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In vitro Antibacterial Activity of Moringa oleifera Ethanolic Extract against Tomato Phytopathogenic Bacteria

Phyton-International Journal of Experimental Botany 2021年第3期90卷 895-906页

作者： Roberto Arredondo-Valdés Francisco D.hernández-Castillo Mario Rocandio-Rodríguez Julia C.Anguiano-Cabello Madai Rosas-Mejía Venancio Vanoye-Eligio Salvador Ordaz-Silva Imelda V.López-Sánchez Laura D.Carrazco-Peña Julio C.Chacón-hernández Institute of Applied Ecology Universidad Autónoma de TamaulipasCiudad VictoriaTamaulipas87019México Parasitology Department Universidad Autónoma Agraria Antonio NarroSaltillo25315México Health Area Universidad La Salle SaltilloSaltillo25298México Faculty of Engineering and Business San Quintin Universidad Autónoma de Baja CaliforniaSan Quintín22930México

The tomato(Solanum lycopersicum L.)is one of the world’s most important vegetable ***,phytopathogenic bacteria affect the yield and quality of tomato cultivation,like Agrobacterium tumefeciens(At),Clavibacter michiganensis ***(Cmm),Pseudomonas syringae ***(Pst),Ralstonia solanacearum(Rs),and Xanthomonas axonopodis(Xa).Synthetic chemical products are used mostly on disease plant control,but overuse generates resistance to bacterial *** study aimed to evaluate the in vitro antibacterial activity of the ethanolic extract of Moringa oleifera *** against At,Cmm,Pst,Rs,and Xa,as well as information about this plant species’chemical *** activity against pathogens observed by microplate technique,phytochemical screening,and FTIR analysis revealed different bio-active compounds on ethanolic extracts with antibacterial *** growth inhibition rate ranged between 0.08%and 99.94%.The inhibitory concentration,IC50,required to inhibit 50%of At,Cmm,Pst,Rs,and Xa bacterial growth,was 276.67,350.48,277.85,351.49,and 283.22 mg/L,*** of phytopathogen bacteria’s growth increased as the concentrations of the extract also *** oleifera extract can be recommended as a potent bio-bactericide.

关键词： Biological control secondary metabolites tomato crop inhibitory concentration botanical extract

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Yearly variation in the structure and diversity of a non-breeding passerine bird community in a Mediterranean wetland

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Avian Research 2020年第3期11卷 238-245页

作者： Juan Arizaga Daniel Alonso ArinCrespo Xabier Esparza Efrén Fernández Iógo López David Martín antonio Vilches Department of Ornithology Aranzadi Sciences Society S. Sebastián Spain

Background:The dynamics and structure of many bird communities are changing due to the global warming and changes in the land use and *** Ebro Valley constitutes one of the chief wintering areas for several passerine species in Iberia,and the reed beds spread across this Valley concentrate huge numbers of birds that use them to roost,while the surrounding agricultural areas serve as main foraging *** aims of this work are(1)to quantify how variable a non-breeding passerine bird community associated to a reed bed area in the Ebro Valley is,and,(2)to test for the effect of weather on possible annual fluctuations in species’proportions at a regional/local ***:We used for that ringing data collected at Badina de Escudera lagoon(Navarra)over a 12-year ***:Though,overall,the assemblage did not vary strongly among years(most similarity values were>0.8),we still found a significant linear effect of year on the proportion of captures of Reed Buntings(Emberiza schoeniclus),i.e.,the dominant species detected in our passerine *** increasing loss of weight of Reed Buntings in the community was due to a progressive decrease in its ***:The structure and diversity of passerine community in Badina Escudera was not influenced by meteorological conditions at a local scale,suggesting that local weather would not have an impact on numbers of Reed Buntings in winter.

