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World Journal of Transplantation 2024年第2期14卷 99-106页

作者： Marco Biolato Luca Miele Giuseppe Marrone Claudia Tarli antonio Liguori Rosaria Calia Giovanni Addolorato Salvatore Agnes antonio Gasbarrini Maurizio Pompili antonio Grieco Department of Medical and Surgical Sciences CEMADFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Translational Medicine and Surgery Catholic University of Sacred HeartRome 00168Italy

BACKGROUND Few studies have evaluated the frequency of and the reasons behind the refusal of listing liver transplantation *** To assess the ineligibility rate for liver transplantation and its *** A single-center retrospective study was conducted on adult patients which entailed a formal multidisciplinary assessment for liver transplantation *** predictors for listing were evaluated using multivariable logistic *** In our center,314 patients underwent multidisciplinary work-up before liver transplantation enlisting over a three-year *** most frequent reasons for transplant evaluation were decompensated cirrhosis(51.6%)and hepatocellular carcinoma(35.7%).The non-listing rate was 53.8%and the transplant rate was 34.4%for the whole *** hundred and five motivations for ineligibility were *** most common contraindications were psychological(9.3%),cardiovascular(6.8%),and surgical(5.9%).Inappropriate or premature referral accounted for 76(37.1%)*** multivariable analysis,a referral from another hospital(OR:2.113;95%CI:1.259–3.548)served as an independent predictor of *** A non-listing decision occurred in half of our cohort and was based on an inappropriate or premature referral in one case out of *** referral from another hospital was taken as a strong predictor of non-listing.

关键词： Controindication Eligibility Evaluation Referral Personalized medicine

ZrB_(2)-SiC ceramics toughened with oriented paper-derived graphite for a sustainable approach

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Journal of Advanced Ceramics 2024年第2期13卷 207-219页

作者： Luca Zoli Francesca Servadei Simone Failla Matteo Mor antonio Vinci Pietro Galizia Diletta Sciti CNR-ISSMC Institute of ScienceTechnology and Sustainability for CeramicsFaenza I-48018Italy

Carbon fibre-reinforced ultra-high temperature ceramics(UHTCs)are considered a class of promising materials for several applications,the most appealing ones being in the aerospace *** is necessary to overcome the brittleness and low thermal shock resistance of ceramics and is often provided through the addition of carbon fibres or other carbon-based phases,such as nanotubes,graphene,and *** present work is focused on the toughening of UHTCs through incorporation of 30-50 vol% thin,ordered graphite layers from conventional filter paper followed by hot pressing *** filter paper was selected because it undergoes thermolysis with no melting stage forming a strong carbonaceous residue that can be used as *** and mechanical properties of toughened composites were compared to those of other materials reinforced with short carbon fibres and the effect of different distribution of graphite was *** of graphite allowed toughness to be increased from 3−4 MPa·m^(1/2)(for unreinforced materials)to 5.1−5.5 MPa·m^(1/2),similar to results obtained with short fibre *** high-temperature properties,such as strength and toughness as well as oxidation resistance at 1500℃,were also examined.

关键词： borides paper-derived graphite microstructure toughness sustainability

Climate change and human health: Last call to arms for us

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World Journal of Clinical Cases 2024年第11期12卷 1870-1874页

作者： antonio Corrente Maria Caterina Pace Marco Fiore Department of Anaesthesiology and Intensive Care Medicine The Anastasia Guerriero HospitalMarcianise 81025CasertaItaly Department of Women Child and General and Specialized SurgeryUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy

Climate change,now the foremost global health hazard,poses multifaceted challenges to human *** editorial elucidates the extensive impact of climate change on health,emphasising the increasing burden of diseases and the exacerbation of health *** highlights the critical role of the healthcare sector,particularly anaesthesia,in both contributing to and mitigating climate *** is a call to action for the medical community to recognise and respond to the health challenges posed by climate change.

