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Doxorubicin-eluting bead vs conventional transcatheter arterial chemoembolization for hepatocellular carcinoma before liver transplantation

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World Journal of Gastroenterology 2013年第34期19卷 5622-5632页

作者： daniele Nicolini Gianluca Svegliati-Baroni Roberto Candelari Cinzia Mincarelli Alessandra Mandolesi Italo Bearzi Federico Mocchegiani Andrea Vecchi Roberto Montalti antonio Benedetti Andrea Risaliti Marco Vivarelli Division of Hepatobiliary and Transplant Surgery Department of Gastroenterology and TransplantationPolytechnic University of Marche Division of Gastroenterology Department of Gastroenterology and TransplantationPolytechnic University of Marche Division of Interventional Radiology Department of Radiological SciencesPolytechnic University of Marche Division of Pathology Department of PathologyPolytechnic University of Marche Division of Hepatobiliary and Transplant Surgery Department of Medical and Biological SciencesUniversityof Udine

AIM:To assess the possible effect of two different types of preoperative transcatheter arterial chemoembolization(TACE)on recurrence-free survival after liver transplantation(LT)in patients with hepatocellular carcinoma(HCC)and to analyze the effects of TACE on tumor ***:We retrospectively analyzed the histological features of 130 HCC nodules in 63 native livers removed at *** who received any other type of treatment such as radiofrequency tumor ablation,percutaneous ethanol ablation or who were not treated at all were *** patients in the present study were within the Milan Criteria at the last imaging findings before *** bead TACE(DEB-TACE)was performed in 22patients(38 nodules),and conventional TACE(c-TACE)in 16(25 nodules).Patients’and tumors’characteristics were retrospectively *** performed a pernodule analysis of the explanted livers to establish the mean percentage of necrosis of any nodule treated by TACE(conventional or DEB)and a per-patient analysis to establish the percentage of necrosis in the cumulative tumor area,including 21 nodules not reached by *** and fibrotic changes in the tissue surrounding the tumor nodule were analyzed and categorized as poor/absent,moderate and enhanced ***-and multivariate analysis of risk factors for HCC-recurrence were ***:The number and diameter of the nodules,the time spent on the waiting list and the number of treatments were similar in the two groups.A trend towards higher appropriate response rates(necrosis≥90%)was observed in the DEB-TACE group(44.7%vs32.0%,P=0.2834).The mean percentage of necrosis in the cumulative tumor area was 58.8%±36.6%in the DEB-TACE group and 50.2%±38.1%in the c-TACE group(P=0.4856).Fibrotic and inflammatory reactions surrounding the tumor nodule were markedly more common in the DEB-TACE group(P<0.0001,for both the parameters).The three-year recurrence-free survival was hig

关键词： Liver transplantation Hepatocellular carcinoma Transcatheter arterial chemoembolization Doxorubicin-eluting bead Tumor histology Recurrence-free survival Locoregional therapies

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Peritoneal seeding from appendiceal carcinoma:A case report and review of the literature

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World Journal of Gastrointestinal Surgery 2010年第8期2卷 265-269页

作者： Valentina R Bertuzzo Federico Coccolini antonio D pinna Department of General Emergency and Transplant Surgery Sant'Orsola-Malpighi University Hospital

Non-carcinoid appendiceal malignancies are rare entities,representing less than 0.5% of all gastrointestinal *** of their rarity and particular biological behavior,a substantial number of patients affected by these neoplasms do not receive appropriate surgical *** this report,we describe a rare case of primary signetring cell carcinoma of the appendix with peritoneal seeding which occurred in a 40-year old man admitted at the Emergency Surgery Department with the clinical suspicion of acute *** a surgical debulking and right hemicolectomy,the patient had systemic chemotherapy according to FOLFOX *** completion of the latter,the patient underwent cytoreductive surgery plus hyperthermic intraperitoneal *** report offers a brief review of the literature and suggests an algorithm for the management of non-carci-noid appendiceal tumors with peritoneal dissemination.

