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Surgical treatment of Lenke 5 adolescent idiopathic scoliosis: Comparison of anterior vs posterior approach

World Journal of Orthopedics 2016年第9期7卷 553-560页

作者： Mark F Abel anuj Singla Mark A Feger Lindsay D Sauer Wendy Novicoff Department of Orthopedic Surgery University of Virginia

AIM To compare the posterior vs anterior approaches for fusion of Lenke 5 adolescent idiopathic scoliosis curves,matched for curve magnitude and for the distal level of fixation(dLOF) standardized to the third lumbar vertebrae(L3).METHODS A prospectively collected multicenter database was used for this retrospective comparative study. Our dependent variables included sagittal and coronal radiographic measurements, number of fused vertebrae, estimated blood loss, length of hospitalization and SRS total and individual domain scores at the two-year follow-up. Subject demographics were similar for all group *** t-test was used to compare groups for all analyses at P < *** For all matched cases of Lenke 5 curves, a selective approach was used only 50% of the time in cases undergoing a posterior fusion. When comparing a posterior selective approach to an anterior selective approach,surgeons utilizing a posterior approach fused significantly more levels than surgeons using an anterior approach with no other significant differences in radiographic or SRS outcomes(Ant = 4.8 ± 1.0 levels vs post = 6.1 ± 1.0 levels, P < 0.0001). When the dLOF was standardized to L3, the anterior approached provided significantly greater lumbar Cobb percent correction than the posterior approach(Ant = 69.1% ± 12.6% vs post =54.6% ± 16.4%, P = 0.004), with no other significant radiographic or SRS score differences between *** Surgeons treating Lenke 5c curves with a posterior instrumentation and fusion vs an anterior approach include more motion segments, even with a selective fusion. When controlled for the distal level of fixation,the anterior approach provides greater correction of the thoracolumbar curve.

关键词： Instrumentation Thoracolumbar curve Selective fusion

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3-year Treatment of Tenofovir Alafenamide *** Disoproxil Fumarate for Chronic HBV Infection in China

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Journal of Clinical and Translational Hepatology 2021年第3期9卷 324-334页

作者： Jinlin Hou Qin Ning Zhongping Duan You Chen Qing Xie Fu-Sheng Wang Lunli Zhang Shanming Wu Hong Tang Jun Li Feng Lin Yongfeng Yang Guozhong Gong John FFlaherty anuj Gaggar Shuyuan Mo Cong Cheng Gregory Camus Chengwei Chen Yan Huang Jidong Jia Mingxiang Zhang GS-US-320-0110 and GS-US-320-0108 China Investigators Nanfang Hospital of Southern Medical University GuangzhouGuangdongChina Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Beijing YouAn Hospital Capital Medical UniversityBeijingChina Shanghai Ruijin Hospital Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing 302 Hospital BeijingChina The First Affiliated Hospital of Nanchang University NanchangJiangxiChina Shanghai Public Health Clinical Center ShanghaiChina West China Hospital Sichuan UniversityChengduSichuanChina The First Affiliated Hospital with Nanjing Medical University NanjingJiangsuChina Hainan General Hospital HaikouHainanChina Nanjing No.2 Hospital NanjingJiangsuChina The 2nd Xiangya Hospital Central South UniversityChangshaHunanChina Gilead Sciences Foster CityCAUSA Liver Disease Center of Naval 905 Hospital ShanghaiChina Xiangya Hospital Central South UniversityChangshaHunanChina Beijing Friendship Hospital Capital UniversityBeijingChina The Sixth People’s Hospital of Shenyang ShenyangLiaoningChina 不详

