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Intelligent Approach for Clustering Mutations’ Nature of COVID-19 Genome

Computers, Materials & Continua 2022年第9期72卷 4453-4466页

作者： Ankur Dumka Parag Verma Rajesh Singh anuj bhardwaj Khalid Alsubhi Divya Anand Irene Delgado Noya Silvia Aparicio Obregon Computer Science and Engineering Women Institute of TechnologyUttarakhand248007India Chitkara University Institute of Engineering and Technology Chitkara University PunjabPunjab140401India Division of Innovation&Entrepreneurship Lovely Professional UniversityPunjab144411India Computer Science and Engineering Chandigarh UniversityPunjab140413India Faculty of Computing and Information Technology King Abdulaziz UniversityJeddah37848Saudi Arabia Computer Science and Engineering Lovely Professional UniversityPunjab144411India Higher Polytechnic School Universidad Europea del AtlánticoSantander39011Spain Universidad Internacional Iberoamericana Campeche24560MexicoC.P Universidade Internacional do Cuanza Bairro Kaluanda BiéAngola

In December 2019,a group of people in Wuhan city of Hubei province of China were found to be affected by an infection called dark etiology *** outbreak of this pneumonia infection was declared a deadly disease by the China Center for Disease Control and Prevention on January 9,2020,named Novel Coronavirus 2019(nCoV-2019).This nCoV-2019 is now known as *** is a big list of infections of this coronavirus which is present in the form of a big *** virus can cause several diseases that usually develop with a serious *** to the World Health Organization(WHO),2019-nCoV has been placed as the modern generation of Severe Acute Respiratory Syndrome(SARS)and Middle East Respiratory Syndrome(MERS)coronaviruses,so COVID-19 can repeatedly change its internal genome structure to extend its *** and accurately predicting the mutational properties of the genome structure of COVID-19 can form a good leadership role in preventing and fighting against *** this research paper,an analytical approach has been presented which is based on the k-means cluster technique of machine learning to find the clusters over the mutational properties of the COVID-19 viruses’complete *** method would be able to act as a promising tool to monitor and track pathogenic infections in their stable and local genetics/hereditary *** paper identifies five main clusters of mutations with k=5 as best in most cases in the coronavirus that could help scientists and researchers develop disease control vaccines for the transformation of coronaviruses.

关键词： nCoV-2019 SARS-CoV-2 COVID-19 genome structure etiology COVID-19 mutations COVID-19 genomes

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Wavelet Optimized Adaptive Mesh for MHD Flow Problems

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Applied Mathematics 2012年第2期3卷 127-134页

作者： Bani Singh anuj bhardwaj Rashid Ali Department of Mathematics Vishveshwarya Institute of Engineering & Technology G. B. Nagar India Jaypee Institute of Information Technology Noida India

There are many problems in science and engineering where the solution shows a boundary layer character. Near the boundary the gradient is large in contrast with the smooth behaviour in the central core. A uniform grid is, therefore, not suitable for a numerical solution. MHD flow problems belong to this category where a velocity and induced magnetic field profiles get flattened in a transverse flow. In the present paper an optimized grid has been generated using interpo-lating wavelets. The results are compared with those obtained using uniform grid, the finite element method and also from the analytical solution.

关键词： MHD Flow Interpolating Wavelet Adaptive Mesh

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Non-Contact Ultrasound for Composites Inspection

Non-Contact Ultrasound for Composites Inspection

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2017远东无损检测新技术论坛

作者： anuj bhardwaj Konstantine FETFATSIDIS Kashyap PATEL The Ultran Group Inc. State College Aurora Flight Sciences

