检索结果-南通市图书馆

Oligodendroctyes:the forgotten players of diabetes pathophysiology

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： Juan antonio l.pez-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(Ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNs),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,Ols provide trophic support to neurons and ***,Ol metabolism is important for Ol well-being and the proper accomplishment of their functions,and Ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander l.Tournier leoni V.Bonamin susann Buchheim-schmidt steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Everine Bvan de Kraats jesús antonio l.pez-Carvallo Papiya Nandy JoséManuel Mazón-suástegui Fateme Mirzajani Bernard Poitevin Claudia scherr Karin Thieves sandra Würtenberger stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern3010 BernBernSwitzerland Institute of Integrative Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Environmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil Department of Medical science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell laboratory for Fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia laboratorio de Homeopatía Acuícola y semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran Department of Medical laboratory science College of ScienceKnowledge University44001 ErbilErbilIraq sociétésavante d’Homéopathie 75009 ParisFrance sola salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany scientific society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objective Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative *** physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

Metastatic pancreatic and lung cancer patient in complete remission following immunotherapy: A case report and review of literature

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 2233-2240页

作者： Joaquina Martínez-Galán Cristina Jiménez-luna Isabel Rodriguez Elisabeth Maza Carlos García-Collado antonio Rodríguez-Fernández Javier luis l.pez-Hidalgo Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Instituto de Investigación Biosanitaria Ibs.GranadaGranada 18012Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain Pharmacogenetics Unit Virgen de las Nieves University HospitalGranada 18014Spain Department of Medicina Nuclear Virgen de las Nieves University HospitalGranada 18014Spain Department of Anatomía Patológica Virgen de las Nieves University HospitalGranada 18014Spain

BACKGROUND Metastatic pancreatic ductal adenocarcinoma(PDAC)is a lethal malignancy with dispiriting survival *** is a promising approach to many cancer types,but achieves poor outcomes in advanced PDAC due to its immunosuppressive tumor *** describe a case of metastatic PDAC effectively treated with *** sUMMARY We report the case of a 67-year-old woman with unresectable locally advanced PDAC,treated with gemcitabine plus nab-paclitaxel followed by radiotherapy plus *** nine months,pancreatic tumor progression was observed at the level of the hepatic hilum with the appearance of a new pulmonary nodule suggestive of a second primary,confirmed by left lung *** immunotherapy was then initiated with pembrolizumab,an immune checkpoint inhibitor targeting programmed cell death protein-1 that covers the two tumor *** patient showed a complete metabolic response that was maintained throughout the *** patient continues to be disease-free at 5.6 years since the start of *** These results suggest that the administration of pembrolizumab after chemoradiotherapy has a beneficial effect in patients with metastatic *** our knowledge,this is the first reported case of a patient with metastatic PDAC and metastatic lung cancer showing such a long-lasting complete response after pembrolizumab treatment without curative *** studies are required to determine biomarkers that identify PDAC patients most likely to benefit from this immunotherapy.

关键词： Pancreatic ductal adenocarcinoma lung cancer Immunotherapy Pembrolizumab Programmed cell death protein-1 Case report

具有Ruddlesden-Popper结构的杂化非本征铁电体(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)陶瓷的制备及其物理性能

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

天津师范大学学报（自然科学版） 2024年第2期44卷 19-25页

作者： MARCO antonio l.pez-Aguila 柳志旭王守宇黄聪刘卫芳天津大学理学院天津300350 天津师范大学物理与材料科学学院天津300387

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了sm^(3+)掺杂的(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPs、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、... 详细信息

为探究稀土离子掺杂对Ca_(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了sm^(3+)掺杂的(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPs、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、光学性能、电学性能和磁学性能进行分析.结果表明:随着sm^(3+)含量的增加,(Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)的晶胞参数逐渐增大.sm^(3+)掺杂导致氧空位减少,因此样品的漏电流随着sm^(3+)掺杂量的增加而减小.同时,随着sm^(3+)掺杂量的增加,样品的光学带隙呈现增大趋势.此外,第一性原理研究表明,sm^(3+)掺杂可在体系中诱导出磁性能,进一步丰富了该材料的物理性能.