关键词： Navarra Emberiza schoeniclus Ringing Long-term monitoring

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A Reward Functional to Solve the Replacement Problem

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Intelligent Control and Automation 2012年第4期3卷 413-418页

作者： Eva Selene hernández Gress Oscar Montano Arango Jose Ramon Corona Armenta antonio Oswaldo Ortega Reyes Academic Area of Engineering Autonomous University of HidalgoPachucaMéxico

The replacement problem can be modeled as a finite, irreducible, homogeneous Markov Chain. In our proposal the problem was modeled using a Markov decision process and then, the instance was optimized using dynamic programming. We proposed a new functional that includes a reward functional, that can be more helpful in processing industries because it considerate instances like incomes, maintenance costs, fixed costs to replace equipment, purchase price and salvage values;and this functional can be solved with dynamic programming and used to make effective decisions. Two theorems are proved related with this new functional. A numerical example is presented in order to demonstrate the utility of this proposal.

关键词： Markov Chains Dynamic Programming Replacement Problem

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Metastatic hormone-sensitive prostate cancer:How should it be treated?

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World Journal of Clinical Oncology 2021年第2期12卷 43-49页

作者： Fernando López-Campos Carmen gonzález-San Segundo antonio JoséConde-Moreno Felipe Couñago Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology HGU Gregorio MarañonComplutense UniversityMadrid 28007Spain Department of Radiation Oncology Hospital Universitario y Politécnico La Fe.CEU Cardenal Herrera UniversityValencia 46026Spain Department of Radiation Oncology Hospital Universitario Quirón Salud MadridHospital La LuzUniversidad Europea de Madrid(UEM)Madrid 28223Spain

The number of treatment options for metastatic hormone-sensitive prostate cancer has increased substantially in recent *** classic treatment approach for these patients—androgen-deprivation therapy alone—is now considered *** randomized phase III clinical trials have demonstrated significant clinical benefits—including significantly better overall survival and quality of life—for treatments that combine androgen-deprivation therapy with docetaxel,abiraterone acetate,enzalutamide,apalutamide,and/or radiotherapy to the primary *** a result,these approaches are now included in treatment guidelines and considered standard of ***,the different treatment strategies have not been directly compared,and thus treatment selection remains at the discretion of the individual physician or,ideally,a multidisciplinary *** the range of available treatment approaches with varying toxicity profiles,treatment selection should be individualized based on the patient’s clinical characteristics and preferences,which implies active patient participation in the decision-making *** the present document,we discuss the changing landscape of the management of patients with metastatic hormonesensitive prostate cancer in the context of several recently-published landmark randomized *** addition,we discuss several unresolved issues,including the optimal sequencing of systemic treatments and the incorporation of local treatment of the primary tumour and metastases.

关键词： Metastatic hormone-sensitive prostate cancer Androgen-receptor signaling inhibitors Abiraterone acetate Enzalutamide Apalutamide Docetaxel

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Alcoholic liver disease and hepatitis C virus infection

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World Journal of Gastroenterology 2016年第4期22卷 1411-1420页

作者： Ignacio Novo-Veleiro Lucía Alvela-Suárez antonio-Javier Chamorro Rogelio gonzález-Sarmiento Francisco-Javier Laso Miguel Marcos Department of Internal Medicine University Hospital of Santiago de Compostela37007 SalamancaSpain Spanish Working Group on Alcohol and Alcoholism Spanish Society of Internal Medicine28016 MadridSpain Alcoholism Unit Department of Internal MedicineUniversity Hospital of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL37007 SalamancaSpain Molecular Medicine Unit Department of MedicineUniversity of SalamancaInstitute of Biomedical Research of Salamanca-IBSAL37007 SalamancaSpain

Alcohol consumption and hepatitis C virus(HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher(up to 50%) in alcoholic patients than in the general po pulation. However, the presence of advanc e d alcoholic liver disease(ALD) or intravenous drug use(IDU) may have confounded the results of previous studies, and the real prevalence of HCV infection in alcoholic patients without ALD or prior IDU has been shown to be lower. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefi t from addi tionalsupport during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. Patients with alcohol dependence and HCV infection, can be treated with acamprosate, nalmefene, topiramate, and disulfiram, although baclofen is the only drug specifically tested for this purpose in patients with ALD and/or HCV infection.

