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JNKs,insulin resistance and inflammation:A possible link between NAFLD and coronary artery disease

World Journal of Gastroenterology 2011年第33期17卷 3785-3794页

作者： Giovanni Tarantino armando caputi Department of Clinical and Experimental Medicine FedericoⅡUniversity Medical School of NaplesVia Sergio Pansini580131 NaplesItaly Department of Clinical Medicine Cardiovascular&Immunological SciencesFederico Ⅱ University Medical School of NaplesVia Sergio Pansini580131 NaplesItaly

The incidence of obesity has dramatically increased in recent ***,obesity and associated disorders such as nonalcoholic fatty liver disease constitute a serious ***,the contribution of adipose tissue to metabolic homeostasis has become a focus of *** this review,we discuss the latest discoveries that support the role of lipids in nonalcoholic fatty liver *** describe the common mechanisms(cJun aminoterminal kinases,endoplasmic reticulum stress,unfolded protein response,ceramide,lowgrade chronic inflammation)by which lipids and their derivatives impair insulin responsiveness and contribute to inflammatory liver and promote plaque instability in the arterial *** the molecular mechanism of lipid activation of proinflammatory pathways,we attempt to find a link between nonalcoholic fatty liver disease,metabolic syndrome and cardiovascular *** the common mechanisms by which lipid derivatives,through modulation of macrophage function,promote plaque instability in the arterial wall,impair insulin responsiveness and contribute to inflammatory liver and discussing the molecular mechanism of lipid activation of proinflammatory pathways,the key roles played by the proliferatoractivated receptor and liver X receptorα,nuclear receptorslipid sensors that link lipid metabolism and inflammation,should be *** studies are warranted of antiinflammatory drugs such as aspirin,antiinterleukin6 receptors,immunemodulators(calcineurin inhibitors),substances enhancing the expression of heat shock proteins(which protect cells from endoplasmic reticulum stressinduced apoptosis),and anticJun aminoterminal kinases in welldesigned trials to try to minimize the high impact of these illnesses,and the different expressions of the diseases,on the whole population.

关键词： Nonalcoholic fatty liver disease cJun aminoterminal kinase Cardiovascular disease

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Kick-start for metabolomics in liver disease

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World Journal of Hepatology 2024年第9期16卷 1206-1210页

作者： armando Guerra-Ruiz Laboratory Medicine University Hospital Marques de ValdecillaSantander 39008CantabriaSpain Commission on Biochemical Assessment of Liver Disease Spanish Society of Clinical Chemistry(SEQC-ML)Barcelona 08025CataloniaSpain Digestive Diseases Valdecilla Research Institute(IDIVAL)Santander 39011CantabriaSpain

It is not complicated for the clinician to diagnose a patient with advanced fibrosis or liver cirrhosis when he has already presented some decompensation of his liver ***,it is in the earliest stages when the patient's prognosis can be modified the *** liver disease is generally asymptomatic,not invasive markers are of great *** the era of omics,it is time for metabolomics to accompany genomics and proteomics,which are more established in the diagno-stics and prognostics clinical ***,understood as the compre-hensive evaluation of the metabolites present in the organism in a specific phys-iological situation,has undoubted advantages in the study and identification of serum markers relevant to a specific *** year,I read with interest two articles published in this journal:“Baseline metabolites could predict responders with hepatitis B virus-related liver fibrosis for entecavir or combined with FuzhengHuayu tablet”by Dai et al and“Metabolomics in chronic hepatitis C:Decoding fibrosis grading and underlying pathways”by Ferrasi et *** papers illuminate the power of metabolomics to provide us with new tools in the management of liver *** this editorial,I comment on these studies and others,and note how they can contribute to our understanding of liver disease in more than one way.

关键词： Metabolomics Liver disease Biomarkers Hepatology Mass spectrometry Hepatitis Clinical biochemistry

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Introduction to the Special Issue on Recent Developments on Computational Biology-I

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Computer Modeling in Engineering & Sciences 2024年第6期139卷 2261-2264页

作者： Carlo Cattani Haci Mehmet Baskonus armando Ciancio Engineering School(DEIM) University of TusciaViterbo01100Italy Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy

In modern time,experts started to use interdisciplinary properties with the development of technology and ***,these disciplines provide more sophisticated properties of real-world *** this sense,some models need to be investigated by using revised and modified traditional *** first discipline is the applied sciences such as physics,engineering,mechanics,electricity,biology,economy and mathematical applications[1-5].In this stage,many methods[5-10]are developed and *** uncover the deep properties of problems is to use the main properties of such interdisciplinary ***,works conducted on such mathematical models including non-local operators,partial,ordinary and integer order have introduced a deeper investigation of problems for *** using technological tools,expertsmay observe more realistic and exact results of models.

