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Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect

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World Journal of Stem Cells 2014年第4期6卷 505-510页

作者： Ali Behnia Abbas Haghighat ardeshir talebi Nosrat Nourbakhsh Fariba Heidari Member of Students’ Research Center Isfahan Uni-versity of Medical Sciences81745-319 IsfahanIran Department of Oral and Maxillofacial Surgery Shahid Saddooghi University of Medical SciencesYazd Dental School*** YazdIran Department of Oral and Maxillofacial Surgery Alzahra HospitalIsfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran Torabinejad Research Center Department of PathologyFaculty of Medical SciencesIsfahan University81746-73461 IsfahanIran Torabinejad Research Center Department of Pediatric DentistryIsfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran Torabinejad Research Center Isfahan University of Medical SciencesIsfahan Dental School81746-73461 IsfahanIran

AIM: To investigate the effect of stem cells from human exfoliated deciduous teeth(SHED) transplanted for bone regeneration in the dog mandibular ***: In this prospective comparative study, SHEDs had been isolated 5 years ago from human exfoliated deciduous teeth. The undifferentiated stem cells were seeded into mandibular bone through-andthrough defects of 4 dogs. Similar defects in control group were filled with cell-free collagen scaffold. After 12 wk, biopsies were taken and morphometric analysis was performed. The percentage of new bone formation and foreign body reaction were measured in each case. The data were subject to statistical analysis using the Mann-Whitney U and Kruskalwalis statistical tests. Differences at P < 0.05 was considered as significant ***: There were no significant differences between control and SHED-seeded groups in connective tissue(P = 0.248), woven bone(P = 0.248) and compact bone(P = 0.082). There were not any side effects in transplanted SHED group such as teratoma or malignancy and abnormalities in this ***: SHEDs which had been isolated and characterized 5 years ago and stored with cryopreservation banking were capable of proliferation and osteogenesis after 5 years, and no immune response was observed after three months of seeded SHEDs.

关键词： Bone regeneration Isolation Stem cells from human exfoliated deciduous teeth

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