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SNARE complex in axonal guidance and neuroregeneration

Neural Regeneration Research 2018年第3期13卷 386-392页

作者： Fausto Ulloa Tiziana Cotrufo Delia Ricolo Eduardo Soriano Sofia J. araújo Department of Cell Biology Physiology and Immunology School of Biology and Institute of Neurosciences University of Barcelona Barcelona Spain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) Instituto de Salud Carlos III (ISCIII) Madrid Spain Institut de Biologia Molecular de Barcelona (IBMB-CSIC) Parc Cientific de Barcelona Barcelona Spain Department of Genetics Microbiology and Statistics School of Biology University of Barcelona Barcelona Spain Vail d 'Hebron Institut de Recerca (VHIR) Barcelona Spain

Through complex mechanisms that guide axons to the appropriate routes towards their targets, axonal growth and guidance lead to neuronal system formation. These mechanisms establish the synaptic circuitry necessary for the optimal performance of the nervous system in all organisms. Damage to these networks can be repaired by neuroregenerative processes which in turn can re-establish synapses between injured axons and postsynaptic terminals. Both axonal growth and guidance and the neuroregenerative response rely on correct axonal growth and growth cone responses to guidance cues as well as correct synapses with appropriate targets. With this in mind, parallels can be drawn between axonal regeneration and processes occurring during embryonic nervous system development. However, when studying parallels between axonal development and regeneration many questions still arise; mainly, how do axons grow and synapse with their targets and how do they repair their membranes, grow and orchestrate regenerative responses after injury. Major players in the cellular and molecular processes that lead to growth cone development and movement during embryonic development are the Soluble N-ethylamaleimide Sensitive Factor （NSF） Attachment Protein Receptor （SNARE） proteins, which have been shown to be involved in axonal growth and guidance. Their involvement in axonal growth, guidance and neuroregeneration is of foremost importance, due to their roles in vesicle and membrane trafficking events. Here, we review the recent literature on the involvement of SNARE proteins in axonal growth and guidance during embryonic development and neuroregeneration.

关键词： SNARE vesicle associated membrane protein synaptosomal associated protein axon guidance neuroregeneration nervous system cell membrane

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Scalable fabrication,compartmentalization and applications of living microtissues

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Bioactive Materials 2023年第1期19卷 392-405页

作者： Maik Schot Nuno araújo-Gomes Bas van Loo Tom Kamperman Jeroen Leijten Department of Developmental Bioengineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522NBEnschedethe Netherlands

Living microtissues are used in a multitude of applications as they more closely resemble native tissue physiology,as compared to 2D *** are typically composed of a combination of cells and materials in varying combinations,which are dictated by the applications’design *** applications range wide,from fundamental biological research such as differentiation studies to industrial applications such as cruelty-free meat ***,their translation to industrial and clinical settings has been hindered due to the lack of scalability of microtissue production *** microfluidic processes provide an opportunity to overcome this limitation as they offer higher throughput production rates as compared to traditional batch techniques,while maintaining reproducible control over microtissue composition and *** this review,we provide a comprehensive overview of the current approaches to engineer microtissues with a focus on the advantages of,and need for,the use of continuous processes to produce microtissues in large ***,an outlook is provided that outlines the required developments to enable large-scale microtissue fabrication using continuous processes.

关键词： Tissue engineering Micromaterials Microfluidics Upscaling Clinical translation Industrial translation

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Influence of variables related to soil weathering on the geomechanical performance of tropical soils

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第9期15卷 2423-2440页

作者： Rodrigo Cesar Pierozan Gregorio Luís Silva araújo Ennio Marques Palmeira Celso Romanel Department of Civil Engineering Federal Institute of EducationScienceand Technology of RondoniaPorto VelhoROBrazil Department of Civil and Environmental Engineering University of BrasiliaBrasiliaDFBrazil Department of Civil and Environmental Engineering Pontifical Catholic University of Rio de JaneiroRio de JaneiroRJBrazil