关键词： properties. integer operators

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Different behavioral profles between invasive and native nudibranchs:means for invasion success?

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Current Zoology 2024年第3期70卷 406-417页

作者： armando Macali Sara Ferretti Serena Scozzafava Elia Gatto Claudio Carere Ichthyogenic Experimental Marine Centre(CISMAR) Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Department of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Department of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior is predicted to be a primary determinant of the success of the invasion process during the early phases of *** invaders with sympatric native species may provide a good approach to unravel behavioral traits involved in an invasion *** this study,we carried out an experimental simulation of the introduction and the acclimatization phase into a new environment and assessed the expression of activity,alertness,and habituation in an invasive Mediterranean population of the South African nudibranch Godiva quadricolor comparing its profles with those of the sympatric Mediterranean native nudibranchs Cratena peregrina and Caloria *** of these 3 species were subjected to 3 behavioral tests:spontaneous activity,carried out in the introduction phase(immediately after sampling)and after a week of acclimatization;alert test,in which a potential threat was simulated by means of a tactile stimulus,and habituation test,in which the same alert test stimulus was repeated 5 times at 30-min *** invasive *** showed higher levels of exploration activity,thigmotaxis,alertness,and sensitization than the native *** behavioral traits may represent pivotal drivers of the ongoing invasion process.

关键词： biological invasion invasive phenotype invertebrate cognition molluscs personality

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Evolutionary Safe Padé Approximation Scheme for Dynamical Study of Nonlinear Cervical Human Papilloma Virus Infection Model

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2275-2296页

作者： Javaid Ali armando Ciancio Kashif Ali Khan Nauman Raza Haci Mehmet Baskonus Muhammad Luqman Zafar-Ullah Khan Department of Mathematics Govt.Graduate College TownshipLahore54770Pakistan Universitàdegli Studi di Messina Dipartimento di Scienze BiomedicheOdontoiatriche e delle Immagini Morfologiche e FunzionaliMessina98122Italy Department of Mathematics University of Engineering and TechnologyLahore54890Pakistan Department of Mathematics University of the PunjabLahore54590Pakistan Mathematics Research Center Near East University TRNCMersin 10Nicosia99138Turkey Department of Mathematics and Science Education Faculty of EducationHarran UniversitySanliurfa63190Turkey Department of Dermatology Rashid Latif Medical CollegeLahore54600Pakistan

This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic(CCE)*** underlying CCE model lacks a closed-form exact *** solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties,such as positivity,boundedness,and ***,the development of structure-preserving semi-analytical approaches is always *** research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization ***-free safe Padérational functions approximate the mathematical shape of state variables,while the model’s physical requirements are treated as problem *** primary model of the governing differential equations is imposed to minimize the error between approximate *** evolutionary algorithm,the Genetic Algorithm with Multi-Parent Crossover(GA-MPC),executes the optimization *** resulting method is the Evolutionary Safe PadéApproximation(ESPA)*** proof of unconditional convergence of the ESPA scheme on the CCE model is supported by numerical *** performance of the ESPA scheme on the CCE model is thoroughly investigated by considering various orders of non-singular Padéapproximants.

