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Nano Research 2014年第2期7卷 219-227页

作者： Zachary Lingley Krishnamurthy Mahalingam Siyuan Lus Gail J. Brown anupam Madhukar Mork Family Department of Chemical Engineering and Materials Science University of Southern California Los Angeles California 90089 USA Air Force Research Laboratory Materials and Manufacturing Directorate Wright-Patterson Air Force Base Ohio 45433-7707 USA Department of Physics and Astronomy University of Southern California Los Angeles California 90089 USA

We report on a cross-sectional high resolution transmission electron microscope study of lead sulfide nanocrystal quantum dots （NCQDs） dispersed on electron-transparent silicon nanopillars that enables nearly atomically-resolved simultaneous imaging of the entire composite： the quantum dot, the interfacial region, and the silicon substrate. Considerable richness in the nanocrystal shape and orientation with respect to the substrate lattice is observed. The average NCQD-substrate separation is found to be significantly smaller than the length of the ligands on the NCQDs. Complementary photoluminescence measurements show that light emission from PbS NCQDs on silicon is effectively quenched which we attribute to intrinsic mechanisms of energy and charge transfer from PbS NCQDs to Si.

关键词： nanocrystal quantum dots semiconductor substrate interface atomic structure high resolutiontransmission electronmicroscopy energy and charge transfer solar cells

Adiponectin in male reproduction and infertility

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Asian pacific Journal of Reproduction 2019年第5期8卷 244-250页

作者： Sulagna Dutta Pallav Sengupta anupam Biswas Department of Oral Biology and Biomedical Sciences Faculty of DentistryMAHSA UniversityMalaysia Department of Physiology Faculty of Medicine and Biomedical SciencesMAHSA UniversityMalaysia

Adiponectin is an adipokine that has the highest plasma concentration among all other adipokines. It is a white adipose tissue secretion essential for the regulation of energy metabolism owing to its antiatherogenic insulin-resistance, and anti-inflammatory properties. Studies have put forth that adiponectin is a potent endocrine regulator with mechanisms relating energy balance with reproductive function in different species, including humans. The two adiponectin receptors, AdipoR1 and AdipoR2 have been found to be expressed in the prime regulatory axis of reproduction, the hypothalamic-pituitary-gonadal axis. The activation of adiponectin receptors has been shown to regulate the secretion and gene expressions of kisspeptin, gonadotropin-releasing hormone and gonadotropins. Adiponectin finds relevance in the regulations of most of the vital testicular functions, such as steroidogenesis, germ cell proliferation and their coordinated apoptosis, as well as in modulation of testicular redox status and oxidative stress. Since metabolic syndrome and their associations with male infertility have been gaining immense research interest, adiponectin seems to be one of the important mediators of metabolic syndrome-induced male reproductive dysfunctions. This article aims to review the patterns of adiponectin expression in the male reproductive tissues and the mechanism by which adiponectin modulates male reproductive functions.

关键词： Adiponectin Male fertility Semen quality

Anemia in cirrhosis:An underestimated entity

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World Journal of Clinical Cases 2022年第3期10卷 777-789页

作者： Manish Manrai Saurabh Dawra Rajan Kapoor Sharad srivastava anupam Singh Department of Internal Medicine Armed Forces Medical CollegePune 411040India Department of Medicine and Gastroenterology Command HospitalPune 411040India Department of Medicine Command HospitalKolkata 70027India Department of Gastroenterology Post Graduate Institute of Medical Education and ResearchChandigarh 160012India

Anemia in a patient with cirrhosis is a clinically pertinent but often overlooked clinical *** guidelines highlight the algorithmic approach of managing a patient of cirrhosis presenting with acute variceal hemorrhage but day-to-day management in hospital and out-patient raises multiple dilemmas:Whether anemia is a disease complication or a part of the disease spectrum?Should iron,folic acid,and vitamin B complex supplementation and nutritional advice,suffice in those who can perform tasks of daily living but have persistently low *** does one investigate and manage anemia due to multifactorial etiologies in the same patient:Acute or chronic blood loss because of portal hypertension and bone marrow aplasia secondary to hepatitis B or C viremia?To add to the clinician’s woes the prevalence of anemia increases with increasing disease *** thus aim to critically analyze the various pathophysiological mechanisms complicating anemia in a patient with cirrhosis with an emphasis on the diagnostic flowchart in such patients and proposed management protocols thereafter.