Background and Aims:Tenofovir alafenamide(TAF)has similar efficacy to tenofovir disoproxil fumarate(TDF)but with improved renal and bone safety in chronic hepatitis B patients studied outside of *** report 3-year results from two phase 3 studies with TAF in China(***:NCT02836249 and NCT02836236).Methods:Chinese hepatitis B e antigen(HBeAg)-positive and-negative chronic hepatitis B patients with viremia and elevated alanine aminotransferase were randomized 2:1 to TAF or TDF treatment groups and treated in a double-blind fashion for 144 weeks(3 years).Efficacy responses were assessed by individual study while safety was assessed by a pooled ***:Of the 334 patients(180 HBeAg-positive and 154 HBeAg-negative)randomized and treated,baseline characteristics were similar between *** overall mean age was 38 years and 73%were *** mean HBV DNA was 6.4 log10 IU/*** median alanine aminotransferase was 88 U/L,and 37%had a history of antiviral *** week 144,the proportion with HBV DNA<29 IU/mL was similar among the two groups,with TAF at 83%*** at 79%,and TAF at 93%*** at 92%for the HBeAg-positive and-negative patients,*** each study,higher proportions of TAF than TDF patients showed normalized alanine aminotransferase(via the American Association for the Study of Liver Diseases and the China criteria)and showed loss of HBsAg;meanwhile,the HBeAg seroconversion rates were *** was well-tolerated among the TAF patients,who showed a smaller median decline in creatinine clearance(−0.4 vs.−3.2 mL/min;p=0.014)and less percentage change in bone mineral density *** at hip(−0.95%vs.−1.93%)and spine(+0.35%vs.−1.40%).Conclusions:In chronic hepatitis B patients from China,TAF treatment provided efficacy similar to TDF but with better renal and bone safety at 3 years.

关键词： Chronic hepatitis B virus Antiviral therapy Bone safety Renal safety

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2-15 Thermonuclear Reaction Rates in rp Process of 64Ge(p,γ)65As and 65As(p,γ)66Se for Type-I X-ray Bursts

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IMP & HIRFL Annual Report 2014年第1期 48-49页

作者： Lam Yihua He Jianjun Parikh anuj 不详 Departament de F待sica i Enginyeria Nuclear Universitat Politecnica de Catalunya (EUETIB) E-08036 Barcelona Spain

We have derived new thermonuclear 64Ge(p, )65As and 65As(p, )66Se reaction rates based on recently evaluatedproton separation energies[1] and large-scale shell model (LSSM) calculation. The precisely measured or evaluatedproton separation energies of Sp(65As) and Sp(66Se), are (90±85) keV and (1720±310) keV, respectively. Weutilized one-zone post-processing type I X-ray burst model[2] to investigate the astrophysical impact of our newrates. We found that the new experimental Sp(65As), resonant energies and spectroscopic factors estimated fromLSSM significantly affects the productions of nuclide in the range of 64≤A≤110 about one to ten times comparedto currently available JINA data sets, REACLIB[3].

关键词： X-ray experimental impact range times sets our

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Improvements in Weather Forecasting Technique Using Cognitive Internet of Things

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Computer Systems Science & Engineering 2023年第9期46卷 3767-3782页

作者： Kaushlendra Yadav anuj Singh Arvind Kumar Tiwari KNIT Sultanpur Sultanpur228118India

Forecasting the weather is a challenging task for human beings because of the unpredictable nature of the ***,effective forecasting is vital for the general growth of a country due to the significance of weather forecasting in science and *** primary motivation behind this work is to achieve a higher level of forecasting accuracy to avoid any ***,most weather forecasting work is based on initially observed numerical weather data that cannot fully cover the changing essence of the *** this work,sensors are used to collect real-time data for a particular location to capture the varying nature of the *** solution can give the anticipated results with the least amount of human engagement by combining human intelligence and machine learning with the help of the cognitive Internet of *** Authors identified weatherrelated parameters such as temperature,humidity,wind speed,and rainfall and then applied cognitive data collection methods to train and validate their *** addition,the Authors have examined the efficacy of various machine learning algorithms by using them on both data sets i.e.,pre-recorded metrological data sets and live sensor data sets collected from multiple *** Authors noticed that the results were superior on the sensor *** Authors developed ensemble learning model using stacked method that achieved 99.25%accuracy,99%recall,99%precision,and 99%F1-score for Sensor *** also achieved 85%accuracy,86%recall,85%precision,and 86%F1 score for Australian rainfall data.

关键词： Internet of Things machine learning weather forecast cognitive computing predictors

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Mortality of critical care interventions in the COVID-19:A systematic review

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World Journal of Meta-Analysis 2021年第1期9卷 64-73页

作者： Joshua Davis Rebecca Leff anuj Patel Sriram Venkatesan Department of Emergency Medicine VituityWichitaKS 67214United States School of Medicine Faculty of Health SciencesBen-Gurion University of the NegevBeer-Sheva 8414501Israel College of Osteopathic Medicine University of New EnglandBiddefordME 04005United States College of Medicine Sri Ramachandra Medical College and Research InstituteChennai 600116India

