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Fabrication and evaluation of carboxymethyl guar gum-chitosan interpenetrating polymer network (IPN) nanoparticles for controlled drug delivery

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Medicine in Novel Technology and Devices 2024年第2期22卷 73-79页

作者： Chandrani Roy arijit gandhi Sreejan Manna Sougata Jana Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol713301West BengalIndia Department of Pharmaceutical Technology Brainware UniversityBarasatKolkataWest Bengal700125India Department of Health and Family Welfare Directorate of Health ServicesKolkataIndia

Guar gum(GG)has drawn more interest from researchers in the last several decades for the controlled delivery of *** aim of the research is to fabricate and evaluate an interpenetrating polymer network(IPN)based nanocarriers system employing chemically modified GG to achieve controlled release of *** present study,we have reported the synthesis of carboxymethyl GG-chitosan IPN nanoparticles for controlled release of metformin *** guar gum(CMGG)was synthesized and employed for developing IPN nanoparticles in combination with chitosan in varying polymeric ratios.A cross-linking agent,sodium tripolyphosphate(Na-TPP)was used for the synthesis of IPN colloidal suspension of nanoparticles which was lyophilized to obtain *** carboxymethylation of GG was confirmed through Fourier transform infra-red spec*** mean particle size was 440.6 nm indicating a polydispersity index of *** drug entrapment efficiency was found to vary between 67.461.64%to 88.232.02%.The differential scanning calorimetry study revealed the presence of amorphous metformin hydrochloride as a homogenous dispersion in nanoparticles(NPs)*** vitro drug release study indicated controlled release ability of developed IPN matrix.A2 formulation(chitosan:CMGG-1:1)exhibited 78.110.27%release after 8 *** evaluation performed in alloxan-treated diabetic rat model exhibited a prolonged hypoglycemic efficacy over 6 h,for A2 formulation treated group,compared to the group receiving only metformin HCl,which demonstrated a reduction in blood glucose levels for up to 4 *** study findings demonstrated the efficacy of the CMGG-chitosan based IPN nanoparticulate system for sustained delivery of therapeutic agents.

关键词： Carboxymethyl guar gum Chitosan Interpenetrating polymer network Nanoparticles Controlled release Metformin hydrochloride

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Studies on thermoresponsive polymers:Phase behaviour,drug delivery and biomedical applications

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Asian Journal of Pharmaceutical Sciences 2015年第2期10卷 99-107页

作者： arijit gandhi Abhijit Paul Suma Oommen Sen Kalyan Kumar Sen Department of Pharmaceutics Gupta College of Technological SciencesAshram MoreG.T.RoadAsansol 713301West BengalIndia

The present review aims to highlight the applications of thermoresponsive ***-responsive polymers show a sharp change in properties upon a small or modest change in *** behaviour can be utilized for the preparation of so-called‘smart’drug delivery systems,which mimic biological response behaviour to a certain *** materials are used in the development of several applications,such as drug delivery systems,tissue engineering scaffolds and gene *** in this field are particularly relevant to applications in the areas of regenerative medicine and drug *** review addresses summary of the main applications of thermoresponsive polymers which are categorized based on their 3-dimensional structure;hydrogels,interpenetrating networks,micelles,films and *** physico-chemical behaviour underlying the phase transition is also discussed in brief.

关键词： Thermoresponsive polymers Phase transition Drug delivery Tissue engineering

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