关键词： Climate change Carbon footprint Sustainability Greenhouse gases Anaesthetic gases Environmental impact Disposable laryngoscope blades

Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis

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Neural Regeneration Research 2024年第8期19卷 1768-1771页

作者： Federica Azzolini Ettore Dolcetti antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari Unit of Neurology IRCCS NeuromedPozzilliItaly Department of System Medicine University of Tor VergataRomeItaly Synaptic Immunopathology Lab Department of Systems MedicineTor Vergata UniversityRomeItaly

In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying *** r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple *** evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully ***,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and *** humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal *** present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies.

关键词： disease-modifying behaviour endocannabinoid system long-term potentiation multiple sclerosis neuroplasticity neuroprotection physical exercise synaptopathy

Robust hybrid bismuth perovskites as potential photocatalysts for overall water splitting

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Nano Research 2024年第5期17卷 4593-4601页

作者： antonio J.Chacón-García Herme G.Baldovi Artem A.Babaryk antonio Rodríguez-Diéguez Sergio Navalón Yolanda Pérez Hermenegildo García Patricia Horcajada Advanced Porous Materials Unit IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departamento de Química Universitat Politècnica de València46022 ValènciaSpain Departamento Química Inorgánica Universidad de Granada1807GranadaSpain Departamento de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain Instituto de tecnología química CSIC-UPV Universitat Politècnica de València(UPV)46022Spain

Organic-inorganic hybrid perovskites have gained great attention as promising photocatalysts for hydrogen ***,due to their poor stability in water,the use of aqueous hydrohalic acid solutions is specifically required for an efficient hydrogen ***,three novel photoactive lead-free hybrid perovskites based on bismuth and triazolium cations(denoted as IEF-15,IEF-16,and IEF-17(IEF stands for IMDEA energy frameworks))were synthesized and fully characterized(structural,compositional,optical,etc.).Further,these solids were proposed as photocatalysts for the challenging gas phase overall water splitting(OWS)***,IEF-16 thin films exhibited a remarkable photocatalytic activity in both H_(2) and O_(2) evolution,as a consequence of its appropriate bandgap and energy-band alignment,achieving hydrogen evolution rates ofμmol·g_(H_(2))^(-)1846 and 360 after 24 h under ultraviolet-visible(UV-vis)irradiation or simulated solar irradiation,*** study additionally highlights the remarkable structural and photochemical stability of IEF-16 under different operational conditions(*** volume,irradiation and temperature),paving the way for green hydrogen production from OWS using perovskite-based photocatalysts.

关键词： bismuth-based hybrid perovskites thin films photocatalysis overall water splitting green hydrogen

Identification of Secondary Metabolites in Tunisian Tilia platyphyllos *** MALDI-TOF and GC-MS

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Journal of Renewable Materials 2024年第4期12卷 827-842页

作者： Ayda Khadhri Mohamed Mendili Marwa Bannour-Scharinger Eric Masson antonio Pizzi University of El-Manar II Faculty of SciencesPlantSoilEnvironment Interactions LaboratoryCampus AcademiaTunis2092Tunisia LERMAB University of Lorraine27 Rue Philippe SeguinEpinal88000France

This study is the first to evaluate the phytochemical content and biological properties of Tunisian *** Scop.A total of 23 compounds of essential oils were identified by gas chromatography-mass spectrometry(GC-MS)analysis of bracts and fruit *** results show that oxygenated monoterpenes were the dominant class of essential *** phenolic composition was investigated by matrix-assisted laser desorption/ionizationtime of flight(MALDI-TOF).The analysis showed that the chemical profiles of the ethanolic extracts of bracts and fruits are substantially *** highest polyphenol content was found in the ethanolic extracts of the fruits(7.65 mg gallic acid equivalents(GAE).g−1 on dry weight(DW).As for the antioxidant capacity,it was recorded in the essential oils of the fruits(IC_(50)=0.91 ***^(−1)).The results obtained showed that the antioxidant activity of the fruit essential oil was higher than that of the ethanol *** fruit essential oil was also found to have the highest reducing power(IC_(50)=0.67 ***^(−1)).In terms of iron-chelating power,fruit essential oil has the highest chelating power(IC_(50)=2.03 ***^(−1)).Compared to the ethanolic extract,the essential oil had the maximum antioxidant *** enzymatic activity of acetylcholinesterase(AChE)inhibition of the essential oil from *** bracts had the most potent inhibitory effect(IC_(50)=0.77 ***^(−1)),followed by the essential oil from the fruits(IC_(50)=0.95 ***^(−1)).The results suggest that *** can be used as a potential source of naturally occurring bioactive compounds and antioxidants.