BACKGROUND The novel coronavirus severe acute respiratory syndrome coronavirus 2 is associated with a severe disease known as coronavirus disease 2019(COVID-19).A small percentage of patients with COVID-19 will require intensive care and possibly mechanical *** mortality of intensive care interventions in patients with COVID-19 remains *** To identify mortality rate of COVID-19 patients receiving different interventions in the critical care *** We searched OVID Medline,SCOPUS,MedRxIv,***,and Centers for Disease Control databases from November 2019 to April 10,2020 for articles on *** of 2 independent reviewers reviewed titles and abstract for studies that reported mortality of human adults with COVID-19 and exposure to a critical care intervention[Intensive care admission,mechanical ventilation,acute hemodialysis,extracorporeal membrane oxygenation,or cardiopulmonary resuscitation(CPR)].We used a descriptive analysis and unweighted averages of mortality across *** Our search identified 6973 articles and 20 met inclusion:17 for intensive care,13 for mechanical ventilation,5 for hemodialysis,2 for extracorporeal membrane oxygenation,and 1 for *** associated with intensive care admission ranged from 9%-83%,with overall mortality 32.5%(95%CI:32.4%-32.6%).Mortality associated with intubation from 16.7%-100%with overall mortality 64.0%(95%CI:62.4%-65.5%).In patients requiring hemodialysis,mortality ranged from 0%-100%,with average mortality 75.3%(95%CI:72.6%-77.4%).CONCLUSION Patients with COVID-19 requiring intensive care have high mortality *** can use this data to establish pharmacoeconomic studies to make decisions about allocation of scarce resources if necessary.

关键词： Coronavirus SARS-CoV-2 COVID-19 Mortality Systematic review Critical care

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肝脏移植术后合并慢性肾脏疾病的患者在接受丙酚替诺福韦HBV预防治疗1年时的安全性和疗效

肝脏移植术后合并慢性肾脏疾病的患者在接受丙酚替诺福韦HBV预防...

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第十届全国疑难及重症肝病大会

作者： Edward J Gane Bibin George Dominic Ray-Chaudhuri Thomas Mules Vithika Suri Hongyuan Wang John F.Flaherty anuj Gaggar New Zealand Liver Transplant Unit Auckland City Hospital Gilead Sciences Inc

背景对于肝脏移植术后的患者,推荐的预防HBV感染复发的抗病毒预防疗法包括长期TDF治疗。然而,由于移植前终末期肝病的情况以及移植后钙调磷酸酶抑制剂和皮质类固醇的共同用药原因,该人群的累积骨骼和肾脏毒性的风险会升高。之前已证明...

背景对于肝脏移植术后的患者,推荐的预防HBV感染复发的抗病毒预防疗法包括长期TDF治疗。然而,由于移植前终末期肝病的情况以及移植后钙调磷酸酶抑制剂和皮质类固醇的共同用药原因,该人群的累积骨骼和肾脏毒性的风险会升高。之前已证明该风险人群使用TAF治疗24周与TDF相似,而且具有骨骼和肾脏参数改善的趋势。本研究是对比肝脏移植术后患者接受48周TAF与TDF

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未发现中国慢性乙型肝炎患者在96周丙酚替诺福韦(TAF)治疗期间出现耐药性

未发现中国慢性乙型肝炎患者在96周丙酚替诺福韦(TAF)治疗期间出...

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第十届全国疑难及重症肝病大会

作者： Jinlin Hou Zhongping Duan Yu Chen Yang Liu Bandita Parhy Gregory Camus Becket Feierbach Hongmei Mo John F Flaherty anuj Gaggar Hong Tang Qing Xie Qin Ning Nanfang Hospital Southern Medical University Beijing YouAn Hospital Capital Medical University Gilead Sciences West China Hospital Sichuan University Shanghai Ruijin Hospital Shanghai Jiao Tong University Tongji Hospital Tongji Medical University

介绍在2项3期研究GS-US-320-0108和GS-US-320-0110中,在第48周和第96周TAF表现出不劣于TDF的疗效。目的在参与有关96周TAF治疗的2项中国3期研究的慢性HBV患者中,进行病毒耐药监测。方法:对于治疗持续时间≥24周,在第96周时出现病毒学突...

介绍在2项3期研究GS-US-320-0108和GS-US-320-0110中,在第48周和第96周TAF表现出不劣于TDF的疗效。目的在参与有关96周TAF治疗的2项中国3期研究的慢性HBV患者中,进行病毒耐药监测。方法:对于治疗持续时间≥24周,在第96周时出现病毒学突破或提前终止治疗时HBV

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从富马酸替诺福韦二吡呋酯(TDF)转换为磷丙替诺福韦(TAF)后骨骼和肾脏安全性改善:两项对HBeAg阳性和HBeAg阴性的慢性乙型肝炎(CHB)患者的3期研究的初步结果

从富马酸替诺福韦二吡呋酯(TDF)转换为磷丙替诺福韦(TAF)后骨骼和...

