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An improved flexible tolerance method for solving nonlinear constrained optimization problems:Application in mass integration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 617-631页

作者： Alice Medeiros lima Wu Hong Kwong antonio José goncalves Cruz Chemical Engineering Graduate Program Federal University of Sao Carlos department of Chemical Engineering department of Chemical Engineering Federal University of Sao Carlos

This paper proposes the use of the flexible tolerance method(FTM) modified with adaptive Nelder–Mead parameters and barrier to solve constrained optimization problems. The problems used to analyze the performance of the methods were taken from G-Suite functions, and the methods with the best performance were applied in mass integration problems. Four methods were proposed:(1) flexible tolerance method(FTM) using adaptive parameters(FTMA),(2) flexible tolerance method with scaling(FTMS) and with adaptive parameters(FTMAS),(3) FTMS including the barrier modification(MFTMS) and(4) MFTMS hybridized with PSO(MFTMS-PSO). The success rates of these methods were 100%(MFTMS), 85%(MFTMS-PSO), 40%(FTMAS) and 30%(FTMA).Numerical experiments indicated that the MFTMS could efficiently and reliably improve the accuracy of global optima. In mass integration, the method was able, from current process situation, to reach the optimum process configuration that includes integration issues, which was not possible using FTM in its standard formulation. The hybridization of FTMS with PSO(without barrier), FTMS-PSO, was also able to solve mass integration problems efficiently.

关键词： Flexible tolerance method Adaptive parameters Scaling Constrained optimization Barrier PSO Mass integration

Nonlinear constrained optimization using the flexible tolerance method hybridized with different unconstrained methods

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Chinese Journal of Chemical Engineering 2017年第4期25卷 442-452页

作者： Alice Medeiros lima antonio Jose goncalves Cruz Wu Hong Kwong Chemical Engineering Graduate Program Federal University of Sdo CarlosRodovia Washington Luizkm 235-5P310Sao CarlosSP 13565-905Brazil department of Chemical Engineering Federal University of Sao CarlosRodovia Washington Luizkm 235-SP 310Silo CarlosSP 13565-905Brazil

This paper proposes the use of the flexible tolerance method(FTM) modified with scaling of variables and hybridized with different unconstrained optimization methods to solve real constrained optimization *** benchmark problems used to analyze the performance of the methods were taken from G-Suite *** original method(FTM) and other four proposed methods:(i) FTM with scaling of variables(FTMS),(ii) FTMS hybridized with BFGS(FTMS-BFGS),(iii) FTMS hybridized with modified Powell's method(FTMS-Powell)and(iv) FTMS hybridized with PSO(FTMS-PSO), were implemented. The success rates of the methods were 80%,100%, 75%, 95% and 85%, for FTM, FTMS, FTMS-BFGS, FTMS-Powell and FTMS-PSO, respectively. Numerical experiments including real constrained problems indicated that FTMS gave the best performance, followed by FTMSPowell and FTMS-PSO. despite the inferior performance compared to FTMS and FTMS-Powell, the FTMS-PSO method presented some advantages since good different initial points could be obtained, which allow exploring different routes through the solution space and to escape from local optima. The proposed methods proved to be an effective way of improving the performance of the original FTM.

关键词： Flexible tolerance method Modified Powell’s method BFGS PSO Scaling Hybridization

H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression

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World Journal of Gastroenterology 2008年第6期14卷 884-891页

作者： Valeska Portela lima marcos antonio Pereira de lima Angela Rosa André Márcia Valéria Pitombeira Ferreira marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst departament of Pathology and Forensic Federal University of Ceará State Brazil Saint House of Mercy in Fortaleza Brazil

AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents.

