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Global epidemiology of sexually transmitted diseases

Asian Journal of Andrology 2008年第1期10卷 110-114页

作者： carlos T. da Ros Caio da silva Schmitt Urology Department Mae de Deus Hospital Porto Alegre RS 90450180 Brazil

Sexually transmitted diseases （STDs） are among the first ten causes of unpleasant diseases in young adult males in developing countries and the second major cause of unpleasant diseases in young adult women. Adolescents and young adults （15-24 years old） make up only 25% of the sexually active population, but represent almost 50% of all new acquired STDs. In general, STDs are epidemics and present an enormous health and economic consequences. An adequate screening for STDs should be done on a routine basis in every part of the world. Many STDs are asymptomatic and therefore can difficult to control. The purpose of reporting of STDs is to ensure that persons who are infected will be quickly diagnosed and appropriately treated to control the spread of infection and also so that partners are notified, tested and appropriately treated. It is estimated that reported cases of STDs represent only 50%-80% of reportable STD infections in the United States, reflecting limited screening and low disease reporting. High-risk sexual behavior is a highly contributive factor of this process as it often leads to teenage pregnancies and HIV/AIDS. One possible explanation for this behavior is that people do not have enough information about the transmission of STDs or ignore the precautions required for safe sex. Approximately 60% of new HIV infections worldwide occur in young people. The frequency of high-risk behaviors among youths may also be influenced by opportunity to engage in them, particularly the amount of time that they are unsupervised by adults. However, in diagnosing and treating these patients, we can effectively prevent the spread of HIV/AIDS. Individuals infected with STDs are 5-10 times more likely than uninfected individuals to acquire or transmit HIV through sexual contact. The breaking of the genital tract lining or skin creates a portal of entry for HIV and, hence, HIV-infected individuals with other STDs are more likely to shed HIV in their genital secretions. T

关键词： sexually transmitted diseases safe sex condom young people

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Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

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World Journal of Gastroenterology 2017年第37期23卷 6854-6867页

作者： Diego Marques Layse Raynara ferreira-Costa Lorenna Larissa ferreira-Costa Romualdo da silva Correa Aline Maciel Pinheiro Borges Fernanda Ribeiro Ito carlos Cesar de Oliveira Ramos Raul Hernandes Bortolin André Ducati Luchessi Andrea Ribeiro-dos-Santos Sidney Santos Vivian Nogueira Silbiger Laboratório de Bioanálise e Biotecnologia Molecular Universidade Federal do Rio Grande do Norte Programa de Pós-graduacao em Ciências Farmacêutica Universidade Federal do Rio Grande do Norte Laboratório de Genética Humana e Médica Universidade Federal do Pará Departamento de Cirurgia Oncológica Liga Norte Riograndense Contra o Cancer Laboratório de Patologia eCitopatologia Liga Norte Riograndense Contra o Cancer Depart-amento de Análises Clínicas e Toxicológicas Universidade Federal do Rio Grande do Norte Núcleo de Pesquisas em Oncologia Universidade Federal do Pará

AIM To investigate the association between 16 insertiondeletions(INDEL) polymorphisms, colorectal cancer(CRC) risk and clinical features in an admixed *** O n e h u n d re d a n d fo r ty p a t i e n t s w i t h C R C a n d 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on Gene Mapper ID v3.2. Clinicopathological data were obtained by consulting the patients' clinical charts, intra-operative documentation, and pathology *** Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis(TNM) stage risk, the Ins alleles of ACE, HLAG and TP53(6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death *** The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings.

关键词： Colorectal cancer Ins-del polymorphism Admixed population Potential biomarker Diagnostic Risk stratification Prognostic Clinical features

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Acclimatization of in Vitro-derived Dendrobium

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Horticultural Plant Journal 2017年第3期3卷 110-124页

作者： Jaime A.Teixeira da silva Mohammad Musharof Hossain Madhu Sharma Judit Dobránszki Jean carlos Cardoso ZENG Songjun Miki-cho post office Department of Botany University of Chittagong Division of Biotechnology CSIR-Institute of Himalayan Bioresource Technology Research Institute of Nyíregyháza University of Debrecen Centro de Ciências Agrárias UFSCar Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenChinese Academy of Sciences

