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Conduit necrosis following esophagectomy: An up-to-date literature review

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World Journal of Gastrointestinal Surgery 2019年第3期11卷 155-168页

作者： antonios athanasiou Mairead Hennessy Eleftherios Spartalis Benjamin H L Tan Ewen A Griffiths Department of Upper GI Bariatric and Minimally Invasive Surgery St.James' University Hospital Leeds Teaching Hospitals NHS Trust Department of Anaesthesia University Hospital of Waterford Laboratory of Experimental Surgery and Surgical Research University of Athens Medical School Department of Upper Gastrointestinal Surgery University Hospitals Birmingham NHS Foundation Trust

Esophageal conduit ischaemia and necrosis is an uncommon but devastating complication of esophagectomy and remains one of the most challenging issues in surgical practice. The incidence, time interval to develop symptoms, and clinical presentation are highly variable with no predictable pattern. Evidence comes from case reports and case series rather than randomized controlled *** describe the issues surrounding conduit necrosis affecting the stomach,jejunum and colon as an esophageal replacement and the advantages,disadvantages and challenges of each type of reconstruction. Diagnosis is challenging for the most experienced surgeon. Upper gastrointestinal endoscopy and computed tomography thorax with both oral and intravenous contrast is the gold standard. Management, either conservative or interventional is also a difficult decision. Management options include conservative treatment and more aggressive treatments such as stent insertion, surgical debridement and repair of the esophagus using jejunum, colon or a musculocutaneous flap. In spite of recent advances in surgical techniques, there is no reliable strategy to manage esophageal conduit necrosis. Our review covers the pathophysiology and clinical significance of esophageal necrosis while highlighting current techniques of prevention, diagnosis and treatment of this life-threatening condition.

关键词： Esophagectomy Esophageal cancers Esophagogastric anastomosis

Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats: What we know so far?

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 91-92页

作者： antonios athanasiou eleftherios spartalis mairead hennessy michael spartalis demetrios moris christos damaskos emmanouil pikoulis department of upper gastrointestinal surgery university hospitals birmingham nhs foundation trustBirmingham UK laboratory of experimental surgery and surgical research university of athens medical schoolAg. Thoma 15B Athens 11527 Greece department of surgery wexford general hospitalIreland department of surgery duke universityDurham NC USA first surgery department laikon general hospital national and kapodistrian university of athensGreece

To the editor:We read with great interest the article entitled "Comparative study of the effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats" by Ulmer et al.[1].The aim o... 详细信息

关键词： Effects of terlipressin versus splenectomy on liver regeneration after partial hepatectomy in rats What we know so far

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From diagnosis to treatment of hepatocellular carcinoma: An epidemic problem for both developed and developing world

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World Journal of Gastroenterology 2017年第29期23卷 5282-5294页

作者： Dimitrios Dimitroulis Christos Damaskos Serena Valsami Spyridon Davakis Nikolaos Garmpis Eleftherios Spartalis antonios athanasiou Demetrios Moris Stratigoula Sakellariou Stylianos Kykalos Gerasimos Tsourouflis Anna Garmpi Ioanna Delladetsima Konstantinos Kontzoglou Gregory Kouraklis Second Department of Propedeutic Surgery Laiko General Hospital Medical School National and Kapodistrian University of Athens Blood Transfusion Department Aretaieion Hospital Medical School National and Kapodistrian Athens University First Department of Surgery Laiko General Hospital Medical School National and Kapodistrian University of Athens N.S. Christeas Laboratory of Experimental Surgery and Surgical Research Medical School National and Kapodistrian University of Athens Department of Surgery Mercy University Hospital Lerner Research Institute Cleveland Clinic Foundation First Department of Pathology Medical School National and Kapodistrian University of Athens Internal Medicine Department Laiko General Hospital University of Athens Medical School

Hepatocellular carcinoma(HCC) is the most frequent primary liver malignancy and the third cause of cancer-related death in the Western Countries. The well-established causes of HCC are chronic liver infections such as hepatitis B virus or chronic hepatitis C virus, nonalcoholic fatty liver disease, consumption of aflatoxins and tobacco smocking. Clinical presentation varies widely; patients can be asymptomatic while symptomatology extends from right upper abdominal quadrant paint and weight loss to obstructive jaundice and lethargy. Imaging is the first key and one of the most important aspects at all stages of diagnosis, therapy and follow-up of patients with HCC. The Barcelona Clinic Liver Cancer Staging System remains the most widely classification system used for HCC management guidelines. Up until now, HCC remains a challenge to early diagnose, and treat effectively; treating management is focused on hepatic resection, orthotopic liver transplantation, ablative therapies, chemoembolization and systemic therapies with cytotocix drugs, and targeted agents. This review article describes the current evidence on epidemiology, symptomatology, diagnosis and treatment of hepatocellular carcinoma.