关键词： Appendiceal neoplasms Signetring cell carcinoma Peritoneal carcinomatosis Hyperthermic intra-peritoneal chemotherapy Therapeutic algorithm

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Use of Perovskite-Type Lanthanum Nickelate Synthesized by the Polymeric Precursor Method in the Steam Reforming Reaction of Methane

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Materials Sciences and Applications 2012年第6期3卷 363-368页

作者： daniele M.H.Martinelli Dulce M.A.Melo Anne M.Garrido Pedrosa antonio E.Martinelli Marcus A.de F.Melo Mary K.S.Batista Roberto C.Bitencourt Department of Chemistry Federal University of Rio Grande do NorteCCETNatalBrazil Department of Chemistry Federal University of SergipeCCETSao CristóvaoBrazil Research Center Petrobras—Cenpes Rio de JaneiroBrazil

In the current work, LaNiO3 perovskite was synthesized using the polymeric precursor method. The materials were thermally treated at 300°C for 2 hours, subsequently supported on alumina or zirconia and finally calcined at 800°C for 4 hours. The resulting samples were characterized by X-ray diffraction, thermogravimetry, BET surface area and thermo-programmed reduction. Steam reforming reactions were carried out at 750°C and 6 bar during 4 hours using a pilot reactor under a H2O:CH4 ratio of 2.5. The mass of catalysts was about 5.7 g. X-ray diffraction patterns confirmed the formation of the perovskite structure in all samples prepared. The results also showed that lanthanum nickelate was more efficient when supported on alumina than zirconia. Finally, it was observed that the methane conversion was approximately 94% and the selectivity to hydrogen was about 70%. In all cases low selectivity to CO and CO2 was verified.

关键词： Lanthanum Nickelate Perovskite Polymeric Precursor Method Steam Reforming Reaction

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Relationship of Morpho-Sedimentological Variations to the Fate of Hg-and Zn-Polluted Sediments in the Contaminated Site of Porto Marghera,Lagoon of Venice,Italy

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Journal of Environmental Protection 2013年第4期4卷 37-49页

作者： Emanuela Molinaroli Alessandro Sarretta Jorge Ade Souza Guimaraes Margherita Botter daniele Cassin Stefano Guerzoni Dipartimento di Scienze Ambientali Informatica e Statistica Universita Ca’Foscari VeneziaVeneziaItaly CNR—Consiglio Nazionale delle Ricerche ISMAR—Istituto di Scienze MarineBolognaItaly Coastal Planning&Engineering do Brasil Santo Antonio de LisboaFlorianopolisBrasil CNR—Consiglio Nazionale delle Ricerche ISMAR—Istituto di Scienze MarineVeneziaItaly CNR—Consiglio Nazionale delle Ricerche ISMAR—Istituto di Scienze MarineLesinaItaly

New data collected from twenty-six sites during 2008 inthe contaminated Site of National Interest (SIN) of Porto Marghera within the Lagoon of Venice (Italy), which has been affected by the presence of an industrial zone for the last 80 years, were compared with data from a campaign performed in the same site 30 years before (1976-1978). The SIN was found to be heavily polluted in the earlier study, and several tons of Hg and Zn are still stored in soils and industrial channel sediments, potentially affecting the lagoon part of the SIN. Bathymetric variations, grain-size, Hg and Zn content in sediments were analysed. The severe contamination of the late 1970s (Hg 1.7 μg/g;Zn 754 μg/g) had fallen by the late 2000s (Hg 0.9 μg/g;Zn 225 μg/g). The fall in Hg and Zn contamination over the 30-year period was mainly linked to the patterns of geomorphological change inside the SIN that affected two distinct sub-areas: 1) a stable-depositional (SD) area in the Northern part, which exerted a “dilution” effect on contaminants, with significant deposition (~11%) of coarse-grained sediments (63 - 8 μm), and 2) an area characterised by moderate-to-severe-erosion (MSE) to the South, which saw the loss (~13%) of pollutant-bearing fine-grained sediments (sion if hydrodynamic conditions change in the future. This study provides useful support to decision-making systems by helping to select hot-spots for remediation measures.

关键词： Lagoon of Venice Sediment Pollution Bathymetry Erosion-Sedimentation Grain-Size Management Plan

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The duration of the conventional chemoembolization for hepatocellular carcinoma:factors affecting the procedural time

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Hepatoma Research 2022年第1期8卷 313-326页

作者： Matteo Renzulli Mattia Gentilini Giovanni Marasco Nicolo Brandi Alessandro Granito Silvia Lo Monaco Anna Maria Ierardi antonio De Cinque Francesco Tovoli Laura Bartalena daniele Spinelli Fabio Piscaglia Rita Golfieri Department of Radiology IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Internal Medicine and Digestive Physiopathology Unit IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Division of Internal Medicine IRCCS Azienda Ospedaliero-Universitaria di BolognaBologna 40138Italy Diagnostic and Interventional Radiology Department Fondazione IRCCS CàGranda Ospedale Maggiore PoliclinicoUniversitàdegli Studi di Milano MilanMilan 20122Italy

