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journal of Cancer Therapy 2017年第7期8卷 637-644页

作者： Arthur j.Weiss Irwin L.Stoloff antonio C.Simoes Division of Medical Oncology Thomas Jefferson School of MedicinePhiladelphiaUSA Division of Surgery North Penn HospitalLandsdaleUSA

It has been demonstrated that it is safe to give Gm-Csf, together with Doxorubicin, by continuous intravenous infusion, thereby substantially increasing the amount of Doxorubicin administered to the average patient, and assuring that each patient receives an individually-determined safe and maximal amount of drug. It is known that Gm-Csf is a potent inducer of components that are major factors in an immunologic attack upon neoplasms. For that reason, we thought it would be worth evaluating in 4 patients’ surface markers of dendritic precursor cells, dendritic cells [DC], and natural killer [NK] cells during the infusion. While there was substantial variation in individual responses, all 4 patients receiving Gm-Csf developed persistent marked increases in cells with each of these markers. The significance of these findings will be discussed.

关键词： Doxorubicin Infusion Dendritic Killer Cells

共振态Z_(cs)(3985)、Z_(cs)(4003):分属SU(3)_f破缺的2个新型四夸克九重态?

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Science Bulletin 2021年第16期66卷 1616-1619,M0003页

作者： Luciano Maiani antonio D.Polosa Verónica Riquer Dipartimento di Fisica and INFN Sapienza Universitàdi RomaPiazzale Aldo Moro 2I-00185 RomaItaly

BESⅢ和LHCb实验上的新实验数据表明了2个显奇异夸克隐粲四夸克态Z_(cs)(3985)和Z_(cs)(4003)的存在.在奇异夸克部分,Z_(cs)(3985)和Z_(cs)(4003)的近简并重现了在X(3872)和Zc(3900)间看到的情形.本文指出,在四夸克态图像下,这些Z_(cs)... 详细信息

BESⅢ和LHCb实验上的新实验数据表明了2个显奇异夸克隐粲四夸克态Z_(cs)(3985)和Z_(cs)(4003)的存在.在奇异夸克部分,Z_(cs)(3985)和Z_(cs)(4003)的近简并重现了在X(3872)和Zc(3900)间看到的情形.本文指出,在四夸克态图像下,这些Z_(cs)共振态与X(3872)、X(4140)以及Zc(3900)等共振态可以被纳入j^(P)=1^(+)的C宇称相反的2个SU(3)_(f)九重态.作者预言了2个九重态中其他未被发现的共振态的质量.这一分类为四夸克态模型提供了关键证据.

关键词：奇异夸克共振态 SU(3) 四夸克态 BESⅢ 九重态宇称简并

Tetrapartite entanglement measures of W-class in noninertial frames

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Chinese Physics B 2019年第7期28卷 122-130页

作者： Ariadna j. Torres-Arenas Edgar O. Lopez-Zuniga j. antonio Saldana-Herrera Qian Dong Guo-Hua Sun Shi-Hai Dong Laboratorio de Información Cuantica CIDETEC Instituto Politecnico Nacional UPALM CDMX 07700 Mexico Facultad de Ciencias Fisico Matematicas Universidad Autónoma de Nuevo Leon San Nicolas de los Garza NL 66450 Mexico Catedratica CONACyT Centro de Investigacion en Computacion Instituto Politecnico Nacional UPALM CDMX 07738 Mexico

We present the entanglement measures of a tetrapartite W-class entangled system in a noninertial frame, where the transformation between Minkowski and Rindler coordinates is *** cases are ***, when one qubit has uniform acceleration whilst the other three remain ***, when two qubits have nonuniform accelerations and the others stay *** 1–1 tangle, 1–3 tangle, and whole entanglement measurements π4 and Π4, are studied and illustrated with graphics through their dependence on the acceleration parameter rd for the first case and rc and rd for the second *** is found that the negativities(1–1 tangle and 1–3 tangle) and π-tangle decrease when the acceleration parameter rd or in the second case rc and rd increase, remaining a nonzero entanglement in the majority of the *** means that the system will be always entangled except for special *** is shown that only the 1–1 tangle for the first case vanishes at infinite accelerations, but for the second case the 1–1 tangle disappears completely when r > *** analytical expression for the von Neumann information entropy of the system is found and we note that it increases with the acceleration parameter.