This paper presents an experimental and analytical investigation of the influence of variables related to soil weathering on the geomechanical performance of sand-silt mixtures containing lateritic soils,*** weathered tropical soils with the influence of interparticle *** sand-silt mixtures containing different relative proportions between uniform sand and lateritic soil were produced,and geomechanical soil characterization tests were *** on the results,a transition from a primarily coarse-to a fine-grained prevailing soil structure was found to cause considerable impact on the geomechanical performance of these soils,as evidenced by design variables related to soil mineralogy and size distribution ***,fines contents of both individual soil particles and soil aggregations were found to correlate with experimental results,while the relative proportion between sesquioxides(aluminum,and iron oxides),and silica,***-silica ratios(SSR^(-1)),facilitated estimates concerning changes in geomechanical ***,the application of the sandsilt mixtures containing lateritic soil on soil walls reinforced with polymeric strips was also evaluated,further emphasizing the potential advantages of adopting variables related to soil weathering on design guidelines concerning tropical soils.

关键词： Sesquioxides-silica ratio Tropical soils Sand-silt mixtures Lateritic soil Reinforced soil walls

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Interactions among dwarf bamboo, litter and consumption by small vertebrates place multiple constraints on the establishment of native tree seedlings in a Japanese agricultural landscape

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Journal of Plant Ecology 2019年第2期12卷 292-305页

作者： Yoshinori Tokuoka Kentaro Ohigashi Koji Watanabe Hiroshi Yamaguchi Takahiro ara Nobukazu Nakagoshi Division of Biodiversity Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Division of Informatics and Inventory Institute for Agro-Environmental SciencesNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Department of Planning and Coordination Tsukuba Technical Support CenterNational Agriculture and Food Research Organization3-1-3KannondaiTsukuba-shiIbaraki 305-8604Japan Graduate School for International Development and Cooperation Hiroshima University1-5-1 KagamiyamaHigashi-Hiroshima 739-8529Japan

Aims Faunal assemblage alterations due to anthropogenic impacts have changed herbivore-vegetation relationships in various ecosystems,but the influences of small vertebrates on revegetation processes remain *** a peri-urban agricultural landscape in eastern Japan that lacks large ungulates but supports small generalist herbivores,fewer native seedlings have become established in thickets dominated by native dwarf bamboo,Pleioblastus chino(*** Sav.)*** mechanisms limiting tree seedling establishment are *** aim here was to evaluate the influence of interactions among the dwarf bamboo,its litter cover and small vertebrate herbivores on the micro-site conditions governing the establishment of native tree seedlings from different successional stages in an old field in temperate *** First,seedling emergence and survival of seeded Pinus densiflora Siebold et Zucc.,Celtis sinensis Pers.,Aphananthe aspera(Thunb.)Planch.,Quercus serrata Murray,Quercus myrsinifolia Blume and Castanopsis sieboldii(Makino)*** *** Mashiba were observed in a factorial design that accounted for the presence or absence of dwarf bamboo and its litter cover,as well as the exclu-sion or access of small vertebrate fauna,in 2009 and *** identify small vertebrate herbivores that reduced the emergence or survival of tree seedlings in the first experiment,reseeding experi-ments using ***,***,*** and *** were conducted by video trapping in 2011 and video and still-cam-era trapping in *** Findings The abiotic conditions under the dwarf bamboo were lethal to early-to mid-successional ***,***,*** and *** but led to better survival-although spindly growth-of late-succes-sional *** and *** main consumers and the plants they found palatable differed between the bamboo thickets and the intervening *** by mice appeared to have severely limited the emergence of

关键词： bamboo cover farmland abandonment microsite limitation selective herbivory Pleioblastus chino

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Nonlocal material properties of single-walled carbon nanotubes

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International Journal of Smart and Nano Materials 2012年第2期3卷 141-151页

作者： J.V.araújo dos Santos C.M.Mota Soares IDMEC Instituto Superior TécnicoUniversidade Técnica de Lisboa1049-001 LisboaPortugal

Natural frequencies of single-walled carbon nanotubes(SWCNTs)obtained using a model based on Eringen’s nonlocal continuum mechanics and the Timoshenko beam theory are compared with those obtained by molecular dynamics *** goal was to determine the values of the material constant,considered here as a nonlocal property,as a function of the length and the diameter of *** present approach has the advantage of eliminating the SWCNT thickness from the computations.A sensitivity analysis of natural frequencies to changes in the nonlocal material constant is also carried out and it shows that the influence of the nonlocal effects decreases with an increase in the SWCNT *** matching of natural frequencies shows that the nonlocal material constant varies with the natural frequency and the SWCNT length and diameter.