关键词： Hepatocellular Cancer Epidemiology Treatment Diagnosis Staging Transplantation

Role of platelet-rich plasma in ischemic heart disease: An update on the latest evidence

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World Journal of Cardiology 2015年第10期7卷 665-670页

作者： Eleftherios Spartalis Periklis Tomos Demetrios Moris antonios athanasiou Charalampos Markakis Michael D Spartalis Theodore Troupis Dimitrios Dimitroulis Despina Perrea Second Department of Propedeutic Surgery Athens University Medical School "Laiko" Hospital Department of Cardiology Onassis Cardiac Surgery Center Department of Anatomy Medical School University of Athens Laboratory of Experimental Surgery and Surgical Research "N.S.Christeas" Medical School University of Athens

Myocardial infarction is the most common cause of congestive heart failure. Novel strategies such as directly reprogramming cardiac fibroblasts into cardiomyocytes are an exciting area of investigation for repair of injured myocardial tissue. The ultimate goal is to rebuild functional myocardium by transplanting exogenous stem cells or by activating native stem cells to induce endogenous repair. Cell-based myocardial restoration, however, has not penetrated broad clinical practice yet. Plateletrich plasma, an autologous fractionation of whole blood containing high concentrations of growth factors, has been shown to safely and effectively enhance healing and angiogenesis primarily by reparative cell signaling. In this review, we collected all recent advances in novel therapies as well as experimental evidence demonstrating the role of platelet-rich plasma in ischemic heart disease, focusing on aspects that might be important for future successful clinical application.

关键词： Platelet-rich plasma Ischemic heart disease Myocar

3D micropattern force regulates stem cell function

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National Science Review 2023年第8期10卷 69-70页

作者： antonios G. Mikos Department of Bioengineering Rice University

Biophysical cues of the cellular microenvironment significantly influence cell behaviors by mechanotransduction [1,2].For example, the mechanical properties of the extracellular matrix modulate human mesenchymal stem ...

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High-fidelity trajectory optimization for aeroassisted vehicles using variable order pseudospectral method

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Chinese Journal of Aeronautics 2021年第1期34卷 237-251页

作者： Runqi CHAI antonios TSOURDOS AI SAVVARIS Senchun CHAI Yuanqing XIA School of Aerospace Transport and ManufacturingCranfield UniversityBedfordshire MK43OALUnited Kingdom School of Automation Beijing Institute of TechnologyBeijing 100081China

In this study,the problem of time-optimal reconnaissance trajectory design for the aeroassisted vehicle is *** from most works reported previously,we explore the feasibility of applying a high-order aeroassisted vehicle dynamic model to plan the optimal flight trajectory such that the gap between the simulated model and the real system can be narrowed.A highly-constrained optimal control model containing six-degree-of-freedom vehicle dynamics is *** solve the formulated high-order trajectory planning model,a pipelined optimization strategy is *** approach is based on the variable order Radau pseudospectral method,indicating that the mesh grid used for discretizing the continuous system experiences several adaption *** of such a strategy can potentially smooth the flight trajectory and improve the algorithm convergence *** simulations are reported to demonstrate some key features of the optimized flight trajectory.A number of comparative studies are also provided to verify the effectiveness of the applied method as well as the high-order trajectory planning model.

