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Asian Pacific Journal of Tropical Medicine 2013年第6期6卷 438-442页

作者： arief Nurrochmad Supardjan Amir Margono Sardjiman arief rahman hakim Ernawati Erna Kurniawati Erva Fatmawati Department of Pharmacology and Clinical Pharmacy Faculty of PharmacyGadjah Mada UniversitySekip Utara Yogyakarta-55281Indonesia Curcumin Research Center Faculty of PharmacyCadjah Mada UniversitySekip Utara Yogyakarta-55281Indonesia

Objective:To investigate the hepatoproteetivc ami antioxidant activity of pentagamavunon-0(PGV-0) against CCl-4-induced hepatic injury in ***:The groups of animals were administered with PGV-0 at die doses 2.5.5,10,and 20 mg/kg b.w.,*** in a day for 6 days and at day 7 the animals were administrated with carbon tetrachloride(CClj)(20%,2 ml/kg *** liquid paraffin dp.).The effect of PGV-0 on serum transaminase(SGPT),alkaline phosphates(ALP and total bilirubin were determined in CCl-4-indueed hepatotoxicity in ***,the effects of PGV-0 on glutathione(GSU) content,cutalase(CAT) and NO free radical scavenging activity also were ***:The results demonstrated that PCV-0 significantly reduced the activity of SGPT,serum ALP and total bilirubin in CCl-4 induced rat ***-0 has effect on the antioxidant and free radical defense *** prevented the depletion level of GSH and decrease activity of CAT in CCl-4-induced liver injury in ***-0 also demonstrated the free radical scavenger effects on NO free radical scavenging activity with ES value of 32.32μM. Convulsion:All of our findings suggests that PGV-0 could protect the liver cells from CCl-4- induced liver damages and the mechanism may through the antioxidative effect of PGV-0 to prevent the accumulation of free radicals and protect the liver damage.

关键词： Hepatoprotective Antioxidant Pentagamavunon-0 Carbon tetrachloride Rats

Fabrication of La,Ce co-doped ZnO nanorods for improving photodegradation of methylene blue

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Journal of Rare Earths 2024年第1期42卷 76-83,I0003页

作者： Erfan hakim Azmal Zaid Jin-Chung Sin Sze-Mun Lam Abdul rahman Mohamed School of Chemical Engineering Universiti Sains Malaysia(USM)14300Nibong TebalPenangMalaysia College of Environmental Science and Engineering Guilin University of TechnologyGuilin541004China Guangxi Key Laboratory of Theory and Technology for Environmental Pollution Control Guilin University of TechnologyGuilin541004China Collaborative Innovation Center for Water Pollution Control and Water Safety in Karst Area Guilin University of TechnologyGuilin541004China Faculty of Engineering and Green Technology Universiti Tunku Abdul RahmanJalan UniversitiBandar Barat31900KamparPerakMalaysia

La,Ce co-doped ZnO nanorods(ZnLC)were synthesized through a one-step solvothermal *** photocatalysts were characterized by X-ray diffraction,Raman spectroscopy,field-emission scanning electron microscopy,energy dispersive X-ray,transmission electron microscopy,UV-vis diffuse reflectance spectroscopy and photo luminescence *** La and Ce doping enhanced the visible light absorption ability of ZnLC and a red shift was detected for *** simulated solar light irradiation,the ZnO doped with 3 at%La and 1 at%Ce(ZnLC1)degrades methylene blue(MB)more effectively than those of pure ZnO,La-doped ZnO(ZnL)and commercially available *** improved photocatalytic performance of ZnLC1 can be attributed to the high charge separation efficiency as demonstrated by the photoluminescence ***,the photocatalytic experiments reveal that several parameters have their own impact on the MB *** a variety of radical scavengers,it is discovered that superoxide anion radical plays a crucial role in the degradation of *** ZnLC1 is also reused several times without noticeable decrease of photoactivity,indicating that it has a substantial potential for environmental remediation applications.