关键词： Anemia Cirrhosis Iron deficiency anemia Macrocytic anemia Normocytic anemia

Theoretical investigation on mechanical,thermal,and ultrasonic properties of epitaxial nanostructured ZrN layers growth on MgO(001)substrate

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ChemPhysMater 2023年第3期2卷 253-258页

作者： Aadesh Kumar Prajapati Sachin Rai Prashant srivastav Pramod Kumar Yadawa Department of Physics Prof.Rajendra Singh(Rajju Bhaiya)Institute of Physical Sciences for Study and ResearchV.B.S.Purvanchal UniversityJaunpur 222003India

In the present study,we calculated the elastic,mechanical,and thermo-physical properties of Zirconium Nitride(ZrN)/Magnesium Oxide(MgO)(001)nanostructures in the temperature range of 50∼300 K using higher-order elastic *** two fundamental factors,nearest-neighbor distance and hardness parameter,in this tem-perature range,the second-and third-order elastic constants(SOECs and TOECs)are estimated using the Coulomb&Born-Mayer *** computed values of SOECs have been used to calculate Young’s modulus,thermal conductivity,Zener anisotropy,bulk modulus,thermal energy density,shear modulus,and Poisson’s ratio to as-sess the thermal and mechanical properties of the ZrN/MgO(001)nanostructured ***,SOECs are used to calculate the wave velocities for shear as well as longitudinal modes of propagation along crystalline orientations,,andin these temperature *** temperature-dependent Debye average velocity,hardness,melting temperature,and ultrasonic Grüneisen parameters(UGPs)were *** frac-ture/toughness(B/G)ratio in the current investigation was greater than 1.75,indicating that the ZrN/MgO(001)nanostructured layer was ductile in this temperature *** selected materials fully satisfied the Born me-chanical stability *** this ambient temperature,it has been computed how long thermal relaxation takes to complete and how ultrasonic waves are attenuated by thermo-elastic relaxation and phonon-phonon interaction *** results,in combination with other well-known physical properties,can be applied to the non-destructive testing of materials for various industrial applications such as microelectronic devices,optical coatings,batteries,and solar cells.

关键词： Nanostructured layers Elastic properties Thermal conductivity Mechanical properties Ultrasonic properties

Mineralogical and Geochemical Evidence of Fluid-rock Interaction at the Shallow Crustal Level in Koyna Seismogenic Region, Maharashtra, India: Impact and Implications

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 40-43页

作者： Halder PIYAL Kumar Shukla MATSYENDRA Kumar KAMLESH Sharma anupam Birbal Sahni Institute of Palaeosciences(DST Govt.of India)LucknowU.P.India Govt.of India Ministry of Earth SciencesBorehole Geophysics Research LaboratoryKaradMaharashtraIndia

The Koyna region of Maharashtra located in the western part of the~65 Myr old Deccan traps province,overlying the Neoarchean cratonic granitoid basement of peninsular India,has been experiencing recurring seismicity s... 详细信息

关键词： Continental Deep Drilling Programme artificial reservoir triggered seismicity fluid-rock interaction shallow crustal level geophysical anomaly clay mineral hydrothermal alteration

Damming of River Indus during Late Quaternary in Ladakh Region of Trans-Himalaya, NW India: Implications to Lake formation-climate and tectonics

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科学通报 2013年第S1期58卷 142-155页

作者： PHARTIYAL Binita SHARMA anupam KOTHYARI Girish Ch Birbal Sahni Institute of Palaeobotany School of Earth and Environmental Sciences Central University of Himachal Pradesh Institute of Seismological Research

