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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： María del Mar Contreras aránzazu morales-soto Antonio Segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

Sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(MS) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation armaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC Sofosbuvir

Role of peripheral amyloid-β aggregates in Alzheimer’s disease: mechanistic, diagnostic, and therapeutic implications

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Neural Regeneration Research 2025年第4期20卷 1087-1089页

作者： Nazaret Gamez Rodrigo morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Compelling evidence demonstrates that the levels of peripheral amyloid-β(Aβ)fluctuate in Alzheimer’s disease(AD)***,Aβdeposits have been identified in peripheral ***,the relevance of peripheral Aβ(misfolded or not)in pathological situations,and the temporal appearance of these pathological fluctuations,are not well *** presence of misfolded Aβin peripheral compartments raises concerns on potential inter-individual transmissions considering the well-reported prion-like properties of this disease-associated *** latter is supported by multiple reports demonstrating that Aβmisfolding can be transmitted between humans and experimental animals through multiple routes of *** this mini-review,we discuss the potential implications of peripheral,disease-associated Aβin disease mechanisms,as well as in diagnostic and therapeutic approaches.

关键词： therapeutic amyloid latter

Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology

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Neural Regeneration Research 2025年第11期20卷 3219-3220页

作者： Salvatore Saieva Rodrigo morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive *** a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of AD patients considering both clinical manifestations and pathological features.

关键词： amyloid Alzheimer clinical

Recent results from NA48/2

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Chinese Physics C 2010年第6期34卷 749-752页

作者： Cristina morales morales Institut für Physik Universitt Mainz

Recent results on radiative K^± decays from the NA48/2 experiment are reported. From the full NA48/2 data set, about a million K^±→π^±π^γ decays were reconstructed. Based on this sample, the first measurement of the interference between direct photon emission and inner bremsstrahlung in K^±→π^±π^γ decays was performed. Stringent limits on CP violation in this decay were also set. In addition, a precise measurement of the branching fraction of K^±→π^±γγ is presented. This measurement was based on a data sample of more than 1000 event candidates. Also the related decay K^±→π^±e^＋e^-γ has first been observed. Results of the measurement of the decay rate and the decay parameter 5 are summarized.

关键词： radiative K^± decays NA48/2 CP violation

Modeling Macrophage Polarization and Its Effect on Cancer Treatment Success

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Open Journal of Immunology 2018年第2期8卷 36-80页

作者： Valentin morales Luis soto-Ortiz Department of Engineering and Technologies East Los Angeles College Monterey Park USA Department of Mathematics East Los Angeles College Monterey Park USA

Positive feedback loops drive immune cell polarization toward a pro-tumor phenotype that accentuates immunosuppression and tumor angiogenesis. This phenotypic switch leads to the escape of cancer cells from immune destruction. These positive feedback loops are generated by cytokines such as TGF-β, Interleukin-10 and Interleukin-4, which are responsible for the polarization of monocytes and M1 macrophages into pro-tumor M2 macrophages, and the polarization of naive helper T cells intopro-tumor Th2 cells. In this article, we present a deterministic ordinary differential equation (ODE) model that includes key cellular interactions and cytokine signaling pathways that lead to immune cell polarization in the tumor microenvironment. The model was used to simulate various cancer treatments in silico. We identified combination therapies that consist of M1 macrophages or Th1 helper cells, coupled with an anti-angiogenic treatment, that are robust with respect to immune response strength, initial tumor size and treatment resistance. We also identified IL-4 and IL-10 as the targets that should be neutralized in order to make these combination treatments robust with respect to immune cell polarization. The model simulations confirmed a hypothesis based on published experimental evidence that a polarization into the M1 and Th1 phenotypes to increase the M1-to-M2 and Th1-to-Th2 ratios plays a significant role in treatment success. Our results highlight the importance of immune cell reprogramming as a viable strategy to eradicate a highly vascularized tumor when the strength of the immune response is characteristically weak and cell polarization to the pro-tumor phenotype has occurred.

关键词： Macrophage Polarization Feedback Loops Immunosuppression Mathematical Modeling Cancer Therapy

On the Complexity of Expansive Measures

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Acta Mathematica Sinica,English Series 2015年第9期31卷 1501-1507页

作者： C.A.morales Instituto de Matem'atica Universidade Federal do Rio de Janeiro

We prove that the existence of positively expansive measures for continuous maps on compact metric spaces implies the existence of e 〉 0 and a sequence of （m, e）-separated sets whose cardinalities go to infinite as m →∞. We then prove that maps exhibiting such a constant e and the positively expansive maps share some properties.