关键词： W-class tetrapartite entanglement Dirac field noninertial frames nonuniform acceleration

Study of the Reactivity of (100) Felodipine Surface Model Based on DFT Concepts

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Open journal of Physical Chemistry 2019年第1期9卷 1-12页

作者： Carlos Tepech-Carrillo Roxana Licona-Ibarra j. Francisco Rivas-Silva antonio Flores-Riveros Instituto de Física “Luis Rivera Terrazas” Benemérita Universidad Autónoma de Puebla Puebla México Facultad de Ciencias Químicas Benemérita Universidad Autónoma de Puebla Puebla Mexico

In this study, Density Functional Theory including a dispersion correction is employed to model and analyze the structural, electronic and local reactivity of the (100) surface of felodipine. The surface energy calculated at the Generalized Gradient Approximation (GGA) level, along with plane waves as basis set and ultrasoft pseudopotentials, shows that the (100) surface is the most stable as compared to the (010) and (110) ones. In particular, we have focused on performing a quantitative study of the reactivity of the surface by means of the Fukui function and through the HOMO and LUMO populations. Our results can be related to some applications in the pharmaceutical chemistry of this compound.

关键词： 1 4-Dihydropyridine Felodipine Density Functional Theory Fukui Functions

Diode-pumped, electro-optically Q-switched, cryogenic Tm:YAG laser operating at 1.88 μm

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High Power Laser Science and Engineering 2021年第1期9卷 107-112页

作者： j?rg K?rner Venkatesan jambunathan Fangxin Yue jürgen Reiter Ondrej Slezák Petr Navrátil Samuel Paul David antonio Lucianetti joachim Hein Tomá? Mocek Malte C.Kaluza HiLASE Centre Institute of Physics of the Czech Academy of Sciences Institute of Optics and Quantum Electronics Friedrich Schiller University Jena Helmholz Institute jena Hi LASE Centre Institute of Physics of the Czech Academy of Sciences

We present a diode-pumped, electro-optically Q-switched Tm:YAG laser with a cryogenically cooled laser crystal at120 K. Output pulses of up to 2.55 mj and 650 ns duration were demonstrated in an actively Q-switched configuration with a repetition rate of 1 Hz. By using cavity dumping the pulse duration was shortened to 18 ns with only a slightly lower output energy of 2.22 mj. Furthermore, using a simplified rate equation model, we discuss design constraints on the pump fluence in a pulse pump approach for Tm:YAG to maximize the energy storage capability at a given pump power.

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Thematic Trends in Complementary and Alternative Medicine Applied in Cancer-Related Symptoms

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journal of Data and Information Science 2018年第2期3卷 1-19页

作者： jose a.moral-munoz manuel arroyo-morales barbara f.piper antonio i.cuesta-vargas lourdes díaz-rodríguez william c.s.cho enrique herrera-viedma manuel j.cobo dept.nursing and physiotherapy university of cádizCadizSpain institute of research and innovation in biomedical sciences of the province of cádiz(ini bica) university of cádizCadizSpain dept.physical therapy university of granadaGranadaSpain dept.nursing school of health and human servicesnational universitysan diegocausa school clinical science queensland university of technologyBrisbaneQLDAustralia instituto biosanitario(ibs) university of granadaGranadaSpain hospital authority Hong KongChina dept.computer science and artificial intelligence university of granadaGranadaSpain dept.of computer science and engineering university of cádizCadizSpain

Purpose： The main goal of this study is to discover the scientific evolution of Cancer-Related Symptoms in Complementary and Alternative Medicine research area, analyzing the articles indexed in the Web of Science database from 1980 to ***/Methodology/Approach： A co-word science mapping analysis is performed under a longitudinal framework（1980 to 2013）. The documental corpus is divided into two subperiods,1980–2008 and 2009–2013. Thus, the performance and impact rates, and conceptual evolution of the research field are ***： According to the results, the co-word analysis allows us to identify 12 main thematic areas in this emerging research field： anxiety, survivors and palliative care,meditation, treatment, symptoms and cancer types, postmenopause, cancer pain, low back pain, herbal medicine, children, depression and insomnia, inflammation mediators, and lymphedema. The different research lines are identified according to the main thematic areas,centered fundamentally on anxiety and suffering prevention. The scientific community can use this information to identify where the interest is focused and make decisions in different *** limitation： Several limitations can be addressed： 1） some of the Complementary and Alternative Medicine therapies may not have been included; 2） only the documents indexed in Web of Science are analyzed; and 3） the thematic areas detected could change if another dataset was *** implications： The results obtained in the present study could be considered as an evidence-based framework in which future studies could be ***/value： Currently, there are no studies that show the thematic evolution of this research area.

关键词： Cancer-related symptoms Complementary and Alternative Medicine Bibliometrics Science mapping analysis Thematic evolution H-index

Wavelets and Entropy for Power Quality Assessment

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American journal of Computational Mathematics 2017年第3期7卷 276-290页

作者： Eduardo antonio Cano-Plata Armando j. Ustariz-Farfán jorge H. Estrada-Estrada Department of Electrical Electronic and Computer Engineering Universidad Nacional de Colombia Manizales Colombia

In this paper, wavelet transform and entropy are evaluated using the mathematical analysis concepts of reflexibility, regularity and series obtention, these concepts remark the reason to make a selective reference framework for power quality applications. With this idea the paper used the same treatment for the two algorithms (Multiresolution and Multiscale Entropy). The wavelet is denoted to have the most power full consistence to the light off the reflexibility, regularity and series obtention. The paper proposes a power quality technique namely MpqAT.