Indus river valley basin in Northwest Indian Himalaya is tectonically unstable, exhibiting a complex topography, landscape relief and varied Quaternary sedimentation. A 422 km transact along the Indus river valley from Nyoma to Batalik in Ladakh(Trans Himalayas) reveals the damming of the river four places and existence of four major palaeolakes in the Late Quaternary Period. The commencement and breeching of the palaeolake sequences and the seismites preserved therein mark of the tectonic pluses in the area but the contribution of climate cannot be ruled out. The major geomorphic landforms are alluvial fans, debris cones, unsorted pedestals, fluvio-lacustrine deposits, scree, talus cone etc. Ubiquitous mass movements and catastrophic land sliding, due to tectonic activity and abnormally high precipitation has transported the material from steep slopes to valley bottoms, was responsible of forming lakes(preserved as thick piles of fine sediment), while the outburst floods redistributed the sediment down valley. Chronologies of two lakes are available which reveal the presence of one during post LGM times around 17000 a BP which breached out prior to Older Dryas indicating of warmer and congenial rainfall and melt water supply between these two globally marked cold episode. Other lake was formed after the Younger Dryas and existed till ~1000 a BP indicative of the Holocene warming responsible for its sustenance.

关键词： Late Quaternary Holocene Trans Himalaya Indus Palaeolake deposits climate

Current and emerging therapeutic strategies in pancreatic cancer: Challenges and opportunities

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World Journal of Gastroenterology 2021年第39期27卷 6572-6589页

作者： Manish Manrai TVSVGK Tilak Saurabh Dawra Sharad srivastava anupam Singh Department of Internal Medicine Armed Forces Medical CollegePune 411040MaharashtraIndia Department of Internal Medicine Command HospitalPune 411040MaharashtraIndia Department of Gastroenterology Post Graduate Institute of Medical Education and ResearchChandigarh 160011India

Pancreatic carcinoma(PC)is one of the leading causes of cancer-related deaths *** early detection and advances in therapeutics,the prognosis remains *** outcome and therapeutic approach are dependent on the stage of PC at the time of *** standard of care is surgery,followed by adjuvant *** advent of newer drugs has changed the landscape of adjuvant ***,recent trials have highlighted the role of neoadjuvant therapy and chemoradiotherapy for resectable and borderline resectable *** we progress towards a better understanding of tumor biology,genetics,and microenvironment,novel therapeutic strategies and targeted agents are now on the *** have described the current and emerging therapeutic strategies in PC.

关键词： Resectable pancreatic carcinoma Borderline resectable pancreatic carcinoma Locally advanced pancreatic carcinoma Adjuvant therapy Neoadjuvant therapy Newer advances in pancreatic carcinoma

Autism Spectrum Disorder Prediction by an Explainable Deep Learning Approach

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Computers, Materials & Continua 2022年第4期71卷 1459-1471页

作者： anupam Garg Anshu Parashar Dipto Barman Sahil Jain Divya Singhal Mehedi Masud Mohamed Abouhawwash Computer Science and Engineering Department Thapar Institute of Engineering and TechnologyPatialaIndia School of Computer Science and Statistics Trinity College DublinDublinIreland University Institute of Biotechnology Chandigarh UniversityMohaliIndia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Department of Mathematics Faculty of ScienceMansoura UniversityMansoura35516Egypt Department of Computational Mathematics Scienceand Engineering(CMSE)Michigan State UniversityEast LansingMI48824USA

Autism Spectrum Disorder (ASD) is a developmental disorderwhose symptoms become noticeable in early years of the age though it canbe present in any age group. ASD is a mental disorder which affects the communicational, social and non-verbal behaviors. It cannot be cured completelybut can be reduced if detected early. An early diagnosis is hampered by thevariation and severity of ASD symptoms as well as having symptoms commonly seen in other mental disorders as well. Nowadays, with the emergenceof deep learning approaches in various fields, medical experts can be assistedin early diagnosis of ASD. It is very difficult for a practitioner to identifyand concentrate on the major feature’s leading to the accurate prediction ofthe ASD and this arises the need for having an automated approach. Also,presence of different symptoms of ASD traits amongst toddlers directs tothe creation of a large feature dataset. In this study, we propose a hybridapproach comprising of both, deep learning and Explainable Artificial Intelligence (XAI) to find the most contributing features for the early and preciseprediction of ASD. The proposed framework gives more accurate predictionalong with the recommendations of predicted results which will be a vital aidclinically for better and early prediction of ASD traits amongst toddlers.