Uncured and continuously produced materials often cannot afford exposure to testing device via contact or be immersed in liquid *** makes conventional contact and immersion ultrasound（UT）poorly suited for ***,UT is highly desirable for inspection of uncured composite materials as amplitude and time of flight measurements often reveal vital material *** in non-contact ultrasound（NCU）now allow efficiency comparable to conventional ultrasound for certain *** at frequencies from 30 k Hz to 5 MHz,NCU can be used to relate signal measurements directly to material properties in materials such as fiber-based composite prepreg and most cured and uncured composites.A safe and non-destructive measurement process of relatively low cost,non-contact ultrasound presents opportunities to lower cost,reduce and identify waste,and improve production *** relationships exist between ultrasonic amplitude in non-contact through transmission and key material properties such as porosity,delamination,and homogeneity in *** converting amplitude and velocity measurements into material property values through characterization formulas（*** of impregnation=[ultrasonic amplitude*x]+y）,one can apply standard methods of manufacturing process control to hold production processes within desired control limits with real-time *** such measurements to webline material positions allows direct identification of sections of undesirable material,reducing waste and improving manufacturing yields by avoiding unnecessary disposal of uninspected *** multiple points of measurement（multiple channels）in the cross-web direction allows for up to 100%inspection and high accuracy of spatial identification on finished products.

关键词： Non-Contact Ultrasound composites inspection prepreg in-line inspection

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Multi-omics:Powerful accelerator for uncovering plant specialized metabolic pathways:The case of leonurine

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Molecular Plant 2024年第1期17卷 13-15页

作者： Priyanka Gupta anuj Sharma Dinesh A.Nagegowda Molecular Plant Biology and Biotechnology Lab CSIR-Central Institute of Medicinal and Aromatic PlantsResearch CentreBengaluru 560065India Academy of Scientific and Innovative Research Ghaziabad 201002India

As sessile organisms,plants employ a unique adaptive strategy to survive harsh terrestrial environments and defend against or interact with coevolving animals and *** strategy involves expanding their metabolic systems,resulting in the production of plant specialized metabolites(PSMs)or natural ***,PSMs constitute a highly diverse group of compounds based on their common core structure,comprising terpenoids,phenylpropanoids,benzenoids,alkaloids and nitrogen-containing compounds,glucosinolates,indoles and sulfur-containing indole compounds,phenolics,and fatty acid derivatives(Garagounis et al.,2021).

关键词： expanding alkaloids sulfur

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高速火焰喷涂VC-CuNiCr涂层的耐腐蚀性能

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Journal of Central South University 2024年第5期31卷 1385-1397页

作者： SINGH Vikrant BANSAL anuj SINGLA Anil Kumar KUMAR Vijay Sant Longowal Institute of Engineering and Technology Longowal Sangrur 148106India Industrial and Production Engineering Department Dr B R Ambedkar National Institute of TechnologyJalandhar 144011India

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS... 详细信息

本研究采用高速火焰喷涂(HVOF)沉积技术,将碳化钒(VC)和铜镍铬(CuNiCr)复合涂层应用于SS316不锈钢上,以解决不锈钢在海洋环境中的腐蚀问题。在室温环境下,在3.5%氯化钠溶液中进行电化学腐蚀,通过扫描电子显微镜(SEM)和能量色散光谱(EDS)对有涂层和未覆涂层样品的表面形貌进行检测。结果表明,涂层内由铜(Cu)、镍(Ni)和铬(Cr)组成的金属间黏合剂在氯化钠介质的影响下发生变质,从而导致出现衬底间的局部点蚀现象。有趣的是,在涂层配方中加入碳化钒(VC)显著地增强了表面的耐腐蚀性能,从而阻止了密闭腐蚀凹坑的出现。在不同类的涂层中,加入VC的效果最好,最小的腐蚀速率为72.38×10^(-3)mm/a,相比之下,SS316基底的腐蚀速率最快。

关键词：高速火焰喷涂碳化钒铜镍铬电化学腐蚀氯化钠溶液

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Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek Kumar anuj Verma Riddhi Singh Priyanshi Garg Santosh Kumar Sharma Himanshu Narayan Singh Santosh Kumar Mishra Sanjay Kumar Department of Allied Medical Sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

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Smart tailoring of molecular catalysts:Mounting approach to oxygen reduction reaction

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Journal of Materials Science & Technology 2024年第1期168卷 169-184页