关键词： Aeroassisted vehicle High-order Radau pseudospectral method Six-degree-of-freedom Trajectory design Variable order

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Deleting Outliers in Robust Regression with Mixed Integer Programming

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Acta Mathematicae Applicatae Sinica 2005年第2期21卷 323-334页

作者： Georgios Zioutas antonios Avramidis Division of Computational Methods and Computer Programming General Department Faculty of Technology Aristotle University of Thessaloniki 541 24 Thessaloniki GreeceDivision of Computational Methods and Computer Programming General Department Faculty of Technology Aristotle University of Thessaloniki 541 24 Thessaloniki Greece

In robust regression we often have to decide how many are the unusualobservations, which should be removed from the sample in order to obtain better fitting for the restof the observations. Generally, we use the basic principle of LTS, which is to fit the majority ofthe data, identifying as outliers those points that cause the biggest damage to the robust ***, in the LTS regression method the choice of default values for high break down-point affectsseriously the efficiency of the estimator. In the proposed approach we introduce penalty cost fordiscarding an outlier, consequently, the best fit for the majority of the data is obtained bydiscarding only catastrophic observations. This penalty cost is based on robust design weights andhigh break down-point residual scale taken from the LTS estimator. The robust estimation is obtainedby solving a convex quadratic mixed integer programming problem, where in the objective functionthe sum of the squared residuals and penalties for discarding observations is minimized. Theproposed mathematical programming formula is suitable for small-sample data. Moreover, we conduct asimulation study to compare other robust estimators with our approach in terms of their efficiencyand robustness.

关键词： Robust regression quadratic mixed integer programming least trimmedsquares deleting outliers penalty methods

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A numerical case study on the long-term seismic assessment of reinforced concrete tunnels in corrosive environments

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 551-572页

作者： Maria Antoniou antonios Mantakas Nikolaos Nikitas Raul Fuentes ETH Zurich ZurichSwitzerland National Technical University of Athens AthensGreece University of Leeds LeedsUK RWTH Aachen University AachenGermany

The paper investigates the long-term seismic behaviour of an underground reinforced concrete(RC)metro tunnel in Santiago,Chile,considering the combined effects of chloride-induced corrosion and cumulative,low-amplitude seismic shaking on the structure’s *** soil-tunnel response is evaluated with the aid of transient,nonlinear finite element analysis using a two-dimensional(2D)plane strain numerical model that adopts advanced nonlinear models for the simulation of soil and concrete plasticity and the dynamic stiffness *** effects of corrosion deterioration are demonstrated in terms of time-dependent loss of rebar area and cover concrete stiffness and *** study illustrates the influence of ageing and repeated seismic shaking on lining deformation,crack development,and the modal characteristics of the intact and degrading *** results indicate that multiple lowamplitude events drive the non-degrading RC tunnel beyond its elastic regime without significant structural response consequences.A noticeable impact of corrosion deterioration on the structure’s seismic performance is revealed,increasing with the number and intensity of earthquake *** different tunnel embedment depths are comparatively *** analyses demonstrate larger coseismic section convergence in the case of the deeper tunnel,yet a less pronounced effect of ageing and successive seismic loading compared to the shallow section,which is evident in the RC lining cracks at the end of shaking.

关键词： Tunnels Reinforcement corrosion Ageing Earthquakes Numerical modelling Long-term performance Concrete cracking behaviour

Advances in In Vitro and In Vivo Bioreactor-Based Bone Generation for Craniofacial Tissue Engineering

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Biomedical Engineering Frontiers 2023年第1期4卷 203-216页

作者： Emma Watson antonios G.Mikos Department of Bioengineering Rice UniversityHoustonTX 77030USA

Craniofacial reconstruction requires robust bone of specified geometry for the repair to be both functional and *** native bone from elsewhere in the body can be harvested,shaped,and implanted within a defect,using either an in vitro or in vivo bioreactors eliminates donor site morbidity while increasing the customizability of the generated *** vitro bioreactors utilize cells harvested from the patient,a scaffold,and a device to increase mass transfer of nutrients,oxygen,and waste,allowing for generation of larger viable *** vivo bioreactors utilize the patient’s own body as a source of cells and of nutrient transfer and involve the implantation of a scaffold with or without growth factors adjacent to vasculature,followed by the eventual transfer of vascularized,mineralized tissue to the defect *** different models of in vitro bioreactors exist,and several different implantation sites have been successfully utilized for in vivo tissue generation and defect repair in *** this review,we discuss the specifics of each bioreactor strategy,as well as the advantages and disadvantages of each and the future directions for the engineering of bony tissues for craniofacial defect repair.

关键词： defect implantation utilize