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Innovative treatments for congenital heart defects

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World Journal of Pediatrics 2023年第1期19卷 1-6页

作者： antonio f.corno Taylor S.Koerner Jorge D.Salazar McGovern Medical School Children's Heart InstituteMemorial Hermann Children's HospitalUniversity of Texas Health Science Center in Houston6410 Fannin StreetMSB 6.274HoustonTX 77030USA

The past few decades have witnessed substantial advances in the treatment of complex congenital heart defects,with most significant advances in surgical treatment strategies and improved outcomes dependent upon well-educated and calculated risk-taking *** the present surgical era,doing nothing for complex congenital heart defects is unacceptable,and pioneering surgeons are willing to under-take and accept the substantial risks of innovative pediatric cardiac surgery[1].

关键词： congenital treatment defects

Automorphism Groups of Pseudo-real Riemann Surfaces of Low Genus

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Acta Mathematica Sinica,English Series 2014年第1期30卷 11-22页

作者： Emilio BUJALANCE antonio f.COSTA Departamento de Matemáticas fundamentales Facultad de CienciasUNEDSenda del rey928040 MadridSpain

A pseudo-real Riemann surface admits anticonformal automorphisms but no anticonformal *** obtain the classifcation of actions and groups of automorphisms of pseudo-real Riemann surfaces of genera 2,3 and *** instance the automorphism group of a pseudo-real Riemann surface of genus 4 is eitherC4orC8or the fro¨benius group of order 20,and in the case ofC4there are exactly two possible topological *** MK P R,g be the set of surfaces in the moduli space MK g corresponding to pseudo-real Riemann *** obtain the equisymmetric stratifcation of MK P R,g for generag=2,3,4,and as a consequence we have that MK P R,gis connected forg=2,3 but MK P R,4has three connected components.

关键词： Riemann surface automorphism anticonformal automorphism moduli space

Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas

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World Journal of Gastroenterology 2015年第12期21卷 3472-3479页

作者： antonio Solinas Diego f Calvisi Department of Biomedical Sciences University of Sassari Department of Clinical and Experimental Medicine University of Sassari Institute of Pathology University of Greifswald

In this review we focus on lymphoepitheliomalike hepatocellular carcinomas(LEL-HCC) and lymphoepithelioma-like cholangiocarcinomas(LEL-ICC). Despite their rarity, these tumors are of general interest because of their epidemiological and clinical features, and because they represent a distinct model of interaction between the immune systemand neoplastic cells. Approximately half of LELHCC arise in the context of chronic hepatitis C virus(HCV) infection and have been described both in Eastern and Western patients. By contrast, LEL-ICC is associated in almost all cases with Epstein-Barr virus(EBV) infection and exhibits the same epidemiological features of EBV related malignancies. Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, both LEL-HCC and LEL-ICC are characterized by lower rates of recurrence after surgery and better overall survival. How this behavior is related to distinct genetic alterations and tumor microenvironment is unclear. The pathophysiological mechanisms of lymphoid infiltrations seem to be different among the two groups of tumors. In fact, LEL-HCC frequently arises in the context of inflammatory changes driven by HCV infection, and has been recognized as a variant of classical hepatocellular carcinoma. At variance, lymphocyte recruitment of LEL-ICC is similar to that described in nasopharyngeal carcinoma and gastric LEL, and possibly depends on the expression pattern of latent EBV infection.

关键词： Lymphoepithelioma Lymphoepithelioma-like carcinoma

Quantifying Electrochemical Processes in Batteries and Beyond

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Energy & Environmental Materials 2022年第4期5卷 1001-1004页

作者： Emma N.antonio Michael f.Toney Materials Science and Engineering Program University of Colorado BoulderBoulderColorado 80309USA Joint Center for Energy Storage Research(JCESR) University of Colorado BoulderBoulderColorado 80309USA Department of Chemical and Biological Engineering University of Colorado BoulderBoulderColorado 80309USA Renewable and Sustainable Energy Institute University of Colorado BoulderBoulderColorado 80309USA

The correlation of electrochemical measurements with materials characterization has advanced our understanding of operation and degradation mechanisms in electrochemical energy storage and many other ***,often these correlations are qualitative,preventing the unambiguous identification of both operational principles and the root causes of performance *** we suggest quantitative approaches to define competing mechanisms and determine their relative *** illustrate the importance of quantitative methodologies over a range of electrochemical systems and highlight the need to consider the effect of the experimental design and measurement *** approaches will reveal the most detrimental degradation mechanisms and enable the development of strategies to suppress,stabilize or eliminate them,leading to materials and devices with longer lifetimes,reduced environmental impact,and improved performance.

