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Cytoreductive surgery and HIPEC after neoadjuvant chemotherapy for advanced epithelial ovarian cancer

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World Journal of Obstetrics and Gynecology 2013年第4期2卷 167-175页

作者： Marco Lotti Luisa Maria Busci Luca Campanati Fausto Catena Federico Coccolini Naoual Bakrin Pierandrea De Iaco giorgio Ercolani Giuseppe Grosso Michele Pisano Elia Poiasina Diego Rossetti Martina Rossi Claudio Zamagni Paolo Bertoli antonio Daniele Pinna Luigi Frigerio Luca Ansaloni Unit of General Surgery 1 Papa Giovanni XXIII Hospital 24128 Bergamo Italy Unit of Gynecology and Obstetrics Papa Giovanni XXIII Hospital 24128 Bergamo Italy Unit of General Surgery St.Orsola-Malpighi University Hospital 40138 Bologna Italy Department of Gynecology Lyon Sud Hospital69310 Pierre Benite France Unit of Gynecology and Obstetrics St.Orsola-Malpighi University Hospital V40138 Bologna Italy Medical Oncology St.Orsola-Malpighi University Hospital 40138 Bologna Italy

AIM: To reduce postoperative complications and to make possible an optimal cytoreduction, neoadjuvant chemotherapy(NACT) followed by interval debulking surgery has been applied with encouraging results. METHODS: Between December 2009 and February 2012, patients with stage ⅢC-Ⅳ epithelial ovarian cancer(EOC) underwent diagnostic laparoscopy, to assess the feasibility of optimal debulking surgery. The modifi ed Fagotti score was applied to assess the feasibility of resection with zero residual tumor. Patients who were not candidate for upfront debulking surgery were submitted to NACT, then reassessed according to the RECIST 1.1 criteria and submitted to cytoreductive surgery(CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) if they showed clinical response or stable disease. The remaining cycles of adjuvant systemic chemotherapy(ASCT) were administered postoperatively, to complete 6 cycles of systemic ***: Nine patients were included. Clinical response to NACT was complete in 3 patients and partial in 5 patients; one patient had stable disease. All patients underwent CRS resulting in CC0 disease prior to HIPEC. Average operative time was 510 min. Average intensive care unit stay was 2 d. Average postoperative hospital stay was 25 d. No postoperative mortality was observed. One patient experienced pelvic abscess. One patient refused ASCT. The remaining 8 patients started ASCT. Average time to chemotherapy was 36 d. All patients are alive, with an average follow up of 11 mo. Eight patients are disease-free at follow ***: HIPEC after CRS for advanced EOC is feasible with acceptable morbidity and mortality. NACT may increase the chance for achieving complete cytoreduction. Phase 3 studies are needed to determine the effects of HIPEC on survival.

关键词： Peritoneal carcinomatosis Ovarian cancer Cytoreductive surgery Intraperitoneal chemotherapy Hyperthermic intraperitoneal chemotherapy Hyperthermia

Hepatitis C virus-related B cell subtypes in non Hodgkin's lymphoma

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World Journal of Hepatology 2011年第11期3卷 278-284页

作者： Adriano M Pellicelli Massimo Marignani Valerio Zoli Mario Romano Aldo Morrone Lorenzo Nosotti Giuseppe Barbaro antonio Picardi Umberto Vespasiani Gentilucci Daniele Remotti Cecilia D'Ambrosio Caterina Furlan Fabrizio Mecenate Ettore Mazzoni Ignazio Majolino Roberto Villani Arnaldo Andreoli giorgio Barbarini Liver Unit Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense 8700149 Rome Italy Department of Digestive and Liver Disease Azienda Ospedaliera Sant’AndreaVia Grottarossa 1035/1039000189 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Liver Unit Ospedale Sandro PertiniVia dei Monti Tiburtini 38500157 Rome Italy Azienda Ospedaliera San Camillo Forlanini Circonvallazione Gianicolense87 00149 Rome Italy Medicine of Migration National Institute for Migrant Health and Poverty Via di S. Gallicano 25/a 00153Rome Italy Department of Medical Pathophysiology University of Rome "La Sapienza" Viale del Policlinico 15500161 Rome Italy Liver Unit Campus Biomedico UniversityVia álvaro del Portillo 21 00128Rome Italy Histopathology Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149Rome Italy Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 Rome Italy Department of Infectious and Tropical Disease University of Rome"La Sapienza"Viale del Policlinico155 00161 Rome Italy Liver Unit Ospedale Villa BetaniaVia Niccolò Piccolomini 2700165 RomeItaly Liver Unit Policlinico CasilinoVia Casilina104900169 Rome Italy Hematology and Bone Marrow Transplantation Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Liver Unit Azienda Ospedaliera San Camillo ForlaniniCirconvallazione Gianicolense 8700149 RomeItaly Infectious and Parasitic Diseases Policlinico San Matteo P.zzale Golgi 2 2710 PaviaItaly