The successful ex vitro establishment of Dendrobium plantlets raised in vitro determines the quality of the end product(cut flowers or potted plants) in commercial production for economic gain. When in vitro Dendrobium plantlets are transplanted from the culture room to greenhouse conditions, they may desiccate or wilt rapidly and can die as a result of changes in the environment, unless substantial precautions are taken to adapt plantlets to a new environment. The acclimatization of in vitro-grown Dendrobium plantlets to an ex vitro environment by gradually weaning them towards ambient relative humidity and light levels facilitates better survival of young and physiologically sensitive *** plantlets raised in vitro must thus undergo a period of acclimatization or transitional development to correct anatomical abnormalities and to enhance their physiological performance to ensure survival under ex vitro conditions. The most common approach to improve the survival of Dendrobium plantlets upon transfer to an ex vitro environment is their gradual adaptation to that environment. Under such conditions, plants convert rapidly from a heterotrophic or photomixotrophic state to an autotrophic growth, develop a fully functional root system,and better control their stomatal and cuticular transpiration. Gradual adaptation is carried out in a greenhouse by decreasing relative humidity using fog or mist chambers and by increasing light intensity using shading techniques. This review details the acclimatization and ex vitro survival of Dendrobium plants produced in vitro. This advice is also useful for other orchids.

关键词： Orchidaceae acclimation hardening autotrophic light intensity medicinal orchid relative humidity

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Prevalence and risk factors for acquired long QT syndrome in the emergency department:a retrospective observational study

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World Journal of Emergency Medicine 2023年第6期14卷 454-461页

作者： Diogo de Almeida Fernandes Guilherme de Freitas Camoes Diana ferreira Carolina Queijo carlos Fontes-Ribeiro Lino Gongalves Rui Pina Natalia antonio Department of Cardiology Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Department of Internal Medicine Coimbra Hospital and University Centre(CHUC)Coimbra 3000-075Portugal Faculty of Medicine University of CoimbraCoimbra 3000-370Portugal Institute for Clinical and Biomedical Research Faculty of MedicineUniversity of CoimbraCoimbra 3000-548Portugal

BACKGROUND: Long QT syndrome(LQTS) is a heterogeneous syndrome that may be congenital or, more frequently, acquired. The real-world prevalence of acquired LQTS(aLQTS) in the emergency department(ED) remains to be determined. The aim of this study was to determine prevalence of aLQTS and its impact on symptoms on ED ***: Electrocardiograms(ECG) of 5,056 consecutively patients admitted in the ED of a tertiary hospital between January 28th and March 17th of 2020 were reviewed. All patients with aLQTS were included. Clinical data with a focus on QT prolonging drugs and clinical factors were recorded. Statistical comparison was made between the groups with and without corrected QT(QTc) interval greater than 500 ms(value that is considered severely increased).RESULTS: A total of 383 ECGs with prolonged QTc were recognized, corresponding to a prevalence of aLQTS at admission of 7.82%. Patients with aLQTS were more commonly men(53.3%) with an age of(73.49±14.79) years old and QTc interval of(505.3±32.4) ms. Only 20.4% of these patients with aLQTS were symptomatic. No ventricular arrhythmias were recorded. Patients with QT interval greater than 500 ms were more frequently female(59.5%;P<0.001) and were more frequently on QT prolonging drugs(77.3%;P=0.025). Main contributing factor was intake of antibiotics(odds ratio [OR] 4.680) followed by female gender(OR 2.473) and intake of antipsychotics(OR 1.925).CONCLUSION: aLQTS is particularly prevalent in the ED. Female patients on antibiotics and antipsychotics are at particularly high risk. Efforts must be made to avoid, detect and treat aLQTS as early as possible.