关键词： ZnO Lanthanum Cerium Co-doping Photodegradation Rare earths

Bayesian Optimized LightGBM model for predicting the fundamental vibrational period of masonry infilled RC frames

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Frontiers of Structural and Civil Engineering 2024年第7期18卷 1084-1102页

作者： Taimur rahman Pengfei ZHENG Shamima SULTANA Department of Civil Engineering World University of BangladeshDhaka 1230Bangladesh School of Civil Engineering Zhengzhou UniversityZhengzhou 450001China Department of Computer Science&Engineering University of Asia PacificDhaka 1205Bangladesh

The precise prediction of the fundamental vibrational period for reinforced concrete(RC)buildings with infilled walls is essential for structural design,especially earthquake-resistant *** learning models from previous studies,while boasting commendable accuracy in predicting the fundamental period,exhibit vulnerabilities due to lengthy training times and inherent dependence on pre-trained models,especially when engaging with continually evolving data *** predicament emphasizes the necessity for a model that adeptly balances predictive accuracy with robust adaptability and swift data *** latter should include consistent re-training ability as demanded by realtime,continuously updated data *** research implements an optimized Light Gradient Boosting Machine(LightGBM)model,highlighting its augmented predictive capabilities,realized through the astute use of Bayesian Optimization for hyperparameter tuning on the FP4026 research data set,and illuminating its adaptability and efficiency in predictive *** results show that the R^(2) score of LightGBM model is 0.9995 and RMSE is 0.0178,while training speed is 23.2 times faster than that offered by XGBoost and 45.5 times faster than for Gradient ***,this study introduces a practical application through a streamlit-powered,web-based dashboard,enabling engineers to effortlessly utilize and augment the model,contributing data and ensuring precise fundamental period predictions,effectively bridging scholarly research and practical applications.

关键词： masonry-infilled RC frame fundamental period LightGBM FP4026 research dataset machine learning data-driven approach Bayesian Optimization

Ion-acoustic waves with non-planar wavefronts

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Plasma Science and Technology 2024年第1期26卷 1-7页

作者： Shujaht BUKHARI Muhammad SHAHID Ata-ur rahman Department of Physics The University of Azad Jummu and KashmirMuzaffarabad 13100Azad Kashmir Department of Physics Women University of Azad Jammu&KashmirBagh 12500Pakistan Department of Physics Islamia College PeshawerPeshawar 25120Pakistan

The ion-acoustic(IA) mode exhibiting various orbital angular momentum(OAM) states is examined in a plasma with drifting *** constituent plasma species are modeled with a non-gyrotropic Maxwellian distribution and discussion of dispersion relation and growth rate of twisted IA waves under various conditions is *** the domain of kinetic model,the twisted IA waves are characterized by Laguerre-Gaussian(LG) solutions,where plasma distribution function and electric field are decomposed into axial and azimuthal *** plasma response function is obtained under paraxial approximations and investigated for threshold condition of instability growth rate with helical electric field *** impact of an extra electron specie on the instability is demonstrated through a comparison of twisted waves for single and double electron species.

关键词： instability twist parameter wave excitation orbital angular momentum threshold limit

Effects of multiple shapes for steady flow with transformer oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 373-388页

作者： M.rahman M.TURKYILMAZOGLU Z.MUSHTAQ Department of Mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of Mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c MATLAB *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,Re=2,M=1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil Brinkman number skin friction coefficient double rotating disk Nusselt number Sherwood number

The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： Md Rakibul Alam Md Mizanur rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

Entrepreneurship training:its influences on innovation potentials among nursing students

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Frontiers of Nursing 2024年第1期11卷 85-98页

作者： Asmaa Abdel rahman Abdel rahman Dalia Abdallah Abdelatief Medical Surgical Nursing Department Faculty of NursingAin Shams UniversityCairoEgypt

Objective:To evaluate the influences of entrepreneurship training on the innovation potential among nursing ***:A quasi-experimental design was utilized to conduct this *** study was conducted in the classroom at the faculty of nursing,and the“i Hub”center at Ain Shams University(ASU)in Cairo,Egypt.A purposive sample of 42 nursing students who participated in the“Ain Shams University-innovate”competition from the Faculty of Nursing of ASU were included in this *** collection tools included(1)Nursing students'innovation skills assessment questionnaire and(2)Innovative projects evaluation ***:There was a statistically significant difference between the mean scores of nursing students'total innovation skills pre-and post-implementation of entrepreneurship training,where P-value<***:The results of the current study support the research hypothesis because the implementation of entrepreneurship training positively affects nursing students'innovation *** entrepreneurship education in nursing and integrating it into nursing programs will stimulate creativity,innovation,and entrepreneurship among nursing students and health care services.