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第九届全国疑难及重症肝病大会

作者： Henry L.Chan Scott Fung Wai Kay Seto Ed Gane John F.Flaherty Vithika Suri Lanjia Lin anuj Gaggar G Mani Subramanian Wan Long Chuang Kosh Agarwal Harry L.Janssen Maria Buti The Chinese University of Hong Kong Toronto General Hospital Queen Mary Hospital Hong Kong Kaohsiung Medical University Hospital Kings College Hospital Toronto Western Hospital Erasmus Medical Center

背景和目的:两项大型多中心3期研究中,在48周治疗后,相比于TDF,TAF治疗对骨骼和肾脏的影响更小,且疗效率相似。本文档评估了完成96周双盲TAF或TDF治疗且换为开放性标签TAF治疗的患者,以确定骨密度、肌酐清除率的变化以及病毒抑制的维持...

背景和目的:两项大型多中心3期研究中,在48周治疗后,相比于TDF,TAF治疗对骨骼和肾脏的影响更小,且疗效率相似。本文档评估了完成96周双盲TAF或TDF治疗且换为开放性标签TAF治疗的患者,以确定骨密度、肌酐清除率的变化以及病毒抑制的维持情况。方法:两项设计相同的3期研究中,HBeAg阴性(GS-US-320-0108;N=425)或HBeAg阳性

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讨论：β受体阻滞剂（普萘洛尔）治疗复杂的面部血管瘤

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中国美容整形外科杂志 2012年第3期23卷 I0017-I0017页

作者： anuj Mishra William Holmes Catherine Gorst Sehwang Liew 魏峰高景恒张晨英国利物浦奥尔赫尔儿童医院血管胎记治疗中心《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

我们带着兴趣读完了《β受体阻滞剂（普萘洛尔）疗法治疗复杂的面部血管瘤》。最近，我们采用普萘洛尔疗法作为首选治疗方式，治疗了31例患儿快速增生的血管瘤。我们同样先行心血管检查，然后开始行普萘洛尔治疗，每天给药3mg／kg。所... 详细信息

我们带着兴趣读完了《β受体阻滞剂（普萘洛尔）疗法治疗复杂的面部血管瘤》。最近，我们采用普萘洛尔疗法作为首选治疗方式，治疗了31例患儿快速增生的血管瘤。我们同样先行心血管检查，然后开始行普萘洛尔治疗，每天给药3mg／kg。所有血管瘤（100％）立刻停止增生，87％明显消退。治疗耐受性良好，基本无不良反应。

关键词：面部血管瘤 β受体阻滞剂治疗方式普萘洛尔心血管检查治疗耐受性不良反应疗法

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慢性乙型肝炎患者144周治疗期间未发现丙酚替诺福韦耐药

慢性乙型肝炎患者144周治疗期间未发现丙酚替诺福韦耐药

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第十届全国疑难及重症肝病大会

作者： Henry Lik-Yuen Chan Patrick Marcellin Calvin Q.Pan Andrea L Cathcart Neeru Bhardwaj Yang Liu Bandta Parhy Eric Zhou David Hsieh Silvia Chang Ross Martin Becket Feierbach Hongmei Mo anuj Gaggar John F Flaherty Shalimar Namiki Izumi Young-Suk Lim The Chinese University of Hong Kong

背景在2项评价丙酚替诺福韦(TAF)或富马酸替诺福韦二吡呋酯(TDF)用于HBeAg+或HBeAg-慢性乙型肝炎初治或经治成人患者时的3期临床研究(GS-US-320-0108,GS-US-320-0110)中进行了累积耐药性分析。方法患者按照2:1的比例进行随机分组,并按照...

背景在2项评价丙酚替诺福韦(TAF)或富马酸替诺福韦二吡呋酯(TDF)用于HBeAg+或HBeAg-慢性乙型肝炎初治或经治成人患者时的3期临床研究(GS-US-320-0108,GS-US-320-0110)中进行了累积耐药性分析。方法患者按照2:1的比例进行随机分组,并按照HBV DNA水平和治疗状态进行分层接受TAF

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