作者： anuj Kumar Mohd Ubaidullah Guoxin Zhang Jasvinder Kaur Saira Ajmal Mudassir Hasan Krishna Kumar Yadav Hafiz M.Adeel Sharif Ram K.Gupta Ghulam Yasin Nano-Technology Research Laboratory Department of ChemistryGLA UniversityMathuraUttar Pradesh 281406India Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Electrical Engineering and Automation Shandong University of Science and TechnologyQingdaoShandong 266590China Institute for Advanced Study Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry Kansas Polymer Research CenterPittsburg State UniversityPittsburgKS 66762United States Faculty of Science and Technology Madhyanchal Professional UniversityRatibadBhopal 462044India Environmental and Atmospheric Sciences Research Group Scientific Research CenterAl-Ayen UniversityThi-QarNasiriyah 64001Iraq Department of Chemical Engineering King Khalid University Saudi Arabia Department of Chemistry School of SciencesIFTM UniversityMoradabadUttar Pradesh 244102India Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan 523808China School of Environment and Civil Engineering Dongguan University of TechnologyDongguanGuangdong 523808China

Efficient electrocatalytic rupture of energy-rich molecules(H_(2)and O_(2))is a green approach for gener-ating clean energy for modern *** this context,porphyry-type molecular electrocatalysts act intelligently toward oxygen reduction reaction(ORR),a fundamental process in fuel cells,due to their redox-rich chemistry,which involves core metal ions and macrocyclic *** concerned scientific community has tried many times to correlate the ORR intermediates with their formation kinetics and simplify the associated multi H+/e-stages during the ORR process,constructing several volcano plots be-tween catalytic Tafel data,turnover frequencies,and overpotentials for many *** the fact that many review articles on molecular electrocatalysts for ORR have been published,understanding the strategic implications and molecular catalyst intelligence towards homogenous ORR has been poorly *** review examined the relationships between volcano plots of current *** parameters and the Sabatier principle in order to explain the intelligence of molecular electrocatalysts and approaches for their creation,as well as the difficulties and potential prospects of molecular *** facts distinguish this review from previously published articles and will pique the scien-tific community’s interest in avoiding trial-and-error procedures for catalyst creation while also allowing for more exact evaluations of the molecular catalyst’s performance.

关键词： Electrocatalysis Molecular catalysts Oxygen reduction reaction Sabatier principle

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Overlap in oncogenic and pro-inflammatory pathways associated with areca nut and nicotine exposure

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Cancer Pathogenesis and Therapy 2024年第3期2卷 187-194页

作者： Krati Garg anuj Kumar Vidisha Kizhakkethil Pramod Kumar Shalini Singh Department of Biochemical Engineering and Biotechnology Indian Institute of Technology(IIT)DelhiDelhi 110016India Division of Molecular Biology ICMR-National Institute of Cancer Prevention and Research(ICMR-NICPR)Indian Council of Medical ResearchNoidaUttar Pradesh 201301India Department of Biotechnology Vellore Institute of Technology(VIT)VelloreTamil Nadu 632024India ICMR-National Institute of Cancer Prevention&Research(ICMR-NICPR) Indian Council of Medical ResearchNoidaUttar Pradesh 201301India

Background:Betel nut/areca nut/Areca catechu is one of the most commonly used psychoactive substance,and is also a major preventable cause of *** other psychoactive substances,such as nicotine,the mechanisms underlying addiction to areca nuts and related oncogenesis remain *** reports suggest a possible overlap in the mechanisms of action of nicotine and areca nuts in the human ***,this study aimed to investigate the interactome of human proteins associated with areca nut exposure and the intricate similarities and differences in the effects of the two psychoactive substances on ***:A list of proteins associated with areca nut use was obtained from the available literature using terms from Medical Subject Headings(MeSH).Protein-protein interaction(PPI)networks and functional enrichment were *** results obtained for both psychoactive substances were ***:Given the limited number of common proteins(36/226,16%)in the two sets,a substantial overlap(612/1176 nodes,52%)was observed in the PPI networks,as well as in Gene *** nuts mainly affect signaling pathways through three hub proteins(alpha serine/threonine-protein kinase,tumor protein 53,and interleukin-6),which are common to both psychoactive substances,as well as two unique hub proteins(epidermal growth factor receptor and master regulator of cell cycle entry and proliferative metabolism).Areca nut-related proteins are associated with unique pathways,such as extracellular matrix organization,lipid storage,and metabolism,which are not found in nicotine-associated ***:Areca nuts affect regulatory mechanisms,leading to systemic toxicity and *** nuts also affect unique pathways that can be studied as potential markers of exposure,as well as targets for anticancer therapeutic agents.

