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Serotonin syndrome controversies:A need for consensus

World Journal of Critical Care Medicine 2024年第2期13卷 150-158页

作者： Sanjay prakash Chetsi S Shah anurag prakash Department of Neurology Smt.B.K.Shah Medical Institute and Research CentreSumandeep VidyapeethVadodara 391760GujarātIndia Medicine Parul Institute of Medical Sciences and Research CentreParul University WaghodiaVadodara 391760India

Serotonin syndrome(SS)is a drug-induced clinical syndrome resulting from increased serotonergic activity in the central nervous *** more than seven decades have passed since the first description of SS,it is still an enigma in terms of terminology,clinical features,etiology,pathophysiology,diagnostic criteria,and therapeutic *** majority of SS cases have previously been reported by toxicology or psychiatry centers,particularly in people with mental ***,serotonergic medications are used for a variety of conditions other than mental *** properties have been discovered in several new drugs,including over-the-counter *** days,cases are reported in non-toxicology centers,such as perioperative settings,neurology clinics,cardiology settings,gynecology settings,and pediatric *** or poisonings of serotonergic agents constituted the majority of the cases observed in toxicology or psychiatry *** or poisoning of serotonergic drugs is uncommon in other clinical *** may develop SS at therapeutic ***,these patients may continue to use serotonergic medications even if they develop mild to moderate SS due to several ***,the clinical presentation(onset,severity,and clinical features)in such instances may not exactly match what toxicologists or psychiatrists observe in their respective *** produce considerable diversity in many aspects of ***,other experts discount these new developments in *** SS is a potentially lethal illness,consensus is required on several concerns related to SS.

关键词： Serotonin Serotonin syndrome Serotonin toxicity Selective serotonin reuptake inhibitors Antidepressants Cyproheptadine

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Structural, Optical, and Ferroelectric Behaviors of Cu_(1-x)Li_xO(0≤x≤0.09) Nanostructures

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Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 306-312页

作者： prakash Chand anurag Gaur Ashavani Kumar Department of Physics National Institute of Technology Kurukshetra

We report structural, optical, and ferroelectric behaviors of lithium-doped copper oxide （CU1-xLixO with x = 0.0, 0.05, 0.07, and 0.09） nanostructures synthesized by hydrothermal method. The XRD pattern indicates the pure phase formation of CuO without any impurity, and the crystallite size is found to be increases for x = 0-0.07 and decreases for x = 0.09. FESEM analysis shows that the average size of Cul xLixO nanostructures increases with the increasing the Li-doping concentrations up to 7% and then decreases for 9% Li doping concentration. Moreover, Raman and photoluminescence spectrum also confirm the phase formation of CuO. A significant reduction in optical band gap is observed up to x = 0.07, and then band gap increases for x ~ 0.09 due to segregation of the impurities on the surface or grain boundaries, which may suppress the grain growth and results the enhancement in optical band gap. Moreover, a weak ferroelectricity is observed in CuO nanostructures for pure and 9% Li doping through polarization versus electric field （P- E）.

关键词： CuO nanostructure Optical properties PL and Raman spectroscopy

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Comparative Analysis of Genetic Diversity among Cultivated Pigeonpea (Cajanus cajan(L) Millsp.) and Its Wild Relatives (C. albicansand C. lineatus) Using Randomly Amplified Polymorphic DNA (RAPD) and Inter Simple Sequence Repeat (ISSR) Fingerprinting

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American Journal of Plant Sciences 2014年第11期5卷 1665-1678页

作者： Kusum Yadav Sanjay Kumar Yadav anurag Yadav Veda prakash Pandey Upendra Nath Dwivedi Department of Biochemistry University of Lucknow Lucknow India Department of Microbiology Sardarkrushinagar Dantiwada Agricultural University Palanpur India

Genetic relationships of 16 cultivars of pigeonpea (Cajanus cajan (L) Millsp.) and its two wild relatives (C. albicans and C. lineatus) from different parts of the India were analysed using 22 random amplified polymorphic DNAs (RAPDs) primers and 10 inter simple sequence repeats (ISSRs) primers. Twenty two RAPD primers yielded 151 polymorphic markers (71.2%) with an average of 6.8 polymorphic band/primer. Cluster analysis based on these 151 RAPD markers revealed relatively low level (0.434 - 0.714) of genetic diversity among cultivars and high level of diversity between cultivars and wild relatives. Ten ISSR primers produced 100 bands across 16 cultivars and its wild relatives out of which 93 (93%) were polymorphic with an average of 9.3 polymorphic band/primer. Cluster analysis based on these 93 ISSR markers also revealed relatively higher level (0.328 - 0.827) of genetic diversity among cultivars as compared to RAPD markers. The polymorphic markers obtained by both RAPD and ISSR primers were pooled and the genetic diversity analysis based on these 244 markers was analysed. Jaccard’s similarity coefficient obtained by pooled data revealed very narrow range (0.477 - 0.720) among cultivated and high range between cultivated and wild species C. albicans (0.240 - 0.331) and C. lineatus (0.163 - 0.193). In the UPGMA based dendrogram the 16 cultivars were grouped into three distinct clusters. Cluster I contained two genotypes, cluster II had six and cluster III had eight genotypes. Principal components analysis (PCA) also resulted in similar pattern as that of UPGMA based analysis. The first three PCs contributed 56.26%, 5.71% and 4.97% of variation, respectively, with cumulative variation of the first three PCs was 66.96%. Both the markers and the combined data revealed similar pattern with narrow diversity among cultivars and higher diversity between cultivars and wild one, but the genetic diversity range obtained by ISSR markers was relatively higher as compared to RA

关键词： Genetic Diversity RAPD ISSR Pigeonpea

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Genetic Diversity of Pigeonpea (Cajanus cajan(L.) Millsp.) Cultivars and Its Wild Relatives Using Randomly Amplified Polymorphic DNA (RAPD) Markers

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American Journal of Plant Sciences 2012年第3期3卷 322-330页

作者： Kusum Yadav Sanjay Kumar Yadav anurag Yadav Veda prakash Pandey Upendra Nath Dwivedi Department of Biochemistry University of Lucknow Lucknow India Department of Microbiology College of Basic Science & Humanities Sardarkrushinagar Dantiwada Agricultural University Palanpur India

Genetic diversity among and between 16 cultivars of pigeonpea (Cajanus cajan (L) Millsp.) and its wild relatives (C. albicans and C. lineatus) analysed using RAPD. Twenty two random primers with an average of 71.2% polymorphism produced 151 polymorphic bands. Cluster analysis based on these 151 RAPD markers revealed relatively low level (0.434 - 0.714) of genetic diversity among cultivars and high level of diversity between cultivars and wild relatives. C. albicans and C. lineatus showed only 0.231 similarity with each other and C. albicans showed relatively higher similarity with C. cajan cultivars than that showed by C. lineatus. In dendrogram the 16 cultivars grouped into two distinct clusters comprising of seven and nine genotypes each while the wild species form out groups. Bootstrap analysis of the dendrogram was performed and resulted in significant bootstrap values. Principal components analysis (PCA) also revealed the similar results that of unweighted pair group method with arithmetic mean (UPGMA). The first, second and third PCs contributed 55.9%, 5.9%, and 5.6% of the variation, respectively, with cumulative variation of the first three PCs was 67.4%.

关键词： Genetic Diversity RAPD Pigeonpea

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