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Drug-eluting beads transarterial chemoembolization for hepatocellular carcinoma: Current state of the art

World Journal of Gastroenterology 2018年第2期24卷 161-169页

作者： antonio Facciorusso Gastroenterology Unit Department of Medical Sciences University of Foggia

Transarterial chemoembolization(TACE) represents the current gold standard for hepatocellular carcinoma(HCC) patients in intermediate stage. Conventional TACE(c TACE) is performed with the injection of an emulsion of a chemotherapeutic drug with lipiodol into the artery feeding the tumoral nodules, followed by embolization of the same vessel to obtain a synergistic effect of drug cytotoxic activity and ischemia. Aim of this review is to summarize the main characteristics of drug-eluting beads(DEB)-TACE and the clinical results reported so far in the literature. A literature search was conducted using Pub Med until June 2017. In order to overcome the drawbacks of c TACE, namely lack of standardization and unpredictability of outcomes, non-absorbable embolic microspheres charged with cytotoxic agents(DEBs) have been developed. DEBs are able to simultaneously exert both the therapeutic components of TACE, either drug-carrier function and embolization, unlike c TACE in which applying the embolic agent is a second moment after drug injection. This way, risk of systemic drug release is minimal due to both high-affinity carrier activity of DEBs and absence of a time interval between injection and embolization. However, despite promising results of preliminary studies, clear evidence of superiority of DEB-TACE over c TACE is still lacking. A number of novel technical devices are actually in development in the field of loco-regional treatments for HCC, but only a few of them have entered the clinical arena. In absence of well-designed randomized-controlled trials, the decision on whether use DEB-TACE or c TACE is still controversial.

关键词： Embolization Doxorubicin Conventional Hepatocarcinoma Liver cancer Survival

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Mixed Convection in Viscoelastic Boundary Layer Flow and Heat Transfer Over a Stretching Sheet

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Advances in Applied Mathematics and Mechanics 2014年第3期6卷 359-375页

作者： antonio Mastroberardino School of Science Penn State ErieThe Behrend CollegeEriePennsylvania 16563USA

An investigation is carried out on mixed convection boundary layer flow of an incompressible and electrically conducting viscoelastic fluid over a linearly stretching surface in which the heat transfer includes the effects of viscous dissipation,elastic deformation,thermal radiation,and non-uniform heat source/sink for two general types of non-isothermal boundary *** governing partial differential equations for the fluid flow and temperature are reduced to a nonlinear system of ordinary differential equations which are solved analytically using the homotopy analysis method(HAM).Graphical and numerical demonstrations of the convergence of the HAM solutions are provided,and the effects of various parameters on the skin friction coefficient and wall heat transfer are *** addition it is demonstrated that previously reported solutions of the thermal energy equation given in[1]do not converge at the boundary,and therefore,the boundary derivatives reported are not correct.

关键词： Viscoelastic fluid non-uniform heat source/sink viscous dissipation thermal radiation homotopy analysis method

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Little Secrets for the Successful Industrial Use of Tannin Adhesives:A review

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Journal of renewable Materials 2023年第9期11卷 3403-3415页

作者： antonio Pizzi LErMAB EA 4370-USC INRAEUniversity of LorraineBlvd des AiguillettesNancy54506France

This brief article reviews a very particular and quite narrowfield,namely what has been done and what is needed to know for tannin adhesives for wood panels to succeed *** present fashionable focus on bioadhe-sives has led to producing chemical adhesive formulations and approaches for tannin adhesives as a subject of academic ***,as good and original they might be,are and will still remain a rather empty aca-demic exercise if not put to the test of real industrial trials and industrial *** will remain so without the“little”secrets and techniques outlined here that show that there is a great gap between developing an adhesive formulation in the laboratory and the hard reality to make it work where it does really count,in its industrial *** outlines the fact that even more modern and excellent,newly developed bioadhesive formulations might well miserably fail once tried in the industry if the problems that always arise in their upgrading are not identified and solved,and solved *** also outlines the fact that not only must costs always be taken into account and that a practical and possibly easy-to-handle approach must always be used,but too expensive or complex and unyielding adhesive systems are also often shown to be unusable or unsuitable in industry.

关键词： Tannin adhesive industrial techniques industrial formulations industrial hardeners wood panels wood composites fast press times

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Magnetic field assisted fluidization:A modified richardson-Zaki equation

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China Particuology 2007年第1期5卷 61-70页

作者： Jose Manuel Valverde antonio Castellanos Faculty of Physics Universidad de Sevilla Avenida Reina Mercedes s/n 41012 Sevilla Spain

Magnetic particles can be uniformly fluidized by coupling the gas flow with an externally imposed magnetic field. Interparticle forces generated by the magnetic field cause aggregation of the particles in chain-like structures preferentially oriented along the magnetic field lines. In the present paper, we study the implications of the formation of these special types of aggregates on the empirical richardson-Zaki （rZ） equation, originally proposed to describe the expansion of fluidized beds of non-aggregated particles. We have addressed two important issues, namely the flow regime, which is a function of the size of the aggregates, and the effect of shape and orientation of the chain-like aggregates with respect to gas flow on fluid drag. We propose a modified rZ equation （MrZE） in which the velocity scale, given by the terminal settling velocity of the individual aggregates, and the rZ exponent are predetermined as a function of the chain length. The chain length depends on the ratio of the magnetic energy to gravitational energy, and is estimated from the magnetic field intensity, and particle magnetization, size and density. Predictions of the MrZE are successfully compared with published results in the literature on the expansion of magnetic particles in the presence of externally applied magnetic fields.