AIM:To evaluate if indolent B cell-non Hodgkin's lymphoma(B-NHL) and diffuse large B-cell lymphoma(DLBCL) in hepatitis C virus(HCV) positive patients could have different biological and clinical characteristics requiring different management ***:A group of 24 HCV related B-NHL patients(11 indolent,13 DLBCL) in whom the biological and clinical characteristics were described and *** with DLBCL were managed with the standard of care of *** with indolent HCV-related B-NHL were managed with antiviral treatment pegylated interferon plus ribavirin and their course *** outcomes of the different approaches were ***:Patients with DLBCL had a shorter duration of HCV infection and a higher prevalence of HCV genotype 1 compared to patients with indolent B-NHL in which HCV genotype 2 was the more frequent *** of the 9 patients with indolent HCV-relatedB-NHL treated with only antiviral therapy,achieved a complete response of their onco-haematological disease(55%).Seven of the 13 DLBCL patients treated with immunochemotheraphy obtained a complete response(54%).CONCLUSION:HCV genotypes and duration of HCV infection differed between B-NHL *** lymphomas can be managed with antiviral treatment,while DLBCL is not affected by the HCV infection.

关键词： Hepatitis C virus infection Diffuse large B cell lymphoma Indolent lymphoma Pegylated interferon Lymphomagenesis

Mosaicism of a novel variant in the ANKRD11 gene in a child with a mild KBG phenotype:A case report

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World Journal of Medical Genetics 2023年第2期11卷 21-27页

作者： Roberto Franceschi Francesca Rivieri antonio Novelli Daniele Ferretti Adriano Anesi Massimo Soffiati Giulia Porretti Evelina Maines Mafalda Mucciolo giorgio Radetti Department of Pediatrics S.Chiara Hospital of TrentoAPSSTrento 38122Italy Genetic Unit Laboratory of Clinical PathologyDepartment of LaboratoriesAPSSTrento 38122Italy Laboratory of Medical Genetics Ospedale Pediatrico Bambino GesùRome 00165Italy Human Genetics Laboratory Ospedale Pediatrico Bambino GesùRome 00165Italy Department of Pediatrics S.Chiara General HospitalAPSSTrento 38122Italy Department of Radiology S.Chiara General HospitalAPSSTrento 38122Italy Department of Pediatrics General Hospital BolzanoMarienklinikBolzano 39100Italy

BACKGROUND KBG syndrome is likely underdiagnosed because of mild and non-specific features in some affected patients especially before the upper permanent central incisors eruption at about the age of 7-8 *** mosaicisms are usually recognized in the parents only after a typically affected son is diagnosed with KBG *** describe for the first time the mosaicism of a novel variant in a child with a mild KBG *** SUMMARY Our patient presented at 24 mo of age with short stature,hand abnormalities,facial dysmorphism and mild developmental *** hypoplasia and central hypothyroidism were also *** next generation sequencing(NGS)analysis we found a novel deletion in the ANKRD11 gene(c.4880_4893del.),that can be classified as likely pathogenic for the syndrome,with the percentage of mutated allele of 36%.We considered this finding as causative of the mild and non-specific phenotype for KBG syndrome in our patient,as previously reported in adults.A heterozygous variant in HESX1 gene,classified as variant of uncertain significance,but suspected of causing pituitary hypoplasia and hormonal deficiency,was also *** patient started levothyroxine and growth hormone *** The increased use of NGS analysis may expand the phenotypic spectrum of KBG syndrome because it allows genetic diagnosis of somatic mosaicisms also in children.