关键词： Positively expansive measure complexity compact metric space

Food allergy among Mexican infants and preschoolers:prevalence and associated factors

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World Journal of Pediatrics 2023年第4期19卷 401-405页

作者： Martín Bedolla-Barajas Jaime morales-Romero Rafael Sánchez-Magallón Jorge Alejandro Valdez-soto Tonatiuh Ramses Bedolla-Pulido Carlos Meza-López Allergy and Immunology Department Nuevo Hospital Civil de Guadalajara Dr.Juan I.MenchacaSalvador Quevedo y Zubieta No.740Colonia La Perla44340GuadalajaraJaliscoMéxico Institute of Public Health Universidad VeracruzanaXalapaMexico Pediatrics Department Nuevo Hospital Civil de Guadalajara Dr.Juan I.MenchacaGuadalajaraMexico

The number of people with food allergy(FA)has increased in recent decades,as has the number of foods to which they are *** of FA prevalence vary widely,likely because of different definitions,evaluated foods and geo-graphic *** developed countries,overall preva-lence estimates range from 1.9%to 7.2%[1,2].In Latin America,the prevalence of FA in children is between 1.4%and 5.3%[3-6],with important age-based variations(from 1.9%in infants to 0.4%in preschoolers)[7].FA is a complex trait in which the interplay of genetic and environmental fac-tors results in disease ***-known factors that increase atopic susceptibility include sex[8,9],age[10],and socioeconomic status[11-13].Furthermore,the asso-ciation between family history of allergies and childhood FA has been consistently reported in recent ***,a maternal history of allergic disease appears to be more strongly associated with FA than paternal history of atopy[14].

关键词： prevalence allergy allergic

Cyber-applications as gateway to data-rich Digital Earth systems

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International Journal of Digital Earth 2014年第7期7卷 576-593页

作者： Javier morales Rolf A.de By Department of Geo-Information Processing Faculty of Geo-Information Science and Earth ObservationUniversity of TwenteEnschedethe Netherlands

The underlying vision of the Digital Earth(DE)calls for applications that can embed vast quantities of geo-referenced data and allow users to study and analyse of our *** the declaration of this vision in the late 90s,a significant number of DE data-sets have been created by the industry,governments,non-governmental organisations and *** overwhelming majority of the successful applications that use DE data-sets has its end-user applications running on the *** these applications are great tools,they remain inaccessible to the community as a *** this paper,we present a framework for the development of *** define an abstract architecture for cyber-applications based on the model-view-controller paradigm,which allows the dynamic inclusion of functional and data components into its execution engine at *** define the operational characteristics of *** also specify the interface of pluggable components to the ***,we demonstrate the appropriateness of the abstract architecture by means of a case study.

关键词： digital earth architecture cyber-application geobrowser design framework hardware independence

Design optimization of multilayer perceptron neural network by ant colony optimization applied to engine emissions data

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Science China(Technological Sciences) 2019年第6期62卷 1055-1064页

作者： MarTINEZ-morales Jose QUEJ-COSGAYA Hector LAGUNAS-JIMENEZ Jose PALACIOS-HERNANDEZ Elvia morales-SALDANA Jorge Faculty of Engineering Autonomous University of Campeche Campeche 24039 Mexico Faculty of Sciences Autonomous University of San Luis Potosi San Luis Potosi 78290 Mexico Faculty of Engineering Autonomous University of San Luis Potosi San Luis Potosi 78290 Mexico

A multilayer perceptron(MLP) artificial neural network(ANN) model has been optimized by the multi-objective ant colony optimization(MOACO) algorithm, which uses three objective functions. A sensitivity analysis to choose MOACO parameter values is carried out by calculating hypervolume metric, and the proposed approach adopts the Vlsekriterijumska Optimizacija I Kompromisno Resenje(VIKOR) decision method to choose final compromised solution on the Pareto front obtained from MOACO. As a result, we used the MLP-MOACO developed model to estimate the value of engine emissions of NOxin a four stroke, spark ignition(SI) gasoline engine and observed acceptable correlation coefficient(R^2) of 0.99978.

关键词： ant colony optimization multilayer perceptron artificial neural networks hypervolume engine emissions

Estimating prion concentration in fluids and tissues by quantitative PMCA

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Estimating prion concentration in fluids and tissues by quan...