关键词： (Ca_(1-x)sm_(x))_(3)Ti_(2)O_(7)陶瓷铁电性氧空位光学带隙第一性原理

Influence of manufacturing process-induced geometrical defects on the energy absorption capacity of polymer lattice structures

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第5期35卷 47-59页

作者： Alexandre Riot Enrico Panettieri antonio Cosculluela Marco Montemurro Universite de Bordeaux Arts et Metiers Institute of TechnologyCNRSINRABordeaux INPHESAM UniversiteI2M UMR 5295F-33405 TalenceFrance French Atomic Energy Commission Route des GargailsCedexF-33114Le BarpFrance

Modern additive manufacturing processes enable fabricating architected cellular materials of complex shape,which can be used for different *** them,lattice structures are increasingly used in applications requiring a compromise among lightness and suited mechanical properties,like improved energy absorption capacity and specific stiffness-to-weight and strength-to-weight ratios.A dedicated modeling strategy to assess the energy absorption capacity of lattice structures under uni-axial compression loading is presented in this *** numerical model is developed in a non-linear framework accounting for the strain rate effect on the mechanical responses of the lattice *** geometries,i.e.,cubic body centered cell,octet cell,rhombic-dodecahedron and truncated cuboctahedron 2+,are ***,the influence of the relative density of the representative volume element of each geometry,the strain-rate dependency of the bulk material and of the presence of the manufacturing process-induced geometrical imperfections on the energy absorption capacity of the lattice structure is *** main outcome of this study points out the importance of correctly integrating geometrical imperfections into the modeling strategy when shock absorption applications are aimed for.

关键词： lattice structures Architected cellular materials Dynamic simulation Energy absorption Geometrical imperfection Additive manufacturing

larval development and voracity of Eupeodes americanus (Diptera: syrphidae): comparison of the focal prey Aphis gossypi (Hemiptera: Aphididae) and the banker prey Rhopalosiphum padi (Hemiptera: Aphididae)

在线全文

学校读者我要写书评

暂无评论

Insect science 2024年第2期31卷 575-586页

作者： Arlette Fauteux antonio Onofre soares Eric lucas laboratoire de lutte biologique Departement des sciences biologiquesUniversite du Quebec a Montreal(UQAM)MontrealQuebecCanada Faculty of science and Technology Center for Ecology Evolution and Environmental ChangesAzorean Biodiversity Group(cE3c-ABG)&CHANGE-Global Change and Sustainability InstitutePonta DelgadaPortugal

Unlike European species,the potential of Nearctic syrphids as biological control agents is still poorly ***,the American hoverfly,Eupeodes americanus(Wiedemann),has recently demonstrated promising traits as a biocontrol agent,notably against the foxglove aphid,Aulacorthum solani Kaltenbach,on *** present study aims to extend our knowledge of the American hoverfly by evaluating its potential as a biocontrol agent in a banker plant system against the melon aphid,Aphis gossypi Glover,in a greenhouse cucumber *** preimaginal development and voracity of *** were compared when preying upon the focal prey/pest(***)or the banker prey(bird cherry-oat aphid,Rhopalosiphum padi l.)by daily observations of larvae from egg to *** development time,survival rate,and occurrence of deformation were similar on both prey *** weight of third instar and pupae,however,was higher for larvae that fed on the banker *** ad libitum voracity of the syrphid larvae was generally very high and did not significantly differ between prey species,except for the third-instar larvae which consumed more focal *** suggest that a banker plant system involving the bird cherry-oat aphid may be a promising tactic for utilizing *** for melon aphid biocontrol.

关键词： american hoverfly banker plant system biological control bird cherry-oat aphid greenhouse cucumber melon aphid

Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-l.pez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello sandra Viz-lasheras antonio Justicia-Grande Julian Montoto-louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres antonio salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-Es) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAs(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness:A multi-country cluster randomized controlled trial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of sport and Health science 2024年第1期13卷 90-98页

作者： Tania Pinto-Escalona Erica Gobbi Pedro l.Valenzuela simon J.Bennett Pierluigi Aschieri Manuel Martin-loeches antonio Paoli Oscar Martinez-de-Quel Faculty of Education Complutense University of MadridMadrid 28040Spain Department of Biomolecular sciences University of Urbino“Carlo Bo”Urbino 61029Italy Department of systems Biology University of AlcaláMadrid 28805Spain Research Institute for sport and Exercise sciences Faculty of ScienceLiverpool John Moores UniversityLiverpoolL33AFUK Italian Judo WrestlingKarate and Martial Arts FederationRome 00122Italy Psychobiology&Methods for the Behavioural sciences Department Complutense University of MadridMadrid 28040Spain Department of Biomedical sciences University of PaduaPadua 35122Italy