关键词： Deep learning explainable artificial intelligence autism spectrum disorder machine learning

The phytochemical, biological, and medicinal attributes of phytoecdysteroids: An updated review

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1740-1766页

作者： Niranjan Das Siddhartha Kumar Mishra Anusha Bishayee Eunüs S.Ali anupam Bishayee Department of Chemistry Iswar Chandra Vidyasagar CollegeBelonia-799155TripuraIndia Cancer Biology Laboratory Department of ZoologySchool of Biological SciencesDr.Harisingh Gour Central UniversitySagar-470003Madhya PradeshIndia Pine View School OspreyFL 34229USA Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611USA Lake Erie College of Osteopathic Medicine BradentonFL 34211USA

The phytoecdysteroids(PEs)comprise a large group of biologically-active plant steroids,which have structures similar to those of insect-molting *** are distributed in plants as secondary metabolites that offer protection against phytophagus(plant-eating)*** insects consume the plants containing these chemicals,they promptly molt and undergo metabolic destruction;the insects eventually ***,ecdysteroids are a group of polyhydroxylated ketosteroids that are structurally similar to *** carbon skeleton of ecdysteroids is termed as cyclopentanoperhydro-phenanthrene with aβ-side chain at *** essential characteristics of ecdysteroids are a cis-(5β-H)junction of rings A and B,a 7-en-6-one chromophore,and a trans(14α-OH)junction of rings C and *** only synthesize PEs from mevalonic acid in the mevalonate pathway of the plant cell using acetyl-CoA as a precursor;the most common PE is *** far,over 400 PEs have been identified and reported,and a compilation of 166 PEs originating from 1998 has been previously *** the present review,we have summarized 212 new PEs reported between 1999 and *** have also critically analyzed the biological,pharmacological,and medicinal properties of PEs to understand the full impact of these phytoconstituents in health and disease.

关键词： Phytoecdysteroids Secondary metabolites Antioxidant Anti-inflammatory Antimicrobial Antidiabetic Anticancer activity

Apoptosis-inducing effects of extracts from desert plants in HepG2 human hepatocarcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2015年第2期5卷 87-92页

作者： Deepak Bhatia Animesh Mandal Eviatar Nevo anupam Bishayee Department of Pharmacogenomics Bernard J Dunn School of PharmacyShenandoah University Department of Pharmaceutical Sciences College of PharmacyNortheast Ohio Medical University Institute of Evolution and International Graduate Center of Evolution University of Haifa Department of Pharmaceutical and Biomedical Sciences College of PharmacyCalifornia Northstate University

Objective:To investigat the mechanism of antitumor efficacy of Origanum clayi(***) and Ochradenus baccatus(***) extracts by exploring apoptosis-inducing ***:The aqueous extracts of aerial parts of aforementioned plants were prepared and used for this ***2 cells were treated with varying concentrations(0,2 and 5 mg/mL)of each plant extract for 24 or 48 *** apoptosis was measured by annexin V-fluorescein isothiocyanate binding assay and flow *** expression levels of various apoptosisrelated genes were determined by semi-quantitative reverse transcription-polymerase chain ***:*** and *** extracts exerted apoptotic effects on HepG2 cells for 48 h following *** extract was found to be a better apoptosis-inducing agent than *** extract as the former delivered greater efficacy at a lower *** extracts manifested upregulation of Bax,*** ***-3,***-9 and poly(adenosine diphosphate-ribose) ***:The aqueous extracts of *** and *** are capable of inducing apoptosis in HepG2 cells through modulation of mitochondrial pathway which explains their antitumor *** desert plants may serve as useful resources to develop effective remedies for hepatocellular carcinoma and other human malignancies.

关键词： Ochradenus baccatus Origanum dayi HepG2 cells,Apoptosis Gene expression