关键词： Gastric carcinoma Helicobacter pylori Epstein-Barr virus, p53, Bax, Bcl-2, c-Myc

Mortality Trends for Neglected Tropical Diseases in the State of Sergipe,Brazil,1980-2013

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Infectious Diseases of Poverty 2017年第1期6卷 173-180页

作者： marcos antonio Costa de Albuquerque Danielle Menezes Dias Lucas Teixeira Vieira Carlos Anselmo lima Angela Maria da Silva University Hospital Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil Post-doc Medicine Unit Federal University of SergipeRua Claudio Batista s/nB.Santo AntonioAracajuSE 49060-108Brazil

Background:Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status,particularly 1.4 billion people who are living below the poverty *** study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe,Northeast Region of ***:We conducted an ecological study of time series,based on secondary data derived from the Mortality Information System of the Ministry of *** mortality rates(crude,age-standardized rates and proportional ratio)were calculated from the deaths due to Neglected Tropical Diseases in the state of Sergipe,from 1980 to *** time trends were obtained using the Joinpoint regression ***:Three hundred six thousand and eight hundred seventy-two deaths were certified in the state and Neglected Tropical Diseases were mentioned as the underlying cause in 1,203 certificates(0.39%).Mean number of deaths was 35.38 per year,and crude and age-standardized mortality rates were,respectively:2.16 per 100000 inhabitants(95%CI:1.45-2.87)and 2.87 per 100000 inhabitants(95%CI:1.93-3.82);the proportional mortality ratio was 0.41%(95%CI:0.27-0.54).In that period,Schistosomiasis caused 654 deaths(54.36%),followed by Chagas disease,with 211(17.54%),and by Leishmaniases,with 142(11.80%)*** other diseases totalized 196 deaths(16.30%).There were increasing mortality trends for Neglected Tropical Diseases,Schistosomiasis and Chagas disease in the last 15 years,according to the age-standardized rates,and stability of the mortality trends for ***:The Neglected Tropical Diseases show increasing trends and are a real public health problem in the state of Sergipe,since they are responsible for significant mortality *** following diseases call attention for showing greater number of deaths in the period of study:Schistosomiasis,Chagas disease and *** finally suggest that public managers take appropri

关键词： Mortality Neglected tropical diseases Trends Joinpoint

Strategies for the analysis of single-tree plot experiments in Eucalyptus plantations

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Journal of Forestry Research 2021年第6期32卷 2437-2445页

作者： Heloisa Guimaraes Santos Flavia Maria Avelar goncalves Jose Luis lima Aurelio Mendes Aguiar Gabriel dehon Sampaio Pecanha Rezende Bruno Marco de lima Magno antonio Patto Ramalho departamento de Biologia Setor de Genetica E Melhoramento de PlantasUniversidade Federal de Lavras-UFLALavrasMGBrasil Suzano Papel E Celulose Sao PauloSPBrasil Bracell SP Celulose Ltda Lencóis PaulistaSPBrasil

To verify if the response by Eucalyptus clones in a single-tree plot is influenced by neighboring plants and to determine the effect of missing and/or dominated plants,seven eucalyptus trials in four Brazilian states were analyzed in a randomized complete block design with one plant/plot and 30 *** annual increment(MAI,m^(3)ha^(-1)per year)was determined for three-year-old *** influence of neighboring clones was estimated by a linear regression coefficient between the MAI of each clone/plot and the average of a clonal MAI and its eight *** determine the effect of missing and/or dominated trees,a correction between the MAI and the area available/plant was *** analysis considered unadjusted and adjusted data for missing and dominated *** of accuracy and index of coincidence were used to compare the *** single-tree plots,clone performances were not influenced by neighboring *** accuracy was not increased by any of the adjustments employed and the clone ranking was not altered,and therefore did not justify their use.