关键词： ANKRD11 KBG Mosaic HESX1 Child Case report

Boceprevir or telaprevir in hepatitis C virus chronic infection:The Italian real life experience

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World Journal of Hepatology 2016年第22期8卷 949-956页

作者： antonio Ascione Luigi Elio Adinolfi Pietro Amoroso Angelo Andriulli Orlando Armignacco Tiziana Ascione Sergio Babudieri giorgio Barbarini Michele Brogna Francesco Cesario Vincenzo Citro Ernesto Claar Raffaele Cozzolongo Giuseppe D’Adamo Emilio D’Amico Pellegrino Dattolo Massimo De Luca Vincenzo De Maria Massimo De Siena Giuseppe De Vita antonio Di Giacomo Rosanna De Marco giorgio De Stefano Giulio De Stefano Sebastiano Di Salvo Raffaele Di Sarno Nunzia Farella Laura Felicioni Basilio Fimiani Luca Fontanella Giuseppe Foti Caterina Furlan Francesca Giancotti Giancarlo Giolitto Tiziana Gravina Barbara Guerrera Roberto Gulminetti Angelo Iacobellis Michele Imparato Angelo Iodice Vincenzo Iovinella antonio Izzi Alfonso Liberti Pietro Leo Gennaro Lettieri Ileana Luppino Aldo Marrone Ettore Mazzoni Vincenzo Messina Roberto Monarca Vincenzo Narciso Lorenzo Nosotti Adriano Maria Pellicelli Alessandro Perrella Guido Piai antonio Picardi Paola Pierri Grazia Pietromatera Francesco Resta Luca Rinaldi Mario Romano Angelo Rossini Maurizio Russello Grazia Russo Rodolfo Sacco Vincenzo Sangiovanni antonio Schiano antonio Sciambra Gaetano Scifo Filomena Simeone Annarita Sullo Pierluigi Tarquini Paolo Tundo Alfredo Vallone Depart-ment of Medicine Center for Liver Diseases "Buon Consiglio" -Fatebenefratelli Hospital Internal Medicine Unit Second University of Naples VI Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Gastro- enterology Casa Sollievo Sofferenza Hospital IRCCS Division of Infectious Diseases Belcolle Hospital IX Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Clinical of Infectious Disease University of Sassari Infectious Disease IRCCS San Matteo Division of Infectious Diseases and Liver Unit "G. Iazzolino" Hospital Division of Infectious Diseases "Annunziata" Hospital Depart-ment of Internal Medicine Umberto I Hospital Internal Medicine Ospedale Evangelico Villa Betania Division of Gastroenterology IRCCS "S.de Bellis" Hospital Internal Medicine Unit Pescara-Penne Hospital Gastroenterology Unit Marcianise Hospital Liver Unit AORN Cardarelli Liver Unit Policlinico "Mater Domini" Service of Medical Day Hospital "Rummo" Hospital Internal Medicine Regina Margherita Hospital Division of Gastroenterology "Annunziata" Hospital Infectious Disease Matera Hospital First Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Division of Infectious Diseases AO Melacrino- Bianchi-Morelli Infectious and Tropical Disease Policlinico Umberto I Division of Infectious Disease Maria SS Addolorata Hospital Division of Infectious Diseases S. Anna and S. Sebastiano Hospital Outpatients Service for Liver Diseases "Loreto Crispi" Hospital V Division of Infectious Diseases Cotugno Hospital AORN "Ospedali dei Colli" Department of Medical Surgical Neurological Geriatric and Metabolic Sciences Second Univer-sity of Naples Liver Unit Policlinico Casilino Medicine and Health Unit for Prisoners Belcolle Hospital Internal Medicine Unit "Ascalesi" Hospital Gastrointestinal and Liver Department National Institute for Health Migration and Poverty Liver Unit Azienda Ospedaliera San Camillo Forlanini VII Division of Infectious Diseases

AIM: To check the safety and efficacy of boceprevir/telaprevir with peginterferon/ribavirin for hepatitis C virus(HCV) genotype 1 in the real-world settings. METHODS: This study was a non-randomized, observational, prospective, multicenter. This study involved 47 centers in Italy. A database was prepared for the homogenous collection of the data, was used by all of the centers for data collection, and was updated continuously. All of the patients enrolled in this study were older than 18 years of age and were diagnosed with chronic infection due to HCV genotype 1. The HCV RNA testing was performed using COBAS-Taq Man2.0(Roche, LLQ 25 IU/m L). RESULTS: All consecutively treated patients were included. Forty-seven centers enrolled 834 patients as follows: Male 64%; median age 57(range 18-78), of whom 18.3% were over 65; mean body mass index 25.6(range 16-39); genotype 1b(79.4%); diagnosis of cirrhosis(38.2%); and fibrosis F3/4(71.2%). The following drugs were used: Telaprevir(66.2%) and PEG-IFN-alpha2a(67.6%). Patients were na?ve(24.4%), relapsers(30.5%), partial responders(14.8%) and null responders(30.3%). Overall, adverse events(AEs) occurred in 617 patients(73.9%) during the treatment. Anemia was the most frequent AE(52.9% of cases), especially in cirrhotic. The therapy was stopped for 14.6% of the patients because of adverse events or virological failure(15%). Sustained virological response was achieved in 62.7% of the cases, but was 43.8% in cirrhotic patients over 65 years of age. CONCLUSION: In everyday practice, triple therapy is safe but has moderate efficacy, especially for patients over 65 years of age, with advanced fibrosis, nonresponders to peginterferon + ribavirin.