Purpose:To examine the effects of a school-based karate intervention on academic achievement,psychosocial functioning,and physical fitness in children aged 7-8 ***:Twenty schools in 5 different European countries(2 second-grade classrooms per school)participated in a cluster randomized controlled trial(sport at school trial).Participants were assigned to either a control group,which continued with their habitual physical education lessons,or to an intervention group,which replaced these lessons with a 1-year karate intervention(Karate Mind and Movement program).A total of 721 children(344 girls and 377 boys,7.4±0.5 years old,mean±sD)completed the study,of which 333 and 388 were assigned to the control group and intervention group,*** included academic performance(average grade),psychosocial functioning(strengths and Difficulties Questionnaire for parents),and different markers of physical fitness(cardiorespiratory fitness,balance,and flexibility).Results:The intervention provided small but significant benefits compared to the control group for academic achievement(d=0.16;p=0.003),conduct problems(d=-0.28;p=0.003),cardiorespiratory fitness(d=0.36;plance(d=0.24;p=0.015).There was a trend towards significant benefits for flexibility(d=0.24;p=0.056).No significant benefits were observed for other variables,including psychosocial difficulties,emotional symptoms,hyperactivity/inattention,peer problems,or prosocial behaviour(all p>0.05).Conclusion:A 1-year school-based karate intervention was effective in improving academic achievement,conduct problems,and physical fitness in primary school *** results support the inclusion of karate during physical education lessons.

关键词： Academic performance Cardiorespiratory fitness Conduct problems Karate Physical fitness

Prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma:Review and bibliometric

在线全文

学校读者我要写书评

暂无评论

ilIVER 2024年第1期3卷 52-61页

作者： Pamela scarlett Espinoza loyola Diana laura Muratalla Bautista Karen Adela Hernández Bautista Elizabeth Gil White Joséantonio González Moreno Daniel Angel Torres del Real Víctor Manuel Páez Zayas Carla Escorza-Molina Fernando Mondragón Rodríguez Omar Vásquez Gómez luis Jorge Fernández l.pez Paul santiago Mogrovejo Vázquez Isidoro Aczel sánchez-Cedillo Víctor Jose Visag Castillo social service Internship Universidad Nacional Autónoma de MéxicoMexico City 04510Mexico social service Internship Universidad AnahuacMexico City 04510Mexico Department of surgery Division of Transplantation surgery Hospital General de MéxicoMexico City 06720Mexico Departament of Gastroenterology Division of HepatologyHospital General de MéxicoMexico City 06720Mexico Departmanet of Anesthesiology Hospital General de MéxicoMexico City 06720Mexico

Hepatocellular carcinoma(HCC)is one of the most common cancers in the world and is one of the leading indications for liver transplantation,liver transplantation is the gold standard treatment for end stage liver *** is based up on radiological characteristics and rarely biopsy *** treatment must be individualized to each patient to improve recurrences and *** this article,we focus on the different selection criteria for liver *** study aimed to investigate the distribution laws and research frontiers of international literature,so as to present holistic bibliometric evaluation of the studies on 5-year survival and disease-free recurrence in 5 years,according to hepatocarcinoma criteria for liver *** paper aims to review and analyze 5-year survival and disease-free recurrence based on hepatocarcinoma criteria for liver *** systematically examines and summarizes distribution characteristics and research frontiers through bibliometric analysis.A bibliographic search was implemented in PubMed/Medline,Clinical Key,science Direct and Index Medicus with MEsH terms,from the year 1996–*** selected for transplantation using the Metroticket 2.0(MT2)criteria had the highest overall survival along with patients selected for transplantation using the Milan Criteria had the best 5-year disease-free *** Metroticket 2.0 criteria(MT2)and Milan Criteria(MC)have shown the most favorable post-transplant outcomes for patients with hepatocellular carcinoma(HCC).However,MC demonstrated the best 5-year disease-free recurrence rate,underscoring the significance of taking into account tumor morphology and biology when determining the eligibility of HCC patients for liver *** distribution characteristics and research frontiers by bibliometrics concerning prognostic role of selection criteria for liver transplantation in patients with hepatocellular carcinoma the collaboration

关键词： Hepatocellular carcinoma liver transplantation survival Criteria Recurrence Bibliometrics