关键词： Fluidization Geldart B Magnetic particles Aggregation richardson-Zaki equation

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Phenomenological model for torsional galloping of an elastic flat plate due to hydrodynamic loads

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Journal of Hydrodynamics 2014年第1期26卷 57-65页

作者： FErNANDES antonio Carlos ArMANDEI Mohammadmehdi Department of Naval and Ocean Engineering COPPE/UFRJ

This study investigates the torsional galloping phenomenon, an instability type flow-induced oscillation, in an elastic stru-cture due to hydrodynamic loads into the water current. The structure applied here is a rectangular flat plate with an elastic axis in its mid-chord length. The elasticity is provided by torsion spring. The flat plate has only one degree of freedom which is rotation in pure yaw about its axis. It is observed that as the current speed is higher than a critical velocity, the flat plate becomes unstable. The instability leads to torsional galloping occurrence, as a result of which the flat plate begins to yaw about the elastic axis. By testing two different chord lengths each with several torsion spring rates, the flat plate behavior is investigated and three different responses are recognized. Then, a phenomenological model is developed with the original kernel in the form of the van der Pol-Duffing equa-tion. The model explains these three responses observed experimentally.

关键词： torsional galloping flow-induced oscillation phenomenological model van der Pol-Duffing equation

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The influence of core affect on cyclo-ergometer endurance performance:Effects on performance outcomes and perceived exertion

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Journal of Sport and Health Science 2020年第6期9卷 578-586页

作者： Selenia di Fronso antonio Aquino réka Zsanett Bondár Cristina Montesano Claudio robazza Maurizio Bertollo Department of Medicine and Aging Sciences Behavioral Imaging and Neural Dynamics(BIND)CenterUniversity“G.d’Annunzio”of Chieti-PescaraChieti 66100Italy Department of Neuroscience Imaging and Clinical SciencesUniversity“G.d’Annunzio”of Chieti-PescaraChieti 66100Italy

Background:Core affect is defined as the most general affective construct consciously accessible that is experienced *** can be experienced as free-floating(mood)or related to prototypical emotional *** aim of this study was to examine the influence of pleasant and unpleasant core affect on cyclo-ergometer endurance ***,we considered the influence of pleasant and unpleasant core affect on performance outcomes(i.e.,time to task completion)and rate of perceived exertion(rPE;Borg Scale,category ratio-10)collected during the ***:Thirty-one participants aged 20-28 years were *** affect was randomly elicited by 2 sets of pleasant and unpleasant pictures chosen from the international affective picture *** were displayed to participants during a cyclo-ergometer performance in 2 days in a counterbalanced *** was collected every minute to detect volunteers’***:The study sample was split into 2 *** 1 comprised participants who performed better with pleasant core affect,whereas Group 2 included participants who performed better with unpleasant core *** between-within subjects analysis of variance revealed a significant 2(group)×2(condition)×5(isotime)interaction(p=0.002,ηp^2=0.158).Post hoc comparisons showed that participants who obtained better performance with pleasant core affect(pleasant pictures;Group 1)reported lower rPE values at 75%of time to exhaustion in a pleasant core affect condition compared to an unpleasant core affect *** the other hand,participants who obtained better performance with unpleasant core affect(unpleasant pictures;Group 2)reported lower rPE values at 75%and 100%of time to exhaustion in an unpleasant core affect ***:Findings suggest differential effects of pleasant and unpleasant core affect on ***,core affect was found to influence perceived exertion and performance according to participants’pref

关键词： Arousal Hedonic tone Pleasant and unpleasant core affect rate of perceived exertion Time-to-exhaustion test

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Stability analysis of the fluttering and autorotation of flow-induced rotation of a hinged flat plate

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Journal of Hydrodynamics 2013年第5期25卷 755-762页

作者： MIrZAEISEFAT Sina FErNANDES antonio Carlos Department of Naval Architecture and Marine Engineering University of Michigan COPPE/UFrJ Federal University of Rio de Janeiro

This work describes investigations performed on the interaction of uniform current and freely rotating plate about a fixed vertical axis. Fluttering and autorotation are two different motions that may occur during the flow induced rotation. The dimensional analysis proves that the motion in flow induced rotation motion is governed essentially by the dimensionless moment of inertia and reynolds number. Certain combinations define the stability boundaries between fluttering and autorotation. Fluttering is oscillation of body about a vertical axis and the autorotation is a name given to the case when the body turns continuously about the vertical axis First, the loads and moment coefficients are calculated by experiments and streamline theory for different angles of attack for a fixed fiat plate. Then for dynamic case, a bifurcation diagram is presented based on experiments to classify different motion states of flow induced rotation. Finally, a dynamical model is proposed for stability analysis of flow induced rotation of a flat plate.

