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World Journal of Gastroenterology 2005年第24期11卷 3762-3766页

作者： Eloy Fernández Sabino Riestra luis Rodrigo Carlos Blanco antonio lópez-vázquez Dolores Fuentes Maria Moreno Carlos lópez-larrea Biochemistry Service Gastroenterology Service Immunology Service

AIM: Celiac disease (CD) is an enteropathic disorder very prevalent in Saharawi people. Our aim was to investigate the diagnostic accuracy of six human tissue transglutaminase (tTG) based ElISA tests in Saharawi CD patients. METHODS: Fifty-two CD patients and 23 controls were selected from the Saharawi refugee camps in Tinduf. CD patients were divided into two groups according to their anti-endomysium (EmA) status: 41 EmA positive and 11 EmA negative. Sera from patients and controls were tested for human tTG using six commercial ElISA kits. We used receiver operating characteristics (ROC) curves and areas under the curve to compare the diagnostic accuracies of the six assays. RESUlTS: In general, there are differences in the sensitivity and specificity of the human tTG ElISA assays used. Diagnostic accuracy of tests was significantly improved by adjusting the cut-off thresholds according to ROC plot analysis; the correction of the cut-off with the employment of the ROC curve analysis modifies the decision limit in more than 50% in five of the six kits evaluated. CONClUSION: Some of the human tTG ElISAs used in this study have a diagnostic accuracy similar to EmA determination for diagnosis of CD in Saharawi people. However, it is necessary to select the assay with a higher sensitivity and specificity, and recalculate the cut-off threshold using samples from the referral population.

关键词： Anti-transglutaminase tests Comparative study Celiac diagnosis Saharawi population

Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan antonio lópez-villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(Ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,Ols provide trophic support to neurons and ***,Ol metabolism is important for Ol well-being and the proper accomplishment of their functions,and Ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina Medina-vera antonio Jesús lópez-Gambero Juan antonio Navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCv) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.l.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado antonio Rodríguez-Fernández Javier luis lópez-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** SUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

具有Ruddlesden-Popper结构的杂化非本征铁电体(Ca_(1-x)Sm_(x))_(3)Ti_(2)O_(7)陶瓷的制备及其物理性能

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天津师范大学学报（自然科学版） 2024年第2期44卷 19-25页

作者： MARCO antonio lópez-Aguila 柳志旭王守宇黄聪刘卫芳天津大学理学院天津300350 天津师范大学物理与材料科学学院天津300387

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了Sm^(3+)掺杂的(Ca_(1-x)Sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPS、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、... 详细信息

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了Sm^(3+)掺杂的(Ca_(1-x)Sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPS、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、光学性能、电学性能和磁学性能进行分析.结果表明:随着Sm^(3+)含量的增加,(Ca_(1-x)Sm_(x))_(3)Ti_(2)O_(7)的晶胞参数逐渐增大.Sm^(3+)掺杂导致氧空位减少,因此样品的漏电流随着Sm^(3+)掺杂量的增加而减小.同时,随着Sm^(3+)掺杂量的增加,样品的光学带隙呈现增大趋势.此外,第一性原理研究表明,Sm^(3+)掺杂可在体系中诱导出磁性能,进一步丰富了该材料的物理性能.

关键词： (Ca_(1-x)Sm_(x))_(3)Ti_(2)O_(7)陶瓷铁电性氧空位光学带隙第一性原理

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala Sara Pischedda Miriam Cebey-lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra viz-lasheras antonio Justicia-Grande Julian Montoto-louzao Alba Camino-Mera Isabel Ferreiros-vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Spectrophotometric determination of the formation constants of Calcium(Ⅱ) complexes with 1,2-ethylenediamine,1,3-propanediamine and 1,4-butanediamine in acetonitrile

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Green Energy & Environment 2017年第1期2卷 51-57页

作者： Jacqueline González González Mónica Nájera-lara varinia lópez-Ramírez Juan antonio Ramírez-vázquez José J.N.Segoviano-Garfias Programa de Maestría en Biociencias División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca Colegio del Nivel Medio Superior de Salamanca(ENMS) Departamento de Ingeniería Bioquímica Instituto Tecnológico Superior de Irapuato (ITESI) Departamento de Ciencias Ambientales División de Ciencias de la Vida (DICIVA) Universidad de Guanajuato Campus Irapuato-Salamanca

In this work, with the purpose to explore the coordination chemistry of calcium complexes which could work as a partial model of manganese-calcium cluster, a spectrophotometric study to evaluate the stability of the complexes: Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine in acetonitrile, were carried on. By processing the spectrophotometric data with the HypSpec program allows the determination of the formation constants. The logarithmic values of the formation constants obtained for Calcium(Ⅱ)-1,2-ethylendiamine, Calcium(Ⅱ)-1,3-propanediamine and Calcium(Ⅱ)-1,4-butanediamine were log β_(110) = 4.69, log β_(110)= 5.25 and log β_(110) = 4.072, respectively.