关键词： Single-tree plot Missing plant adjustment Eucalyptus breeding

Chlamydoconidium-producing Trichophyton tonsurans: Atypical morphological features of strains causing tinea capitis in Ceará, Brazil

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Asian Pacific Journal of Tropical Medicine 2019年第8期12卷 380-384页

作者： Raimunda Samia Nogueira Brilhante Germana Costa Paixao Jonathas Sales de Oliveira Vandbergue Santos Pereira marcos Fábio Gadelha Rocha Reginaldo goncalves de lima-Neto Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro JoséJúlio Costa Sidrim Specialized Medical Mycology Center Postgraduate Program in Medical MicrobiologyFederal University of CearáRua Nunes de Melo1315FortalezaBrazil Postgraduate Program in Veterinary Sciences State University of CearáAv.Dr.Silas Munguba1700FortalezaBrazil department of Tropical Medicine Center for Health SciencesFederal University of PernambucoRecife-PEBrazil

Objective: To report atypical morphological features of Trichophyton(T.) tonsurans strains associated with tinea capitis. Methods: Eighty-two T. tonsurans strains isolated in Ceará, Brazil, were analyzed regarding macro and micromorphological features and nutritional patterns. Results: Fifty-two samples presented abundant chlamydoconidia, which were produced in chains. Macroscopically, these strains developed small glabrous colonies that were firmly attached to the surface of the culture medium, with few or no aerial mycelia and intense rusty yellow pigmentation. Seven strains did not grow with stimulus from thiamine. Samples were heterogeneous regarding urease production and none presented in vitro hair perforation. Conclusions: The observation of T. tonsurans strains with distinct phenotypic features indicates the need to revise the taxonomic criteria for routine identification of this dermatophyte.

关键词： Trichophyton tonsurans Chlamydoconidia dermatophyte Phenotyping

Impact,economic evaluation,and sustainability of integrated vector management in urban settings to prevent vector-borne diseases:a scoping review

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Infectious Diseases of Poverty 2018年第1期7卷 830-843页

作者： Jorge marcos-marcos antonio Olry de Labry-lima Silvia Toro-Cardenas Marina Lacasaña Stephanie degroote Valery Ridde Clara Bermudez-Tamayo Public Health Research Group University of AlicanteAlicanteSpain Andalusian School of Public Health GranadaSpain Biomedical Research Centre Network for Epidemiology and Public Health(CIBERESP) MadridSpain Biomedical Research Centre(ibs.GRANADA) GranadaSpain Public Health Research Institute(IRSPUM) University of MontrealMontrealQuebecCanada IRD(French Institute for Research on Sustainable development) CEPED(IRD-Universite Paris Descartes)Universites Paris Sorbonne CitesERL INSERM SAGESUDParisFrance

Background:The control of vector-borne diseases(VBD)is one of the greatest challenges on the global health *** and uncontrolled urbanization has heightened the interest in addressing these challenges through an integrated vector management(IVM)*** aim was to identify components related to impacts,economic evaluation,and sustainability that might contribute to this integrated approach to VBD *** body:We conducted a scoping review of available literature(2000-2016)using PubMed,Web of Science,Cochrane,CINAHL,Econlit,LILACS,Global Health Database,Scopus,and Embase,as well as Tropical Diseases Bulletin,WHOLIS,WHO Pesticide Evaluation Scheme,and Google *** terms and free-text terms were used.A data extraction form was used,including TIDieR and *** and CHEERS were used to evaluate *** the 42 documents reviewed,30 were focused on dengue,eight on malaria,and two on *** than a half of the studies were conducted in the *** used a quantitative descriptive approach(n=21),followed by cluster randomized controlled trials(n=11).Regarding impacts,outcomes were:a)use of measures for vector control;b)vector control;c)health measures;and d)social *** reduced breeding sites,the entomology index,and parasite *** were heterogeneous,with variable magnitudes,but in all cases were favourable to the *** of IVM impacts on health outcomes was very limited but showed reduced *** outcomes were improved abilities and capacities,empowerment,and community *** economic evaluation,only four studies performed an economic analysis,and intervention benefits outweighed *** was dependent on illness *** results provided key elements to analyze sustainability in terms of three dimensions(social,economic,and environmental),emphasizing the implementation of a community-focused eco-bio-social ***:IVM has an impact on redu

关键词： Vector-borne diseases Integrated vector management Urban health Intervention Scoping review