关键词： electrochemistry in situ and operando characterization batteries quantification materials science

Affinity-Based Network Interfaces for Efficient Communication on Multicore Architectures

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Journal of Computer Science & Technology 2013年第3期28卷 508-524页

作者： Andrés Ortiz Julio Ortega antonio f.Díaz Alberto Prieto Department of Communications Engineering University of Málaga Department of Computer Architecture and Technology/CITIC University of Granada

Improving the network interface performance is needed by the demand of applications with high communication requirements （for example, some multimedia, real-time, and high-performance computing applications）, and the availability of network links providing multiple gigabits per second bandwidths that could require many processor cycles for communication tasks. Multicore architectures, the current trend in the microprocessor development to cope with the difficulties to further increase clock frequencies and microarchitecture efficiencies, provide new opportunities to exploit the parallelism available in the nodes for designing efficient communication architectures. Nevertheless, although present OS network stacks include multiple threads that make it possible to execute network tasks concurrently in the kernel, the implementations of packet-based or connection-based parallelism are not trivial as they have to take into account issues related with the cost of synchronization in the access to shared resources and the efficient use of caches. Therefore, a common trend in many recent researches on this topic is to assign network interrupts and the corresponding protocol and network application processing to the same core, as with this affinity scheduling it would be possible to reduce the contention for shared resources and the cache misses. In this paper we propose and analyze several configurations to distribute the network interface among the different cores available in the server. These alternatives have been devised according to the affinity of the corresponding communication tasks with the location （proximity to the memories where the different data structures are stored） and characteristics of the processing core. As this approach uses several cores to accelerate the communication path of a given connection, it can be seen as complementary to those that consider several cores to simultaneously process packets belonging to either the same or different connections.

关键词： interrupt affinity processor affinity network interface offioading, SIMICS

Mortality from liver cirrhosis and HCC in the DAA era:success in viral control is darkened by raise of metabolic disease

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 307-310页

作者： antonio Saviano Thomas f.Baumert Inserm U1110 Institut de Recherche sur les Maladies Virales et HépatiquesUniversite de StrasbourgF-67000 StrasbourgFrance Pole Hépatodigestif Institut Hopitalo-UniversitaireHopitaux UniversitairesF-67000 StrasbourgFrance

Liver cirrhosis and primary liver cancers are leading causes of mortality worldwide with over than 1.7 million of deaths in 2010 representing about 3.4%of the overall deaths(1).Global liver cirrhosis deaths ceaselessly increased by 52.2%from 1980 to 2010(1).Similarly,primary liver cancers global deaths increased by 62.4%from 1990 to 2010(2).

关键词： cirrhosis liver mortality

Machine learning-based zero-touch network and service management:a survey

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Digital Communications and Networks 2022年第2期8卷 105-123页

作者： Jorge Gallego-Madrid Ramon Sanchez-Iborra Pedro M.Ruiz antonio f.Skarmeta Department of Information and Communication Engineering University of Murcia30100MurciaSpain Department of Engineering and Applied Techniques University Center of Defense30729San Javier Air Force BaseSpain

The exponential growth of mobile applications and services during the last years has challenged the existing network ***,the arrival of multiple management solutions to cope with this explosion along the end-to-end network chain has increased the complexity in the coordinated orchestration of different segments composing the whole *** Zero-touch Network and Service Management(ZSM)concept has recently emerged to automatically orchestrate and manage network resources while assuring the Quality of Experience(QoE)demanded by *** Learning(ML)is one of the key enabling technologies that many ZSM frameworks are adopting to bring intelligent decision making to the network management *** paper presents a comprehensive survey of the state-of-the-art application of ML-based techniques to improve ZSM *** this end,the main related standardization activities and the aligned international projects and research efforts are deeply *** this dissection,the skyrocketing growth of the ZSM paradigm can be ***,different standardization bodies have already designed reference architectures to set the foundations of novel automatic network management functions and resource *** with these advances,diverse ML techniques are being currently exploited to build further ZSM developments in different aspects,including multi-tenancy management,traffic monitoring,and architecture coordination,among ***,different challenges,such as the complexity,scalability,and security of ML mechanisms,are also identified,and future research guidelines are provided to accomplish a firm development of the ZSM ecosystem.

