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Degradation Pathway for Pitavastatin Calcium by Validated Stability Indicating UPLC Method

American Journal of Analytical Chemistry 2010年第2期1卷 83-90页

作者： antony raj Gomas Pannala Raghu Ram Nimmakayala Srinivas Jadi Sriramulu 不详

Degradation pathway for pitavastatin calcium is established as per ICH recommendations by validated and stability indicating reverse phase liquid chromatographic method. Pitavastatin is subjected to stress conditions of acid, base, oxidation, thermal and photolysis. Significant degradation is observed in acid and base stress conditions. Four impurities are studied among which impurity-4 is found prominent degradant. The stress samples are assayed against a qualified reference standard and the mass balance is found close to 99.5%. Efficient chromatographic separation is achieved on a BEH C18 stationary phase with simple mobile phase combination delivered in gradient mode and quantification is carried at 245 nm at a flow rate of 0.3 mL min-1. In the developed UPLC method the resolution between pitavastatin calcium and four potential impurities is found to be greater than 4.0. Regression analysis shows an r value (correlation coefficient) of greater than 0.998 for pitavastatin calcium and four potential impurities. This method is capable to detect the impurities of pitavastatin calcium at a level of 0.006% with respect to test concentration of 0.10 mg/mL for a 2-μL injection volume. The developed UPLC method is validated with respect to specificity, linearity & range, accuracy, precision and robustness for impurities determination and assay determination.

关键词： Column Liquid Chromatography Pitavastatin Calcium Forced Degradation Validation Stability Indicating

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Performance analysis of thermal storage unit with possible nano enhanced phase change material in building cooling applications

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储能科学与技术 2013年第2期2卷 91-102页

作者： Solomon G Ravikumar Ravikumar T S raj V antony Aroul Velraj R Department of Mechanical Engineering Hindustan Institute of Technology and Science Department of Mechanical Engineering Easwari Engineering College Institute for Energy Studies Anna University

The heat transfer performance of the phase change materials used in free cooling and air conditioning applications is low,due to the poor thermal conductivity of the *** recent phenomenal advancement in nano technology provides an opportunity for an appreciable enhancement in the thermal conductivity of the phase change *** order to explore the possibilities of using nano technology for various applications,a detailed parametric study is carried out,to analyse the heat transfer enhancement potential with the thermal conductivity of the conventional phase change materials and nano enhanced phase change materials under various flow conditions of the heat transfer ***,the theoretical equation,used to determine the time for outward cylindrical solidification of the phase change material,is validated with the experimental *** is inferred from the parametric studies,that for paraffinic phase change materials with air as the heat transfer fluid,the first step should be to increase the heat transfer coefficient to the maximum extent,before making any attempt to increase the thermal conductivity of the phase change materials,with the addition of nano *** water is used as the phase change material,the addition of nano particles is recommended to achieve better heat transfer,when a liquid is used as the heat transfer fluid.

关键词： thermal storage phase change material nano particle solidification time building cooling doi.3969/j.issn.2095-4239.2013.02.002 CLC number:TK 51 Document code:A Article ID-4239(2013)02-091-12

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A geo-spatial database about the eco-environment and its key issues in South Asia

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Big Earth Data 2018年第3期2卷 298-319页

作者： Ainong Li Wei Deng Wei Zhao Bintao Liu Jianqiang Zhang Bo Kong Xi Nan Jinhu Bian Hriday Lal Koirala Hammad Gilani Vishwambhar Prasad Sati Pattiyage I.A.gomes Narendra raj Khanal Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengduChina Branch of Mountain Sciences Kathmandu Center for Research and EducationCASChengduChina Central Department of Geography Tribhuvan UniversityKathmanduNepal Institute of Space Technology IslamabadPakistan Department of Geography and Resource Management School of Earth SciencesMizoram UniversityAizawlIndia Department of Civil Engineering Institute of Information TechnologyMalabeSri Lanka

The South Asia has high variability in geographical features,climate,*** the rapid economic development and population growth,the increased pressure on natural resources,land degradation,water crisis,and climate change become the common concerns forthe countries in the *** get a deep and general idea about the land and water natural resources and environment in South Asia,a knowl-edge database was constructed based on the climatic condition,land use/cover,waterresources,water disasters,and *** sults presented a scientific insight regarding the spatio-temporal changing pattern of the eco-environ mental components in this *** assessments were performed for the floods,droughts,and geohazards which occurred with a high *** general,the big knowledge database established in this study would be helpful to aid the devel-opment of future policies and programs(like the Belt and Road Initiative)for environmental issues adaptation in the region,including initiatives for regional cooperation and capacity building in natural resources and environment management.

关键词： South Asia eco-environment water resource geohazard climate change assessment

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Ovicidal activity of Atalantia monophylla(L)Correa against Spodoptera litura Fab.(Lepidoptera:Noctuidae)

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Asian Pacific Journal of Tropical Biomedicine 2012年第12期2卷 987-991页

作者： Kathirvelu Baskar Chellaiah Muthu Gnanaprakasam antony raj Selvadurai Kingsley Savarimuthu Ignacimuthu Entomology Research Institute Loyola College PG and Research Department of Advanced Zoology and Biotechnology Loyola College

Objective:To evaluate the efficacy of Atalantia monophylla(***)leaf in different solvent crude extracts and fractions against eggs of Spodoptera litura(***).Methods:Hexane,ethyl acetate and chloroform solvent extracts of *** leaf and 12 fractions from hexane extract were screened at 5.0%t,2.5%,1.0%and 0.5%for crude extracts and 1000,500,250 and 125 mg/kg for fractions against the eggs of *** for the ovicidal ***_(50)and LC_(90)were calculated using probit ***:Hexane crude extract showed maximum ovicidal activity of 61.94%at 5.0%concentration with a correlation value of r^2=0.81,and least LC_(50)value of3.06%.Hexane extract was fractionated using silica gel column chromatography and 12 fractions were *** 9 was active which showed maximum ovicidal activity of 75.61%at 1000mg/kg with the LC_(50)value of 318.65 mg/kg and LC_(90)value of 1473.31 mg/*** linear regression analysis,significant and high correlation(r^2=0.81%)was seen between concentration and ovicidal activity of hexane crude extracts and its active ***:As per our knowledge,this is the first report for ovicidal activity of *** against ***,*** could be used for the management of *** and other insect pests.

关键词： Atalantia monophylla Crude extracts Fractions Ovicidal activity Spodoptera litura

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