Aim:The present study evaluated the duration of chemoembolization in patients with hepatocellular carcinoma,analyzing possible factors affecting the procedural ***:In total,175 patients who underwent chemoembolization have been prospectively *** procedural length was considered the time between the insertion and the removal of the angiographic *** features related to the tumor burden and angiographic procedures,which could be related to the procedural time,were ***:The chemoembolization time resulted in a mean of 58.1 *** longer procedural time was associated with a number of nodules treated per patient≥2(P<0.001),a number of segments with nodules≥2(P<0.001),the presence of more than 1 nodule in the same segment(P<0.001),the location of the tumor in the left lobe(P=0.001),the exclusion from the Milan criteria(P<0.001),and a number of segments treated≥2(P<0.001).Only the number of nodules treated per patient resulted significantly in multivariate analysis(OR 2.927,95%CI:2.015-4.251,P<0.001).Conclusion:The factors related to longer procedural time are the number of nodules treated≥2,the number of segments with nodules≥2,the involvement of the left lobe,the tumor burden outside the Milan criteria,and the number of segments treated≥*** these characteristics,known in the pre-procedural phase,represent useful tools for a correct planning of the angiographic room’s workflow during the pandemic era as well as in the future to reduce downtime and increase productivity.

关键词： Chemoembolization hepatocellular carcinoma procedural time angiographic room management

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Microcavity exciton polaritons at room temperature

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Photonics Insights 2022年第1期1卷 60-103页

作者： Sanjib Ghosh Rui Su Jiaxin Zhao antonio Fieramosca Jinqi Wu Tengfei Li Qing Zhang Feng Li Zhanghai Chen Timothy Liew daniele Sanvitto Qihua Xiong Beijing Academy of Quantum Information Sciences BeijingChina Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Peking UniversityBeijingChina Research Center for Wide Gap Semiconductor Peking UniversityBeijingChina Key Laboratory for Physical Electronics and Devices of the Ministry of Education&Shaanxi Key Laboratory of Information Photonic Technique School of Electronic Science and EngineeringFaculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’anChina Department of Physics College of Physical Science and TechnologyXiamen UniversityXiamenChina CNR NANOTEC Campus EcotekneLecceItaly State Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijingChina Frontier Science Center for Quantum Information BeijingChina Beijing Innovation Center for Future Chips Tsinghua UniversityBeijingChina

The quest for realizing novel fundamental physical effects and practical applications in ambient conditions has led to tremendous interest in microcavity exciton polaritons working in the strong coupling regime at room *** the past few decades,a wide range of novel semiconductor systems supporting robust exciton polaritons have emerged,which has led to the realization of various fascinating phenomena and practical *** paper aims to review recent theoretical and experimental developments of exciton polaritons operating at room temperature,and includes a comprehensive theoretical background,descriptions of intriguing phenomena observed in various physical systems,as well as accounts of optoelectronic ***,an in-depth review of physical systems achieving room temperature exciton polaritons will be presented,including the early development of ZnO and GaN microcavities and other emerging systems such as organics,halide perovskite semiconductors,carbon nanotubes,and transition metal ***,a perspective of outlooking future developments will be elaborated.

关键词： microcavity exciton polariton Bose-Einstein condensation exciton binding energy quantum simulation nonequilibrium dynamics

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Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

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World Journal of Hepatology 2011年第11期3卷 278-284页

作者： Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro antonio Picardi Umberto Vespasiani Gentilucci daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli Giorgio Barbarini Liver Unit Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense 8700149 Rome Italy Department of Digestive and Liver Disease Azienda Ospedaliera Sant’AndreaVia Grottarossa 1035/1039000189 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Liver Unit Ospedale Sandro PertiniVia dei Monti Tiburtini 38500157 Rome Italy Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense87 00149 Rome Italy Medicine of Migration National Institute for Migrant Health and Poverty Via di S. Gallicano 25/a 00153Rome Italy Department of Medical Pathophysiology University of Rome "La Sapienza" Viale del Policlinico 15500161 Rome Italy Liver Unit Campus Biomedico UniversityVia álvaro del Portillo 21 00128Rome Italy Histopathology Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149Rome Italy Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Department of Infectious and Tropical Disease University of Rome"La Sapienza"Viale del Policlinico155 00161 Rome Italy Liver Unit Ospedale Villa BetaniaVia Niccolò Piccolomini 2700165 RomeItaly Liver Unit Policlinico CasilinoVia Casilina104900169 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Infectious and Parasitic Diseases Policlinico San Matteo P.zzale Golgi 2 2710 PaviaItaly

AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management ***:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and *** with DLBCL were managed with the standard of care of *** with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course *** outcomes of the different approaches were ***:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent *** of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL *** lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection.