Regression of Barrett＇s Esophagus： Is There a Difference between Clinical and Surgical Treatment？

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Journal of Pharmacy and Pharmacology 2017年第12期5卷 928-933页

作者： Ramon Rawache Barbosa Moreira de lima Fernando antonio Siqueira Pinheiro Joao Odilo goncalves Pinto marcos Andre Araujo Accioly Filho Mateus Alves de Araujo Paulo Henrique Araujo Parente department of Digestive Surgery Walter Cantideo University Hospital Federal University of Ceara Fortaleza 60430-380 Brazil

Objective： To evaluate the response to clinical and surgical treatment of Walter Cantidio University Hospital patients who were diagnosed with Barrett＇s esophagus between 2012 and 2016. Methodology： From the database analysis of Walter Cantidio University Hospital＇s pathology service, we identified all patients with a diagnosis of Barrett＇s esophagus between 2012 and 2016. We analyzed the patients＇ medical records and collected epidemiological and clinical data. Results： 22 patients were included in the study, 13 of whom were surgically treated and 9 were clinically treated. The regression was 33.3% in the clinical group and 30.7% in the surgical group, with no statistical difference between these two groups. Conclusions： The results show synchrony with data from the medical literature regarding the response of Barrett＇s esophagus to clinical and surgical treatment.

关键词： Barrett's esophagus treatment regression.

Effect of heat stress on the maturation,fertilization and development rates of in vitro produced bovine embryos

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Open Journal of Animal Sciences 2013年第3期3卷 174-178页

作者： Mayra Fernanda Alves Roseli Fernandes goncalves Danielle Labadessa Pavao Eduardo Gimenes Palazzi Flavio Souza Roberta Kelly Ribeiro de Queiróz Magali D’Angelo marcos antonio de Achilles Cell Biology Laboratory Research and Development Center for Animal HealthSao Paulo Biological InstituteSao PauloBrazil department of Animal Reproduction College of Medicine Veterinary and Animal ScienceSao Paulo UniversitySao PauloBrazil

Heat stress is one of the main reasons for reproductive performance decrease in cattle, resulting in severe economic losses. The aim of this study was to evaluate the effect of heat stress during maturation, fertilization and development of in vitro produced bovine embryos. Cumulus oocyte complexes (COCs) were obtained by follicular puncture from slaughterhouse ovaries and after identification, were divided into four groups: control (CG), exposed 1 (EG1), exposed 2 (EG2), and exposed 3 (EG3). The oocytes of the group CG and CG3 were cultured at 38°C and the oocytes of group EG1 and EG2 were cultured at 40°C during the maturation period (24 hours at 5% CO2 in air). After the maturation period, oocytes of group CG, EG1, EG2, and EG3 were fecundated with frozen thawed semen. The oocytes of CG, EG2 and EG3 groups were cultured at 38°C, and the group EG1 was cultured at 40°C (18 hours at 5% CO2 in air). After that, the CG and EG2 groups were cultured in SOF at 38°C and the groups EG1 and EG3 at 40°C during embryonic development. The embryos were evaluated for cleavage, morula and blastocyst rates by optical microscopy. In control (CG) and EG3 groups, the oocytes showed uniform expansion of cumulus cells, classified as moderate to high, with brown color and uniform appearance of the ooplasm. In the oocytes exposed to 40°C (EG1 and EG2) we observed a decrease in the expansion of cumulus cells, and the same showed rounded appearance and retraction of the ooplasm with dark coloration. The control group (CG) had 68.23% ± 2% of cleavage, 50.16% ± 2% morulas, and 43.28% ± 1% blastocysts. Whereas the EG2 had 31.46% ± 2% cleavage, 35.64% ± 2% morula, and no blastocysts development. The EG3 had 3.7% ± 2% cleavage, and no embryo production. These data suggest that in all stages of exposure to heat stress, the embryos and the gametes are susceptible, leading to a decrease in embryonic development.

关键词： Bovine Embryo Heat Stress in vitro Fertilization