关键词： entrepreneurship training innovation potentials nursing students creative skills energy/motivation

Evolution of blockchain consensus algorithms: a review on the latest milestones of blockchain consensus algorithms

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Cybersecurity 2024年第3期7卷 80-101页

作者： Ziad Hussein May A.Salama Sahar A.El-rahman Electrical Engineering Department Faculty of Engineering-ShoubraBenha UniversityCairoEgypt

Blockchain technology has gained widespread adoption in recent years due to its ability to enable secure and trans-parent record-keeping and data transfer.A critical aspect of blockchain technology is the use of consensus algorithms,which allow distributed nodes in the network to agree on the state of the *** this review paper,we exam-ine various consensus algorithms that are used in blockchain systems,including proof-of-work,proof-of-stake,and hybrid *** go over the trade-offs and factors to think about when choosing a consensus algorithm,such as energy efficiency,decentralization,and *** also look at the strengths and weaknesses of each algorithm as well as their potential impact on the scalability and adoption of blockchain technology.

关键词： Blockchain Consensus Proof of work Proof of stake Decentralization

Thermal noise-driven resonant sensors

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Microsystems & Nanoengineering 2024年第3期10卷 259-271页

作者： Yan Qiao Alaaeldin Elhady Mohamed Arabi Eihab Abdel-rahman Wenming Zhang School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghaiChina Department of Systems Design Engineering University of WaterlooWaterlooONCanada

MEMS/NEMS resonant sensors hold promise for minute mass and force ***,one major challenge is that conventional externally driven sensors inevitably encounter undesired intrinsic noise,which imposes a fundamental limitation upon their signal-to-noise ratio(SNR)and,consequently,the ***,this restriction becomes increasingly pronounced as sensors shrink to the *** this work,we propose a counterintuitive paradigm shift that turns intrinsic thermal noise from an impediment to a constituent of the sensor by harvesting it as the driving force,obviating the need for external actuation and realizing‘noise-driven’*** sensors employ the dynamically amplified response to thermal noise at resonances for stimulus *** demonstrate that lightly damped and highly compliant nano-structures with high aspect ratios are promising candidates for this class of *** overcome the phase incoherence of the drive force,three noise-enabled quantitative sensing mechanisms are *** validated our sensor paradigm by experimental demonstrating noise-driven pressure and temperature ***-driven sensors offer a new opportunity for delivering practical NEMS sensors that can function at room temperature and under ambient pressure,and a development that suggests a path to cheaper,simpler,and low-power-consumption sensors.

关键词： noise resonant overcome

Spatial dynamics and Palestinian resilience:The lifestyle of Al-Kurshan Bedouins in Bethlehem District

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Frontiers of Architectural Research 2024年第3期13卷 439-458页

作者： Maha Samman Sarah Mitwassi Abdel rahman Kaloti Department of Architecture Faculty of EngineeringAl-Quds UniversityJerusalemPalestine

This study explores the role of Bedouins in preserving Palestinian land through their own means of community resilience through the concept of“Art of being”and its entailed“Arts of presence and persistence”.This is examined through the correlation between Bedouin lifestyle and the spatial distribution of structures within“Al-Kurshan”Bedouin clan in Area C in the West *** on a mixed qualitative and spatial methodologies,information was gathered through semi-structured interviews with Al-Kurshan Bedouins and employees of organizations supporting Bedouins,on-site observation,and analyses of maps and photos,in addition to drawings and *** spatial distribution of Bedouin built structures is analyzed in relation to landscape and climate,social aspects within the families,and available service and sectorial *** analyses give insight on how Bedouins struggle against adopting other *** study shows that the Bedouins are slowly forced to negotiate their semi-nomadic lifestyle,but resist giving up their right to exist against the threat of forced *** maintain their“Art of being”which partly represents their own way of safeguarding Palestinian lands from *** study contributes to the wider discussion of spatial dynamics of Bedouins and their community resilience within the Palestinian geopolitical context.

关键词： Bedouin everyday life Spatial distribution Community resilience Art of being Palestine Area C