关键词： Boceprevir Telaprevir Chronic hepatitis Antiviral therapy Peg-interferon Ribavirin

Impaired diastolic function in nave untreated human immunodeficiency virus infected patients

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World Journal of Cardiology 2010年第4期2卷 98-103页

作者： Ugo Oliviero Giovanni Bonadies giorgio Bosso Maria Foggia Valentina Apuzzi Mariarosaria Cotugno antonio Valvano Enrico Leonardi Guglielmo Borgia Giuseppe Castello Raffaele Napoli Luigi Saccà Department of Inter-nal Medicine University Federico Ⅱ80131 NaplesItaly Department of Infectious Diseases University Federico Ⅱ80131 NaplesItaly National Cancer Institute G.Pascale Foundation80131 NaplesItaly

AIM:To evaluate cardiac function and structure in un-treated human immunodeficiency virus(HIV) patients without clinical evidence of cardiovascular ***:Fifty-three nave untreated HIV-infected patients and 56 healthy control subjects underwent clinical assessment,electrocardiography(ECG) and echocardiography,including tissue doppler ***,a set of laboratory parameters was obtained from all subjects,including HIV-RNA plasma levels,CD4 cell counts and tumor necrosis factor-α ***:The two groups showed normal ECG traces and no differences regarding systolic morphologic *** contrast,a higher prevalence of left ventricular diastolic dysfunction(abnormal relaxation or pseudonormal filling pattern) was found in the HIV patients(36% vs 9% in patients and controls,respec-tively,P <0.001).CONCLUSION:Subclinical cardiac abnormalities ap-pear in an early stage of the HIV infection,indepen-dent of antiretroviral *** data suggest that HIV per se plays a role in the genesis of diastolic dys-function.

关键词： Diastolic function Human immunodeficiency virus Naive subjects Cardiovascular risk factors

Management of chronic heart failure:Role of home echocardiography in monitoring care programs

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World Journal of Cardiology 2012年第3期4卷 72-76页

作者： Silvia Soreca Sergio Aprile Andrea Cardone Giovanni Carella Biagio Fimiani Franco Guarnaccia Giosuè Santoro Valentina Apuzzi giorgio Bosso antonio Valvano Giovanni Zito Ugo Oliviero Associazioni Regionali Cardiologi Ambulatoriali CampaniaVia M.Testa 884127 SalernoItaly Department of Clinical Medicine and Cardiovascular Sciences Federico Ⅱ UniversityVia S.Pansini 580131 NaplesItaly

AIM:To identify a possible role of home echocardiography for monitoring chronic heart failure(CHF)***:We prospectively investigated 118 patients hospitalized during the last year for CHF who could not easily reach the pertaining District Healthcare *** patients were followed up with 2 home management programs:one including clinical and electrocardiographic evaluations and also periodic home echocardiographic examinations(group A),the other including clinical and electrocardiographic evaluations only(group B).RESULTS:At the end of the 18-mo follow-up no significant differences were observed between the 2 groups as regards the primary endpoint:rehospitalization occurred in 4 patients of the group A and in 6 patients of the group B;major cardiovascular events occurred in 2 and in 3 patients,*** significant differences were observed with respect to the secondary endpoints:one vascular event appeared in both the groups,3 cardiovascular deaths occurred in group A and 2 in group *** significant differences were observed between the 2 groups as regards the composite endpoint of death plus ***:Home echocardiography for monitoring of CHF patients does not improve the cardiovascular *** our CHF patients,a low incidence of vascular events was observed.