关键词： Wavelets Entropy Reflexibility Regularity Multiresolution Multiscale

Antifungal Activity and Toxicity of the 3,4,5-Trihydroxybenzoic and 3,4,5-Tris(Acetyloxy)Benzoic Acids

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Advances in Microbiology 2015年第7期5卷 517-522页

作者： jéssica Pinto Diego Silva joao Honorato antonio Menezes Eugénia Pinto Plínio Naves Unit of Exact and Technological Sciences Universidade Estadual de GoiásAnápolisBrazil Department of Chemistry Universidade Federal de Sao CarlosSao CarlosBrazil Department of Biological Sciences Faculty of PharmacyUniversidade do PortoPortoPortugal

Invasive fungal infections have been gaining notoriety due to several factors, mainly their increasing incidence in immunocompromised patients. The aim of the present study was to evaluate the antifungal activity and toxicity of the 3,4,5-trihydroxybenzoic acid (3,4,5-THB) and of its derivative, the 3,4,5-tris(acetyloxy)benzoic acid (3,4,5-TAB). The 3,4,5-THB was purchased and its derivative was obtained by purifying and characterizing performed using semisynthesis reactions (esterification), recrystallization, column chromatography and infrared analytical techniques and nuclear magnetic resonance. Minimum inhibitory concentration (MIC) and minimum lethal concentration (MLC) were determined in order to evaluate the antifungal activity of the compounds against four clinical isolates and four standard strains of Candida sp. and five clinical isolates of dermatophytes, following the Clinical and Laboratory Standards Institute protocols. The toxicity of the compounds was evaluated by determining the lethal dosis (LD50) using lethality assay of Artemia salina. The most sensitive yeasts to the 3,4,5-THB were C. albicans ATCC 10231 and C. krusei ATCC 6258, both presenting a MIC of 128 μg·mL-1. For Trichophyton sp. and Epidermophyton floccosum, the MIC was 32 μg·mL-1. The 3,4,5-TAB showed a lower inhibitory activity against Candida and dermatophyte species tested. The LD50 of 3,4,5-THB was 222.60 μg·mL-1 and the 3,4,5-TAB showed 481.69 μg·mL-1 of LD50. In conclusion, the 3,4,5-trihydroxybenzoic acid showed antifungal activity against species of medical importance, mainly dermatophytosis-causing fungi, and the 3,4,5-tris(acetyloxy)benzoic acid showed no increasing antifungal activity and toxicity in relation to the original compound.

关键词： Antifungal Toxicity Candida Dermatophytes 3,4,5-Trihydroxybenzoic Acid 3,4,5-Tris(Acetyloxy)Benzoic Acid

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孕期母猫和新生幼猫的营养学综述

畜牧产业 2022年第2期 56-61页

作者：张云阳(译) 米雁(译) Francisco antonio Félix Xavier júnior Karen Denise da Silva Macambira Steffi Lima Araujo 亘泰集团上海吉宠(上海)国际贸易有限公司上海不详

猫营养学知识及其影响动物健康有关知识是兽医学的一大实际内容。由于日粮管理可防止许多器官系统的某些疾病的发展,并有助于治疗某些胃肠道疾病和其他疾病,因此人们在日粮管理领域的投资日益增多。因为猫的日粮会根据其生理阶段和营养... 详细信息

猫营养学知识及其影响动物健康有关知识是兽医学的一大实际内容。由于日粮管理可防止许多器官系统的某些疾病的发展,并有助于治疗某些胃肠道疾病和其他疾病,因此人们在日粮管理领域的投资日益增多。因为猫的日粮会根据其生理阶段和营养需求存在差异,因此猫营养界定很重要。众所周知,不同生理阶段的营养差异甚至比同一生理阶段不同物种的差异更明显。与犬相比,猫的营养管理方面有着很多不同之处。由于日粮中蛋白质和脂质的含量取决于必需维生素和矿物质含量,了解猫科动物的营养需求对于配制营养均衡、健康的日粮至关重要,从而可为动物提供更长的预期寿命和高质量生活。本研究旨在对家猫最重要的营养方面进行文献综述,重点介绍在其不同生理阶段对日粮进行妥善管理的需求。

关键词：小动物营养猫新生幼崽

HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-jin Kim jose-antonio Perez-Simon Maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation