinnae and entire to erose indusia. After that, the third species differs from D. werckleanum Christ by thicker rhizome, bigger rhizome scales and blade with 1 - 2 buds at apex. Consecutively, the fourth species differs from D. lindbergii (Mett.) H. Christ by thinner rhizome, shorter fronds, longer stipe, smaller blade, less pinnae pairs, shiny laminar tissue and veins 3 - 5 pairs per segment. Finally, the fifth species is related to D. tungurahuae (Sodiro) C. Chr., but with abaxially glabrous rachis and costae, pinnules 4 - 5 times longer than wide and entire, costules adaxially without wings, veins abaxially glabrous and reticulate along costae and between pinnate veins.

关键词： Athyriaceae Diplazium Ferns Neotropics Taxonomy

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Quantum Instability of Magnetized Stellar Objects

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Chinese Journal of Astronomy and Astrophysics 2005年第4期5卷 399-411页

作者： R.González Felipe H.J.Mosquera Cuesta A.Pérez Martínez H.Pérez rojas Departamento de Física and Centro de Física Teórica de Partículas Instituto Superior TécnicoAv.Rovisco Pais1049-001 LisboaPortugal Instituto de Cosmologia Relatividade e Astrofísica(ICRA-BR)Centre Brasileiro de Pesquisas FísicasRua Dr.Xavier Sigaud 150CEP 22290-180UreaRio de JaneiroRJBrazil Centro Latino-Americano de Física Avenida Wenceslau Braz 71CEP 22290-140 fundosBotafogoRio de JaneiroBrazil Instituto de Cibernética Matemática y FísicaCalle E No.30910400 La HabanaCuba

The equations of state for degenerate electron and neutron gases are studied in the presence of magnetic *** including quantum effects in the investigation of the structural properties of these systems,it is found that some hypermagnetized stars can be unstable according to the criterion of stability of *** magnetized white dwarfs should collapse producing a supernova type Ia,while superstrong magnetized neutron stars cannot stand their own magnetic field and must implode,too.A comparison of our results with a set of the available observational data of some compact stars is also presented,and the agreement between this theory and observations is verified.

关键词： dense matter-equation of state-instabilities-stars:magnetic fields-stars:neutron white dwarfs

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Three New Species of Ferns (Pteridophyta) from Mesoamerica

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American Journal of Plant Sciences 2017年第6期8卷 1329-1338页

作者： Alexander Francisco rojas-Alvarado Universidad Nacional de Costa Rica Heredia Costa Rica

In this research three new species of ferns of the Polypodiales Order are described: Ctenitis leonii A. rojas, Elaphoglossum karinae A. rojas and Pecluma celaquensis A. rojas. Ctenitis leonii is characterized by its apical stipe scales marginally erose to ciliate, blade surfaces with two types of hairs present in both surfaces, ones 0.7 - 1.5 mm long and not glandular, the others 0.3 - 0.5 mm long and glandular and indusia are absent. Elaphoglossum karinae differs from Elaphoglossum dissitifrons Mickel by shorter rhizome, longer and relatively narrower rhizome scales, they lanceolate to linear-lanceolate and blackish costal scales. Pecluma celaquensis is similar to Polypodium martensii Mett., but differs by its thinner rhizome, smaller rhizome scales and these with a crown of brown cilia at the attaching point, relatively shorter stipe with longer hairs and these commonly no glandular, scaly rachis and it with longer and denser hairs, inframedial sori and glabrous sporangia.

关键词： Ctenitis Elaphoglossum Honduras New Speciefs Pecluma Polypodiales

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Four New Species and Additional Distributions of ElaphoglossumSection Elaphoglossum(Dryopteridaceae) from the Neotropics

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American Journal of Plant Sciences 2017年第6期8卷 1234-1247页

作者： Alexander Francisco rojas-Alvarado Universidad Nacional de Costa Rica Heredia Costa Rica

Four new species of Elaphoglossum sect. Elaphoglossum are described: E. Amparoanum A. rojas, E. Chocoense A. rojas, E. Fayorum A. rojas and E. Luciae A. rojas. The first species is related to E. Variolatum Mickel, but differs from it by having rhizome scales bicolorous and long ciliate margin. The second species is different to E. moranii Mickel by having narrower rhizome, shorter stipe, elliptic blade, attenuate blade base, shorter fertile fronds with blackish costa and present at lower altitudinal distribution. After that, the third species differs from E. lingua (C. Presl) Brack. by pale rhizome scales with long ciliate margin, shorter fronds and blade scales denser and lighter. Finally, the fourth species is related to E. atrosquamatum Mickel, but with relative longer fronds and broader blade. The geographical distributions of E. guatemalense (Klotzsch) T. Moore, E. longicrure Christ, E. minutum (Pohl ex Fée) T. Moore and E. nicaragüense A. rojas are expanded.