关键词： T.platyphyllos antioxidant activity acetylcholinesterase inhibition essential oil MALDI-TOF GC-MS

Risk of hepatitis B virus reactivation in oncological patients treated with tyrosine kinase inhibitors:A case report and literature analysis

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World Journal of Gastroenterology 2024年第9期30卷 1253-1256页

作者： Francesca Colapietro Nicola Pugliese antonio Voza Alessio Aghemo Stella De Nicola Department of Biomedical Sciences Humanitas UniversityMilan 20072Italy Division of Internal Medicine and Hepatology Department of GastroenterologyHumanitas Research HospitalMilan 20089Italy Department of Emergency Humanitas Research HospitalMilan 20089Italy

Hepatitis B virus(HBV)reactivation(HBVr)represents a severe and potentially life-threatening condition,and preventive measures are available through blood test screening or prophylactic therapy *** assessment of HBVr traditionally considers factors such as HBV profile,including hepatitis B surface antigen(HBsAg)and antibody to hepatitis B core antigen,along with type of medication(chemotherapy;immunomodulants).Nevertheless,consideration of possible patient’s underlying tumor and the specific malignancy type(solid or hematologic)plays a crucial role and needs to be assessed for decision-making process.

关键词： Chronic hepatitis B Reactivation Nucleoside analogue Tyrosine kinase inhibitors Onco-hematology

Application of Plant-Based Coagulants and Their Mechanisms in Water Treatment:A Review

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Journal of Renewable Materials 2024年第4期12卷 667-698页

作者： Abderrezzaq Benalia Kerroum Derbal Zahra Amrouci Ouiem Baatache Amel Khalfaoui antonio Pizzi Higher Normal School of Constantine Ali Mendjeli Nouvelle VilleConstantine25000Algeria Laboratory of Process Engineering for Sustainable Development and Health Products(GPDDPS) Department of Process EngineeringNational Polytechnic School of ConstantineConstantine25000Algeria Department of Environmental Engineering Laboratoire de Recherche sur le Médicament et le Développement Durable(ReMeDD)University of Salah Boubnider Constantine 3El Khroub25012Algeria Laboratory LIPE Faculty Process EngineeringUniversity of Constantine 3Ali Mendjeli Nouvelle VilleConstantine25000Algeria Laboratoire d’Etude et Recherche sur le Matériau Bois(LERMAB).Ecole Nationale Supérieure des Technologies et Industries du Bois(ENSTIB)—University of Lorraine Epinal88000France

This review describes the mechanisms of natural *** provides a good understanding of the two key processes of coagulation-flocculation:adsorption and charge neutralization,as well as adsorption and *** factors have influence the coagulation/flocculation process,including the effect of pH,coagulant dosage,coagulant type,temperature,initial turbidity,coagulation speed,flocculation speed,coagulation and flocculation time,settling time,colloidal particles,zeta potential,the effects of humic acids,and extraction density are *** bio-coagulants derived from plants are *** impact of organic coagulants on water quality,focusing on their effects on the physicochemical parameters of water,heavy metals removal,and bacteriological water quality,is *** methods of extraction and purification of plant-based coagulants,highlighting techniques such as solvent extraction and ultrasonic extraction,are *** also examines the parameters that influence these *** methods and principles of purification of coagulating agents,including dialysis,freeze-drying,ion exchange,electrophoresis,filtration,and centrifugation,are ***,it evaluates the sustainability of natural coagulants,focusing on the environmental,technical,and economic aspects of their *** the end of this review,the readers should have a comprehensive understanding of the mechanisms,selection,extraction,purification,and sustainability of plant-based natural coagulants in water treatment.