关键词： nonlocal mechanics molecular dynamics simulation single-walled carbon nanotube Timoshenko beam

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Flow of micropolar fluid over an off centered rotating disk with modified Darcy's law

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Propulsion and Power Research 2017年第4期6卷 285-295页

作者： N.A.Khan S.Khana A.ara Department of Mathematics University of KarachiKarachiSindh 75270Pakistan Department of Computer Science Mohammad Ali Jinnah UniversityKarachiSindh 75400Pakistan

The problem of the steady, incompressible, three dimensional stagnation point flow of a micropolar fluid over an off centered infinite rotating disk in a porous medium is studied in this article. Injection/suction is applied uniformly throughout the surface of porous disk. The Darcy's resistance for the micropolar fluid is also formulated. The partial differential equations are converted into the set of ordinary differential equation by utilizing the suitable transformation. The system of equations is analytically solved by the means of a non-perturbative technique, homotopy analysis method (HAM). The influence of rotational parameter, material parameter, spin gradient viscosity parameter, micro-inertia density parameter, porosity parameter and suction/injection parameter on velocity functions is presented in graphical form and discussed in detail. Verification of the solutions is made by a numerical comparison with the previous study.

关键词： Micropolar fluid Stagnation point Modified Darcy'slaw Porous medium

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Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais araujo Lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de Castro Danielle Lopes Rocha Lucas Crespo de Barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto Ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

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Performance index: An expeditious tool to screen for improved drought resistance in the Lathyrus genus

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Journal of Integrative Plant Biology 2014年第7期56卷 610-621页

作者： Susana Silvestre Susana de Sousa araújo Maria Carlota Vaz Patto Jorge Marques da Silva Center for Biodiversity Functional and Integrative Genomics(BioFIG)and Department of Plant BiologyFaculty of ScienceUniversity of LisbonCampo Grande Animal and Veterinary Sciences Research Center Tropical Research Institute(IICT‐CVZ)Faculty of Veterinary Medicine Plant Cell Biotechnology Lab Institute for Chemistry and Biological Technology António Xavier-New University of Lisbon(ITQB‐UNL)

Some species of the Lathyrus genus are among the most promising crops for marginal lands, with high resilience to drought, flood, and fungal diseases, combined with high yields and seed nutritional value. However, lack of knowledge on the mechanisms underlying its outstanding performance and methodologies to identify elite genotypes has hampered its proper use in breeding. Chlorophyl a fast fluorescence transient （JIP test）, was used to evaluate water deficit （WD） resistance in Lathyrus genus. Our results reveal unaltered photochemical values for al studied genotypes showing resistance to mild WD. Under severe WD, two Lathyrus sativus genotypes showed remarkable resilience maintaining the photochemical efficiency, contrary to other genotypes studied. Performance index （PIABS） is the best parameter to screen genotypes with improved performance and grain production under WD. Moreover, we found that JIP indices are good indicators of genotypic grain production under WD. Quantum yield of electron transport （wEo） and efficiency with which＆trapped excitons can move electrons further than QA （c0） revealed as important traits related to improved photosyn-thetic performance and should be exploited in future Lathyrus germplasm improvements. The JIP test herein described showed to be an expeditious tool to screen and to identify elite genotypes with improved drought resistance.