关键词： Hepatitis C virus infection Diffuse large B cell lymphoma Indolent lymphoma Pegylated interferon Lymphomagenesis

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The Tianjin geothermal field (northeastern China): Geochemistry and implications for possible plugging phenomena

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Chinese Journal Of Geochemistry 2006年第B8期25卷 148-148页

作者： Angelo Minissale daniele Borrini Giordano Montegrossi Franco Tassi Orlando Vaselli antonio Delgado Huertas Wanqing CHENG Jincheng YANG Xuzhou CHENG CNR-Institute of Geosciences and Earth Resources Via G La Pira 4-50121 Florence Italy Department of Earth Sciences Via G La Pira 4-50121 Florence ltaly Estaciōn Experimental del Zaidin （CSIC） Prof. Albareda 1 18008 Granada Spain Tianjin Aode Renewable Energy Research Institute Tianjin 300381 China Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China

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Mosaicism of a novel variant in the ANKRD11 gene in a child with a mild KBG phenotype:A case report

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World Journal of Medical Genetics 2023年第2期11卷 21-27页

作者： Roberto Franceschi Francesca Rivieri antonio Novelli daniele Ferretti Adriano Anesi Massimo Soffiati Giulia Porretti Evelina Maines Mafalda Mucciolo Giorgio Radetti Department of Pediatrics S.Chiara Hospital of TrentoAPSSTrento 38122Italy Genetic Unit Laboratory of Clinical PathologyDepartment of LaboratoriesAPSSTrento 38122Italy Laboratory of Medical Genetics Ospedale Pediatrico Bambino GesùRome 00165Italy Human Genetics Laboratory Ospedale Pediatrico Bambino GesùRome 00165Italy Department of Pediatrics S.Chiara General HospitalAPSSTrento 38122Italy Department of Radiology S.Chiara General HospitalAPSSTrento 38122Italy Department of Pediatrics General Hospital BolzanoMarienklinikBolzano 39100Italy

BACKGROUND KBG syndrome is likely underdiagnosed because of mild and non-specific features in some affected patients especially before the upper permanent central incisors eruption at about the age of 7-8 *** mosaicisms are usually recognized in the parents only after a typically affected son is diagnosed with KBG *** describe for the first time the mosaicism of a novel variant in a child with a mild KBG *** SUMMARY Our patient presented at 24 mo of age with short stature,hand abnormalities,facial dysmorphism and mild developmental *** hypoplasia and central hypothyroidism were also *** next generation sequencing(NGS)analysis we found a novel deletion in the ANKRD11 gene(c.4880_4893del.),that can be classified as likely pathogenic for the syndrome,with the percentage of mutated allele of 36%.We considered this finding as causative of the mild and non-specific phenotype for KBG syndrome in our patient,as previously reported in adults.A heterozygous variant in HESX1 gene,classified as variant of uncertain significance,but suspected of causing pituitary hypoplasia and hormonal deficiency,was also *** patient started levothyroxine and growth hormone *** The increased use of NGS analysis may expand the phenotypic spectrum of KBG syndrome because it allows genetic diagnosis of somatic mosaicisms also in children.

关键词： ANKRD11 KBG Mosaic HESX1 Child Case report

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Collateral findings during computed tomography scan for atrial fibrillation ablation:Let's take a look around

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World Journal of Cardiology 2016年第4期8卷 310-316页

作者： Francesco Perna Michela Casella Maria Lucia Narducci antonio Dello Russo Gianluigi Bencardino Gianluca Pontone Gemma Pelargonio daniele Andreini Nicola Vitulano Francesca Pizzamiglio Edoardo Conte Filippo Crea Claudio Tondo Cardiac Arrhythmia Unit Agostino Gemelli University Hospital Cardiac Arrhythmia Research Centre Centro Cardiologico MonzinoIRCCS

The growing number of atrial fibrillation catheter ablation procedures warranted the development of advanced cardiac mapping techniques, such as image integration between electroanatomical map and cardiac computed tomography. While scanning the chest before catheter ablation, it is frequent to detect cardiac and extracardiac collateral findings. Most collateral findings are promptly recognized as benign and do not require further attention. However, sometimes clinically relevant collateral findings are detected, which often warrant extra diagnostic examinations or even invasive procedure, and sometimes need to be followed-up over time. Even though reporting and further investigating collateral findings has not shown a clear survival benefit, almost all the working groups providing data on collateral findings reported some collateral findings eventually coming out to be malignancies, sometimes at an early stage. Therefore, there is currently no clear agreement about the right strategy to be followed.

关键词： Collateral findings Incidental findings Incidentalomas Cardiac computed tomography Image integration

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