关键词： Zero-touch network and service management(ZSM) Next generation networks(NGN) Artificial intelligence(AI) Machine learning(ML)

Stochastic seismic inversion and Bayesian facies classification applied to porosity modeling and igneous rock identification

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Petroleum Science 2024年第2期21卷 918-935页

作者： fábio Júnior Damasceno fernandes Leonardo Teixeira antonio fernando Menezes freire Wagner Moreira Lupinacci Exploratory Interpretation and Reservoir Characterization Group(GIECAR) Department of Geology and GeophysicsFederal Fluminense UniversityNiter oiRJ24210-346Brazil Petrobras Rio de JaneiroRJ20231-030Brazil National Institute of Science and Technology of Petroleum Geophysics(INCT-GP/CNPQ) Niter oiRJ24210-346Brazil

We apply stochastic seismic inversion and Bayesian facies classification for porosity modeling and igneous rock identification in the presalt interval of the Santos Basin. This integration of seismic and well-derived information enhances reservoir characterization. Stochastic inversion and Bayesian classification are powerful tools because they permit addressing the uncertainties in the model. We used the ES-MDA algorithm to achieve the realizations equivalent to the percentiles P10, P50, and P90 of acoustic impedance, a novel method for acoustic inversion in presalt. The facies were divided into five: reservoir 1,reservoir 2, tight carbonates, clayey rocks, and igneous rocks. To deal with the overlaps in acoustic impedance values of facies, we included geological information using a priori probability, indicating that structural highs are reservoir-dominated. To illustrate our approach, we conducted porosity modeling using facies-related rock-physics models for rock-physics inversion in an area with a well drilled in a coquina bank and evaluated the thickness and extension of an igneous intrusion near the carbonate-salt interface. The modeled porosity and the classified seismic facies are in good agreement with the ones observed in the wells. Notably, the coquinas bank presents an improvement in the porosity towards the top. The a priori probability model was crucial for limiting the clayey rocks to the structural lows. In Well B, the hit rate of the igneous rock in the three scenarios is higher than 60%, showing an excellent thickness-prediction capability.

关键词： Stochastic inversion Bayesian classification Porosity modeling Carbonate reservoirs Igneous rocks

Pan-enteric dysmotility,impaired quality of life and alexithymia in a large group of patients meeting ROMEⅡ criteria for irritable bowel syndrome

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World Journal of Gastroenterology 2003年第10期9卷 2293-2299页

作者： Piero Portincasa antonio Moschetta Giuseppe Baldassarre Donato f. Altomare Giuseppe Palasciano Section of Internal Medicine Department of Internal Medicine and Public Medicine(DIMIMP)University Medical SchoolBari Division of Geriatrics Hospital"Miulli"Acquaviva delle FontiBariItaly Section of-Surgery Department of Emergency and Organ Transplant(DETO)University Medical SchoolBariItaly

AIM:Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern ***: One hundred IBS patients (f:M=73:27, age 48±2 years, mean±SE) fulfilling ROME Ⅱ criteria matched with 100 healthy subjects (f:M=70:30, 45±2 years). Dyspepsia,bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT)were measured respectively by ultrasonography and H2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue ***: Compared with controls, IBS patients had increased dyspepsia (score 12.6±0.7 VS 5.1±0.2, P＜0.0001),weekly bowel movements (12.3±0.4 VS 5.5±0.2, P＜0.00001, comparable stool shape), alexithymia (score 59.11.1 VS40.5±1.0, P=0.001), poor quality of life and psychoaffective profile. IBS patients had normal gallbladderemptying, but delayed gastric emptying (T50:35.5±1.0 VS 26.1±0.6 min, P=0.00001) and OCTT (163.0±5.4 VS96.6±1.8min, P=0.00001). fullness, nausea, and epigastric pain/discomfort were greater in IBS than in ***: ROME Ⅱ IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of *** presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy.

关键词：肠易激综合征述情障碍生活质量临床研究