关键词： Grain production JIP test Lathyrus germplasm photochemical performance water deficit

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An Adaptive Load Stepping Algorithm for Path-Dependent Problems Based on Estimated Convergence Rates

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Computer Modeling in Engineering & Sciences 2017年第3期113卷 325-342页

作者： M.T.C.araújo Fernandes C.O.Cardoso W.J.Mansur Civil Engineering Department/COPPE/Federal University of Rio de Janeiro Ilha do FundaoP.B.6850621945-970 Rio de JaneiroRJBrazil Petrobras/Cenpes Av.Horácio Macedo950Ilha do Fundao21941-915 Rio de JaneiroRJBrazil Civil Engineering Department/COPPE/Federal University of Rio de Janeiro Ilha do FundaoP.B.6850621945-970 Rio de JaneiroRJBrazil

A new adaptive(automatic)time stepping algorithm,called RCA(Rate of Convergence Algorithm)is *** new algorithm was applied in nonlinear finite element analysis of path-dependent *** step size is adjusted by monitoring the estimated convergence rate of the nonlinear iterative *** RCA algorithm is relatively simple to implement,robust and its performance is comparable to,and in some cases better than,the automatic load incrementaion algorithm existent in commercial *** about the convergence rate of nonlinear iterative processes,an estimation of the rate and a study of the parameters of the RCA algorithm are *** show the capacity of the algorithm to adjust the increment size,detailed discussions based on results for different limit load analyses are *** results obtained by RCA algorithm are compared with those by ABAQUS?,one of the most powerful nonlinear FEA(Finite Element Analysis)commercial software,in order to verify the capability of RCA algorithm to adjust the increment size along nonlinear analyses.

关键词： Rate of convergence nonlinear automatic load incrementation limit load

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How does the brown mussel Perna perna respond to environmental pollution?A review on pollution biomarkers

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Journal of Environmental Sciences 2022年第1期34卷 412-428页

作者： Fernanda Silva dos Santos Raquel A.F.Neves Mirian araújo Carlos Crapez Valéria Laneuville Teixeira Natascha Krepsky Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Science and BiotechnologyMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Neotropical Biodiversity(PPGBIO)Pasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil Fluminense Federal University(UFF) Institute of BiologyGraduate Program in Marine Biology and Coastal EnvironmentsMario Santos Braga Streets/n.CentroNiteróiRJ CEP 24.020-141Brazil Federal University of the State of Rio de Janeiro(UNIRIO) Institute of Biosciences(IBIO)Graduate Program in Ecotourism and ConservationPasteur Avenue458.UrcaRio de JaneiroRJ CEP 22.290-255Brazil

The brown mussel Perna perna(Linnaeus,1758)is a valuable resource for aquaculture in tropical and subtropical coastal *** presents desirable characteristics for biomonitoring,including being sessile,widely distributed and abundant,and is a filter-feeder able to accumulate several classes of pollutants(e.g.,metals,hydrocarbons,among others).Mussels’biological responses to pollution exposure can be measured as biomarkers,which include alterations ranging from molecular to physiological levels,to estimate the degree of environmental contamination and its effects on *** full review compiles two decades(2000–2020)of literature concerning biological effects on *** mussel caused by environmental pollutants(i.e.,metals,hydrocarbons,and emerging pollutants),considering environmental and farm-based *** markers related to mussels’oxidative status were efficient for the biomonitoring of metals(i.e.,antioxidant enzymes associated with oxidative damage in biomolecules).Genotoxicity and cytotoxicity indicators(i.e.,comet,micronucleus,and neutral red assays)provided a depiction of hydrocarbon *** neutral red assay gave a time-concentration cytotoxic response to a wide range of pollutants,including emerging pollutants(e.g.,pharmaceuticals and biocides)and *** perna hemocyte parameters provided a useful approach for biocide *** paper summarizes useful biomarkers from molecular to physiological levels in this mussel species used to identify and quantify the degree of coastal *** integrated biomarker analysis may provide a way to overcome possible biomarker variations and assess multi-polluted ***,it is necessary to investigate biomarker variations according to natural factors(e.g.,season and gonad maturation stage)to standardize them for trustworthy biomonitoring.

关键词： Biological indexes Biomonitoring Emerging pollutants Hydrocarbons Metals Sentinel species

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