关键词： Dryopteridaceae Elaphoglossum Ferns New Records New Species Section Elaphoglossum Taxonomy

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Characterization of the Attended Surgical Patients in the Assisted Reproduction Territorial Centre, Cienfuegos 2015-2016

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Modern Research in Inflammation 2020年第3期9卷 19-31页

作者： Felix Arístides Somarriba Aráuz Práxedes de Regla rojas Quintana Santiago Bernia Sarría María Elizabeth Ixcoy García Aimé Reyes Pérez armando Bernia González Gustavo Aldereguía Lima General University Hospital Cienfuegos Cuba

Introduction: Infertility is a health problem that does not cause death, disability or physical pain;however, it is a crisis for couples who see their life plans threatened and suffer not only at the time of diagnosis and during treatments, but in multiple daily situations. Scientific Problem: There are no published studies on the characteristics of the infertile patient who has required surgical treatment, which is attended at the Territorial Center for Assisted Reproduction, Cienfuegos. Objective: To characterize the patients with infertility diagnosis who underwent surgical treatment and were treated at the Territorial Center for the care of the infertile couple in the province of Cienfuegos. Methodological Design: A descriptive, prospective, cross-sectional study of a series of cases was carried out at the Territorial Center for Assisted Reproduction, inserted in the Department of External Consultation of the General University Hospital, Dr. “Gustavo Aldereguía Lima” in Cienfuegos, in the period from January 2015 to December 2016. The variables studied were: age, skin color, pelvic inflammatory disease, personal pathological history, number of pregnancies, number of deliveries, number of abortions, age of the first sexual relations, cause of infertility, time attending the consultation, previous pelvic surgery, preoperative diagnosis, type of surgery, type of treatment and results of the surgery. Results: A predominance of age was obtained between 26 and 35 years of previous pelvic inflammatory disease, Bronchial Asthma as a personal pathological antecedent, previous pelvic surgery, number of pregnancies between 1 and 2, induced abortion among other results.

关键词： Infertility Pelvic Inflammatory Disease Pregnancies Abortion Surgery

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Torin 1,TOR Inhibitor Enhances Cellular Proliferation in NT-1 Tobacco Suspension Cell Cultures

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Phyton-International Journal of Experimental Botany 2019年第2期88卷 131-137页

作者： Grisel Fierros-Romero MElena Mellado-rojas Reynaldo CPless Juan Ignacio Valiente-Banuet Ashutosh Sharma Elda MBeltrán-Peña Tecnológico de Monterrey School of Engineering and SciencesCampus Querétaro76130QuerétaroMéxico Instituto de Investigaciones Químico Biológicas.Universidad Michoacana de San Nicolás de Hidalgo 58030.MoreliaMéxico CICATA-Instituto Politécnico Nacional Querétaro76090México.

Torin 1 is an ATP-competitive TOR inhibitor which inhibits the signaling of TOR and S6K kinase in mammals and *** objective of this research is to determine the effect of Torin 1 in a relatively simple and homogeneous plant system such as the NT-1 tobacco suspension cell *** of NT-1 cells were tested with 5,50,150 and 250 nM of Torin *** kinetics growth of NT-1 tobacco suspension cell cultures,150 and 250 nM Torin 1 inhibits the early growth and later enhanced the cellular proliferation during exponential growth by means of an increased expression of E2F1 and cyclin ***,Torin 1 stimulates the growth of NT-1 cells during log phase with small shaped cell,characteristic of tobacco suspension cell cultures with high mitotic activity.

关键词： Torin 1 TOR S6K proliferation NT-1 tobacco cells

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Clove(Syzygium aromaticum):a precious spice

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Asian Pacific Journal of Tropical Biomedicine 2014年第2期4卷 90-96页

作者： Diego Francisco Cortés-rojas Claudia Regina Fernandes de Souza Wanderley Pereira Oliveira Laboratory of R&D on Pharmaceutical Processes-LAPROFAR-Faruldade de Ciencias Farmaceuticas de Ribeirao Preto/USP Av.do Cafe s/nBloco Q.14040-903Ribeirao PretoSPBrazil

Clove(Syzygium aromaticum) is one of the most valuable spices that has been used for centuries as food preservative and Tor many medicinal *** is native of Indonesia but nowadays is cultured in several parts of the world including Brazil in the slate of *** plant represents one of the richest source of phenolic compounds such as eugenol,eugenol acetate and gallic acid and posses great potential for pharmaceutical,cosmetic,food and agricultural *** review includes the main studies reporting the biological activities of clove and *** antioxidant and antimicrobial activity of clove is higher than many fruits,vegetables and other spices and should deserve special attention.A new application of clove as larvicidal agent is an interesting strategy to combat dengue which is a serious health problem in Brazil and other tropical *** and lexicological studies were also *** different studies reviewed in this work confirm the traditional use of clove as food preservative and medicinal plant standing out the importance of this plant for different applications.

关键词： Spice Clove Aromatic plant Volatile Antioxidant Dengue fever Larvicidal

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