关键词： Long QT syndrome Epidemiology Drug interactions Emergency department

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Anther Culture and Induced Mutation for wheat Improvement

Anther Culture and Induced Mutation for wheat Improvement

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小麦遗传育种国际学术讨论会

作者： carlos Eduardo de Oliveira Camargo Luiz carlos da silva Ramos antonio Wilson Penteado ferreira Filho Augusto Tulmann Neto Instituto Agronomico（IAC） CampinasSo PauloBrazil Instituto Agronomico（IAC） CampinasSo PauloBrazil Instituto Agronomico（IAC） CampinasSo PauloBrazil Cetro de Energia Nuclear na Agricultura（CENA） PiracicabaSao PauloBrazil

＜正＞The IAC wheat breeding program has already released several improved cultivars to the farmers of theState of S（?）o Paulo,Brazil,since 1970,contributing to the increase in acreage and *** are still a longway to go though,before Brazil stops importing wheat from other *** grain yield potential,semi-dwarf plant type,disease resistance to rusts,to powdery mildew and to leaf spot,and tolerance to aluminumtoxicity are the main goals of the bread wheat improvement program for acid soils of the *** released

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Glial fibrillary acidic protein levels are associated with global histone H4 acetylation after spinal cord injury in rats

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Neural Regeneration Research 2018年第11期13卷 1945-1952页

作者： Mayara Ferraz de Menezes Fabricio Nicola Ivy Reichert Vital da silva Adriana Vizuete Viviane Rostirola Eisner Leder Leal Xavier carlos Alberto Saraiva Goncalves carlos Alexandre Netto Regis Gemerasca Mestriner Neurorehabilitation and Neural Repair Research Group Pontificia Universidade Catolica do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Cellular and Molecular Biology Pontificia Universidade Catolica do Rio Grande do SUl Porto Alegre RS Brazil Department of Biochemistry Basic Science Institute Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil Graduate Program in Biosciences and Rehabilitation. Centro Universitairio Metodista IPA Porto Alegre RS Brazil

Emerging evidence has suggested global histone H4 acetylation status plays an important role in neural plasticity. For instance, the imbalance of this epigenetic marker has been hypothesized as a key factor for the development and progression of several neurological diseases. Likewise, astrocytic reactivity-a wellknown process that markedly influences the tissue remodeling after a central nervous system injury-is crucial for tissue remodeling after spinal cord injury（SCI）. However, the linkage between the above-mentioned mechanisms after SCI remains poorly understood. We sought to investigate the relation between both glial fibrillary acidic protein（GFAP） and S100 calcium-binding protein B（S100B）（astrocytic reactivity classical markers） and global histone H4 acetylation levels. Sixty-one male Wistar rats（aged ~3 months） were divided into the following groups： sham; 6 hours post-SCI; 24 hours post-SCI; 48 hours post-SCI; 72 hours post-SCI; and 7 days post-SCI. The results suggested that GFAP, but not S100B was associated with global histone H4 acetylation levels. Moreover, global histone H4 acetylation levels exhibited a complex pattern after SCI, encompassing at least three clearly defined phases（first phase： no changes in the 6, 24 and 48 hours post-SCI groups; second phase： increased levels in the 72 hours post-SCI group; and a third phase： return to levels similar to control in the 7 days post-SCI group）. Overall, these findings suggest global H4 acetylation levels exhibit distinct patterns of expression during the first week post-SCI, which may be associated with GFAP levels in the perilesional tissue. Current data encourage studies using H4 acetylation as a possible biomarker for tissue remodeling after spinal cord injury.

关键词： histones spinal cord injury glial fibrillary acidic protein S100 calcium-binding protein B neuralplasticity astrocyte ELISA-immunoassay recovery neural repair rats

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Landesman–Lazer Type Conditions and Multiplicity Results for Nonlinear Elliptic Problems with Neumann Boundary Values

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Acta Mathematica Sinica,English Series 2014年第2期30卷 229-250页

作者： Edcarlos Domingos da silva Francisco Odair DE PAIVA Universidade Federal de Gois Departamento de Matemtica Universidade Federal de So carlos Departamento de Matemtica

We establish the existence and multiplicity of solutions for Steklov problems under non- resonance or resonance conditions using variational methods. In our main theorems, we consider a weighted eigenvalue problem of ... 详细信息

关键词： Neumann-Steklov eigenvalue problems resonance Landesman-Lazer conditions

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Dietary xylanase and live yeast supplementation influence intestinal bacterial populations and growth performance of piglets fed a sorghum-based diet

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Animal Nutrition 2020年第4期6卷 457-466页