关键词： Bio-coagulants coagulating agents extraction water treatment

Quantitative assessment of self-management in patients with nonalcoholic fatty liver disease: An unmet clinical need

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World Journal of Gastroenterology 2024年第25期30卷 3143-3146页

作者： Raffaele Borriello Giorgio Esposto Irene Mignini antonio Gasbarrini Maria Assunta Zocco CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli IRCCSCatholic University of RomeRome 00168Italy

In this editorial we comment on the article titled“Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease”by Zeng et al published in a recent issue of the World Journal of ***-alcoholic fatty liver disease(NAFLD)represents one of the current challenges in hepatology and public health,due to its continuous growing prevalence and the rising incidence of NAFLD-related fibrosis,non-alcoholic steatohepatitis and *** only effective therapeutic strategy for this dis-ease is represented by encouraging patients to improve their lifestyle through the modification of dietary intake and increased physical exercise,but the effective application of such modifications is often limited by various factors such as lack of information,psychological barriers or poor social *** poor adherence to a healthy lifestyle can be decisive in determining the clinical outcome,in daily practice there is a lack of quantitative instruments aimed at identifying patients with the lowest adherence to lifestyle changes and higher risk of disease progre-ssion in the course of *** this article,Zeng et al propose a quantitative scale to assess the grade of adherence of patients with NAFLD to hea-lthy lifestyle intervention,called the Exercise and Diet Adherence Scale(EDAS).This scale,consisting of 33 items divided into 6 dimensions which relates to six subjective aspects in the self-management of NAFLD,has shown a good correlation with the identification of the sub-cohort of patients with the highest reduction in caloric intake,increase in physical exercise,probability of a reduction in liver stiffness measurement and alanine aminotransferase *** cor-relation among clinical outcomes and specific dimensions of this scale also highlights the pivotal role of a good and confidential doctor-patient relationship and of an effective *** is an urgent need for practical and e

关键词： Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Liver cirrhosis Metabolic associated fatty liver disease Metabolic associated steatohepatitis Insulin resistance Self-management Self-management measurement Patient education

Prevalence and ecological factors affecting the distribution of plant-parasitic nematodes in Prunus groves in Spain

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Journal of Integrative Agriculture 2024年第2期23卷 566-589页

作者： Ilenia Clavero-Camacho antonio Archidona-Yuste Carolina Cantalapiedra-Navarrete Pablo Castillo Juan Emilio Palomares-Rius Institute for Sustainable Agriculture(IAS) Spanish National Research Council(CSIC)Córdoba 14004Spain Andalusian Institute of Agricultural and Fisheries Research and Training(IFAPA) Centro Alameda del ObispoCórdoba 14004Spain

A wide survey was conducted to study plant-parasitic nematodes(PPNs)associated with Prunus groves in *** research aimed to determine the prevalence and distribution of PPNs in Prunus groves,as well as the influence of explanatory variables describing soil,climate and agricultural management in structuring the variation of PPNs community composition.A total of 218 sampling sites were surveyed and 84 PPN species belonging to 32 genera were identified based of an integrative taxonomic *** species considered as potential limiting factors in Prunus production,such as Meloidogyne arenaria,***,***,Pratylenchus penetrans and ***,were identified in this *** soil physico-chemical(C,Mg,N,Na,OM,P,pH and clay,loamy sand and sandy loam texture classes),four climate(Bio04,Bio05,Bio13 and Bio14)and four agricultural management variables(grove-use history less than 10 years,irrigation,apricot seedling rootstock,and Montclar rootstock)were identified as the most influential variables driving spatial patterns of PPNs *** particular,younger plantations showed higher values for species richness and diversity indices than groves cultivated for more than 20 years with Prunus *** study increases the knowledge of the distribution and prevalence of PPNs associated with Prunus rhizosphere,as well as on the influence of explanatory variables driving the spatial structure PPNs communities,which has important implications for the successful design of sustainable management strategies in the future in this agricultural system.

关键词： nematodes Meloidogyne Pratylenchus Paratylenchus rootstock distribution soil grove-use almond peach