关键词： Alcohol use disorder Alcohol dependence Alcoholism Alcoholic liver disease Hepatitis C virusinfection Hepatitis C virus infection treatment

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GOECP/SEOR radiotherapy guidelines for small-cell lung cancer

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World Journal of Clinical Oncology 2021年第3期12卷 115-143页

作者： Felipe Couñago Carolina de la Pinta Susana gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust Joséantonio gonzálezFerreira AnaÁlvarez gonzález Francesc Casas Department of Radiation Oncology Hospital Universitario Quirónsalud MadridHospital La LuzUniversidad Europea de MadridMadrid 28223MadridSpain Department of Radiation Oncology Hospital Universitario Ramón y CajalMadrid 28034Spain Department of Radiation Oncology Hospital Universitario La PrincesaMadrid 28006Spain Department of Radiation Oncology GenesisCare MadridMadrid 28043Spain Department of Radiation Oncology Hospital General UniversitarioValencia 46014Spain Department of Radiation Oncology Hospital Clínico Universitario Santiago de CompostelaSantiago de Compostela 15706Spain Department of Radiation Oncology Hospital Universitario Virgen del RocíoSevilla 41013Spain Department of Radiation Oncology Fundación Instituto Valenciano de OncologíaValencia 46009Spain Department of Radiation Oncology GenesisCare-SpainSevilla 41092Spain Department of Radiation Oncology HGU Gregorio MarañónMadrid 28007Spain Department of Radiation Oncology Thoracic UnitHospital ClinicBarcelona 08036Spain

Small cell lung cancer(SCLC)accounts for approximately 20%of all lung *** main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to *** cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic *** 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of *** guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and ***,we discuss the main indications for reirradiation in local recurrence.

关键词： Small cell lung cancer Chemotherapy Hyperfractionated radiation therapy Prophylactic brain irradiation Brain metastases Reirradiation

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Tax avoidance and earnings management:a neural network approach for the largest European economies

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Financial Innovation 2023年第1期9卷 558-582页

作者： Francisco J.Delgado Elena Fernández‑Rodríguez Roberto García‑Fernández Manuel Landajo antonio Martínez‑Arias Department of Economics Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain Department of Accounting Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain Department of Applied Economics Faculty of Economics and BusinessUniversity of OviedoAvda.del CristoS/N33071 OviedoSpain

In this study,we investigate the relationship between tax avoidance and earnings management in the largest five European Union economies by using artificial neural network *** methodology allows us to deal with nonlinearities detected in the data,which is the principal contribution to the previous *** ana-lyzed Compustat data for Germany,the United Kingdom,France,Italy,and Spain for the 2006–2015 period,focusing on discretionary *** considered three tax avoidance measures,two based on the effective tax rate(ETR)and one on book-tax differences(BTD).Our results indicate the presence of nonlinear patterns and a posi-tive,statistically significant relationship between discretionary accruals and both ETR indicators implying that when companies resort to earnings management,a larger tax-able income—and thus higher ETR and lesser tax avoidance–would ***,as also highlighted by the fact that discretionary accruals do not appear to affect BTD,our evidence does not suggest that companies are exploiting tax manipulation to reduce their tax payments;thus,the gap between accounting and taxation seems largely unaf-fected by earnings management.

关键词： Tax avoidance Earnings management Artificial neural networks European Union

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Comparison of clinical outcomes between unrelated single umbilical cord blood and"ex-vivo"T-cell depleted haploidentical transplantation in children with hematological malignancies

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World Journal of Pediatrics 2021年第6期17卷 609-618页

作者： Carmen Gomez-Santos Marta gonzalez-Vicent Blanca Molina Natalia Deltoro Blanca Herrero Julia Ruiz antonio Perez-Martinez Miguel A Diaz Department of Pediatrics Hematopoietic Stem Cell Transplantation UnitHospital Infantil Universitario"Nino Jesus"Menedez Pelayo 6528009 MadridSpain Hospital Infantil Universitario"La Pa"Madrid MadridSpain