关键词： Nonlinear cervical cancer epidemic non-singular Padéapproximants approximate solutions computational biology

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Emerging and multifaceted potential contributions of polyphenols in the management of type 2 diabetes mellitus

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World Journal of Diabetes 2024年第2期15卷 154-169页

作者： Ileana González Cristian Lindner Ivan Schneider Erik Diaz Miguel Angel Morales armando Rojas Biomedical Research Laboratories Faculty of MedicineCatholic University of MauleTalca 34600000Chile Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Centre of Primary Attention South Metropolitan Health ServiceSantiago 3830000Chile Faculty of Medicine Catholic University of MauleTalca 3460000Chile Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Type 2 diabetes mellitus(T2DM)is recognized as a serious public health concern with a considerable impact on human life,long-term health expenditures,and substantial health *** this context,the use of dietary polyphenols to prevent and manage T2DM is widely *** dietary compounds exert their beneficial effects through several actions,including the protection of pancreatic islet β-cell,the antioxidant capacities of these molecules,their effects on insulin secretion and actions,the regulation of intestinal microbiota,and their contribution to ameliorate diabetic complications,particularly those of vascular *** the present review,we intend to highlight these multifaceted actions and the molecular mechanisms by which these plant-derived secondary metabolites exert their beneficial effects on type 2 diabetes patients.

关键词： Polyphenols Antioxidants Oxidative stress Type 2 diabetes mellitus Health benefits

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Device-assisted enteroscopy: Are we ready to dismiss the spiral?

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World Journal of Gastroenterology 2024年第26期30卷 3185-3192页

作者： Alessandro Mussetto Elettra Merola Cesare Casadei Daniele Salvi Fabiola Fornaroli Silvia Cocca Margherita Trebbi armando Gabbrielli Cristiano Spada Andrea Michielan Department of Gastroenterology S Maria della Croci HospRavenna 48121Italy Department of Gastroenterology Unit G.B.Grassi Hospital(ASL Roma 3)Roma 00122Italy Section of Digestive Endoscopy and Gastroenterology Fondazione PoliambulanzaBrescia 25124Italy Gastroenterology and Endoscopy Unit Department of Medicine and SurgeryUniversity of ParmaParma 43125Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Center for Medical Sciences(CISMed) University of TrentoTrento 38122Italy Gastroenterology and Digestive Endoscopy Unit Santa Chiara HospitalAzienda Provinciale per i Servizi SanitariTrento 38122Italy Digestive Endoscopy Unit Fondazione Policlinico Universitario A.Gemelli IRCSSRoma 00168Italy

Motorized spiral enteroscopy(MSE)is the latest advance in device-assisted *** events related to MSE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled *** the real-life application of MSE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic *** conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MSE from the *** primary goals were the evaluation of MSE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MSE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MSE as a rescue *** its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MSE in the future rather than completely abandoning it.

关键词： Motorized spiral enteroscopy Rescue enteroscopy Diagnostic yield Adverse events AGREE classification

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Complications Associated with Autologous Fat Transfer: Case Report and Literature Review

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Modern Plastic Surgery 2024年第1期14卷 1-8页

作者： Bryan armando Morales Eslava Carlos Emiliano García Cordova Antoine Arturo Lagunes Gasca Department of Surgery Hospital Regional Petróleos Mexicanos Villahermosa Tabasco Mexico Department of Surgery Hospital Central Sur Petróleos Mexicanos Mexico City Mexico

Undoubtedly, since its appearance, the interest and use of autologous fat transfer (AFT) as a breast reconstruction technique have been increasing, becoming one of the main surgical alternatives for aesthetic breast augmentation. This increase in its popularity has led to the development of new technologies to increase its efficacy and safety, however, it has inherently implied the inadequate use of this procedure, mainly when performed by unqualified medical personnel. We present the case of a patient with complications following a breast AFT for aesthetic purposes, performed by a general practitioner without a specialty in plastic and reconstructive surgery.

关键词： Breast Breast Reconstruction Breast Surgery Autologous Fat Transfer Intramammary Abscess

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Occupational physical activity, all-cause, cardiovascular disease, and cancer mortality in 349,248 adults: Prospective and longitudinal analyses of the MJ Cohort

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Journal of Sport and Health Science 2024年第4期13卷 579-589页

作者： Emmanuel Stamatakis Matthew N.Ahmadi Tiana-Lee Elphick Bo-Huei Huang Susan Paudel armando Teixeira-Pinto Li-Jung Chen Borja del Pozo Cruz Yun-Ju Lai Andreas Holtermann Po-Wen Ku Sydney School of Health Sciences Faculty of Medicine and HealthCharles Perkins CentreUniversity of SydneySydneyNSW 2006Australia Sydney School of Public Health Faculty of Medicine and HealthUniversity of SydneySydneyNSW 2006Australia Department of Exercise Health Science “National”Taiwan University of SportTaichung 40404China Department of Sports Science and Clinical Biomechanics University of Southern DenmarkOdense 5230Denmark Division of Endocrinology and Metabolism Department of Internal MedicinePuli Branch of Taichung Veterans General HospitalNantou 54552China National Research Centre for the Working Environment Copenhagen 2100Denmark Graduate Institute of Sports and Health Management “National”Chung Hsing UniversityTaichung 40227China