关键词： Echocardiography Chronic heart failure Home monitoring Care programs Cardiovascular events

开放性网膜疝修补术中，采用保留或分离髂腹股沟神经、髂腹下神经和生殖神经方案间的影响：一项对慢性疼痛的前瞻性、多中心研究

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医学信息（手术学分册） 2007年第8期20卷 745-745页

作者： Alfieri, Sergio Rotondi, Fabio Di giorgio, Andrea Fumagalli, Uberto Salzano, antonio Di Miceli, Dario Ridolfni, Marco Pericoli Sgagari, antonio Doglietto, Giovannibattista Groin Pain Trial Group

目的：旨在评价在开放性网膜疝修补术中，通过采用不同的保留生殖股神经的生殖支、髂腹股沟神经、髂腹下神经的手术方案，是否能有效缓解慢性术后疼痛。背景：近年来，出于对其治疗和法律意义的关注，疝修补术后出现的慢性腹股沟疼痛日... 详细信息

目的：旨在评价在开放性网膜疝修补术中，通过采用不同的保留生殖股神经的生殖支、髂腹股沟神经、髂腹下神经的手术方案，是否能有效缓解慢性术后疼痛。背景：近年来，出于对其治疗和法律意义的关注，疝修补术后出现的慢性腹股沟疼痛日益引起人们的兴趣。然而，应采取何种治疗方案以保留3支腹股沟感觉神经仍存在许多争议。方法：一项由11家意大利研究中心参与多中心、前瞻性研究、募集了973例疝修补病例。要求所有手术医生报告是否每一根神经都被识别，并予以保留或分离。本研究的主要终点为评价6个月和1年时中重度慢性疼痛的情况。结果：6个月和1年随访时，分别有9．7％和4．1％的患者出现腹股沟疼痛。在6个月时，7．9％的患者为轻度疼痛，2．1％为中重度疼痛，而在1年时，3．6％的患者为轻度疼痛，0．5％的患者为中重度疼痛。单变量和多变量分析显示，并未发现与慢性疼痛存在显著相关的神经，随着未检测到的神经数量的增加，腹股沟疼痛的发生危险也随之增加。同样的，神经分离与慢性疼痛的发生明显相关。结论：目前的研究结果显示，在开放性腹股沟疝修补术中，分辨并保留神经可减少慢性失能性腹股沟疼痛，并且对于大多数6个月时出现慢性疼痛的患者，只有采取保守或内科治疗方法才能缓解其1年时的疼痛症状。

关键词：腹股沟疝修补术髂腹股沟神经生殖股神经慢性疼痛髂腹下神经多中心研究分离腹股沟疼痛

小胶质细胞在光/暗周期过程中调节海马突触传递和睡眠持续时间

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神经损伤与功能重建 2022年第5期17卷 310-310页

作者：杜一星(编译) Department of Physiology and Pharmacology Sapienza University of Rome Axe Neurosciences Centre de Recherche du CHU de Québec Université Laval Quebec City Department of Neurology San Raffaele of Cassino 4. National Research Council Institute of Biochemistry and Cell Biology (EMMA/Infrafrontier/IMPC ) International Campus "A. Buzzati-Traverso" INRAE Bordeaux INP NutriNeuro UMR 1286 Bordeaux University Tecniplast S.P.A. Buguggiate Department of Molecular Medicine Sapienza University INSERM Neurocentre Magendie Physiopathologie de la Plasticité Neuronale Division of Medical Sciences University of Victoria The Department of Biochemistry and Molecular Biology The University of British Columbia Department of Physiology and Pharmacology Sapienza University Laboratory affiliated to Istituto Pasteur Italia Department of Neurophysiology Neuropharmacology Inflammaging IRCCS Neuromed

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研... 详细信息

小胶质细胞是大脑的常驻巨噬细胞,通过感知神经元活动并支持突触重塑和可塑性积极促进脑实质的稳态。虽然已有研究表明星形胶质细胞在睡眠中的不同作用,但小胶质细胞在调节睡眠/觉醒周期和白天不同阶段调节突触活动中的作用尚未深入研究。以光作为授时提示,我们研究了用集落刺激因子-1受体拮抗剂PLX5622消除小胶质细胞对雄性小鼠睡眠/觉醒周期和海马突触传递的影响。我们的数据表明,小胶质细胞几乎完全的耗竭会增加NREM睡眠的持续时间并减少海马兴奋性神经传递。由于cx3cr1GFP/GFP小鼠显现与PLX5622处理的小鼠中发现的相同情况,趋化因子fractalkine受体CX3CR1在这些效应中起相关作用。此外,在光照阶段小胶质细胞表达较低水平的cx3cr1;当培养的小胶质细胞受到ATP(一种在睡眠期间释放的嘌呤能分子)的刺激时其cx3cr1表达降低。我们的研究结果表明,小胶质细胞参与调节睡眠,调整其cx3cr1表达以响应光/暗阶段,并以时相依赖性方式调节突触活动。

关键词： cx3cr1 脑电图长期增强小胶质细胞耗竭微型兴奋性突触后电流睡觉眠自发兴奋性突触后电流