关键词： Cancer Areca nut Nicotine Interactome Cell signaling

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Exploring the Potential of Syzygium cumini(L.)Skeels(Jamun)Seed Powder as an Eco-Friendly Agent for Developing Friction Ridges on Porous and Nonporous Surfaces

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Journal of Forensic Science and Medicine 2024年第2期10卷 75-83页

作者： Vaibhav Sharma Abhishek R.Rai Divyansh Jain Poonam Kumari Varad Nagar Anubhav Singh Kumud Kant Awasthi Archana Gautam Tina Sharma Mahipal Singh Sankhla anuj Sharma Department of Forensic Science Vivekananda Global UniversityJaipurRajasthanIndia School of Forensics Risk Management and National SecurityRashtriya Raksha UniversityLavadGujaratIndia Department of Life Sciences Vivekananda Global UniversityJaipurRajasthanIndia Department of Forensic Science UIAHSChandigarh UniversityMohaliPunjabIndia University Centre for Research and Development Chandigarh UniversityMohaliPunjabIndia Department of Forensic Science ITM UniversityGwaliorM.P.India

Background:Development of obscured fingerprints on a diverse range of surfaces is a crucial aspect of forensic *** and Objectives:In this particular study,the utilization of Syzygium cumini(L.)Skeels(Jamun)seed powder was examined for the purpose of revealing hidden fingerprints on a variety of surfaces,including both permeable and impermeable *** and Methods:The seed powder was extracted using a simple process and was analysed using multiple analytical *** efficacy of the jamun seed powder in developing latent fingerprints was ***:The findings of this investigation demonstrate that the jamun seed powder was capable of producing fingerprint patterns of exceptional quality and clarity on numerous ***:This research highlights the potential use of jamun seed powder as a practical and effective alternative for the development of hidden fingerprints in forensic investigations,while also providing cost-effectiveness.

关键词： Forensic investigation jamun seed latent fingerprints medicinal value

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A Case Report: Emergency Management of a Pregnant Trauma Patient—An Anesthesiologist’s Perspective and Role

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Open Journal of Anesthesiology 2024年第2期14卷 25-39页

作者： Kalpana Tyagaraj Candice Ibarra Kimberly Moy Nina Luksanapol Gianna Torre Raymond Powers anuj Bapodra Maimonides Medical Center New York USA

Trauma is the leading cause of death for all women of childbearing age. Motor vehicle accidents account for almost two-thirds of all maternal non-obstetric, trauma-related deaths, while falls and domestic violence comprise a large percentage of the rest. The leading causes of obstetric trauma are motor vehicle accidents, falls, assaults, and gunshots, and ensuing injuries are classified as blunt abdominal trauma, pelvic fractures, or penetrating trauma . The causes are different with different life styles and different socio-economic and cultural background. Pregnant trauma victims tend to be younger, less severely injured, and more likely African American or of Hispanic descent compared with nonpregnant victims of trauma. Drugs and alcohol are a factor in about 20 percent of maternal trauma. With pregnancy comes the challenge and responsibility of caring for two patients at once, the mother and the fetus. In general, providing optimal maternal care is the best strategy to optimize fetal survival. Decision-making including the condition of the mother, gestational age, status of the fetus, and interventions are based on these key factors. Many providers are involved in the care of the pregnant patient: at the trauma scene, in the emergency department, and in the operating room. The anesthesiologist plays a key role in the care and management of the pregnant trauma patient. All anesthesiologists have ample training in obstetric anesthesia during their residency and frequently cover obstetric units in hospitals where pregnant patients are cared for. On the other hand, most nonobstetric physicians have little obstetric exposure and may be uncomfortable caring for the pregnant patient because of unfamiliarity with the physiologic changes of pregnancy or the evaluation of fetal well-being. This is not only a source of stress for other trauma providers, but can put maternal well-being at risk. Non-obstetric physicians may hesitate to order necessary diagnostic and therapeu

关键词： Obstetric Anesthesiology Ob Trauma Maternal and Fetal Resuscitation

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