关键词： Calcium(Ⅱ)complexes Solution equilibria Artificial photosynthesis Absorbance molar Speciation

The spectrum of building block conformers sustains the biophysical properties of clinically-oriented self-assembling protein nanoparticles

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Science China Materials 2022年第6期65卷 1662-1670页

作者： Eric voltà-Durán Julieta M Sánchez Hèctor-lópez-laguna Eloi Parladé laura Sánchez-García Alejandro Sánchez-Chardi Ario de Marco Ugutz Unzueta Esther vázquez antonio villaverde Institut de Biotecnologia i de Biomedicina Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Genètica i de Microbiologia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain CIBER de Bioingeniería Biomateriales y Nanomedicina(CIBER-BBN) Bellaterra 08193BarcelonaSpain Instituto de Investigaciones Biológicas y Tecnológicas(IIBYT)(CONICET-Universidad Nacional de Córdoba) ICTA&Cátedra de Química BiológicaDepartamento de QuímicaFCEFyNUNC.Av.Velez Sarsfield 1611X 5016GCA CórdobaArgentina Servei de Microscòpia Universitat Autònoma de BarcelonaBellaterra 08193BarcelonaSpain Departament de Biologia Evolutiva Ecologia i Ciències AmbientalsFacultat de BiologiaUniversitat de Barcelona08028 BarcelonaSpain laboratory for Environmental and life Sciences University of Nova GoricaNova Gorica 5000Slovenia Biomedical Research Institute Sant Pau(IIB Sant Pau) Sant Antoni Ma Claret 16708025 BarcelonaSpain

Histidine-rich peptides confer self-assembling properties to recombinant proteins through the supramolecular coordination with divalent *** fact allows the cost-effective,large-scale generation of microscopic and macroscopic protein materials with intriguing biomedical *** such materials,resulting from the simple bioproduction of protein building blocks,homomeric nanoparticles are of special value as multivalent interactors and drug ***,we have here identified that the assembly of a given His-tagged protein might render distinguishable categories of self-assembling protein *** fact has been scrutinized through the nanobody-containing fusion proteins EM1-GFP-H6 and A3C8-GFP-H6,whose biosynthesis results in two distinguishable populations of building *** one of them,the assembling and disassembling is controllable by ***,a second population immediately self-assembles upon purification through a non-regulatable pathway,rendering larger nanoparticles with specific biological *** structural analyses of both model proteins and nanoparticles revealed important conformational variability in the building *** fact renders different structural and functional categories of the final soft materials resulting from the participation of energetically unstable intermediates in the oligomerization *** data illustrate the complexity of the Hismediated protein assembling in recombinant proteins but they also offer clues for a better design and refinement of protein-based nanomedicines,which,resulting from biological fabrication,show an architectonic flexibility unusual among biomaterials.

关键词： recombinant proteins self-assembling protein materials nanoparticles biomaterials

Comorbidity in inflammatory bowel disease

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World Journal of Gastroenterology 2011年第22期17卷 2723-2733页

作者： antonio lópez San Román Fernando Muoz Gastroenterology Ramón y Cajal Hospital E28034 Madrid Spain Digestive Diseases Complejo Hospitalario Hospital Altos de Nava 24080 León Spain

Patients with inflammatory bowel disease (IBD) can be affected by other unrelated diseases. These are called comorbid conditions, and can include any secondary health problem that affects a person suffering from a primary or main disease, and which is neither linked physiopathologically to the primary condition, nor is it due to the treatments used for the primary condition or to its long-term anatomical or physiological consequences. Different comorbid conditions, as well as their influence on IBD, are discussed.

关键词： Comorbidity Comorbid conditions Crohn’ disease Inflammatory bowel disease Ulcerative colitis

Effect of Zn binding to phytate and humic substances on its uptake by wheat(Triticum durum l.)as affected by carbonates and Fe oxides

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Pedosphere 2022年第6期32卷 823-832页

作者： Ana M.GARCÍA-lÓpez Ramiro RECENA antonio DElGADO Department of Agronomy ETSIAUniversity of SevilleSeville 41013(Spain)

Although complexation with soil organic matter may improve zinc(Zn)bioavailability to plants,the effect of Zn sorbent surface on the use of complexed Zn by plants remains *** objective of this research was to elucidate how Zn complexation with humic substances(HS)and phytate affects the uptake of Zn by wheat plants depending on the main sorbent surface in growth media,i.e.,carbonates and Fe *** this end,two pot experiments were performed,one using Fe oxide-coated siliceous as the siliceous growth medium sand and the other using a mixture of calcareous sand and siliceous sand as the calcareous growth *** experiment involved three Zn sources,Zn-HS complex,Zn phytate,and ZnSO_(4).All sources were applied with surface irrigation at two Zn rates(0.25 and 2 mg kg^(-1) growth medium).The Zn-HS complex significantly increased Zn uptake by plants in both media,relative to the other two Zn sources,but no significant difference was observed between Zn phytate and ZnSO_(4).In the calcareous medium,Zn-HS complex and Zn phytate resulted in significantly higher dry biomass yields of wheat than ZnSO_(4).In the siliceous medium,spike and shoot dry biomass yields with Zn-HS complex at the low rate and Zn phytate at both rates were not significantly different from those with ZnSO_(4) at the high *** harvest,approximately 50%of the Zn applied as Zn-HS complex remained extractable by diethylenetriaminepentaacetic acid(DTPA),while this proportion was less than 20%for the other Zn ***,Zn-HS complex and Zn phytate are sources of available Zn for plants,and they are more effective than ZnSO_(4) in increasing plant growth,particularly when carbonates are the main Zn sorbent surface.

关键词： calcareous growth medium micronutrient organic matter organic phosphorus Zn availability Zn deficiency Zn sorbent surface Zn source