Background:Evidence on the health benefits of occupational physical activity(OPA)is *** examined the associations of baseline OPA and OPA changes with all-cause,cardiovascular disease(CVD),and cancer mortality and survival ***:This study included prospective and longitudinal data from the MJ Cohort,comprising adults over 18 years recruited in 1998-2016,349,248 adults(177,314 women)with baseline OPA,of whom 105,715(52,503 women)had 2 OPA measures at 6.3±4.2 years(mean±SD)*** were baseline OPA,OPA changes,and baseline leisure-time physical ***:Over a mean mortality follow-up of 16.2±5.5 years for men and 16.4±5.4 years for women,11,696 deaths(2033 of CVD and 4631 of cancer causes)in men and 8980 deaths(1475 of CVD and 3689 of cancer causes)in women *** moderately heavy/heavy baseline OPA was beneficially associated with all-cause mortality in men(multivariable-adjusted hazard ratio(HR)=0.93,95%confidence interval(95%CI):0.89-0.98 compared to light OPA)and women(HR=0.86,95%CI:0.79-0.93).Over a mean mortality follow-up of 12.5±4.6 years for men and 12.6±4.6 years for women,OPA decreases in men were detrimentally associated(HR=1.16,95%CI:1.01-1.33)with all-cause mortality,while OPA increases in women were beneficially(HR=0.83,95%CI:0.70-0.97)associated with the same *** or changes in OPA showed no associations with CVD or cancer ***:Higher baseline OPA was beneficially associated with all-cause mortality risk in both men and *** longitudinal OPA analyses partly confirmed the prospective findings,with some discordance between sex groups.

关键词： Cancer Cardiovascular disease Epidemiology Mortality

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超声辅助乙醇提取富硒金花葵花朵中的硒及抗氧化活性分析

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食品工业科技 2024年第16期45卷 201-208页

作者：张文开鲍征宇 Diego armando PINZON NUNEZ 邵玲玲徐峰张宏宇赵月华田欢中国地质大学(武汉)材料与化学学院湖北武汉430000 安康国硒源科技有限公司陕西安康725000 紫阳中地大硒科技有限公司陕西安康725000 西北大学地质学系陕西西安710000 武汉测绘研究院湖北武汉430000

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花... 详细信息

为促进优质天然富硒植物资源的科学开发利用,本文选取富硒金花葵为研究对象,采用氢化物发生-原子荧光光谱法(Hydride Generation-Atomic Fluorescence Spectrometry,HG-AFS)检测不同植物器官样品中的硒含量,超声波辅助乙醇提取金花葵花朵中的含硒有机活性组分并使用响应面法优化获得最佳提取工艺,同时对含硒提取物开展抗氧化活性研究。结果显示,金花葵各器官中硒含量从高到低依次为叶、果、花、根和茎,分别为21.99、14.29、12.93、10.90和10.23 mg/kg。响应面优化结果表明,含硒有机活性成分最佳提取参数为提取温度40℃、固液比1:60、提取时间40 min、超声功率350 W、乙醇浓度50%(V/V)和提取次数1次。在最佳提取参数下,硒的提取率为35.65%±0.65%。DPPH抗氧化活性测定结果显示,含硒有机活性成分的半抑制浓度(IC_(50))为0.048 mg/mL(硒元素浓度为0.79μg/mL),羟基自由基清除实验显示样品浓度为8 mg/mL时达到最大清除率97%,IC_(50)为0.56 mg/mL,还原力实验表明样品的还原能力随样品浓度的增大而增强。证明金花葵的含硒乙醇提取物具有良好的抗氧化能力。本研究可以为合理利用富硒金花葵和研发加工富硒农副作物提供一些理论依据。

关键词：金花葵硒含硒活性成分提取工艺优化响应面抗氧化活性

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