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Safety and Tolerability of Transdermal Rotigotine in a Clinical Practice Cohort for 2 Years

World Journal of Neuroscience 2014年第5期4卷 443-449页

作者： Iria Rodriguez Constenla antonio pato pato Icíar Cimas Hernando José Ramón Lorenzo Gonzalez Servicio de Neurología Hospital Povisa Vigo Spain

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disease that occurs as a result of loss of dopaminergic neurons from the substantia nigra. Rotigotine is a non-ergolinic dopamine agonist available as a silicone-based transdermal patch for the treatment of PD. In the European Union, rotigotine transdermal patch is indicated for use as monotherapy in early idiopathic PD, or in combination with levodopa through the disease course to the late stages where motor complications with levodopa become an issue. Objective: To investigate the safety and tolerability of transdermal rotigotine, in patients with PD being treated during routine clinical practice for 2 years. Results: 114 patients were enrolled, and evaluated for adverse events over a 24-month period. Adverse events occurred in 39 patients (34.21%). 23 patients (20.17%) reported application site reactions (dermatitis, erythema, itching), and 16 (14.03%) had systemic adverse events. Sleep disorders were the most common problem;the others were hallucinations, depression, dizziness, and syncope. No patient experienced dyskinesia. Adverse events necessitated the discontinuation of rotigotine for application site reactions in fourteen patients (12.28%) and 11 patients (9.64%);reasons for discontinuation were systemic adverse events. Conclusion: Rotigotine is safe and well tolerated when used to treat PD in routine clinical practice.

关键词： Rotigotine Parkinson’s Disease Tolerability Safety Clinical Practice

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FIB-4 score and hepatocellular carcinoma risk after hepatitis C virus cure:time to revise surveillance?

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Hepatobiliary Surgery and Nutrition 2020年第5期9卷 661-664页

作者： antonio Saviano Simona Tripon Thomas F.Baumert Institut de Recherche sur les Maladies Virales et Hépatiques(IVH) Inserm U1110StrasbourgFrance Institut Hospitalo-Universitaire Pôle Hépato-digestifHôpitaux Universitaires de StrasbourgStrasbourgFrance University of Strasbourg StrasbourgFrance Institut Universitaire de France(IUF) ParisFrance

Hepatitis C virus(HCV)is a main cause and important risk factor for hepatocellular carcinoma(HCC)in Western countries(1).Direct antiviral agents(DAAs)for HCV are highly effective and well-tolerated antiviral drugs which allow HCV cure even in patients with advanced liver ***,whilst HCV cure improves liver function and decreases overall HCC risk,a significant HCC risk persists in particular in patients with advanced fibrosis including cirrhosis who have the highest risk of developing HCC(2-4).

关键词： drugs liver carcinoma

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Hepatitis C treatment in patients with substance use disorder:the faster the better

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 129-131页

作者： antonio Saviano Lucile Heroin Pierre Mayer Thomas F.Baumert Institut de Recherche sur les Maladies et Hépatiques(IVH) Inserm U1110StrasbourgFrance Institut Hospitalo-Universitaire Service d’hépato-gastroentérologieHôpitaux Universitaires de StrasbourgStrasbourgFrance University of Strasbourg StrasbourgFrance Institut Universitaire de France(IUF) ParisFrance

Hepatitis C virus(HCV)infection is a major cause of liver disease and hepatocellular carcinoma worldwide(1).HCV is a blood-borne infection and prevalence is particularly high in patients with a history of injective drug use or unsafe health care or sexual *** use disorder(SUD),and especially opioid misuse is a growing problem worldwide(2).This is particularly relevant in the United States(US)where opioid misuse has raised sharply in the last years(3,4),termed also opioid *** is associated with an increase incidence of HCV infections and reinfections and associated liver disease(2,4).Moreover,alcohol use disorder is frequent in patients with SUD(5),representing another major risk factor for chronic liver disease in this *** with SUD often experience poor access to health care resulting in higher mortality(5,6).Finally,SUD is associated with psychiatric conditions and social problems such as housing instability,unemployment,and reduced access to medical care(7)which could result in a reduced access and compliance to HCV treatment.

关键词： patients mortality faster

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