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Advanced glycation end products:Key mediator and therapeutic target of cardiovascular complications in diabetes

World Journal of Diabetes 2023年第8期14卷 1146-1162页

作者： Savita Bansal archana burman Asok Kumar Tripathi Department of Biochemistry Institute of Home SciencesUniversity of DelhiNew Delhi 110016India Department of Biochemistry Institute of Home EconomicsUniversity of DelhiNew Delhi 110016India Department of Biochemistry University College of Medical SciencesUniversity of DelhiNew Delhi 110095India

The incidence of type 2 diabetes mellitus is growing in epidemic proportions and has become one of the most critical public health *** complications associated with diabetes are the leading cause of morbidity and *** cardiovascular diseases that accompany diabetes include angina,myocardial infarction,stroke,peripheral artery disease,and congestive heart *** the various risk factors generated secondary to hyperglycemic situations,advanced glycation end products(AGEs)are one of the important targets for future diagnosis and prevention of *** the last decade,AGEs have drawn a lot of attention due to their involvement in diabetic *** can be derived exogenously and endogenously through various *** are a nonhomogeneous,chemically diverse group of compounds formed nonenzymatically by condensation between carbonyl groups of reducing sugars and free amino groups of protein,lipids,and nucleic *** mediate their pathological effects at the cellular and extracellular levels by multiple *** the cellular level,they activate signaling cascades via the receptor for AGEs and initiate a complex series of intracellular signaling resulting in reactive oxygen species generation,inflammation,cellular proliferation,and fibrosis that may possibly exacerbate the damaging effects on cardiac functions in *** also cause covalent modifications and cross-linking of serum and extracellular matrix proteins;altering their structure,stability,and *** diagnosis of diabetes may prevent its progression to complications and decrease its associated *** the present review,we recapitulate the role of AGEs as a crucial mediator of hyperglycemia-mediated detrimental effects in diabetes-associated ***,this review presents an overview of future perspectives for new therapeutic interventions to ameliorate cardiovascular complications in diabetes.

关键词： Type 2 diabetes mellitus Cardiovascular complications Hyperglycemia Advanced glycation end products Reactive oxygen species Oxidative stress Endothelial cells Receptor of advanced glycation end products Anti-advanced glycation end products strategies

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