作者： Gemma González-Ortiz Marco A.Callegari Pete Wilcock Diego Melo-Duran Michael R.Bedford Hilário R.V.Oliveira Marcos A.A.da silva carlos R.Pierozan Caio A.da silva AB Vista MarlboroughWiltshireSN84ANUnited Kingdom AKEI Animal Research Fartura18870000Brazil Servei de Nutricio i Benestar Animal(SNiBA) Department de Ciencia Animal i dels AlimentsUniversitat Autonoma de Barcelona(UAB)08193Spain Universidade Estadual Norte do Parana Bandeirantes86360000Brazil Universidade Estadual de Londrina Londrina86051990Brazil

This study was to evaluate the effect of xylanase supplementation and the addition of live yeast,Saccharomyces cerevisiae,on growth performance and intestinal microbiota in *** hundred and eighty commercial crossbred 23-d-old piglets(PIC 417)were sorted by initial BW and allocated to 3 treatments:control(CTR)diet,CTR diet supplemented with xylanase at 16,000 birch xylan units/kg(XYL)and XYL diet supplemented with live yeast(2 x 1010 CFU/g)at 1 kg/t(XYL+LY).Each treatment had 10 replicates,with 6 animals each.A sorghum-based diet and water were available ad libitum for 42 d of the *** daily gain(ADG)and average daily feed intake(ADFI)were measured from 0 to 42 d(23-to 65-d-old)and feed conversion ratio(FCR)*** the end of the study,bacterial identification through 16 S rRNA(V3 to V4)sequencing of the ileal and caecal digesta from one piglet per replicate was *** treatment effects were observed on *** offered the live yeast in addition to the xylanase had increased ADG compared with those supplemented with xylanase alone(XYL+LY ***;P=0.655).FCR was improved with XYL and XYL+LY compared with CTR(P=0.018).Clostridiaceae counts in the ileum tended to reduce by 10%with XYL and 14%with XYL+LY compared to CTR(P=0.07).XYL and XYL+LY increased the counts of Lactobacillaceae in the caecum compared with CTR(P<0.0001).Dietary supplementation of live yeast combined with xylanase improved growth performance and microbial balance of piglets during the nursery phase.

关键词： Sorghum Nursery piglet Xylanase Live yeast Growth performance Microbiota

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Probing the nature of the contact between fine particles by using ultrasound propagation

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Particuology 2011年第6期9卷 659-662页

作者： antonio Castellanos Xiaoping Jia carlos Soria-Hoyo Jose Manuel Valverde Faculty of Physics University of Seville Avda. Reina Mercedes s/n 41012 Seville Spain LPMDI Universite de Marne-la-Vallee CNRS UMR 8108 Champs sur Marne France

The propagation velocity （Vs） of an ultrasonic signal through a granular material depends on the type of interparticle contact. For noncohesive glass beads, a power law behavior Vs α σc1/6 for consolidation stresses applied （σc） above 1 MPa has been measured in previous work. This equation is compatible with Hertz＇s interaction law between elastic solids. In the present work, we have tested the propagation velocity of ultrasound signals through a sample of fine powder. The tensile strength and compactivity of the powder were previously measured by means of the Seville powder tester （SPT）, indicating plastic deformation of the surface asperities in contact for small to moderate consolidation stresses. However, the measurements of ultrasound propagation at high consolidations presented here are compatible with Hertz＇s law. This finding suggests that for high consolidation stresses, surface asperities are flattened, and it is therefore the elastic deformation of the bulk of the particles that determines the transmission of ultrasonic pulses.

关键词： JFine cohesive powder Ultrasound propagation Interparticle contact

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Renin-angiotensin system in the central nervous system:focus on Huntington’s disease

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Neural Regeneration Research 2023年第10期18卷 2206-2207页

作者： Aline silva de Miranda antonio Lucio Teixeira Laboratório de Neurobiologia Departamento de MorfologiaInstituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Laboratório Interdisciplinar de Investigação Médica(LIIM) Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTXUSA Faculdade Santa Casa BH Belo HorizonteMGBrasil

The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal *** the discovery of local RAS components in diverse organs,including t... 详细信息

关键词： Huntington organs angiotensin

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