Background Over the last two decades,umbilical cord blood(UCB)and haploidentical transplantation(HaploHSCT)have emerged as alternative sources of hematopoietic stem cell for allogeneic *** are few retrospective studies and no prospective studies comparing both types of alternative transplantation in pediatric *** We analyzed the data of 134 children with hematological malignancies who received a hematopoietic stem cell transplantation from a single umbilical cord blood(UCB)(n=42)or an"tex-vivo"T-cell depleted transplant from a haploi-dentical-related donor(HaploHSCT)(n=92)between 1996 and *** recovery was faster after HaploHSCT than the UCB transplant group(median times to neutrophil and platelet recovery:13 vs.16 days,10 vs.57 days,respectively)(P<0.001).The HaploHSCT group had a significantly early immune reconstitution based on NK and CD8+T cells compared with the UCB ***,after the first year *** had a lower number of CD4+ T and B lymphocytes compared with the UCB transplant *** cumulative incidence of TRM was 29±8%in the HaploHSCT group versus 40±5%in the UCB *** incidence was 21±7%in the HaploHSCT group and 19±8%in the UCB *** of DFS was 58±8%in the HaploHSCT group versus 40±9%in the UCB group(P=0.051).Conclusions TCD haploidentical transplant is associated with advantages in terms of engraftment and early immune reconstitution *** haploidentical transplant was associated with lower incidence of infectious and non-infectious complications,especially in the early phases of the transplant compared with UCB transplant ***,there are no advantages in transplant outcomes compared with UCB transplant.

关键词： Children Cord blood transplant Hematologic malignancies Immune reconstitution TCD haploidentical transplant

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Gastric necrosis: A late complication of nissen fundoplication

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World Journal of Gastrointestinal Surgery 2014年第9期6卷 183-186页

作者： Javier Salinas Tihomir Georgiev Juan antonio gonzález-Sánchez Elena López-Ruiz José antonio Rodríguez-Montes Department of General Surgery Hospital Universitario La Paz Department of Pathology Hospital Universi-tario La Paz

Gastric necrosis is a rare condition because of the rich blood supply and the extensive submucosal vascular network of the stomach. "Gas-bloat" syndrome is a well known Nissen fundoplication postoperative complica-tion. It may cause severe gastric dilatation, but very rarely an ischemic compromise of the organ. Other factors, such as gastric outlet obstruction, may concur to cause an intraluminal pressure enough to blockade venous return and ultimately arterial blood supply and oxygen deliver, leading to ischaemia. We report a case of a 63-year-old women, who presented a total gastric necrosis following laparoscopic Nissen fundoplication and a pyloric phytobezoar which was the trigger event. No preexisting gastric motility disorders were present by the time of surgery, as demonstrated in the preop-erative barium swallow, thus a poor mastication(patient needed no dentures) of a high fiber meal(cabbage) may have been predisposing factors for the develop-ment of a bezoar in an otherwise healthy women at the onset of old age. A total gastrectomy with esophagojejunostomy was performed and patient was discharged home after a 7-d hospital stay with no immediate com-plications. We also discuss some technical aspects of the procedure that might be important to reduce the incidence of this complication.

关键词： Gastric dilatation Gastric outlet obstruction Necrosis Fundoplication Nissen operation

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Unusual clinical presentation of oral pyogenic granuloma with severe alveolar bone loss:A case report and review of literature

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World Journal of Clinical Cases 2023年第16期11卷 3907-3914页

作者： Sarah Monserrat LomelíMartínez Dennisse Bocanegra Morando Ana Esther Mercado gonzález Juan Ramón Gómez Sandoval Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Wellbeing and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludGuadalajara 44340Mexico Antiguo Hospital Civil de Guadalajara“Fray antonio Alcalde” Guadalajara 44280Mexico Research Institute of Dentistry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico

BACKGROUND Pyogenic granuloma(PG)is a localized,reddish and vascularized hyperplastic lesion of the connective tissue which occurs in the oral *** most cases,the presence of this lesion does not show alveolar bone *** pathology is diagnosed clinically with some ***,the diagnosis and treatment are usually corroborated with histopathological *** SUMMARY Three clinical cases of PG associated with bone loss were described in this *** three patients presented tumor-like growth which bled on touch,and were associated with local irritant *** showed bone *** cases were treated with conservative surgical *** scarring was satisfactory,and there was no case of *** diagnoses were based on clinical findings,and were confirmed *** The occurrence of oral PG with bone loss is ***,clinical and radiographic evaluations are important for the diagnosis.

关键词： Hyperplastic lesion Pyogenic granuloma Alveolar bone loss Case report

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