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Assessment of ghrelin and leptin receptor levels in postmenopausal women who received oral or transdermal menopausal hormonal therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 35-42页

作者： Barbara RUSZKOWSKA Alina SOKUP arleta kulwas Maciej W.SOCHA Krzysztof GóRALCZYK Barbara GóRALCZYK Danuta ROS Department of Pathophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Gastroenterology Angiology and Internal DiseasesCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Obstetrics Gynecology and Oncological GynecologyCollegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective:In postmenopausal women,an increased leptin concentration and reduced levels of ghrelin and adiponectin were *** aim of this study was to evaluate the concentrations of the active form of ghrelin,total ghrelin,leptin receptor,lipoprotein(a)(Lp(a)),and plasminogen activator inhibitor type 1(PAI-1) in postmenopausal women who received oral or transdermal menopausal hormonal therapy(MHT).Methods:The study involved 76 healthy women:46 women aged from 44 to 58 years who received oral(26) or transdermal(20) MHT;the control group consisted of 30 women aged from 44 to 54 years who did not receive *** plasma concentrations of total ghrelin,the active form of ghrelin,Lp(a),and PAI-1:Ag were measured by enzyme-linked immunosorbent assay(ELISA).The concentration of the leptin receptor was measured by enzyme immunometric assay(EIA).Results:We observed a significantly higher concentration of total ghrelin and the active form of ghrelin in women who received transdermal MHT in comparison with those who took oral *** also found a significantly lower concentration of total ghrelin in women who received oral MHT compared with the control group.A higher concentration of PAI-1:Ag was found in the group of women who took transdermal MHT in comparison with those who took oral MHT and with the control *** differences were statistically ***,we found a significant negative correlation between the concentrations of total ghrelin and PAI-1:Ag and a positive correlation between the concentrations of total ghrelin and leptin receptor in women who received transdermal ***:The study showed that women who used transdermal MHT had higher levels of total ghrelin than women who took oral *** indicates a beneficial effect of the transdermal route of ***,transdermal therapy was associated with adverse effects with regard to the observed higher levels of PAI-1:Ag,which in turn,can lead to a reduction in fibrinolytic activity.

关键词： ghrelin 瘦素受体激素治疗绝经后妇女纤溶酶原激活物抑制物高水口服

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严重肢体缺血患者血浆中促血管生成潜力与血浆MMP-9、TIMP-1和TIMP-2水平升高的相关性研究（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第8期20卷 687-692页

作者： Radoslaw Wieczór Anna Maria Wieczór arleta kulwas Grzegorz Pulkowski Jacek Budzyński Danuta Rosc Department of Pathophysiology Faculty of Pharmacy Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz Bydgoszcz PL 85-094 Poland Clinic of Vascular and Internal Medicine Dr Jan Biziel University Hospital No. 2 in Bydgoszcz Bydgoszcz PL 85-168 Poland Department of Vascular and Internal Medicine Faculty of Health Sciences Nicolaus Copernicus University in Toruń Ludwik Rydygier Collegium Medicum in Bydgoszcz Bydgoszcz PL 85-168 Poland

本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会... 详细信息

本研究通过比较间歇性跛行(IC)和严重肢体缺血(CLI)患者的血液参数,选择合适的临床和生化特指标,以评估促血管生成的潜力和抑制血管生成的作用.结果表明,通过刺激下肢动脉疾病(LEAD)病人血浆中的血管生成,内皮生长因子A(VEGF-A)浓度会显著增加,同时依赖于循环受体sVEGFR-1和sVEGFR-2的抑制也会显著减少.与IC病人相比,CLI病人具有较高的VEGF-A、金属蛋白酶9(MMP-9)、金属蛋白酶组织抑制因子1(TIMP-1)和TIMP-2浓度.

关键词：严重肢体缺血间歇性跛行血管内皮生长因子金属蛋白酶

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