关键词： flow-induced rotation autorotation fluttering stability analysis

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Litter production and leaf nutrient concentration and remobilization in response to climate seasonality in the central Amazon

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Journal of Forestry research 2024年第3期35卷 131-141页

作者： ricardo antonio Marenco Saul Alfredo Antezana-Vera Daniela Pereira Dias Luiz antonio Candido Instituto Nacional de Pesquisas da Amazonia Coordenagao de Uso da Terra e Mudanca ClimaticaAv.Andre Araujo 2936ManausAM69067-375Brazil Programa de pos-Graduagao em Agricultura no Tropico Umido Instituto Nacional de Pesquisas da Amazonia-INPAManausAMBrazil Unidade Academica de Ciencias Agrarias Universidade Federal de JataiBR 364km 195JataiGO 75801-615Brazil

Litterfall is the largest source of nutrients to for-est soils of tropical ***,variability in lit-terfall production,nutrient remobilization,and changes in leaf nutrient concentration with climate seasonality remain largely unknown for the central *** study meas-ured litterfall production,leaf nutrient remobilization,and leaf area index on a forest plateau in the central *** was measured at monthly intervals during 2014,while nitrogen,phosphorus,potassium,calcium and mag-nesium concentrations of leaf litter and canopy leaves were measured in the dry and rainy seasons,and remobilization rates *** area index was also recorded in the dry and rainy *** litterfall varied from 33.2(in the rainy season)to 87.6 g m^(-2) in the dry season,while leaf area index increased slightly in the rainy *** seasonality had no effect on concentrations of nitrogen,calcium,and magnesium,whereas phosphorous and potassium responded to rainfall seasonality *** phosphorous increased,potassium decreased during the dry *** seasons,nitrogen,potassium,and phosphorous decreased in leaf litter;calcium increased in leaf litter,while magnesium remained unaffected with leaf ***,the five nutrients had similar remobilization rates over the *** absence of climate seasonality on nutrient remobilization suggests that the current length of the dry season does not alter nutrient remobilization rates but this may change as dry periods become more prolonged in the future due to climate change.

关键词： Throughfall Nutrient cycling Climatic seasonality Leaf mass per area

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Seismic performance of a reinforced concrete building retrofitted with self-centering shape memory alloy braces

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 785-809页

作者： Massimiliano Ferraioli antonio Concilio Carmine Molitierno Department of Engineering University of Campania“Luigi Vanvitelli”via Roma 2981031 Aversa(CE)Italy Adaptive Structures Div. the Italian Aerospace Research Centre(CIRA)via Maiorise81043 Capua(CE)Italy Department of Structures for Engineering and Architecture University of Naples“Federico Ⅱ”via Claudio 2180125NapoliItaly

Self-centering earthquake-resistant structures have received increased attention due to their ability to reduce post-earthquake residual deformations and,thus,repair time and *** stimulated the development of recentering shape memory alloy(SMA)dampers that use superelastic nitinol wires to dissipate energy and self-center the ***,there are still a few case studies applications on full-scale rC buildings in the ***,general guidelines or even simplified approaches for the practical design of SMA damped braces are still *** paper focuses on evaluating the effect of using self-centering shape memory alloy dampers for buckling-restrained braces applied for the seismic retrofit of a complex rC building structure.A design method originally proposed for elastoplastic dampers was implemented to size the SMA dampers to be placed on selected spans and stories of a *** effectiveness of the design procedure was demonstrated by nonlinear time-history analyses under different sets of earthquake strong ground *** analysis results show that the recentering shape memory alloy bracing system is effective in limiting the maximum transient inter-story drifts and reducing the residual inter-story drifts after strong seismic events,due to its excellent recentering behavior together with its not negligible energy dissipation capacity.

关键词： rC buildings seismic retrofit buckling-restrained braces shape memory alloys dampers self-centering

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Ligninolytic Peroxidase-Like Activity of a Synthetic Metalloporphine Immobilized onto Mercapto-Grafted Crosslinked PVA Inspired by the Active Site of Cytochrome P450

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催化学报 2011年第11期32卷 1663-1666页

作者： Paolo ZUCCA antonio rESCIGNO Enrico SANJUST Dipartimento di Scienze e Tecnologie Biomediche Università di Cagliari Monserrato 09042 Italy Consorzio per lo Sviluppo dei Sistemi a Grande Interfase Sesto Fiorentino 50019 Italy

A synthetic metalloporphine was immobilized onto a PVA-based and mercapto-grafted solid support, emulating the active site of cytochrome P450. Its ligninolytic peroxidase-like catalytic activity was studied. The coordinated mercapto ligand significantly affected the catalytic features of the catalyst because the oxidation of lignin-model compounds was very slow by comparison with imidazoleand pyridine-coordinated immobilized metalloporphines. Conversely, the catalyst efficiently bleached several industrial dyes and thus demonstrated promising activity for this application. Based on this altered substrate specificity the oxygen-donor catalytic route seems to be more favorable than a single electron oxidation pathway.

关键词： porphine porphyrin lignin peroxidase cytochrome P450 biomimetic

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